pentobarbital has been researched along with Encephalopathy, Traumatic in 9 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pentobarbital coma is often instituted following the failure of osmotic interventions and sedation to control intracranial pressure (ICP)." | 8.31 | Pentobarbital coma for management of intracranial hypertension following traumatic brain injury: Lack of early response to treatment portends poor outcomes. ( Bonnin, SS; Chapple, KM; Huang, DD; Kelley, CJ; Rudy, RF; Snyder, LA; Stansbury, BM; Weinberg, JA, 2023) |
| " Prospective PK studies with pharmacodynamic endpoints, are imperative to optimise pentobarbital dosing in terms of safety and clinical efficacy in critically ill children." | 5.91 | A Population Pharmacokinetic Model of Pentobarbital for Children with Status Epilepticus and Severe Traumatic Brain Injury. ( de Hoog, M; de Vries, JMP; de Winter, BCM; Ketharanathan, N; Koch, BCP; Lili, A; Wildschut, ED, 2023) |
| " Pentobarbital coma is often instituted following the failure of osmotic interventions and sedation to control intracranial pressure (ICP)." | 4.31 | Pentobarbital coma for management of intracranial hypertension following traumatic brain injury: Lack of early response to treatment portends poor outcomes. ( Bonnin, SS; Chapple, KM; Huang, DD; Kelley, CJ; Rudy, RF; Snyder, LA; Stansbury, BM; Weinberg, JA, 2023) |
| "Pentobarbital is a short-acting barbiturate with anticonvulsant and sedative-hypnotic properties." | 2.44 | Liquid Chromatography-Tandem Mass Spectrometry for Quantitation of Serum Pentobarbital. ( Kyle, PB; Yahya, HA, 2024) |
| " Prospective PK studies with pharmacodynamic endpoints, are imperative to optimise pentobarbital dosing in terms of safety and clinical efficacy in critically ill children." | 1.91 | A Population Pharmacokinetic Model of Pentobarbital for Children with Status Epilepticus and Severe Traumatic Brain Injury. ( de Hoog, M; de Vries, JMP; de Winter, BCM; Ketharanathan, N; Koch, BCP; Lili, A; Wildschut, ED, 2023) |
| "Fentanyl was significantly associated with the most frequent treatment failure." | 1.43 | Effectiveness of Pharmacological Therapies for Intracranial Hypertension in Children With Severe Traumatic Brain Injury--Results From an Automated Data Collection System Time-Synched to Drug Administration. ( Balasubramani, GK; Bayir, H; Bell, MJ; Clark, RS; Ferguson, NM; Fink, EL; Kochanek, PM; Shein, SL; Tian, Y; Tyler-Kabara, EC; Wisniewski, SR, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Ketharanathan, N | 1 |
| Lili, A | 1 |
| de Vries, JMP | 1 |
| Wildschut, ED | 1 |
| de Hoog, M | 1 |
| Koch, BCP | 1 |
| de Winter, BCM | 1 |
| Stansbury, BM | 1 |
| Kelley, CJ | 1 |
| Rudy, RF | 1 |
| Bonnin, SS | 1 |
| Chapple, KM | 1 |
| Snyder, LA | 1 |
| Weinberg, JA | 1 |
| Huang, DD | 1 |
| Yahya, HA | 1 |
| Kyle, PB | 1 |
| Kannan, G | 1 |
| Kambhampati, SP | 1 |
| Kudchadkar, SR | 1 |
| Hensler, DM | 1 |
| McConnell, DP | 1 |
| Levasseur-Franklin, KE | 1 |
| Greathouse, KM | 1 |
| Wolahan, SM | 1 |
| Lebby, E | 1 |
| Mao, HC | 1 |
| McArthur, D | 1 |
| Real, C | 1 |
| Vespa, P | 3 |
| Braas, D | 1 |
| Glenn, TC | 1 |
| Shein, SL | 1 |
| Ferguson, NM | 1 |
| Kochanek, PM | 1 |
| Bayir, H | 1 |
| Clark, RS | 1 |
| Fink, EL | 1 |
| Tyler-Kabara, EC | 1 |
| Wisniewski, SR | 1 |
| Tian, Y | 1 |
| Balasubramani, GK | 1 |
| Bell, MJ | 1 |
| Connolly, M | 2 |
| Liou, R | 1 |
| Hu, X | 2 |
9 other studies available for pentobarbital and Encephalopathy, Traumatic
| Article | Year |
|---|---|
A Population Pharmacokinetic Model of Pentobarbital for Children with Status Epilepticus and Severe Traumatic Brain Injury.
Topics: Anti-Bacterial Agents; Brain Injuries, Traumatic; Child; Creatinine; Critical Illness; Humans; Infan | 2023 |
Pentobarbital coma for management of intracranial hypertension following traumatic brain injury: Lack of early response to treatment portends poor outcomes.
Topics: Adult; Brain Injuries; Brain Injuries, Traumatic; Coma; Female; Glasgow Coma Scale; Humans; Intracra | 2023 |
Liquid Chromatography-Tandem Mass Spectrometry for Quantitation of Serum Pentobarbital.
Topics: Brain Injuries, Traumatic; Chromatography, High Pressure Liquid; Chromatography, Liquid; Coma; Human | 2024 |
Effect of anesthetics on microglial activation and nanoparticle uptake: Implications for drug delivery in traumatic brain injury.
Topics: Anesthetics; Animals; Brain Injuries, Traumatic; Carbocyanines; Cell Line; Dendrimers; Drug Delivery | 2017 |
Pentobarbital Removal During Continuous Venovenous Hemofiltration: Case Report and Review of the Literature.
Topics: Acute Kidney Injury; Adult; Brain Injuries, Traumatic; Female; Hemofiltration; Humans; Metabolic Cle | 2018 |
Novel Metabolomic Comparison of Arterial and Jugular Venous Blood in Severe Adult Traumatic Brain Injury Patients and the Impact of Pentobarbital Infusion.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain Injuries, Traumatic; Cohort Studies; Female; Humans; Hypn | 2019 |
Effectiveness of Pharmacological Therapies for Intracranial Hypertension in Children With Severe Traumatic Brain Injury--Results From an Automated Data Collection System Time-Synched to Drug Administration.
Topics: Adolescent; Antihypertensive Agents; Brain Injuries, Traumatic; Cerebrovascular Circulation; Child; | 2016 |
Identification of an Intracranial Pressure (ICP) Response Function from Continuously Acquired Electroencephalographic and ICP Signals in Burst-Suppressed Patients.
Topics: Adult; Aneurysm, Ruptured; Brain Injuries, Traumatic; Brain Waves; Electroencephalography; Female; G | 2016 |
Characterization of Cerebral Vascular Response to EEG Bursts Using ICP Pulse Waveform Template Matching.
Topics: Adult; Aneurysm, Ruptured; Brain Injuries, Traumatic; Brain Waves; Cerebrovascular Circulation; Elec | 2016 |