pentobarbital and Fascioliasis studies

Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.

Fascioliasis: Liver disease caused by infections with parasitic flukes of the genus FASCIOLA, such as FASCIOLA HEPATICA.

Research Excerpts

Excerpt	Relevance	Reference
" A significant increase in elimination half-life (around 180 per cent), volume of distribution (130 per cent) and mean residence time (154 to 170 per cent) was observed in sheep infected by the parasite for four to 12 weeks."	5.28	Pharmacokinetics of ampicillin and pentobarbital in the course of subclinical fascioliasis in sheep. ( Alvinerie, M; Galtier, P; Houin, G; Larrieu, G; Tufenkji, AE, 1991)
" A significant increase in elimination half-life (around 180 per cent), volume of distribution (130 per cent) and mean residence time (154 to 170 per cent) was observed in sheep infected by the parasite for four to 12 weeks."	1.28	Pharmacokinetics of ampicillin and pentobarbital in the course of subclinical fascioliasis in sheep. ( Alvinerie, M; Galtier, P; Houin, G; Larrieu, G; Tufenkji, AE, 1991)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

pentobarbital and Fascioliasis

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