pentobarbital has been researched along with Nerve Degeneration in 16 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs), mossy fibre sprouting and hippocampal neurodegeneration in rats." | 7.75 | Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy. ( Lebrun, I; Luongo, R; Oliveira, DA; Sandoval, MR, 2009) |
| " The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs), mossy fibre sprouting and hippocampal neurodegeneration in rats." | 3.75 | Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy. ( Lebrun, I; Luongo, R; Oliveira, DA; Sandoval, MR, 2009) |
| " Two animal models of TLE--amygdala kindling and pilocarpine-induced status epilepticus (Pilo-SE)--were tested." | 3.75 | Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics. ( Leung, LS; Long, JJ; Luo, T; McMurran, TJ; Shen, B; Stewart, L, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (50.00) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Luongo, R | 1 |
| Oliveira, DA | 1 |
| Lebrun, I | 1 |
| Sandoval, MR | 1 |
| Long, JJ | 1 |
| Shen, B | 1 |
| Luo, T | 1 |
| Stewart, L | 1 |
| McMurran, TJ | 1 |
| Leung, LS | 1 |
| Yamada, A | 1 |
| Yamamoto, K | 1 |
| Imamoto, N | 1 |
| Momosaki, S | 1 |
| Hosoi, R | 1 |
| Yamaguchi, M | 1 |
| Inoue, O | 1 |
| Andrews-Zwilling, Y | 1 |
| Bien-Ly, N | 1 |
| Xu, Q | 1 |
| Li, G | 1 |
| Bernardo, A | 1 |
| Yoon, SY | 1 |
| Zwilling, D | 1 |
| Yan, TX | 1 |
| Chen, L | 1 |
| Huang, Y | 1 |
| Grant, RJ | 1 |
| Clarke, PB | 1 |
| Magloczky, Z | 1 |
| Freund, TF | 1 |
| Ishimaru, H | 1 |
| Takahashi, A | 1 |
| Ikarashi, Y | 1 |
| Maruyama, Y | 1 |
| Lemos, T | 1 |
| Cavalheiro, EA | 1 |
| Precht, W | 1 |
| Volkind, R | 1 |
| Blanks, RH | 1 |
| Wakade, AR | 1 |
| Moroni, F | 1 |
| Malthe-Sorenssen, D | 1 |
| Cheney, DL | 1 |
| Costa, E | 1 |
| Trolin, GG | 1 |
| Emmers, R | 1 |
| Feltz, P | 1 |
| Albe-Fessard, D | 1 |
| Praestholm, J | 1 |
| Winkler, BS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Longitudinal Early-onset Alzheimer's Disease Study Protocol[NCT03507257] | 700 participants (Anticipated) | Observational | 2018-04-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 other studies available for pentobarbital and Nerve Degeneration
| Article | Year |
|---|---|
Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Count; Cell Death; Diazepam; Electroencephalogr | 2009 |
Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics.
Topics: Anesthetics, General; Animals; Brain; Consciousness Disorders; Convulsants; Disease Models, Animal; | 2009 |
Lactate is an alternative energy fuel to glucose in neurons under anesthesia.
Topics: Anesthetics, General; Animals; Autoradiography; Brain; Brain Chemistry; Carbon Radioisotopes; Cell D | 2009 |
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.
Topics: Age Factors; Analysis of Variance; Animals; Apolipoprotein E4; Cells, Cultured; Dentate Gyrus; Elect | 2010 |
Susceptibility of ascending dopamine projections to 6-hydroxydopamine in rats: effect of hypothermia.
Topics: Animals; Body Temperature; Cell Survival; Cocaine; Disease Susceptibility; Dopamine; Efferent Pathwa | 2002 |
Selective neuronal death in the contralateral hippocampus following unilateral kainate injections into the CA3 subfield.
Topics: Anesthetics; Animals; Biomarkers; Calbindin 2; Cell Death; Chloral Hydrate; Disease Models, Animal; | 1993 |
Effects of MK-801 and pentobarbital on cholinergic terminal damage and delayed neuronal death in the ischemic gerbil hippocampus.
Topics: Acetylcholine; Animals; Brain Ischemia; Cell Death; Choline O-Acetyltransferase; Dizocilpine Maleate | 1997 |
Status epilepticus and the late development of spontaneous seizures in the pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Brain Mapping; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy | 1996 |
Functional organization of the vestibular input to the anterior and posterior cerebellar vermis of cat.
Topics: Animals; Axonal Transport; Cats; Cerebellar Cortex; Electric Stimulation; Evoked Potentials; Horsera | 1977 |
Time course of degeneration of short and long postganglionic sympathetic nerve fibres and effect of pentobarbitone and colchicine on degeneration.
Topics: Animals; Colchicine; Ether; Male; Nerve Degeneration; Norepinephrine; Pentobarbital; Rats; Spleen; S | 1978 |
Modulation of ACh turnover in the septal-hippocampal pathway by electrical stimulation and lesioning.
Topics: Acetylcholine; Afferent Pathways; Animals; Cerebral Cortex; Choline O-Acetyltransferase; Diencephalo | 1978 |
Involvement of alpha-adrenergic receptors at different levels of the central nervous system in the regulation of blood pressure and heart frequency.
Topics: Animals; Blood Pressure; Central Nervous System; Clonidine; Dopamine; Heart Rate; Hydroxydopamines; | 1975 |
Thalamic mechanisms that process a temporal pulse code for pain.
Topics: Action Potentials; Animals; Electric Stimulation; Electrocoagulation; Morphine; Nerve Degeneration; | 1976 |
A study of an ascending nigro-caudate pathway.
Topics: Anesthesia, General; Animals; Cats; Caudate Nucleus; Cerebral Cortex; Electric Stimulation; Female; | 1972 |
Water-soluble contrast medium myelography in the experimental animal. A preliminary report.
Topics: Anesthesia, Intravenous; Animals; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Injections, Spi | 1972 |
Analysis of the rabbit's electroretinogram following unilateral transection of the optic nerve.
Topics: Adaptation, Ocular; Animals; Denervation; Electroretinography; Nerve Degeneration; Neurons; Neurons, | 1972 |