pentobarbital has been researched along with Neuroblastoma in 8 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
Excerpt | Relevance | Reference |
---|---|---|
"The gamma-aminobutyric acid (GABA) response profiles of IMR-32 human neuroblastoma cells were examined using whole-cell patch clamp and RT-PCR techniques." | 3.70 | Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line. ( Sapp, DW; Yeh, HH, 2000) |
"Exposure to the pentobarbital potently inhibited the 2-deoxy glucose uptake in cultured neuroblastoma cells." | 3.68 | Barbiturates suppress glucose utilization by inhibition of hexokinase in neuroblastoma cells. ( Ishibashi, S; Ishii, K; Okazaki, H; Tokuda, H, 1992) |
"An increase in susceptibility of neuroblastoma cells to calcium was inhibited when the cells were treated with hypothermia, diphenylhydantoin, chlorpromazine or pentobarbital; all of these treatments affect membrane permeability to calcium or membrane-associated cell metabolism." | 3.67 | Prevention of an increase in susceptibility to calcium in a neuroblastoma cell line. ( Abe, K; Kogure, K, 1987) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (25.00) | 18.7374 |
1990's | 4 (50.00) | 18.2507 |
2000's | 1 (12.50) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 1 (12.50) | 2.80 |
Authors | Studies |
---|---|
Kim, M | 1 |
Kim, Y | 1 |
Lee, HW | 1 |
Jung, JC | 1 |
Oh, S | 1 |
Rohde, BH | 1 |
Harris, RA | 1 |
Rehberg, B | 1 |
Wittmann, M | 1 |
Urban, BW | 1 |
Sapp, DW | 1 |
Yeh, HH | 1 |
Kokoz, YM | 1 |
Tsyganova, VG | 1 |
Korystova, AF | 1 |
Grichenko, AS | 1 |
Zenchenko, KI | 1 |
Drinyaev, VA | 1 |
Mosin, VA | 1 |
Kruglyak, EB | 1 |
Sterlina, TS | 1 |
Victorov, AV | 1 |
Okazaki, H | 1 |
Tokuda, H | 1 |
Ishii, K | 1 |
Ishibashi, S | 1 |
Peruche, B | 1 |
Krieglstein, J | 1 |
Abe, K | 1 |
Kogure, K | 1 |
8 other studies available for pentobarbital and Neuroblastoma
Article | Year |
---|---|
Topics: Animals; Chlorides; Humans; Mice; Neuroblastoma; Pentobarbital; Rats; Receptors, GABA-A; Rodentia; S | 2023 |
GABA and flunitrazepam binding to neuroblastoma cell membranes--effects of growth conditions, ethanol and pentobarbital.
Topics: Anti-Anxiety Agents; Binding, Competitive; Cell Line; Culture Media; Culture Techniques; Ethanol; Fl | 1982 |
Sodium channels (from rat, mouse, and man) in neuroblastoma cells and different expression systems have similar sensitivities to pentobarbital.
Topics: Action Potentials; Animals; Differential Threshold; Electrophysiology; GABA Modulators; Humans; Ion | 1999 |
Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line.
Topics: Anticonvulsants; Bicuculline; Diazepam; Dose-Response Relationship, Drug; GABA Modulators; gamma-Ami | 2000 |
Selective cytostatic and neurotoxic effects of avermectins and activation of the GABAalpha receptors.
Topics: Animals; Bicuculline; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; GABA Ag | 1999 |
Barbiturates suppress glucose utilization by inhibition of hexokinase in neuroblastoma cells.
Topics: 3-O-Methylglucose; Barbiturates; Biological Transport; Cell Line; Deoxyglucose; gamma-Aminobutyric A | 1992 |
Neuroblastoma cells for testing neuroprotective drug effects.
Topics: Cell Hypoxia; Central Nervous System Depressants; N-Methylaspartate; Neuroblastoma; Neurons; Pentoba | 1991 |
Prevention of an increase in susceptibility to calcium in a neuroblastoma cell line.
Topics: Calcium; Cell Membrane Permeability; Cell Survival; Chlorpromazine; Cold Temperature; Flunarizine; H | 1987 |