Page last updated: 2024-11-02

pentobarbital and Neuroblastoma

pentobarbital has been researched along with Neuroblastoma in 8 studies

Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
"The gamma-aminobutyric acid (GABA) response profiles of IMR-32 human neuroblastoma cells were examined using whole-cell patch clamp and RT-PCR techniques."3.70Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line. ( Sapp, DW; Yeh, HH, 2000)
"Exposure to the pentobarbital potently inhibited the 2-deoxy glucose uptake in cultured neuroblastoma cells."3.68Barbiturates suppress glucose utilization by inhibition of hexokinase in neuroblastoma cells. ( Ishibashi, S; Ishii, K; Okazaki, H; Tokuda, H, 1992)
"An increase in susceptibility of neuroblastoma cells to calcium was inhibited when the cells were treated with hypothermia, diphenylhydantoin, chlorpromazine or pentobarbital; all of these treatments affect membrane permeability to calcium or membrane-associated cell metabolism."3.67Prevention of an increase in susceptibility to calcium in a neuroblastoma cell line. ( Abe, K; Kogure, K, 1987)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's4 (50.00)18.2507
2000's1 (12.50)29.6817
2010's0 (0.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Kim, M1
Kim, Y1
Lee, HW1
Jung, JC1
Oh, S1
Rohde, BH1
Harris, RA1
Rehberg, B1
Wittmann, M1
Urban, BW1
Sapp, DW1
Yeh, HH1
Kokoz, YM1
Tsyganova, VG1
Korystova, AF1
Grichenko, AS1
Zenchenko, KI1
Drinyaev, VA1
Mosin, VA1
Kruglyak, EB1
Sterlina, TS1
Victorov, AV1
Okazaki, H1
Tokuda, H1
Ishii, K1
Ishibashi, S1
Peruche, B1
Krieglstein, J1
Abe, K1
Kogure, K1

Other Studies

8 other studies available for pentobarbital and Neuroblastoma

ArticleYear
    Nutrients, 2023, Mar-07, Volume: 15, Issue:6

    Topics: Animals; Chlorides; Humans; Mice; Neuroblastoma; Pentobarbital; Rats; Receptors, GABA-A; Rodentia; S

2023
GABA and flunitrazepam binding to neuroblastoma cell membranes--effects of growth conditions, ethanol and pentobarbital.
    Brain research, 1982, Dec-16, Volume: 253, Issue:1-2

    Topics: Anti-Anxiety Agents; Binding, Competitive; Cell Line; Culture Media; Culture Techniques; Ethanol; Fl

1982
Sodium channels (from rat, mouse, and man) in neuroblastoma cells and different expression systems have similar sensitivities to pentobarbital.
    Neuroscience letters, 1999, Apr-02, Volume: 264, Issue:1-3

    Topics: Action Potentials; Animals; Differential Threshold; Electrophysiology; GABA Modulators; Humans; Ion

1999
Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line.
    Journal of neuroscience research, 2000, May-15, Volume: 60, Issue:4

    Topics: Anticonvulsants; Bicuculline; Diazepam; Dose-Response Relationship, Drug; GABA Modulators; gamma-Ami

2000
Selective cytostatic and neurotoxic effects of avermectins and activation of the GABAalpha receptors.
    Bioscience reports, 1999, Volume: 19, Issue:6

    Topics: Animals; Bicuculline; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; GABA Ag

1999
Barbiturates suppress glucose utilization by inhibition of hexokinase in neuroblastoma cells.
    Biochemical and biophysical research communications, 1992, Apr-30, Volume: 184, Issue:2

    Topics: 3-O-Methylglucose; Barbiturates; Biological Transport; Cell Line; Deoxyglucose; gamma-Aminobutyric A

1992
Neuroblastoma cells for testing neuroprotective drug effects.
    Journal of pharmacological methods, 1991, Volume: 26, Issue:2

    Topics: Cell Hypoxia; Central Nervous System Depressants; N-Methylaspartate; Neuroblastoma; Neurons; Pentoba

1991
Prevention of an increase in susceptibility to calcium in a neuroblastoma cell line.
    Neuroscience letters, 1987, Oct-05, Volume: 80, Issue:3

    Topics: Calcium; Cell Membrane Permeability; Cell Survival; Chlorpromazine; Cold Temperature; Flunarizine; H

1987