pentobarbital has been researched along with Muscle Relaxation in 17 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " serraefolia significantly delayed the onset of tonic seizures induced by strychnine and pentylenetetrazol; besides, it diminished the death rate and number of animals that exhibited convulsions." | 3.69 | Evaluation of the calcium-antagonist, antidiarrhoeic and central nervous system activities of Baccharis serraefolia. ( Aguilar-Santamaría, L; Tortoriello, J, 1996) |
| "Loreclezole is an anticonvulsant and anxiolytic compound which has been reported to potentiate GABA via a novel allosteric site on the beta-subunit of the receptor." | 1.29 | A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor. ( Cross, AJ; Green, AR; Misra, A; Murray, TK; Snape, MF, 1996) |
| "The effects of chronic administration of phencyclidine (PCP) or CGS 19755 (cis-4-phosphonomethyl-2-piperidine-carboxylic acid) on the cataleptic effects of N-methyl-D-aspartate (NMDA) receptor antagonists were studied in pigeons." | 1.28 | Tolerance to the cataleptic effect of the N-methyl-D-aspartate (NMDA) receptor antagonists in pigeons: cross-tolerance between PCP-like compounds and competitive NMDA antagonists. ( France, CP; Lu, Y; Woods, JH, 1992) |
| "For PTZ-induced convulsions, DN-2327, 0." | 1.28 | Pharmacologic profile of a new anxiolytic, DN-2327: effect of Ro15-1788 and interaction with diazepam in rodents. ( Fukuda, N; Wada, T, 1991) |
| " PB shifted the dose-response curve for GABA in the presence of bicuculline methochloride to the left without altering the slope or the dose ratio, and not only displaced the dose-response curve for GABA in the presence of picrotoxinin but also restored the slope and the maximum response towards that of the control GABA-induced response." | 1.27 | Potentiation of GABAA-receptor-mediated responses by barbiturates in the guinea-pig ileum. ( Kerr, DI; Ong, J, 1984) |
| "Pentobarbital was found to inhibit both the spontaneous mechanical activity and the basal tone of these vessels." | 1.26 | Effect of pentobarbital on the reactivity of isolated human cerebral arteries. ( Benitez, J; Lobato, RD; Marín, J; Rico, ML; Salaices, M, 1981) |
| "Pentobarbital and Sulpiride produce a biphasyc effect of opposite sign: at small doses Pentobarbital increases the stretch response while Sulpiride reduces it." | 1.26 | [Action of some psychotropic drugs on the electrmyographic response evoked by stretches of the gastrocnemius muscle of rats submitted to stress]. ( Eandi, M; Ricci Gamalero, S; Taglia, P, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (41.18) | 18.7374 |
| 1990's | 9 (52.94) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Buhaĭchenko, LA | 1 |
| Ong, J | 1 |
| Kerr, DI | 1 |
| Radulović, S | 1 |
| Kazić, T | 1 |
| Khan, AR | 1 |
| Marín, J | 1 |
| Lobato, RD | 1 |
| Rico, ML | 1 |
| Salaices, M | 1 |
| Benitez, J | 1 |
| Eandi, M | 1 |
| Ricci Gamalero, S | 1 |
| Taglia, P | 1 |
| Nakashima, Y | 1 |
| Yuasa, S | 1 |
| Hukamizu, Y | 1 |
| Okuyama, H | 1 |
| Ohhara, T | 1 |
| Kameyama, T | 1 |
| Nabeshima, T | 1 |
| Terasako, K | 1 |
| Nakamura, K | 2 |
| Toda, H | 1 |
| Kakuyama, M | 1 |
| Hatano, Y | 2 |
| Mori, K | 2 |
| Tortoriello, J | 1 |
| Aguilar-Santamaría, L | 1 |
| Green, AR | 1 |
| Misra, A | 1 |
| Murray, TK | 1 |
| Snape, MF | 1 |
| Cross, AJ | 1 |
| Vanover, KE | 1 |
| Pal, S | 1 |
| Sen, T | 1 |
| Chaudhuri, AK | 1 |
| Lu, Y | 1 |
| France, CP | 1 |
| Woods, JH | 1 |
| Wada, T | 1 |
| Fukuda, N | 1 |
| Moriyama, S | 1 |
| Harioka, T | 1 |
| Robertson, B | 1 |
| Longo, VG | 1 |
| De Medici, D | 1 |
| Gatta, F | 1 |
| Massotti, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Perceived Changes in Anxiety Symptom Burden During Treatment With Bryophyllum Pinnatum and Tolerability: a Prospective, Single-Group Pre-post Observational Study as Investigator-Initiated Trial (IIT)[NCT04825171] | Phase 4 | 51 participants (Anticipated) | Interventional | 2021-08-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17 other studies available for pentobarbital and Muscle Relaxation
| Article | Year |
|---|---|
[Fatigue-related changes in dynamic and static components of eccentric contraction of the gastrocnemius muscle in the narcotized cat].
Topics: Animals; Biomechanical Phenomena; Cats; Hindlimb; Isometric Contraction; Muscle Fatigue; Muscle Rela | 2004 |
Potentiation of GABAA-receptor-mediated responses by barbiturates in the guinea-pig ileum.
Topics: Animals; Barbiturates; Bicuculline; Drug Interactions; Female; Guinea Pigs; Ileum; In Vitro Techniqu | 1984 |
Calcium antagonistic action of pentobarbitone on the isolated terminal ileum of the guinea-pig.
Topics: Acetylcholine; Animals; Calcium; Calcium Channel Blockers; Guinea Pigs; Ileum; In Vitro Techniques; | 1983 |
Mechanism of action of pentobarbital on the contractile system of isolated frog muscle fibres.
Topics: Action Potentials; Animals; Calcium; Membrane Potentials; Muscle Contraction; Muscle Relaxation; Mus | 1980 |
Effect of pentobarbital on the reactivity of isolated human cerebral arteries.
Topics: Cerebral Arteries; Dose-Response Relationship, Drug; Humans; Muscle Contraction; Muscle Relaxation; | 1981 |
[Action of some psychotropic drugs on the electrmyographic response evoked by stretches of the gastrocnemius muscle of rats submitted to stress].
Topics: Amitriptyline; Animals; Chlorpromazine; Dextroamphetamine; Meprobamate; Muscle Contraction; Muscle R | 1980 |
Effect of a high linoleate and a high alpha-linolenate diet on general behavior and drug sensitivity in mice.
Topics: alpha-Linolenic Acid; Analgesia; Animals; Behavior, Animal; Brain; Cholesterol; Diazepam; Dietary Fa | 1993 |
Barbiturates inhibit endothelium-dependent and independent relaxations mediated by cyclic GMP.
Topics: Acetylcholine; Animals; Aorta; Bradykinin; Cyclic GMP; Dogs; Endothelium, Vascular; In Vitro Techniq | 1994 |
Evaluation of the calcium-antagonist, antidiarrhoeic and central nervous system activities of Baccharis serraefolia.
Topics: Administration, Oral; Analysis of Variance; Animals; Antidiarrheals; Calcium; Convulsants; Dose-Resp | 1996 |
A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor.
Topics: Allosteric Regulation; Animals; Behavior, Animal; Brain Chemistry; Bridged Bicyclo Compounds, Hetero | 1996 |
Interaction of ethanol with excitatory amino acid receptor antagonists in mice.
Topics: Animals; Ataxia; Behavior, Animal; Benzodiazepines; Central Nervous System Depressants; Chlordiazepo | 1999 |
Neuropsychopharmacological profile of the methanolic fraction of Bryophyllum pinnatum leaf extract.
Topics: Analgesia; Animals; Anticonvulsants; Behavior, Animal; Brain Chemistry; Dose-Response Relationship, | 1999 |
Tolerance to the cataleptic effect of the N-methyl-D-aspartate (NMDA) receptor antagonists in pigeons: cross-tolerance between PCP-like compounds and competitive NMDA antagonists.
Topics: Animals; Binding, Competitive; Columbidae; Dose-Response Relationship, Drug; Drug Tolerance; Etomida | 1992 |
Pharmacologic profile of a new anxiolytic, DN-2327: effect of Ro15-1788 and interaction with diazepam in rodents.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Conditioning, Operant; Conflict, Psychological; Diaz | 1991 |
Responses to barbiturates of isolated dog cerebral and mesenteric arteries contracted with KCl and prostaglandin F2 alpha.
Topics: Animals; Barbiturates; Calcium; Cerebral Arteries; Dinoprost; Dogs; In Vitro Techniques; Mesenteric | 1990 |
Actions of anaesthetics and avermectin on GABAA chloride channels in mammalian dorsal root ganglion neurones.
Topics: Anesthetics; Animals; Cats; Cell Membrane; Chlorides; gamma-Aminobutyric Acid; Ganglia, Spinal; Hydr | 1989 |
Effects of drugs on the electrical activity of the red nucleus in the rabbit. Activation of benzodiazepine and barbiturate receptors.
Topics: Animals; Bicuculline; Carbolines; Diazepam; Drug Interactions; Electroencephalography; Flumazenil; M | 1988 |