pentobarbital has been researched along with Hypercapnia in 30 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The respiratory response to hypercapnia in dogs anaesthetized with ketamine was increased." | 7.65 | Response to hypercapnia under ketamine anaesthesia. ( Brindle, GF; Kuster, G; Soliman, MG, 1975) |
| " We tested the hypothesis that asphyxia alone can cause cardiorespiratory failure ("failure") in pentobarbital-anesthetized rats." | 3.80 | Hypoxia, not hypercapnia, induces cardiorespiratory failure in rats. ( Iscoe, S; Simpson, JA, 2014) |
| " In vivo, pregnancy rendered respiratory motor output insensitive to otherwise lethal doses of pentobarbital, a barbiturate previously used to categorize the ε subunit." | 3.78 | Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy. ( Behan, M; Crader, SM; Hengen, KB; Johnson, SM; Mitchell, GS; Nelson, NR; Stang, KM; Watters, JJ, 2012) |
| "Previously, we demonstrated that dobutamine was more effective than dopamine for the improvement of diaphragmatic contractility during hypercapnia." | 3.74 | The effects of different dobutamine infusion rates on hypercapnic depression of diaphragmatic contractility in pentobarbital-anesthetized dogs. ( Fujii, Y; Uemura, A, 2007) |
| "Anesthesia was induced with 65 and 45 mg/kg pentobarbital in male and female rats, respectively." | 3.70 | Experimental critical care in rats: gender differences in anesthesia, ventilation, and gas exchange. ( Camacho, MT; Hon, E; Ramirez, J; Raszynski, A; Sussmane, JB; Torbati, D; Wolfsdorf, J, 1999) |
| "Systemic dexmedetomidine (DXM) attenuates the cerebral vasodilation induced by hypercapnia and decreases the cerebral blood flow response to hypoxia." | 3.70 | Intrathecal dexmedetomidine attenuates hypercapnic but not hypoxic cerebral vasodilation in anesthetized rabbits. ( Dohi, S; Iida, H; Iida, M; Takenaka, M, 2000) |
| " We assessed the effects of dexmedetomidine (DEX), a highly selective alpha 2-adrenergic agonist, on the cerebrovascular response to hypercapnia in dogs anesthetized with either pentobarbital (PENTO) or isoflurane (ISO), drugs which produce different levels of CBF at a similar level of cerebral oxygen consumption (CMRO2)." | 3.69 | Alpha 2-adrenergic agonist effects on normocapnic and hypercapnic cerebral blood flow in the dog are anesthetic dependent. ( Fale, A; Kirsch, JR; McPherson, RW, 1994) |
| "We evaluated the effect of general anesthesia induced by 45 mg/kg iv pentobarbital sodium or by 75 mg/kg iv alpha-chloralose plus 500 mg/kg iv urethan on the response of cerebral arterioles to hypercapnia in rabbits equipped with chronically implanted cranial windows for the observation of the cerebral microcirculation." | 3.67 | Effects of anesthesia on cerebral arteriolar responses to hypercapnia. ( Kontos, HA; Levasseur, JE, 1989) |
| "The respiratory response to hypercapnia in dogs anaesthetized with ketamine was increased." | 3.65 | Response to hypercapnia under ketamine anaesthesia. ( Brindle, GF; Kuster, G; Soliman, MG, 1975) |
| "The ventilatory responses to isocapnic hypoxia and hypercapnia were studied in seven chronically tracheostomized dogs awake and during anesthesia with pentobarbital (30 mg/kg, iv), ketamine, or thiopental (10 and 15 mg/kg, respectively, followed by infusion)." | 3.65 | Hypoxic ventilatory drive in dogs during thiopental, ketamine, or pentobarbital anesthesia. ( Cohen, PJ; Hirshman, CA; McCullough, RE; Weil, JV, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (70.00) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 3 (10.00) | 29.6817 |
| 2010's | 3 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Svorc, P | 2 |
| Petrášová, D | 1 |
| Simpson, JA | 1 |
| Iscoe, S | 1 |
| Hengen, KB | 1 |
| Nelson, NR | 1 |
| Stang, KM | 1 |
| Johnson, SM | 1 |
| Crader, SM | 1 |
| Watters, JJ | 1 |
| Mitchell, GS | 1 |
| Behan, M | 1 |
| Yamazaki, H | 1 |
| Okazaki, M | 1 |
| Takeda, R | 1 |
| Haji, A | 1 |
| KRUPP, P | 1 |
| CARPI, A | 1 |
| Fujii, Y | 1 |
| Uemura, A | 1 |
| Hemmingsen, R | 2 |
| Barry, DI | 2 |
| Craigen, ML | 1 |
| Jennett, S | 1 |
| Fale, A | 1 |
| Kirsch, JR | 1 |
| McPherson, RW | 1 |
| Torbati, D | 1 |
| Ramirez, J | 1 |
| Hon, E | 1 |
| Camacho, MT | 1 |
| Sussmane, JB | 1 |
| Raszynski, A | 1 |
| Wolfsdorf, J | 1 |
| Takenaka, M | 1 |
| Iida, H | 1 |
| Iida, M | 1 |
| Dohi, S | 1 |
| Kobayasi, S | 1 |
| Murata, K | 1 |
| Hertz, MM | 1 |
| Phillipson, EA | 1 |
| Kozar, LF | 1 |
| Murphy, E | 1 |
| Soliman, MG | 1 |
| Brindle, GF | 1 |
| Kuster, G | 1 |
| Hirshman, CA | 1 |
| McCullough, RE | 1 |
| Cohen, PJ | 1 |
| Weil, JV | 1 |
| Wagner, PG | 1 |
| Eldridge, FL | 1 |
| Dowell, RT | 1 |
| Glebovskiĭ, VD | 1 |
| Pashkevich, BP | 1 |
| Fregosi, RF | 1 |
| Bartlett, D | 1 |
| Levasseur, JE | 1 |
| Kontos, HA | 1 |
| Berga, P | 1 |
| Beckett, PR | 1 |
| Roberts, DJ | 1 |
| Llenas, J | 1 |
| Massingham, R | 1 |
| Blake, CI | 1 |
| Banchero, N | 1 |
| St John, WM | 1 |
| Bledsoe, TA | 1 |
| Sylvester, JT | 1 |
| Whipp, BJ | 1 |
| Wasserman, K | 1 |
| Ylitalo, P | 1 |
| Linden, RJ | 1 |
| Norman, J | 1 |
| Shimizu, H | 2 |
| Barker, JN | 1 |
| Pontén, U | 1 |
30 other studies available for pentobarbital and Hypercapnia
| Article | Year |
|---|---|
Arterial pH and blood gas values in rats under three types of general anesthesia: a chronobiological study.
Topics: Anesthesia, General; Anesthetics, General; Animals; Blood Gas Analysis; Chronobiology Phenomena; Dru | 2018 |
Hypoxia, not hypercapnia, induces cardiorespiratory failure in rats.
Topics: Anesthesia; Animals; Arterial Pressure; Asphyxia; Diaphragm; Heart Failure; Heart Rate; Heart Ventri | 2014 |
Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy.
Topics: Anesthesia; Animals; Base Sequence; Bicuculline; Brain Stem; Cerebral Cortex; Electrophysiological P | 2012 |
Hypercapnic and hypoxic ventilatory responses in long-term streptozotocin-diabetic rats during conscious and pentobarbital-induced anesthetic states.
Topics: Aging; Anesthetics; Animals; Blood Glucose; Body Weight; Consciousness; Diabetes Mellitus, Experimen | 2002 |
[THE RELATION BETWEEN THE CEREBROVASCULAR AND ELECTROGRAPHIC EFFECT OF HYPERCAPNIA UNDER THE INFLUENCE OF BARBITURATES].
Topics: Animals; Barbiturates; Brain; Carbon Dioxide; Cerebrovascular Circulation; Dogs; Electrophysiologica | 1964 |
The effects of different dobutamine infusion rates on hypercapnic depression of diaphragmatic contractility in pentobarbital-anesthetized dogs.
Topics: Adjuvants, Anesthesia; Animals; Diaphragm; Dobutamine; Dogs; Female; Hypercapnia; Infusions, Intrave | 2007 |
Cerebral oxygen consumption in the rat: pharmacological stimulation and suppression, role of catecholaminergic mechanisms.
Topics: Adrenergic beta-Antagonists; Animals; Brain; Cerebrovascular Circulation; Ethanol; Halothane; Hyperc | 1981 |
Pial arterial response to systemic hypoxia in anaesthetised cats.
Topics: Animals; Blood Pressure; Cats; Cerebral Arteries; Chloralose; Female; Hypercapnia; Hypoxia; Male; Ox | 1981 |
Alpha 2-adrenergic agonist effects on normocapnic and hypercapnic cerebral blood flow in the dog are anesthetic dependent.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Cerebrovascular Circulatio | 1994 |
Experimental critical care in rats: gender differences in anesthesia, ventilation, and gas exchange.
Topics: Anesthesia; Anesthetics; Animals; Critical Care; Disease Models, Animal; Dose-Response Relationship, | 1999 |
Intrathecal dexmedetomidine attenuates hypercapnic but not hypoxic cerebral vasodilation in anesthetized rabbits.
Topics: Adjuvants, Anesthesia; Administration, Topical; Adrenergic alpha-Agonists; Adrenergic alpha-Antagoni | 2000 |
Phrenic activity during severe hypercapnia in vagotomized rabbits.
Topics: Anesthesia, General; Animals; Blood Pressure; Carbon Dioxide; Decerebrate State; Female; Heart Rate; | 1979 |
Cerebrovascular effects of central depressants: a study of nitrous oxide, halothane, pentobarbital and ethanol during normocapnia and hypercapnia in the rat.
Topics: Anesthesia, General; Anesthetics; Animals; Brain; Carbon Dioxide; Central Nervous System Depressants | 1979 |
Respiratory load compensation in awake and sleeping dogs.
Topics: Animals; Dogs; Hypercapnia; Hypoxia; Lung Compliance; Pentobarbital; Respiration; Sleep; Tidal Volum | 1976 |
Response to hypercapnia under ketamine anaesthesia.
Topics: Acid-Base Equilibrium; Anesthesia, Intravenous; Animals; Atropine; Blood Pressure; Carbon Dioxide; C | 1975 |
Hypoxic ventilatory drive in dogs during thiopental, ketamine, or pentobarbital anesthesia.
Topics: Anesthesia, Intravenous; Animals; Carbon Dioxide; Dogs; Female; Hypercapnia; Hypoxia; Ketamine; Male | 1975 |
Anesthesia affects respiratory and sympathetic nerve activities differentially.
Topics: Anesthesia; Animals; Carbon Dioxide; Cats; Chloralose; Decerebrate State; Hypercapnia; Pentobarbital | 1991 |
[Regulation of the duration of expiratory phases in decerebrate cats].
Topics: Animals; Cats; Decerebrate State; Electromyography; Hypercapnia; Pentobarbital; Phrenic Nerve; Pulmo | 1989 |
Internal intercostal nerve discharges in the cat: influence of chemical stimuli.
Topics: Action Potentials; Animals; Cats; Chemoreceptor Cells; Female; Hypercapnia; Hypoxia; Intercostal Ner | 1989 |
Effects of anesthesia on cerebral arteriolar responses to hypercapnia.
Topics: Anesthesia; Animals; Arterioles; Cerebrovascular Circulation; Hypercapnia; Oxygen Consumption; Pento | 1989 |
Synergistic interactions between piracetam and dihydroergocristine in some animal models of cerebral hypoxia and ischaemia.
Topics: Anesthesia; Animals; Avoidance Learning; Brain Ischemia; Cerebrovascular Circulation; Dihydroergotox | 1986 |
Ventilation and oxygen consumption in the guinea pig.
Topics: Anesthesia; Animals; Body Weight; Guinea Pigs; Hypercapnia; Male; Oxygen Consumption; Pentobarbital; | 1985 |
Comparison of respiratory-related trigeminal, hypoglossal and phrenic activities.
Topics: Animals; Cats; Chemoreceptor Cells; Decerebrate State; Diazepam; Doxapram; Electromyography; Electro | 1985 |
Ventilatory control during brief infusions of CO2-laden blood in the awake dog.
Topics: Animals; Aorta, Thoracic; Carbon Dioxide; Carotid Body; Chemoreceptor Cells; Dogs; Hydrogen-Ion Conc | 1973 |
Effect of anaesthetics with excitatory properties, hypoxia, hypercapnia and hypoglycaemia on toxicity of 5HT in rats.
Topics: Anesthetics; Animals; Chloralose; Depression, Chemical; Hydroxybutyrates; Hypercapnia; Hypoglycemia; | 1972 |
The imprecision arising from the application of the Henderson-Hasselbalch relationship to the blood of anesthetized dogs.
Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Respiratory; Alkalosis, Respiratory; Anesthesia, General; | 1971 |
[Pharmacological and physiological studies on renal circulation. (3). Effects of general anesthetics and changes in blood gas tension].
Topics: Acetylcholine; Anesthesia, General; Animals; Blood Gas Analysis; Blood Pressure; Carbon Dioxide; Che | 1967 |
[Pharmacological and physiological studies on renal circulation. (4). Effects of changes in blood gas tension on the circulation of the perfused kidney].
Topics: Acetylcholine; Animals; Blood Gas Analysis; Blood Pressure; Carbon Dioxide; Chloralose; Dogs; Electr | 1967 |
Fetal and neonatal cerebral blood flow.
Topics: Animals; Animals, Newborn; Antipyrine; Blood Chemical Analysis; Blood Flow Velocity; Blood Gas Analy | 1966 |
Consecutive acid-base changes in blood, brain tissue and cerebrospinal fluid during respiratory acidosis and baseosis.
Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Anesthesia; Animals; Bicarbonates; Carbon Dioxide; Hyd | 1966 |