pentobarbital has been researched along with Sarcoma 180 in 2 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Sarcoma 180: An experimental sarcoma of mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Correlation between antitumor activity and effects on some biological properties, such as phagocytic activity of the reticuloendothelial system, the third component of complement (C3) activation, hepatic drug-metabolizing activities and pentobarbital-induced narcosis, of antitumor agents from various natural sources such as B B (Broncasma Berna), GU-P (Grifora umbellata polysaccharide), OK-432, PS-K (Polysaccharide Kureha), and RA-P (Rumex acetosa polysaccharide) were studied with female ICR mice implanted with Sarcoma 180 solid tumor." | 3.67 | Effects of the antitumor agents from various natural sources on drug-metabolizing system, phagocytic activity and complement system in sarcoma 180-bearing mice. ( Ito, H, 1986) |
| "Seven-day Ehrlich ascites tumor-bearing animals treated with pentobarbital slept about three times longer than normal mice, but both groups awoke at the same plasma levels of the unbound drug." | 1.25 | Physiological disposition of pentobarbital in tumor-bearing mice. ( Beck, WT; Fabro, S; Mandel, HG, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beck, WT | 1 |
| Mandel, HG | 1 |
| Fabro, S | 1 |
| Ito, H | 1 |
2 other studies available for pentobarbital and Sarcoma 180
| Article | Year |
|---|---|
Physiological disposition of pentobarbital in tumor-bearing mice.
Topics: Animals; Blood Proteins; Carcinoma, Ehrlich Tumor; DNA, Neoplasm; Half-Life; In Vitro Techniques; Ma | 1975 |
Effects of the antitumor agents from various natural sources on drug-metabolizing system, phagocytic activity and complement system in sarcoma 180-bearing mice.
Topics: Animals; Antineoplastic Agents; Complement Activation; Complement C3; Female; Liver; Mice; Mice, Inb | 1986 |