pentobarbital has been researched along with Critical Illness in 4 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is considerable debate regarding the appropriateness of feeding patients by the enteral route in conjunction with pentobarbital coma therapy." | 7.74 | Evaluation of feeding intolerance in patients with pentobarbital-induced coma. ( Beynnon, BJ; Commichau, C; Crookes, BA; Frock, KM; Marden, BT; Rebuck, JA; Stevens, AM; Then, JE, 2008) |
| " Prospective PK studies with pharmacodynamic endpoints, are imperative to optimise pentobarbital dosing in terms of safety and clinical efficacy in critically ill children." | 5.91 | A Population Pharmacokinetic Model of Pentobarbital for Children with Status Epilepticus and Severe Traumatic Brain Injury. ( de Hoog, M; de Vries, JMP; de Winter, BCM; Ketharanathan, N; Koch, BCP; Lili, A; Wildschut, ED, 2023) |
| "There is considerable debate regarding the appropriateness of feeding patients by the enteral route in conjunction with pentobarbital coma therapy." | 3.74 | Evaluation of feeding intolerance in patients with pentobarbital-induced coma. ( Beynnon, BJ; Commichau, C; Crookes, BA; Frock, KM; Marden, BT; Rebuck, JA; Stevens, AM; Then, JE, 2008) |
| " Prospective PK studies with pharmacodynamic endpoints, are imperative to optimise pentobarbital dosing in terms of safety and clinical efficacy in critically ill children." | 1.91 | A Population Pharmacokinetic Model of Pentobarbital for Children with Status Epilepticus and Severe Traumatic Brain Injury. ( de Hoog, M; de Vries, JMP; de Winter, BCM; Ketharanathan, N; Koch, BCP; Lili, A; Wildschut, ED, 2023) |
| "Status epilepticus was convulsive in 132 cases (92%)." | 1.38 | Third-line antiepileptic therapy and outcome in status epilepticus: the impact of vasopressor use and prolonged mechanical ventilation. ( Geocadin, RG; Goodwin, H; Kim, G; Kowalski, RG; Rees, RN; Werner, JK; Ziai, WC, 2012) |
| " Plasma concentrations of total phenytoin, unbound phenytoin, and the major metabolite of phenytoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin, were measured, and pharmacokinetic variables obtained before and after barbiturate therapy were compared." | 1.29 | Effect of barbiturate therapy on phenytoin pharmacokinetics. ( Abe, J; Asada, A; Fujimori, M; Kaji, A; Nishi, S; Oda, Y; Yoshida, N, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ketharanathan, N | 1 |
| Lili, A | 1 |
| de Vries, JMP | 1 |
| Wildschut, ED | 1 |
| de Hoog, M | 1 |
| Koch, BCP | 1 |
| de Winter, BCM | 1 |
| Kowalski, RG | 1 |
| Ziai, WC | 1 |
| Rees, RN | 1 |
| Werner, JK | 1 |
| Kim, G | 1 |
| Goodwin, H | 1 |
| Geocadin, RG | 1 |
| Stevens, AM | 1 |
| Then, JE | 1 |
| Frock, KM | 1 |
| Crookes, BA | 1 |
| Commichau, C | 1 |
| Marden, BT | 1 |
| Beynnon, BJ | 1 |
| Rebuck, JA | 1 |
| Yoshida, N | 1 |
| Oda, Y | 1 |
| Nishi, S | 1 |
| Abe, J | 1 |
| Kaji, A | 1 |
| Asada, A | 1 |
| Fujimori, M | 1 |
4 other studies available for pentobarbital and Critical Illness
| Article | Year |
|---|---|
A Population Pharmacokinetic Model of Pentobarbital for Children with Status Epilepticus and Severe Traumatic Brain Injury.
Topics: Anti-Bacterial Agents; Brain Injuries, Traumatic; Child; Creatinine; Critical Illness; Humans; Infan | 2023 |
Third-line antiepileptic therapy and outcome in status epilepticus: the impact of vasopressor use and prolonged mechanical ventilation.
Topics: Adult; Age Factors; Aged; Analysis of Variance; Anticonvulsants; APACHE; Confidence Intervals; Criti | 2012 |
Evaluation of feeding intolerance in patients with pentobarbital-induced coma.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Brain Injuries; Coma; Cr | 2008 |
Effect of barbiturate therapy on phenytoin pharmacokinetics.
Topics: Adult; Aged; Aged, 80 and over; Critical Illness; Epilepsy; Female; Humans; Intracranial Pressure; M | 1993 |