pentobarbital has been researched along with Glioma in 6 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Malignant gliomas are common and aggressive brain tumors in adults." | 5.35 | Anesthetic pentobarbital inhibits proliferation and migration of malignant glioma cells. ( Huang, Y; Li, Y; Ou, Y; Qiu, P; Shu, M; Xie, J; Yan, G; Zhu, W, 2009) |
| " Local coupling of blood flow and metabolism was studied under different types of anesthesia (barbiturate, halothane), following experimental tumor implantation, and during penicillin seizures or spreading depression." | 3.66 | A double tracer autoradiographic technique for simultaneous measurement of cerebral blood flow and cerebral metabolism in rats. ( Hossmann, KA; Mies, G; Niebuhr, I, 1981) |
| "Malignant gliomas are common and aggressive brain tumors in adults." | 1.35 | Anesthetic pentobarbital inhibits proliferation and migration of malignant glioma cells. ( Huang, Y; Li, Y; Ou, Y; Qiu, P; Shu, M; Xie, J; Yan, G; Zhu, W, 2009) |
| "In animals without tumors, the temperature subcutaneously on the foot was 0." | 1.29 | Use of the vasodilator sodium nitroprusside during local hyperthermia: effects on tumor temperature and tumor response in a rat tumor model. ( Dahl, O; Krossnes, BK; Mella, O, 1996) |
| "Pentobarbital acts as a cerebral radioprotectant, but the selectivity of its protection for the central nervous system has not been demonstrated." | 1.28 | Enhancement of the efficacy of x-irradiation by pentobarbital in a rodent brain-tumor model. ( Delaney, T; Friedman, R; Oldfield, EH; Olson, JJ; Orr, K, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, J | 1 |
| Li, Y | 1 |
| Huang, Y | 1 |
| Qiu, P | 1 |
| Shu, M | 1 |
| Zhu, W | 1 |
| Ou, Y | 1 |
| Yan, G | 1 |
| Mies, G | 1 |
| Niebuhr, I | 1 |
| Hossmann, KA | 1 |
| Kimler, BF | 1 |
| Liu, C | 1 |
| Evans, RG | 1 |
| Morantz, RA | 1 |
| Krossnes, BK | 1 |
| Mella, O | 1 |
| Dahl, O | 1 |
| Friedman, SJ | 1 |
| Skehan, P | 1 |
| Olson, JJ | 1 |
| Friedman, R | 1 |
| Orr, K | 1 |
| Delaney, T | 1 |
| Oldfield, EH | 1 |
6 other studies available for pentobarbital and Glioma
| Article | Year |
|---|---|
Anesthetic pentobarbital inhibits proliferation and migration of malignant glioma cells.
Topics: Animals; Brain Neoplasms; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Movement; Cell Survival; | 2009 |
A double tracer autoradiographic technique for simultaneous measurement of cerebral blood flow and cerebral metabolism in rats.
Topics: Animals; Antipyrine; Autoradiography; Brain; Brain Neoplasms; Cerebrovascular Circulation; Cortical | 1981 |
Effect of pentobarbital on normal brain protection and on the response of 9L rat brain tumor to radiation therapy.
Topics: Animals; Brain; Brain Neoplasms; Dose-Response Relationship, Radiation; Glioma; Ketamine; Male; Pent | 1993 |
Use of the vasodilator sodium nitroprusside during local hyperthermia: effects on tumor temperature and tumor response in a rat tumor model.
Topics: Animals; Blood Pressure; Body Temperature; Butyrophenones; Fentanyl; Glioma; Hyperthermia, Induced; | 1996 |
The inhibition of sterol synthesis by anesthetics.
Topics: Acetates; Anesthetics, Local; Animals; Cell Line; Chlorpromazine; Diphenylacetic Acids; Glioma; Halo | 1979 |
Enhancement of the efficacy of x-irradiation by pentobarbital in a rodent brain-tumor model.
Topics: Animals; Brain; Brain Neoplasms; Disease Models, Animal; Glioma; Male; Pentobarbital; Radiation-Prot | 1990 |