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pentobarbital and Glioma

pentobarbital has been researched along with Glioma in 6 studies

Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"Malignant gliomas are common and aggressive brain tumors in adults."5.35Anesthetic pentobarbital inhibits proliferation and migration of malignant glioma cells. ( Huang, Y; Li, Y; Ou, Y; Qiu, P; Shu, M; Xie, J; Yan, G; Zhu, W, 2009)
" Local coupling of blood flow and metabolism was studied under different types of anesthesia (barbiturate, halothane), following experimental tumor implantation, and during penicillin seizures or spreading depression."3.66A double tracer autoradiographic technique for simultaneous measurement of cerebral blood flow and cerebral metabolism in rats. ( Hossmann, KA; Mies, G; Niebuhr, I, 1981)
"Malignant gliomas are common and aggressive brain tumors in adults."1.35Anesthetic pentobarbital inhibits proliferation and migration of malignant glioma cells. ( Huang, Y; Li, Y; Ou, Y; Qiu, P; Shu, M; Xie, J; Yan, G; Zhu, W, 2009)
"In animals without tumors, the temperature subcutaneously on the foot was 0."1.29Use of the vasodilator sodium nitroprusside during local hyperthermia: effects on tumor temperature and tumor response in a rat tumor model. ( Dahl, O; Krossnes, BK; Mella, O, 1996)
"Pentobarbital acts as a cerebral radioprotectant, but the selectivity of its protection for the central nervous system has not been demonstrated."1.28Enhancement of the efficacy of x-irradiation by pentobarbital in a rodent brain-tumor model. ( Delaney, T; Friedman, R; Oldfield, EH; Olson, JJ; Orr, K, 1990)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19902 (33.33)18.7374
1990's3 (50.00)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Xie, J1
Li, Y1
Huang, Y1
Qiu, P1
Shu, M1
Zhu, W1
Ou, Y1
Yan, G1
Mies, G1
Niebuhr, I1
Hossmann, KA1
Kimler, BF1
Liu, C1
Evans, RG1
Morantz, RA1
Krossnes, BK1
Mella, O1
Dahl, O1
Friedman, SJ1
Skehan, P1
Olson, JJ1
Friedman, R1
Orr, K1
Delaney, T1
Oldfield, EH1

Other Studies

6 other studies available for pentobarbital and Glioma

ArticleYear
Anesthetic pentobarbital inhibits proliferation and migration of malignant glioma cells.
    Cancer letters, 2009, Sep-08, Volume: 282, Issue:1

    Topics: Animals; Brain Neoplasms; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Movement; Cell Survival;

2009
A double tracer autoradiographic technique for simultaneous measurement of cerebral blood flow and cerebral metabolism in rats.
    European neurology, 1981, Volume: 20, Issue:3

    Topics: Animals; Antipyrine; Autoradiography; Brain; Brain Neoplasms; Cerebrovascular Circulation; Cortical

1981
Effect of pentobarbital on normal brain protection and on the response of 9L rat brain tumor to radiation therapy.
    Journal of neurosurgery, 1993, Volume: 79, Issue:4

    Topics: Animals; Brain; Brain Neoplasms; Dose-Response Relationship, Radiation; Glioma; Ketamine; Male; Pent

1993
Use of the vasodilator sodium nitroprusside during local hyperthermia: effects on tumor temperature and tumor response in a rat tumor model.
    International journal of radiation oncology, biology, physics, 1996, Sep-01, Volume: 36, Issue:2

    Topics: Animals; Blood Pressure; Body Temperature; Butyrophenones; Fentanyl; Glioma; Hyperthermia, Induced;

1996
The inhibition of sterol synthesis by anesthetics.
    FEBS letters, 1979, Jun-15, Volume: 102, Issue:2

    Topics: Acetates; Anesthetics, Local; Animals; Cell Line; Chlorpromazine; Diphenylacetic Acids; Glioma; Halo

1979
Enhancement of the efficacy of x-irradiation by pentobarbital in a rodent brain-tumor model.
    Journal of neurosurgery, 1990, Volume: 72, Issue:5

    Topics: Animals; Brain; Brain Neoplasms; Disease Models, Animal; Glioma; Male; Pentobarbital; Radiation-Prot

1990