pentobarbital has been researched along with Elevated ICP (Intracranial Pressure) in 18 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The objectives of the present study were to assess the effectiveness of pentobarbital and thiopental in terms of controlling refractory intracranial hypertension in patients with severe traumatic brain injury, and to evaluate the adverse effects of treatment." | 9.13 | Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial. ( Abadal, JM; Brell, M; Frontera, G; Homar, J; Ibáñez, J; Llompart-Pou, JA; Pérez-Bárcena, J; Raurich, JM, 2008) |
| "These preliminary results indicate that thiopental could be more effective than pentobarbital in patients with refractory intracranial hypertension." | 9.11 | [Comparison of the effectiveness of pentobarbital and thiopental in patients with refractory intracranial hypertension. Preliminary report of 20 patients]. ( Abadal, JM; Barceló, B; de la Peña, A; Homar, J; Ibáñez, J; Molina, FJ; Pérez-Bárcena, J; Sahuquillo, J, 2005) |
| " Pentobarbital coma is often instituted following the failure of osmotic interventions and sedation to control intracranial pressure (ICP)." | 8.31 | Pentobarbital coma for management of intracranial hypertension following traumatic brain injury: Lack of early response to treatment portends poor outcomes. ( Bonnin, SS; Chapple, KM; Huang, DD; Kelley, CJ; Rudy, RF; Snyder, LA; Stansbury, BM; Weinberg, JA, 2023) |
| "To identify predictors of mortality and long-term outcomes in survivors after pentobarbital coma (PBC) in patients failing current treatment standards for severe traumatic brain injuries (TBI)." | 7.76 | Pentobarbital coma for refractory intra-cranial hypertension after severe traumatic brain injury: mortality predictions and one-year outcomes in 55 patients. ( Cotton, BA; Hansen, EN; James, RF; Landman, MP; Marshall, GT; May, AK; Morris, JA; O'Neill, PJ, 2010) |
| "Pentobarbital sodium coma is a second-tier treatment that can be used to treat RICH." | 6.42 | Pentobarbital sodium coma for refractory intracranial hypertension. ( Censullo, JL; Sebastian, S, 2003) |
| "Propylene glycol is a rarely reported toxicity from high-dose administration of certain intravenous drugs, including lorazepam and pentobarbital." | 5.56 | Iatrogenic Propylene Glycol Intoxication Due to High-Dose Pentobarbital for Refractory Intracranial Hypertension: A Case Report. ( Barthol, CA; Garvin, RE; Rios, D; Smedley, LW, 2020) |
| " The objectives of the present study were to assess the effectiveness of pentobarbital and thiopental in terms of controlling refractory intracranial hypertension in patients with severe traumatic brain injury, and to evaluate the adverse effects of treatment." | 5.13 | Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial. ( Abadal, JM; Brell, M; Frontera, G; Homar, J; Ibáñez, J; Llompart-Pou, JA; Pérez-Bárcena, J; Raurich, JM, 2008) |
| "These preliminary results indicate that thiopental could be more effective than pentobarbital in patients with refractory intracranial hypertension." | 5.11 | [Comparison of the effectiveness of pentobarbital and thiopental in patients with refractory intracranial hypertension. Preliminary report of 20 patients]. ( Abadal, JM; Barceló, B; de la Peña, A; Homar, J; Ibáñez, J; Molina, FJ; Pérez-Bárcena, J; Sahuquillo, J, 2005) |
| " Pentobarbital coma is often instituted following the failure of osmotic interventions and sedation to control intracranial pressure (ICP)." | 4.31 | Pentobarbital coma for management of intracranial hypertension following traumatic brain injury: Lack of early response to treatment portends poor outcomes. ( Bonnin, SS; Chapple, KM; Huang, DD; Kelley, CJ; Rudy, RF; Snyder, LA; Stansbury, BM; Weinberg, JA, 2023) |
| "To identify predictors of mortality and long-term outcomes in survivors after pentobarbital coma (PBC) in patients failing current treatment standards for severe traumatic brain injuries (TBI)." | 3.76 | Pentobarbital coma for refractory intra-cranial hypertension after severe traumatic brain injury: mortality predictions and one-year outcomes in 55 patients. ( Cotton, BA; Hansen, EN; James, RF; Landman, MP; Marshall, GT; May, AK; Morris, JA; O'Neill, PJ, 2010) |
| "Pentobarbital sodium coma is a second-tier treatment that can be used to treat RICH." | 2.42 | Pentobarbital sodium coma for refractory intracranial hypertension. ( Censullo, JL; Sebastian, S, 2003) |
| "Propylene glycol is a rarely reported toxicity from high-dose administration of certain intravenous drugs, including lorazepam and pentobarbital." | 1.56 | Iatrogenic Propylene Glycol Intoxication Due to High-Dose Pentobarbital for Refractory Intracranial Hypertension: A Case Report. ( Barthol, CA; Garvin, RE; Rios, D; Smedley, LW, 2020) |
| "Fentanyl was significantly associated with the most frequent treatment failure." | 1.43 | Effectiveness of Pharmacological Therapies for Intracranial Hypertension in Children With Severe Traumatic Brain Injury--Results From an Automated Data Collection System Time-Synched to Drug Administration. ( Balasubramani, GK; Bayir, H; Bell, MJ; Clark, RS; Ferguson, NM; Fink, EL; Kochanek, PM; Shein, SL; Tian, Y; Tyler-Kabara, EC; Wisniewski, SR, 2016) |
| "No patient died from isolated cerebral edema." | 1.35 | Results of a protocol for the management of patients with fulminant liver failure. ( Curry, SC; Gerkin, R; Leibowitz, AI; Little, E; Manch, R; Ramos, A; Raschke, RA; Rempe, S; Wong, M, 2008) |
| "The diagnosis of brain death and the implications of pentobarbital intoxication during a brain death examination are discussed." | 1.35 | Head injuries, pentobarbital, and the determination of death. ( McCutcheon, JR; Molina, DK; Rulon, JJ, 2009) |
| "Pentobarbital doses were titrated based on the raw EEG to attain a burst-suppression pattern with a goal of 3-5 bursts/minute." | 1.32 | Comparing the bispectral index and suppression ratio with burst suppression of the electroencephalogram during pentobarbital infusions in adult intensive care patients. ( Fraser, GL; Riker, RR; Wilkins, ML, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 10 (55.56) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Stansbury, BM | 1 |
| Kelley, CJ | 1 |
| Rudy, RF | 1 |
| Bonnin, SS | 1 |
| Chapple, KM | 1 |
| Snyder, LA | 1 |
| Weinberg, JA | 1 |
| Huang, DD | 1 |
| Smedley, LW | 1 |
| Rios, D | 1 |
| Barthol, CA | 1 |
| Garvin, RE | 1 |
| Shore, PM | 1 |
| Mansour, N | 1 |
| deSouza, RM | 1 |
| Sikorski, C | 1 |
| Kahana, M | 1 |
| Frim, D | 1 |
| Wakai, A | 1 |
| McCabe, A | 1 |
| Roberts, I | 1 |
| Schierhout, G | 1 |
| Shein, SL | 1 |
| Ferguson, NM | 1 |
| Kochanek, PM | 1 |
| Bayir, H | 1 |
| Clark, RS | 1 |
| Fink, EL | 1 |
| Tyler-Kabara, EC | 1 |
| Wisniewski, SR | 1 |
| Tian, Y | 1 |
| Balasubramani, GK | 1 |
| Bell, MJ | 1 |
| Connolly, M | 2 |
| Liou, R | 1 |
| Vespa, P | 2 |
| Hu, X | 2 |
| Raschke, RA | 1 |
| Curry, SC | 1 |
| Rempe, S | 1 |
| Gerkin, R | 1 |
| Little, E | 1 |
| Manch, R | 1 |
| Wong, M | 1 |
| Ramos, A | 1 |
| Leibowitz, AI | 1 |
| Pérez-Bárcena, J | 2 |
| Llompart-Pou, JA | 1 |
| Homar, J | 2 |
| Abadal, JM | 2 |
| Raurich, JM | 1 |
| Frontera, G | 1 |
| Brell, M | 1 |
| Ibáñez, J | 3 |
| Molina, DK | 1 |
| McCutcheon, JR | 1 |
| Rulon, JJ | 1 |
| Marshall, GT | 1 |
| James, RF | 1 |
| Landman, MP | 1 |
| O'Neill, PJ | 1 |
| Cotton, BA | 1 |
| Hansen, EN | 1 |
| Morris, JA | 1 |
| May, AK | 1 |
| Kontogiorgi, M | 1 |
| Opsimoulis, P | 1 |
| Diamanti-Kandarakis, E | 1 |
| Karabinis, A | 1 |
| Rodríguez-Boto, G | 1 |
| Rivero-Garvía, M | 1 |
| Márquez-Rivas, J | 1 |
| Mellion, SA | 1 |
| Bennett, KS | 1 |
| Ellsworth, GL | 1 |
| Moore, K | 1 |
| Riva-Cambrin, J | 1 |
| Metzger, RR | 1 |
| Bratton, SL | 1 |
| Riker, RR | 1 |
| Fraser, GL | 1 |
| Wilkins, ML | 1 |
| Censullo, JL | 1 |
| Sebastian, S | 1 |
| Barceló, B | 1 |
| Molina, FJ | 1 |
| de la Peña, A | 1 |
| Sahuquillo, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension.[NCT00622570] | Phase 3 | 44 participants (Actual) | Interventional | 2002-05-31 | Terminated (stopped due to Slowly recruitment rate. Intermediate analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for pentobarbital and Elevated ICP (Intracranial Pressure)
| Article | Year |
|---|---|
Mannitol for acute traumatic brain injury.
Topics: Acute Disease; Brain Injuries; Diuretics, Osmotic; Humans; Intracranial Hypertension; Intracranial P | 2013 |
[Intracranial hypertension].
Topics: Decompressive Craniectomy; Humans; Hypothermia, Induced; Intracranial Hypertension; Neuroprotective | 2012 |
Pentobarbital sodium coma for refractory intracranial hypertension.
Topics: Critical Care; Disease Progression; Drug Monitoring; Electroencephalography; Humans; Hypnotics and S | 2003 |
2 trials available for pentobarbital and Elevated ICP (Intracranial Pressure)
| Article | Year |
|---|---|
Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Brain Injuries; Cohort Studies; Female; Humans; Intracranial Hypertension; | 2008 |
[Comparison of the effectiveness of pentobarbital and thiopental in patients with refractory intracranial hypertension. Preliminary report of 20 patients].
Topics: Adult; Cohort Studies; Female; GABA Modulators; Humans; Intracranial Hypertension; Male; Pentobarbit | 2005 |
13 other studies available for pentobarbital and Elevated ICP (Intracranial Pressure)
| Article | Year |
|---|---|
Pentobarbital coma for management of intracranial hypertension following traumatic brain injury: Lack of early response to treatment portends poor outcomes.
Topics: Adult; Brain Injuries; Brain Injuries, Traumatic; Coma; Female; Glasgow Coma Scale; Humans; Intracra | 2023 |
Iatrogenic Propylene Glycol Intoxication Due to High-Dose Pentobarbital for Refractory Intracranial Hypertension: A Case Report.
Topics: Humans; Iatrogenic Disease; Infusions, Intravenous; Intracranial Hypertension; Pentobarbital; Propyl | 2020 |
Pentobarbital for refractory intracranial hypertension: time to "go retro"?
Topics: Brain Injuries; Female; GABA Modulators; Humans; Intracranial Hypertension; Male; Pentobarbital | 2013 |
Role of barbiturate coma in the management of focally induced, severe cerebral edema in children.
Topics: Brain Edema; Brain Neoplasms; Cerebral Hemorrhage; Child; Child, Preschool; Coma; Drug Administratio | 2013 |
Effectiveness of Pharmacological Therapies for Intracranial Hypertension in Children With Severe Traumatic Brain Injury--Results From an Automated Data Collection System Time-Synched to Drug Administration.
Topics: Adolescent; Antihypertensive Agents; Brain Injuries, Traumatic; Cerebrovascular Circulation; Child; | 2016 |
Identification of an Intracranial Pressure (ICP) Response Function from Continuously Acquired Electroencephalographic and ICP Signals in Burst-Suppressed Patients.
Topics: Adult; Aneurysm, Ruptured; Brain Injuries, Traumatic; Brain Waves; Electroencephalography; Female; G | 2016 |
Characterization of Cerebral Vascular Response to EEG Bursts Using ICP Pulse Waveform Template Matching.
Topics: Adult; Aneurysm, Ruptured; Brain Injuries, Traumatic; Brain Waves; Cerebrovascular Circulation; Elec | 2016 |
Results of a protocol for the management of patients with fulminant liver failure.
Topics: Adolescent; Adult; Brain Edema; Female; Hemostatics; Hospital Mortality; Humans; Hypnotics and Sedat | 2008 |
Head injuries, pentobarbital, and the determination of death.
Topics: Accidents, Traffic; Adolescent; Adult; Brain Death; Coma; Female; Forensic Pathology; Head Injuries, | 2009 |
Pentobarbital coma for refractory intra-cranial hypertension after severe traumatic brain injury: mortality predictions and one-year outcomes in 55 patients.
Topics: Adolescent; Adult; Brain Injuries; Child; Child, Preschool; Cohort Studies; Coma; Confidence Interva | 2010 |
Cerebral salt wasting syndrome in traumatic brain injury following therapeutic barbiturate coma.
Topics: Brain Injuries; Coma; Humans; Hypnotics and Sedatives; Hyponatremia; Inappropriate ADH Syndrome; Int | 2011 |
High-dose barbiturates for refractory intracranial hypertension in children with severe traumatic brain injury.
Topics: Adolescent; Brain Injuries; Child; Child, Preschool; Drug Administration Schedule; Drug Monitoring; | 2013 |
Comparing the bispectral index and suppression ratio with burst suppression of the electroencephalogram during pentobarbital infusions in adult intensive care patients.
Topics: Adult; Cohort Studies; Electroencephalography; Humans; Infusions, Intravenous; Inpatients; Intensive | 2003 |