pentobarbital has been researched along with Experimental Neoplasms in 23 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of pentobarbital anesthesia on the energy metabolism of FSaII and MCaIV foot tumors in mice were studied by 31P MRS." | 7.67 | Effects of pentobarbital anesthesia on the energy metabolism of murine tumors studied by in vivo 31P nuclear magnetic resonance spectroscopy. ( Neuringer, LJ; Okunieff, P; Rummeny, E; Skates, S; Suit, HD; Vaupel, P; Willett, C, 1988) |
| "Studies of the effect of pentobarbital anesthesia on the radiation response have been performed using early generation isotransplants of three spontaneous tumors of the C3H mouse: a mammary carcinoma (MCaIV), a fibrosarcoma (FSaII), and a squamous cell carcinoma (SCCVII)." | 7.67 | Pentobarbital anesthesia and the response of tumor and normal tissue in the C3Hf/sed mouse to radiation. ( Dosoretz, D; Sedlacek, RS; Silver, G; Suit, HD, 1985) |
| "The influence of anaesthetics on the in vivo response of B16 melanoma to melphalan was studied using an in vitro cell-survival assay." | 7.66 | Influence of anaesthetics on tumour-cell kill and repopulation in B16 melanoma treated with melphalan. ( Peacock, JH; Stephens, TC, 1978) |
| "The effects of pentobarbital anesthesia on the energy metabolism of FSaII and MCaIV foot tumors in mice were studied by 31P MRS." | 3.67 | Effects of pentobarbital anesthesia on the energy metabolism of murine tumors studied by in vivo 31P nuclear magnetic resonance spectroscopy. ( Neuringer, LJ; Okunieff, P; Rummeny, E; Skates, S; Suit, HD; Vaupel, P; Willett, C, 1988) |
| "Studies of the effect of pentobarbital anesthesia on the radiation response have been performed using early generation isotransplants of three spontaneous tumors of the C3H mouse: a mammary carcinoma (MCaIV), a fibrosarcoma (FSaII), and a squamous cell carcinoma (SCCVII)." | 3.67 | Pentobarbital anesthesia and the response of tumor and normal tissue in the C3Hf/sed mouse to radiation. ( Dosoretz, D; Sedlacek, RS; Silver, G; Suit, HD, 1985) |
| "The influence of anaesthetics on the in vivo response of B16 melanoma to melphalan was studied using an in vitro cell-survival assay." | 3.66 | Influence of anaesthetics on tumour-cell kill and repopulation in B16 melanoma treated with melphalan. ( Peacock, JH; Stephens, TC, 1978) |
| "Pentobarbital anesthesia has been observed to increase markedly the effectiveness of respiration of oxygen at 3 atmospheres of pressure absolute to increase the response of early generation isotransplants of C3H mouse tumors to two-dose irradiation." | 1.27 | On the mechanism for enhancement of tumor radiation to hyperbaric oxygen in sodium pentobarbital anesthetized rodents. ( Biaglow, JE; Dosoretz, DE; Durand, RE; Suit, HD, 1984) |
| "Seven-day Ehrlich ascites tumor-bearing animals treated with pentobarbital slept about three times longer than normal mice, but both groups awoke at the same plasma levels of the unbound drug." | 1.25 | Physiological disposition of pentobarbital in tumor-bearing mice. ( Beck, WT; Fabro, S; Mandel, HG, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (91.30) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Biaglow, JE | 1 |
| Suit, HD | 3 |
| Durand, RE | 1 |
| Dosoretz, DE | 1 |
| Beck, WT | 2 |
| Dedmon, ML | 1 |
| Ouellette, MA | 1 |
| Brennan, LM | 1 |
| Creasia, DA | 1 |
| Honess, DJ | 1 |
| Workman, P | 1 |
| Morgan, JE | 1 |
| Bleehen, NM | 2 |
| Gerweck, LE | 1 |
| Hetzel, FW | 1 |
| Jayasundar, R | 1 |
| Hall, LD | 1 |
| Sabine, JR | 1 |
| Sheldon, PW | 3 |
| Hill, SA | 1 |
| Moulder, JE | 1 |
| Denekamp, J | 1 |
| Terry, NH | 1 |
| Chu, AM | 2 |
| Rosengren, JE | 1 |
| Peacock, JH | 1 |
| Stephens, TC | 1 |
| Zanelli, GD | 2 |
| Lucas, PB | 2 |
| Mandel, HG | 1 |
| Fabro, S | 1 |
| Fowler, JF | 1 |
| Okunieff, P | 1 |
| Rummeny, E | 1 |
| Vaupel, P | 1 |
| Skates, S | 1 |
| Willett, C | 1 |
| Neuringer, LJ | 1 |
| Gomer, CJ | 1 |
| Hayashi, N | 1 |
| Murphree, AL | 1 |
| Sedlacek, RS | 1 |
| Silver, G | 1 |
| Dosoretz, D | 1 |
| Hilz, H | 1 |
| Jarmers, G | 1 |
| Gullino, PM | 1 |
| Grantham, FH | 1 |
| Courtney, AH | 1 |
| Lappé, MA | 1 |
| Steinmuller, DS | 1 |
| Saunders, RN | 1 |
| Miya, TS | 1 |
| Bousquet, WF | 1 |
| Rosso, R | 1 |
| Donelli, MG | 1 |
| Franchi, G | 1 |
| Garattini, S | 1 |
23 other studies available for pentobarbital and Experimental Neoplasms
| Article | Year |
|---|---|
On the mechanism for enhancement of tumor radiation to hyperbaric oxygen in sodium pentobarbital anesthetized rodents.
Topics: Animals; Body Temperature; Combined Modality Therapy; Fibrosarcoma; Hyperbaric Oxygenation; Mammary | 1984 |
Biochemical basis for impaired drug metabolism in tumor-bearing rats. Evidence for altered regulation of hepatic microsomal hemeprotein synthesis.
Topics: 5-Aminolevulinate Synthetase; Animals; Cytochrome P-450 Enzyme System; Female; Heme Oxygenase (Decyc | 1982 |
The effects of methapyrilene hydrochloride on hepatocarcinogenicity and pentobarbital-induced sleeping time in rats and mice.
Topics: Aminopyridines; Animals; Enzyme Induction; Female; Liver; Liver Neoplasms; Male; Methapyrilene; Mice | 1982 |
Effects of local hyperthermia on the pharmacokinetics of misonidazole in the anaesthetized mouse.
Topics: Abdomen; Anesthesia; Animals; Drug Administration Schedule; Drug Interactions; Half-Life; Hindlimb; | 1980 |
PO2 in irradiated versus nonirradiated tumors of mice breathing oxygen at normal and elevated pressure.
Topics: Animals; Cell Hypoxia; Hyperbaric Oxygenation; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Oxyg | 1995 |
The effects of anesthesia and physical restraint on intra- and extracellular tumor pH, tumor temperature and bioenergetics in murine RIF-1 tumors.
Topics: Adjuvants, Anesthesia; Animals; Energy Metabolism; Fibrosarcoma; Hydrogen-Ion Concentration; Magneti | 1997 |
Exposure to an environment containing the aromatic red cedar, Juniperus virginiana: procarcinogenic, enzyme-inducing and insecticidal effects.
Topics: Animals; Carcinoma, Hepatocellular; Cockroaches; Environment; Enzyme Induction; Insecta; Liver Neopl | 1975 |
Radioprotection by pentobarbitone sodium of a murine tumour in vivo.
Topics: Anesthesia; Animals; Dose-Response Relationship, Radiation; Female; Mice; Neoplasm Transplantation; | 1977 |
The effect of pentobarbital anaesthesia on the radiosensitivity of four mouse tumours.
Topics: Animals; Carcinoma, Squamous Cell; Dose-Response Relationship, Radiation; Male; Methods; Mice; Neopl | 1979 |
The effect of anesthetics on the radiosensitivity of a murine tumor.
Topics: Anesthetics; Animals; Body Temperature; Chloral Hydrate; Diazepam; Ethanol; Fentanyl; Mice; Mice, In | 1979 |
Experimental colonic tumours in the rat. I. Preparation and technique of examination.
Topics: Anesthesia, General; Animals; Atropine; Chloral Hydrate; Colon; Colonic Neoplasms; Contrast Media; D | 1978 |
Influence of anaesthetics on tumour-cell kill and repopulation in B16 melanoma treated with melphalan.
Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Butyrophenones; Cell Survival; Dose-Response Re | 1978 |
Effects of X-rays on vascular function in transplanted tumours and normal tissues in the mouse.
Topics: Anesthesia; Animals; Blood Vessels; Dose-Response Relationship, Radiation; Male; Mice; Muscles; Neop | 1976 |
Physiological disposition of pentobarbital in tumor-bearing mice.
Topics: Animals; Blood Proteins; Carcinoma, Ehrlich Tumor; DNA, Neoplasm; Half-Life; In Vitro Techniques; Ma | 1975 |
The effect of anaesthetics on blood perfusion in transplanted mouse tumours.
Topics: Animals; Capillary Permeability; Intestine, Small; Kidney; Mice; Mice, Inbred C3H; Mice, Inbred CBA; | 1975 |
Effects of pentobarbital anesthesia on the energy metabolism of murine tumors studied by in vivo 31P nuclear magnetic resonance spectroscopy.
Topics: Anesthesia; Animals; Body Temperature; Dose-Response Relationship, Radiation; Energy Metabolism; Hyd | 1988 |
The influence of sodium pentobarbital anesthesia on in vivo photodynamic therapy.
Topics: Anesthesia; Animals; Female; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Oxygen; Pentobarbita | 1987 |
Pentobarbital anesthesia and the response of tumor and normal tissue in the C3Hf/sed mouse to radiation.
Topics: Anesthesia; Animals; Carcinoma, Squamous Cell; Female; Fibrosarcoma; Hyperbaric Oxygenation; Lung Di | 1985 |
[Stimulation of tumor growths by anesthesia].
Topics: Adrenalectomy; Anesthesia; Anesthetics; Animals; Carcinogens; Carcinoma, Ehrlich Tumor; Cell Differe | 1967 |
Utilization of oxygen by transplanted tumors in vivo.
Topics: Anemia; Anesthesia, General; Animals; Blood Flow Velocity; Carbon Dioxide; Carcinoma 256, Walker; Ca | 1967 |
Depression of weak allograft immunity in the mouse by neonatal or adult exposure to urethan.
Topics: Animals; Animals, Newborn; Immunosuppressive Agents; Mice; Neoplasms; Neoplasms, Experimental; Pento | 1970 |
Stimulation of DOPA14C incorporation into melanoma tissue by chlorpromazine and reserpine.
Topics: Animals; Carbon Isotopes; Catechol Oxidase; Chlorpromazine; Dihydroxyphenylalanine; In Vitro Techniq | 1970 |
Impairement of drug metabolism in tumor-bearing animals.
Topics: Animals; Brain Chemistry; Female; Liver; Male; Mice; Microsomes, Liver; Neoplasm Transplantation; Ne | 1971 |