pentobarbital has been researched along with Respiratory Insufficiency in 22 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Respiratory Insufficiency: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We tested the hypothesis that asphyxia alone can cause cardiorespiratory failure ("failure") in pentobarbital-anesthetized rats." | 3.80 | Hypoxia, not hypercapnia, induces cardiorespiratory failure in rats. ( Iscoe, S; Simpson, JA, 2014) |
| " We characterized the distribution of infant characteristics and evaluated the relationship between drug administration and any adverse event." | 1.56 | Comparative safety profile of chloral hydrate versus other sedatives for procedural sedation in hospitalized infants. ( Balevic, S; Chu, V; Clark, R; Crenshaw, EG; Dallefeld, SH; Daniel, KR; Gilleskie, ML; Greenberg, RG; Kumar, KR; Smith, DS; Smith, PB; Zimmerman, KO, 2020) |
| " Dosing of the analgesics and sedatives was based on a neonatal sedation score for ventilated infants." | 1.32 | Endogenous distress in ventilated full-term newborns with acute respiratory failure. ( Aretz, S; Licht, C; Roth, B, 2004) |
| "The results support the hypothesis that respiratory depression by barbiturates is due to GABAA receptor-mediated inhibition, with the principal effects on rhythm generation." | 1.32 | GABAA receptors mediate postnatal depression of respiratory frequency by barbiturates. ( Fregosi, RF; Iizuka, M; Luo, Z, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (72.73) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Dallefeld, SH | 1 |
| Smith, PB | 1 |
| Crenshaw, EG | 1 |
| Daniel, KR | 1 |
| Gilleskie, ML | 1 |
| Smith, DS | 1 |
| Balevic, S | 1 |
| Greenberg, RG | 1 |
| Chu, V | 1 |
| Clark, R | 1 |
| Kumar, KR | 1 |
| Zimmerman, KO | 1 |
| Simpson, JA | 1 |
| Iscoe, S | 2 |
| Othman, M | 1 |
| Gordon, SP | 1 |
| Manzke, T | 1 |
| Niebert, M | 1 |
| Koch, UR | 1 |
| Caley, A | 1 |
| Vogelgesang, S | 1 |
| Bischoff, AM | 1 |
| Hülsmann, S | 1 |
| Ponimaskin, E | 1 |
| Müller, U | 1 |
| Smart, TG | 1 |
| Harvey, RJ | 1 |
| Richter, DW | 1 |
| GETTLER, DT | 1 |
| ALLBRITTEN, FF | 1 |
| YELNOSKY, J | 1 |
| FIELD, WE | 1 |
| Aretz, S | 1 |
| Licht, C | 1 |
| Roth, B | 1 |
| Fregosi, RF | 1 |
| Luo, Z | 1 |
| Iizuka, M | 1 |
| Jacobs, R | 1 |
| Krohn, DL | 1 |
| Johansson, I | 1 |
| Linder, J | 1 |
| Bratt, P | 1 |
| Nishie, K | 1 |
| Gumbmann, MR | 1 |
| Keyl, AC | 1 |
| Vedrinne, J | 1 |
| Dô, JP | 1 |
| Doroshchuk, VP | 1 |
| Gold, MI | 1 |
| Reichenberg, S | 1 |
| Freeman, E | 1 |
| Ylitalo, P | 1 |
| Stemmer, EA | 1 |
| Crawford, DW | 1 |
| List, JW | 1 |
| Heber, RE | 1 |
| Connolly, JE | 1 |
| Hartung, R | 1 |
| Pittle, LB | 1 |
| Cornish, HH | 1 |
| Roquefeuil, B | 1 |
| Lefebvre, F | 1 |
| Kienlein, J | 1 |
| Du Cailar, J | 1 |
| Mithoefer, JC | 1 |
| Bossman, OG | 1 |
| Thibeault, DW | 1 |
| Tammisto, T | 1 |
| Birzis, L | 1 |
| Carregal, EJ | 1 |
| Ramos, JG | 1 |
| Rosenblueth, A | 1 |
1 review available for pentobarbital and Respiratory Insufficiency
| Article | Year |
|---|---|
[Serotonin receptor 1A-modulated dephosphorylation of glycine receptor α3: a new molecular mechanism of breathing control for compensation of opioid-induced respiratory depression without loss of analgesia].
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics, Opioid; Animals; Buspirone; Cyclic AMP; | 2011 |
1 trial available for pentobarbital and Respiratory Insufficiency
| Article | Year |
|---|---|
Respiratory depression in the sedated bronchitic patient rapid version of the CO2 response curve.
Topics: Bronchitis; Carbon Dioxide; Clinical Trials as Topic; Humans; Pentobarbital; Placebos; Respiration; | 1969 |
20 other studies available for pentobarbital and Respiratory Insufficiency
| Article | Year |
|---|---|
Comparative safety profile of chloral hydrate versus other sedatives for procedural sedation in hospitalized infants.
Topics: Chloral Hydrate; Diagnostic Imaging; Diagnostic Techniques, Ophthalmological; Electroencephalography | 2020 |
Hypoxia, not hypercapnia, induces cardiorespiratory failure in rats.
Topics: Anesthesia; Animals; Arterial Pressure; Asphyxia; Diaphragm; Heart Failure; Heart Rate; Heart Ventri | 2014 |
Repeated inspiratory occlusions in anesthetized rats acutely increase blood coagulability as assessed by thromboelastography.
Topics: Adjuvants, Anesthesia; Anesthesia; Animals; Blood Coagulation; Continuous Positive Airway Pressure; | 2010 |
EFFECT OF ALCOHOL INTOXICATION ON THE RESPIRATORY EXCHANGE AND MORTALITY RATE ASSOCIATED WITH ACUTE HEMORRHAGE IN ANESTHETIZED DOGS.
Topics: Alcoholic Intoxication; Anesthesia; Anesthesia, Intravenous; Animals; Dogs; Hemorrhage; Pentobarbita | 1963 |
A PRELIMINARY REPORT ON THE USE OF A COMBINATION OF DROPERIDOL AND FENTANYL CITRATE IN VETERINARY MEDICINE.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Behavior, Animal; Benperidol; Birds; Ca | 1964 |
Endogenous distress in ventilated full-term newborns with acute respiratory failure.
Topics: Acute Disease; Analgesia; Female; Fentanyl; Humans; Hypnotics and Sedatives; Infant, Newborn; Intens | 2004 |
GABAA receptors mediate postnatal depression of respiratory frequency by barbiturates.
Topics: Animals; Animals, Newborn; Bicuculline; Drug Interactions; Female; GABA Agents; Hypnotics and Sedati | 2004 |
Anesthesia in rabbits by intrahepatic sodium pentobarbital.
Topics: Anesthesia, General; Animals; Atropine; Cheyne-Stokes Respiration; Female; Heart; Injections; Liver; | 1975 |
Comparison of saliva secretion rate and composition in the rat using a pentobarbital or a neuroleptanalgesic type of anaesthesia.
Topics: Anesthesia, General; Animals; Butyrophenones; Diazepam; Drug Combinations; Fentanyl; Hypnotics and S | 1989 |
Pharmacology of solanine.
Topics: Abdomen; Abnormalities, Drug-Induced; Animals; Anophthalmos; Cardiac Complexes, Premature; Central N | 1971 |
[Acute poisoning by short-acting barbiturates. Current clinical and medico-legal aspects].
Topics: Adolescent; Adult; Autopsy; Barbiturates; Coma; Female; Forensic Medicine; Humans; Hypertension; Mal | 1969 |
[Principles of treatment of imminent respiratory disorders in acute poisoning with polychlorcamphen and polychlorpinen].
Topics: Acute Disease; Animals; Atropine; Cats; Chlorpromazine; Intubation; Pentobarbital; Pesticides; Rats; | 1974 |
Effect of anaesthetics with excitatory properties, hypoxia, hypercapnia and hypoglycaemia on toxicity of 5HT in rats.
Topics: Anesthetics; Animals; Chloralose; Depression, Chemical; Hydroxybutyrates; Hypercapnia; Hypoglycemia; | 1972 |
Diaphragmatic pacing in the treatment of hypoventilation syndrome.
Topics: Acid-Base Equilibrium; Animals; Apnea; Blood Gas Analysis; Carbon Dioxide; Diaphragm; Dogs; Electric | 1967 |
Convulsions induced by 2-N-Di-n-butylaminoethanol.
Topics: Acetylcholine; Amino Alcohols; Animals; Cholinesterase Inhibitors; Diaphragm; Electric Stimulation; | 1970 |
[Acute pulmonary edema in barbiturate poisoning (apropos of 3 cases)].
Topics: Adult; Barbiturates; Female; Humans; Lung; Middle Aged; Pentobarbital; Pulmonary Edema; Respiratory | 1970 |
The effect of metabolic acidosis on the CO2 titration curve.
Topics: Acidosis; Acidosis, Respiratory; Anesthesia, General; Animals; Bicarbonates; Buffers; Dogs; Homeosta | 1969 |
The acute toxicity of 5-hydroxytryptamine in anaesthetized rats.
Topics: Anesthesia, General; Animals; Bemegride; Blood Pressure; Brain; Denervation; Electric Stimulation; E | 1965 |
Electrical impedance and vasomotor changes accompanying synaptic transmission in sympathetic ganglia.
Topics: Animals; Asphyxia; Cats; Decerebrate State; Electrocardiography; Extracellular Space; Fatigue; Femor | 1966 |
Slow potential changes in the spinal cord.
Topics: Animals; Cats; Electric Stimulation; Electrophysiology; Hyperventilation; Hypoventilation; Pentobarb | 1966 |