pentobarbital has been researched along with Heart Failure in 27 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intravenous drip of sodium pentobarbital 6 mg/kg per min induced obvious heart failure of anesthetic dogs (n = 11) followed by an infusion of 0." | 7.68 | [Effect of Chinese-made vesnarinone on experimental heart failure of dog]. ( Du, J; Yang, Z, 1992) |
| "In previous studies racemic bucindolol was found to reverse the effects of pentobarbital-induced heart failure in anesthetized dogs." | 7.67 | Differential cardioprotective properties of the l- and d- enantiomers of bucindolol in a canine model of heart failure. ( Hanson, RC; Snyder, RW; Weyl, JD, 1985) |
| "The efficacy of MCI-154, a new pyridazinone cardiotonic agent, in improving heart failure was assessed in dog heart-lung preparations in which cardiac function had been severely depressed by pentobarbital." | 7.67 | Improvement of pentobarbital-induced heart failure by MCI-154, a novel and potent cardiotonic agent, in the dog heart-lung preparation. ( Goto, T; Hashimoto, H; Hosono, M; Nunoki, K; Sato, Y; Satoh, K; Taira, N, 1988) |
| "Amrinone, a positive inotropic-vasodilator agent, was administered to anaesthetised dogs in an attempt to reverse heart failure induced by drugs possessing negative inotropic properties." | 7.67 | The beneficial effect of amrinone on acute drug-induced heart failure in the anaesthetised dog. ( Alousi, AA; Canter, JM; Fort, DJ, 1985) |
| "Heart failure was induced in barbital-anesthetized dogs by administering high doses of pentobarbital." | 7.66 | Beneficial effects of bucindolol in a canine model of pentobarbital-induced heart failure. ( Deitchman, D; Snyder, RW, 1981) |
| " We tested the hypothesis that asphyxia alone can cause cardiorespiratory failure ("failure") in pentobarbital-anesthetized rats." | 3.80 | Hypoxia, not hypercapnia, induces cardiorespiratory failure in rats. ( Iscoe, S; Simpson, JA, 2014) |
| "Intravenous drip of sodium pentobarbital 6 mg/kg per min induced obvious heart failure of anesthetic dogs (n = 11) followed by an infusion of 0." | 3.68 | [Effect of Chinese-made vesnarinone on experimental heart failure of dog]. ( Du, J; Yang, Z, 1992) |
| " In the acute heart failure models induced by either propranolol or pentobarbital, MS-857 reversed the cardiac depressant effects of these drugs." | 3.67 | Cardiovascular properties of MS-857, a new and potent cardiotonic agent, on normal and failing hearts. ( Kaiho, T; Kamiya, J; Kobari, T; Maruyama, M, 1988) |
| "In previous studies racemic bucindolol was found to reverse the effects of pentobarbital-induced heart failure in anesthetized dogs." | 3.67 | Differential cardioprotective properties of the l- and d- enantiomers of bucindolol in a canine model of heart failure. ( Hanson, RC; Snyder, RW; Weyl, JD, 1985) |
| "The efficacy of MCI-154, a new pyridazinone cardiotonic agent, in improving heart failure was assessed in dog heart-lung preparations in which cardiac function had been severely depressed by pentobarbital." | 3.67 | Improvement of pentobarbital-induced heart failure by MCI-154, a novel and potent cardiotonic agent, in the dog heart-lung preparation. ( Goto, T; Hashimoto, H; Hosono, M; Nunoki, K; Sato, Y; Satoh, K; Taira, N, 1988) |
| "Amrinone, a positive inotropic-vasodilator agent, was administered to anaesthetised dogs in an attempt to reverse heart failure induced by drugs possessing negative inotropic properties." | 3.67 | The beneficial effect of amrinone on acute drug-induced heart failure in the anaesthetised dog. ( Alousi, AA; Canter, JM; Fort, DJ, 1985) |
| "Heart failure was induced in barbital-anesthetized dogs by administering high doses of pentobarbital." | 3.66 | Beneficial effects of bucindolol in a canine model of pentobarbital-induced heart failure. ( Deitchman, D; Snyder, RW, 1981) |
| " When heart failure was induced by pentobarbital or by chloroform, the equilibrium point shifted downwards to the right, depicting the VR-curve." | 3.66 | Direct recording of cardiac output- and venous return-curves in the dog heart-lung preparation for a graphical analysis of the effects of cardioactive drugs. ( Hagino, Y; Hojo, Y; Ishikawa, N; Shigei, T; Taki, K, 1978) |
| "The effects of acute cardiac failure induced by pentobarbital or pronethalol on the basic mechanical properties of the intact left ventricle were examined in the dog, and the influence on auxotonic and isovolumic contractions of the increase in end-diastolic volume that usually accompanies cardiac failure was assessed." | 3.64 | The mechanics of left ventricular contraction in acute experimental cardiac failure. ( Covell, JW; Ross, J; Sonnenblick, EH, 1967) |
| "Milrinone (Win 47203) is a dipyridine related to amrinone, which is about 20-50 times as effective as amrinone when assayed on cardiac contractility." | 1.27 | The search for a digitalis substitute II milrinone (Win 47203). Its action on the heart-lung preparation of the dog. ( Farah, A; Kabela, E; Mendez, R; Pastelin, G, 1983) |
| "In contrast, cardiac failure caused by volatile anesthetics proved to be resistant to this therapy." | 1.25 | Reversible and irreversible forms of contractile failure caused by disturbances by general anesthetics in myocardial ATP utilization. ( Höring, HJ, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (81.48) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 1 (3.70) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Lu, H | 1 |
| Xu, W | 1 |
| Shang, Y | 1 |
| Zhao, C | 1 |
| Wang, Y | 1 |
| Yang, R | 1 |
| Jin, S | 1 |
| Wu, Y | 1 |
| Wang, X | 1 |
| Teng, X | 1 |
| Simpson, JA | 1 |
| Iscoe, S | 1 |
| Ohno, R | 1 |
| Miyata, H | 1 |
| Kimura, M | 1 |
| GRUHZIT, CC | 1 |
| FARAH, AE | 1 |
| SIEGEL, JH | 1 |
| SONNENBLICK, EH | 2 |
| Pastelin, G | 2 |
| Mendez, R | 2 |
| Kabela, E | 2 |
| Farah, A | 1 |
| Satoh, K | 2 |
| Kawada, M | 1 |
| Taira, N | 2 |
| Deitchman, D | 1 |
| Snyder, RW | 2 |
| Minatoguchi, S | 1 |
| Majewski, H | 1 |
| Higgins, CB | 1 |
| Schmidt, W | 1 |
| Ishikawa, N | 1 |
| Taki, K | 1 |
| Hojo, Y | 1 |
| Hagino, Y | 1 |
| Shigei, T | 1 |
| Höring, HJ | 1 |
| Du, J | 1 |
| Yang, Z | 1 |
| Maruyama, M | 1 |
| Kamiya, J | 1 |
| Kaiho, T | 1 |
| Kobari, T | 1 |
| Falotico, R | 1 |
| Haertlein, BJ | 1 |
| Lakas-Weiss, CS | 1 |
| Salata, JJ | 1 |
| Tobia, AJ | 1 |
| Weyl, JD | 1 |
| Hanson, RC | 1 |
| Nunoki, K | 1 |
| Goto, T | 1 |
| Hosono, M | 1 |
| Hashimoto, H | 1 |
| Sato, Y | 1 |
| Alousi, AA | 1 |
| Canter, JM | 1 |
| Fort, DJ | 1 |
| Sakai, K | 1 |
| Sugano, S | 1 |
| Isono, C | 1 |
| Luchi, RJ | 1 |
| Kritcher, EM | 1 |
| Ross, J | 1 |
| Covell, JW | 1 |
| Barrett, AM | 1 |
| Nunn, B | 1 |
| Lochner, W | 1 |
| Raff, WK | 1 |
| Kosche, F | 1 |
| Arora, RB | 1 |
| Bagchi, N | 1 |
| Gupta, OP | 1 |
| Feola, M | 1 |
| Haiderer, O | 1 |
| Kennedy, JH | 1 |
| Hegglin, R | 1 |
| Turina, M | 1 |
27 other studies available for pentobarbital and Heart Failure
| Article | Year |
|---|---|
Apelin ameliorated acute heart failure via inhibiting endoplasmic reticulum stress in rabbits.
Topics: Acute Disease; Animals; Apelin; Apelin Receptors; Disease Models, Animal; Endoplasmic Reticulum Stre | 2021 |
Hypoxia, not hypercapnia, induces cardiorespiratory failure in rats.
Topics: Anesthesia; Animals; Arterial Pressure; Asphyxia; Diaphragm; Heart Failure; Heart Rate; Heart Ventri | 2014 |
[Circadian rhythms and effects of anesthesia on plasma natriuretic peptide levels in rats].
Topics: Anesthesia; Animals; Atrial Natriuretic Factor; Biomarkers; Circadian Rhythm; Ether; Heart Failure; | 2009 |
A comparison of the positive inotropic effects of ouabain and epinephrine in heart failure induced in the dog heart-lung preparation by sodium pentobarbital, dinitrophenol, sodium cyanide and sodium azide.
Topics: Animals; Dinitrophenols; Dogs; Epinephrine; Heart; Heart Failure; Ouabain; Pentobarbital; Sodium; So | 1955 |
QUANTIFICATION AND PREDICTION OF MYOCARDIAL FAILURE.
Topics: Barbiturates; Dogs; Heart Arrest; Heart Failure; Heart Function Tests; Myocardium; Pentobarbital; Re | 1964 |
The search for a digitalis substitute II milrinone (Win 47203). Its action on the heart-lung preparation of the dog.
Topics: Animals; Cardiotonic Agents; Dinitrophenols; Dogs; Heart; Heart Failure; Milrinone; Nifedipine; Papa | 1983 |
Improvement by trapidil of cardiac function of the dog heart-lung preparation depressed by pentobarbital.
Topics: Animals; Blood Pressure; Cardiac Output; Cardiotonic Agents; Dogs; Female; Heart Failure; Heart Rate | 1983 |
Beneficial effects of bucindolol in a canine model of pentobarbital-induced heart failure.
Topics: Animals; Blood Pressure; Dogs; Female; Heart Failure; Heart Rate; Hypertension; Indoles; Male; Pento | 1981 |
Modulation of norepinephrine release in adriamycin-induced heart failure in rabbits: role of presynaptic alpha 2-adrenoceptors and presynaptic angiotensin II receptors.
Topics: Anesthesia; Angiotensin II; Animals; Captopril; Catecholamines; Decerebrate State; Doxorubicin; Elec | 1994 |
Alterations in calcium levels of coronary sinus blood during coronary arteriography in the dog.
Topics: Animals; Calcium; Coronary Angiography; Diatrizoate Meglumine; Dogs; Edetic Acid; Heart Failure; Hem | 1978 |
Direct recording of cardiac output- and venous return-curves in the dog heart-lung preparation for a graphical analysis of the effects of cardioactive drugs.
Topics: Animals; Blood Pressure; Bufanolides; Cardiac Output; Chloroform; Dogs; Heart Failure; Male; Models, | 1978 |
Reversible and irreversible forms of contractile failure caused by disturbances by general anesthetics in myocardial ATP utilization.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Anesthetics; Animals; Calcium; Chloroform; Guinea Pig | 1975 |
[Effect of Chinese-made vesnarinone on experimental heart failure of dog].
Topics: Animals; Cardiac Output; Cardiotonic Agents; Dogs; Female; Heart Failure; Hemodynamics; Male; Myocar | 1992 |
Cardiovascular properties of MS-857, a new and potent cardiotonic agent, on normal and failing hearts.
Topics: Anesthesia; Animals; Cardiotonic Agents; Dogs; Female; Heart; Heart Failure; Isoquinolines; Lung; Ma | 1988 |
Positive inotropic and hemodynamic properties of flosequinan, a new vasodilator, and a sulfone metabolite.
Topics: Amrinone; Anesthesia; Animals; Ferrets; Heart Failure; Heart Rate; Hemodynamics; In Vitro Techniques | 1989 |
Differential cardioprotective properties of the l- and d- enantiomers of bucindolol in a canine model of heart failure.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Dogs; Female; Heart; Heart Failure; Male; Pent | 1985 |
Improvement of pentobarbital-induced heart failure by MCI-154, a novel and potent cardiotonic agent, in the dog heart-lung preparation.
Topics: Animals; Atenolol; Blood Pressure; Cardiac Output; Cardiotonic Agents; Disease Models, Animal; Dogs; | 1988 |
The beneficial effect of amrinone on acute drug-induced heart failure in the anaesthetised dog.
Topics: Aminopyridines; Amrinone; Animals; Blood Pressure; Cardiac Output; Cardiotonic Agents; Central Venou | 1985 |
Effects of oxyfedrine and ouabain on the heart-lung preparation of the dog.
Topics: Amino Alcohols; Animals; Arrhythmias, Cardiac; Cardiac Output; Disease Models, Animal; Dogs; Female; | 1973 |
Drug effects on cardiac myosin adenosine triphosphatase activity.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Angiotensin II; Animals; Binding Sites; Calcium; | 1967 |
The mechanics of left ventricular contraction in acute experimental cardiac failure.
Topics: Animals; Blood Pressure Determination; Dogs; Ethanolamines; Extracorporeal Circulation; Heart Failur | 1967 |
Intrinsic sympathomimetic activity in relation to the precipitation of heart failure by beta-adrenoceptive blockade.
Topics: Adrenergic beta-Antagonists; Animals; Cardiac Output; Drug Antagonism; Extracorporeal Circulation; F | 1971 |
[Coronary flow resistance in heart failure and circulatory insufficiency].
Topics: Animals; Coronary Circulation; Coronary Disease; Coronary Vessels; Dogs; Heart Failure; Pentobarbita | 1972 |
The influence of the position of attachment of the lactone ring to the steroid nucleus on the action of cardiac glycosides.
Topics: Animals; Blood Pressure; Blood Volume; Cardanolides; Cardiac Glycosides; Cardiac Output; Dogs; Femal | 1974 |
The effects of reserpine and propranolol on the therapeutic and toxic effects of peruvoside in the heart-lung preparation and intact dogs.
Topics: Animals; Arrhythmias, Cardiac; Cardanolides; Cardiac Glycosides; Dogs; Drug Antagonism; Extracorpore | 1972 |
Experimental graded "pump failure" of the left ventricle.
Topics: Animals; Aorta, Thoracic; Blood Flow Velocity; Blood Pressure; Carbon Dioxide; Cardiac Output; Cardi | 1971 |
Changes in duration of electro-mechanical systole in cardiac failure of chemical origin.
Topics: Animals; Dogs; Heart; Heart Failure; Pentobarbital | 1968 |