pentobarbital has been researched along with Hypotension in 52 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pentobarbital-anesthetized rats subjected to traumatic shock developed a shock state characterized by marked hypotension to 65-70 mmHg, a survival time of 88 +/- 13 min, significant increases in ileal myeloperoxidase activity (P < 0." | 3.70 | Cellular mechanisms of heparinase III protection in rat traumatic shock. ( Appel, JZ; Hayward, R; Hopper, B; Lefer, AM; Scalia, R, 1998) |
| "Pentobarbital is standard treatment for refractory status epilepticus (SE) and is almost uniformly effective, but the morbidity of treatment and the mortality of refractory SE are high." | 3.69 | Relapse and survival after barbiturate anesthetic treatment of refractory status epilepticus. ( Drislane, FW; Krishnamurthy, KB, 1996) |
| "Hemodynamic mechanisms of Co(2+)-evoked hypotension were studied in pentobarbital--anesthetised male Wistar rats." | 3.68 | [Hemodynamic mechanisms of the hypotensive effect of cobalt in anesthetized rats]. ( Dugin, SF; Medvedev, OS; Zakharova, NV, 1991) |
| "Our objectives were 1) to investigate the extent to which the pulmonary vascular response to increasing cardiac index after a period of hypotension and hypoperfusion (defined as reperfusion) measured in conscious dogs is altered during pentobarbital sodium anesthesia, and 2) to determine whether pentobarbital anesthesia modifies autonomic nervous system (ANS) regulation of the pulmonary circulation during reperfusion." | 3.67 | Pentobarbital anesthesia modifies pulmonary vasoregulation after hypoperfusion. ( Chen, BB; Clougherty, PW; Fehr, DM; Goll, HM; Murray, PA; Nyhan, DP, 1988) |
| "The effect of bleeding against a predetermined pressure on the relative oxygen tension in the kidney was studied in rats anesthetized with either pentobarbital-Na or ethylurethane." | 3.66 | Effect of pentobarbital and urethane on the oxygen tension in the kidney of hypotensive rats. ( Valkenburg, PW; Van der Meer, C, 1979) |
| "The effects of vasopressor therapy on intracranial pressure (ICP) during hypotension were evaluated in 45 adult cats anesthetized with pentobarbital and hyperventilated via an endotracheal tube with nitrous oxide, 70 per cent, and oxygen, 30 per cent, to maintain Paco2 25 plus or minus 5 torr." | 3.65 | Intracranial pressure during hypotension and subsequent vasopressor therapy in anesthetized cats. ( Sokoll, MD; Stullken, EH, 1975) |
| " We characterize the fasting status of patients receiving procedural sedation and analgesia in a pediatric ED and assess the relationship between fasting status and adverse events." | 1.32 | Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department. ( Agrawal, D; Gupta, R; Krauss, B; Manzi, SF, 2003) |
| "Depth of hypotension is more important than duration in causing intrinsic cardiac dysfunction." | 1.30 | Heart function after severe hemorrhagic shock. ( Barbee, RW; Kline, JA; Lopaschuk, GD; Thornton, LR; Watts, JA, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (73.08) | 18.7374 |
| 1990's | 8 (15.38) | 18.2507 |
| 2000's | 3 (5.77) | 29.6817 |
| 2010's | 3 (5.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pugin, D | 1 |
| Foreman, B | 1 |
| De Marchis, GM | 1 |
| Fernandez, A | 1 |
| Schmidt, JM | 1 |
| Czeisler, BM | 1 |
| Mayer, SA | 1 |
| Agarwal, S | 1 |
| Lesch, C | 1 |
| Lantigua, H | 1 |
| Claassen, J | 1 |
| Edge, D | 1 |
| Shortt, CM | 1 |
| Johns, EJ | 1 |
| Gobbo, OL | 1 |
| Markos, F | 1 |
| Abdulla, MH | 1 |
| Barry, EF | 1 |
| Mason, KP | 1 |
| Prescilla, R | 1 |
| Fontaine, PJ | 1 |
| Zurakowski, D | 1 |
| GALVAO, PE | 1 |
| de MAGALHAES, C | 1 |
| TARASANTCHI, J | 1 |
| PANDEY, K | 1 |
| KUMAR, S | 1 |
| BADOLA, RP | 1 |
| CLEMENTSEN, HJ | 1 |
| HAGELSTEN, JO | 1 |
| BISCOE, TJ | 1 |
| MILLAR, RA | 1 |
| CASTBERG, T | 1 |
| SAURBREY, J | 1 |
| SIVERTSEN, U | 1 |
| WANDALL, HH | 1 |
| SEKIYA, A | 1 |
| VAUGHANWILLIAMS, EM | 2 |
| MORALES AGUILERA, A | 1 |
| Agrawal, D | 1 |
| Manzi, SF | 1 |
| Gupta, R | 1 |
| Krauss, B | 1 |
| Springell, DA | 1 |
| Costin, NS | 1 |
| Pilowsky, PM | 1 |
| Goodchild, AK | 1 |
| Schwartze, P | 1 |
| Göppert, E | 1 |
| Schadt, JC | 1 |
| York, DH | 1 |
| De Wildt, DJ | 1 |
| Van der Ven, JC | 1 |
| Van Bergen, P | 1 |
| De Lang, H | 1 |
| Versteeg, DH | 1 |
| Cochrane, KL | 2 |
| Nathan, MA | 2 |
| Krishnamurthy, KB | 1 |
| Drislane, FW | 1 |
| Anand, A | 1 |
| Taylor, PM | 1 |
| Hayward, R | 1 |
| Scalia, R | 1 |
| Hopper, B | 1 |
| Appel, JZ | 1 |
| Lefer, AM | 1 |
| Kline, JA | 1 |
| Thornton, LR | 1 |
| Lopaschuk, GD | 1 |
| Barbee, RW | 1 |
| Watts, JA | 1 |
| Noguchi, K | 1 |
| Yamashiro, S | 1 |
| Matsuzaki, T | 1 |
| Sakanashi, M | 2 |
| Nakasone, J | 1 |
| Miyagi, K | 1 |
| Herman, EH | 1 |
| Balazs, T | 1 |
| Young, R | 1 |
| Earl, FL | 1 |
| Krop, S | 1 |
| Ferrans, VJ | 1 |
| Van der Meer, C | 1 |
| Valkenburg, PW | 1 |
| Bhargava, KP | 1 |
| Srivastava, VK | 1 |
| Barthwal, JP | 1 |
| Sinha, JN | 1 |
| Stullken, EH | 1 |
| Sokoll, MD | 1 |
| Myers, RE | 2 |
| Gygax, P | 1 |
| Schweizer, A | 1 |
| Dugin, SF | 1 |
| Zakharova, NV | 1 |
| Medvedev, OS | 1 |
| Hohimer, AR | 1 |
| Bissonnette, JM | 1 |
| Chen, BB | 1 |
| Nyhan, DP | 1 |
| Goll, HM | 1 |
| Clougherty, PW | 1 |
| Fehr, DM | 1 |
| Murray, PA | 1 |
| Buchholz, RA | 1 |
| Hubbard, JW | 1 |
| Keeton, TK | 1 |
| Wagner, KR | 1 |
| Ting, P | 1 |
| Westfall, MV | 1 |
| Yamaguchi, S | 1 |
| Bacher, JD | 1 |
| McCullough, LS | 1 |
| Reier, CE | 1 |
| Delaunois, AL | 1 |
| Gardier, RW | 1 |
| Hamelberg, W | 2 |
| Ponessa, JT | 1 |
| De Boer, B | 1 |
| Webb-Peploe, MM | 1 |
| Shepherd, JT | 1 |
| Nelson, NC | 1 |
| Nelson, JL | 1 |
| Vela, AR | 1 |
| Soler, F | 1 |
| Chopdar, A | 1 |
| Forsling, ML | 1 |
| Ullmann, E | 1 |
| Goyal, RK | 1 |
| Rattan, S | 1 |
| Hersh, T | 1 |
| Yashon, D | 1 |
| Stone, W | 1 |
| Magness, A | 1 |
| Hunt, WE | 1 |
| Siegel, JH | 1 |
| Morishima, HO | 1 |
| Hyman, AI | 1 |
| Adamsons, K | 1 |
| James, LS | 1 |
| Ueda, I | 1 |
| Kohama, A | 1 |
| Hordan, WS | 1 |
| Graves, CL | 1 |
| Wolner, E | 1 |
| Enenkel, W | 1 |
| Thoma, H | 1 |
| Deutsch, M | 1 |
| Fasching, W | 1 |
| Raberger, G | 1 |
| Riedl, W | 1 |
| Navratil, J | 1 |
| Dilts, PV | 1 |
| Kammerer, T | 1 |
| Tyano, S | 1 |
| Rosenthal, SL | 1 |
| Guyton, AC | 1 |
| Bird, TD | 1 |
| Plum, F | 1 |
| Bhargava, UC | 1 |
| Westfall, BA | 1 |
| Siehr, DJ | 1 |
| Rushmer, RF | 1 |
| Watson, N | 1 |
| Harding, D | 1 |
| Baker, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Do Patients Need Pre-Procedural Fasting for Coronary Artery Procedures?[NCT02562638] | 240 participants (Anticipated) | Interventional | 2015-10-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pentobarbital and Hypotension
| Article | Year |
|---|---|
The myocardial contractile state and its role in the response to anesthesia and surgery.
Topics: Anesthesia; Anesthetics; Animals; Biomechanical Phenomena; Blood Pressure; Blood Volume; Calcium; Di | 1969 |
51 other studies available for pentobarbital and Hypotension
| Article | Year |
|---|---|
Is pentobarbital safe and efficacious in the treatment of super-refractory status epilepticus: a cohort study.
Topics: Adult; Aged; Cohort Studies; Electroencephalography; Female; Humans; Hypotension; Infusions, Intrave | 2014 |
Assessment of renal function in the anaesthetised rat following injection of superparamagnetic iron oxide nanoparticles.
Topics: Anesthesia, Intravenous; Animals; Diuresis; Drug Delivery Systems; Ferric Compounds; Glomerular Filt | 2017 |
Pediatric CT sedation: comparison of dexmedetomidine and pentobarbital.
Topics: Akathisia, Drug-Induced; Child, Preschool; Dexmedetomidine; Female; Hemodynamics; Humans; Hypnotics | 2011 |
Energy metabolism in dogs during anesthesia, curarization, or acute arterial hypotension.
Topics: Anesthesia; Animals; Barbiturates; Dogs; Energy Metabolism; Gallamine Triethiodide; Hypotension; Mor | 1963 |
NEUROMUSCULAR BLOCKING AND HYPOTENSIVE ACTIONS OF STREPTOMYCIN, AND THEIR REVERSAL.
Topics: Autonomic Nerve Block; Calcium; Chloralose; Chlorides; Dogs; Hypotension; Neostigmine; Neuromuscular | 1964 |
HALOTHANE AND HALOTHANE-ETHER AZEOTROPE AS ALTERNATING ANAESTHETICS.
Topics: Anesthesia; Anesthesia, Inhalation; Anesthesiology; Anesthetics; Biomedical Research; Ether; Geriatr | 1964 |
FLUOTHANE-ETHER AZEOTROPIC MIXTURE.
Topics: Chlorpromazine; Curare; Ether; Ethers; Geriatrics; Halothane; Humans; Hypotension; Meperidine; Morph | 1964 |
THE EFFECT OF HALOTHANE ON CAROTID SINUS BARORECEPTOR ACTIVITY.
Topics: Animals; Bradycardia; Carotid Sinus; Cats; Chloralose; Dogs; Goats; Halothane; Hypotension; Neurophy | 1964 |
EXTRACORPOREAL CIRCULATION WITH HYPOTHERMIA AND SYMPATHETIC BLOC.
Topics: Autonomic Nerve Block; Creatine; Creatinine; Dogs; Extracorporeal Circulation; Heart; Heart, Artific | 1964 |
CENTRAL AND PERIPHRAL ACTIONS OF PRONETHALOL.
Topics: Arrhythmias, Cardiac; Blood Pressure; Chloroform; Electrocardiography; Epinephrine; Ethanolamines; E | 1965 |
THE ACTION OF PRONETHALOL ON SPINAL REFLEXES.
Topics: Anesthetics; Anesthetics, Local; Blood Pressure; Electrophysiology; Electroshock; Ethanolamines; Gui | 1965 |
Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department.
Topics: Adjuvants, Anesthesia; Analgesia; Anesthetics, Combined; Child; Child, Preschool; Chloral Hydrate; C | 2003 |
Hypotension and short-term anaesthesia induce ERK1/2 phosphorylation in autonomic nuclei of the brainstem.
Topics: Analysis of Variance; Anesthetics; Animals; Brain Stem; Carbon Dioxide; Cell Count; Cell Death; Halo | 2005 |
[The hypoxia-conditioned EEG arousal stage under the influence of pentobarbital and urethane].
Topics: Animals; Arousal; Electroencephalography; Hypotension; Hypoxia; Nitrogen; Pentobarbital; Rabbits; Ra | 1967 |
The reversal of hemorrhagic hypotension by naloxone in conscious rabbits.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hemorrhage; Hypotension; Male | 1981 |
A hypotensive and bradycardic action of gamma 2-melanocyte-stimulating hormone (gamma 2-MSH) microinjected into the nucleus tractus solitarii of the rat.
Topics: Anesthesia; Animals; Blood Pressure; Bradycardia; Heart Rate; Hypotension; Injections, Intravenous; | 1994 |
Cardiovascular effects of lesions of the rostral ventrolateral medulla and the nucleus reticularis parvocellularis in rats.
Topics: Animals; Arginine Vasopressin; Blood Pressure; Captopril; Hypotension; Male; Medulla Oblongata; Neur | 1993 |
Relapse and survival after barbiturate anesthetic treatment of refractory status epilepticus.
Topics: Adult; Anesthetics, Intravenous; Electroencephalography; Humans; Hypotension; Infusions, Intravenous | 1996 |
Reflex stimulation of aortic chemoreceptors through the stellate ganglion during hypoxia and hypotension in cats.
Topics: Animals; Aorta; Carotid Body; Cats; Chemoreceptor Cells; Ganglionectomy; Hypnotics and Sedatives; Hy | 1996 |
Endocrine and metabolic effects of hypotension or halothane inhalation in sheep anaesthetized with pentobarbital.
Topics: Adrenocorticotropic Hormone; Anesthetics, Inhalation; Animals; Arginine Vasopressin; Female; Halotha | 1998 |
Cellular mechanisms of heparinase III protection in rat traumatic shock.
Topics: Anesthesia, General; Animals; Cell Adhesion; Endothelium, Vascular; Hypotension; Ileum; Infusions, I | 1998 |
Heart function after severe hemorrhagic shock.
Topics: Adenosine Triphosphate; Animals; Coenzyme A; Esters; Heart; Heart Function Tests; Hypnotics and Seda | 1999 |
Effect of 1-week treatment with erythropoietin on the vascular endothelial function in anaesthetized rabbits.
Topics: Acetylcholine; Anesthesia; Animals; Blood Pressure; Endothelium, Vascular; Epoprostenol; Erythropoie | 2001 |
Acute cardiomyopathy induced by the vasodilating antihypertensive agent minoxidil.
Topics: Anesthesia; Animals; Arteritis; Cardiomyopathies; Coronary Vessels; Dogs; Hemorrhage; Hypotension; M | 1979 |
Effect of pentobarbital and urethane on the oxygen tension in the kidney of hypotensive rats.
Topics: Animals; Female; Hemorrhage; Hypotension; Kidney; Kidney Diseases; Oxygen Consumption; Pentobarbital | 1979 |
Significance of spinal autonomic loci in post coronary ligation arrhythmia.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Catecholamines; Chloralose; Chlorisondamine | 1976 |
Intracranial pressure during hypotension and subsequent vasopressor therapy in anesthetized cats.
Topics: Anesthesia, Inhalation; Animals; Cats; Electroencephalography; Ephedrine; Ferricyanides; Hemorrhage; | 1975 |
Maternal psychological stress and fetal asphyxia: a study in the monkey.
Topics: Acid-Base Equilibrium; Animals; Animals, Newborn; Asphyxia; Asphyxia Neonatorum; Blood Pressure; Bra | 1975 |
Proceedings: The influence of anesthesia on cortical microflow and EEG in arterial hypotension.
Topics: Anesthesia; Animals; Cats; Cerebral Cortex; Cerebrovascular Circulation; Electroencephalography; Hyp | 1975 |
[Hemodynamic mechanisms of the hypotensive effect of cobalt in anesthetized rats].
Topics: Anesthesia, General; Animals; Cobalt; Disease Models, Animal; Dose-Response Relationship, Drug; Hemo | 1991 |
Effects of cephalic hypotension, hypertension, and barbiturates on fetal cerebral flood flow and metabolism.
Topics: Animals; Brain; Cerebrovascular Circulation; Cerebrovascular Disorders; Fetus; Hypertension; Hypoten | 1989 |
Pentobarbital anesthesia modifies pulmonary vasoregulation after hypoperfusion.
Topics: Acetylcholine; Anesthesia, General; Animals; Autonomic Nervous System; Blood Pressure; Cardiac Outpu | 1988 |
Hypotensive effects of lesions of the rostral ventrolateral medulla in rats are anesthetic-dependent.
Topics: Anesthetics; Animals; Blood Pressure; Chloralose; Heart Rate; Hypotension; Male; Medulla Oblongata; | 1988 |
Brain metabolic correlates of hypoxic-ischemic cerebral necrosis in mid-gestational sheep fetuses: significance of hypotension.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Energy Metabolism; Female; Fetal Diseases; Hypotensi | 1986 |
The effects of d-tubocurarine on spontaneous postganglionic sympathetic activity and histamine release.
Topics: Animals; Arteries; Blood Pressure; Catecholamines; Cats; Celiac Plexus; Ganglia, Autonomic; Heart Ra | 1970 |
The effect of reserpine and syrosingopine upon pentobarbital depression.
Topics: Animals; Blood Pressure; Body Temperature; Central Nervous System; Drug Synergism; Hypotension; Hypo | 1966 |
Responses of the superficial limb veins of the dog to changes in temperature.
Topics: Animals; Blood Pressure; Body Temperature Regulation; Chloralose; Dogs; Forelimb; Ganglionic Blocker | 1968 |
The effect of alpha and beta adrenergic blockade on thoracic duct lymph flow in normovolemic and hypovolemic dogs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blood | 1969 |
Sedation for cataract surgery. Comparison of Carbrital and neuroleptanalgesia.
Topics: Aged; Apnea; Arrhythmias, Cardiac; Benperidol; Butyrates; Cataract Extraction; Fentanyl; Humans; Hyp | 1970 |
Proceedings: Plasma vasopressin and renal concentrating ability in the anaesthetized dog.
Topics: Anesthesia; Animals; Arginine; Dogs; Hypotension; Hypoxia; Kidney Concentrating Ability; Osmolar Con | 1974 |
Comparison of the effects of prostaglandins E1, E2, and A2, and of hypovolumic hypotension on the lower esophageal sphincter.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Esophagogastric Junction; Female; Hemorrh | 1973 |
Evidence of preservation of aerobic cerebral metabolism during halothane-induced hypotension.
Topics: Aerobiosis; Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Blood Pressure; Carbon Dioxide | 1973 |
Anesthetic management for fetal operation in the subhuman primate.
Topics: Acidosis, Respiratory; Anesthesia, Inhalation; Animals; Anxiety; Arteries; Blood Gas Analysis; Blood | 1971 |
Reversal of chlorpromazine-induced hypotension by calcium chloride in dogs.
Topics: Animals; Blood Pressure; Calcium Chloride; Cardiac Output; Chlorpromazine; Dogs; Drug Antagonism; Fe | 1971 |
[Assisted circulation with the aid of an intra-aortal balloon pump].
Topics: Anesthesia, Inhalation; Animals; Aorta, Thoracic; Assisted Circulation; Blood Pressure; Blood Vessel | 1969 |
Effect of ethanol on maternal and fetal acid-base balance.
Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Anesthesia, Spinal; Animals; Carbon Dioxide; Ethanol; | 1970 |
[Correction by dihydroergotamine of arterial pressure disorders induced by psychiatric chemotherapy].
Topics: Adolescent; Adult; Aged; Amitriptyline; Amobarbital; Antidepressive Agents; Barbiturates; Butyrophen | 1968 |
Hemodynamics of collateral vasodilatation following femoral artery occlusion in anesthetized dogs.
Topics: Animals; Blood Pressure; Collateral Circulation; Dogs; Femoral Artery; Hemodynamics; Hindlimb; Hypot | 1968 |
Recovery from barbiturate overdose coma with a prolonged isoelectric electroencephalogram.
Topics: Adult; Coma; Electroencephalography; Headache; Humans; Hypertension; Hypotension; Male; Pentobarbita | 1968 |
Preliminary pharmacology of ellagic acid from Juglans nigra (black walnut).
Topics: Animals; Anticonvulsants; Ataxia; Benzopyrans; Blood Pressure; Duodenum; Electroshock; Female; Heart | 1968 |
Compensation to exsanguination hypotension in health conscious dogs.
Topics: Animals; Aorta; Blood Pressure; Cardiac Output; Dogs; Heart Rate; Heart Ventricles; Hypotension; Pen | 1963 |