pentobarbital has been researched along with Craniocerebral Trauma in 22 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Craniocerebral Trauma: Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structures). Injuries may be classified by whether or not the skull is penetrated (i.e., penetrating vs. nonpenetrating) or whether there is an associated hemorrhage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neurosurgical patients in pentobarbital coma are a complex nutrition support population." | 8.79 | Pentobarbital coma in neurosurgical patients: nutrition considerations. ( Hatton, J; Magnuson, B; Young, B; Zweng, TN, 1994) |
| "Forty-five patients in deep coma resulting from head injury were treated with pentobarbital in doses adjusted to maintain serum barbiturate levels between 15 and 25 mg/l and short burst suppression phases on EEG." | 7.66 | [Treatment of head injury coma with prolonged pentobarbital anaesthesia (author's transl)]. ( Artru, F; Deleuze, R; Guerin, JM; Latarjet, J, 1981) |
| "Specifically, induction of thiopental coma to manage severe increased intracranial pressure in seven patients was associated with a 37% reduction of lactate, 59% reduction of glutamate, and 66% reduction in aspartate in the extracellular space of the brain." | 6.68 | Lactate and excitatory amino acids measured by microdialysis are decreased by pentobarbital coma in head-injured patients. ( Cormio, M; Goodman, JC; Gopinath, SP; Robertson, CS; Valadka, AB, 1996) |
| "In summary, barbiturate coma can be a useful treatment modality for acutely reducing ICP in selected patients." | 5.30 | Cerebral hemodynamic effects of pentobarbital coma in head-injured patients. ( Cormio, M; Gopinath, SP; Robertson, CS; Valadka, A, 1999) |
| "Neurosurgical patients in pentobarbital coma are a complex nutrition support population." | 4.79 | Pentobarbital coma in neurosurgical patients: nutrition considerations. ( Hatton, J; Magnuson, B; Young, B; Zweng, TN, 1994) |
| "Forty-five patients in deep coma resulting from head injury were treated with pentobarbital in doses adjusted to maintain serum barbiturate levels between 15 and 25 mg/l and short burst suppression phases on EEG." | 3.66 | [Treatment of head injury coma with prolonged pentobarbital anaesthesia (author's transl)]. ( Artru, F; Deleuze, R; Guerin, JM; Latarjet, J, 1981) |
| "Specifically, induction of thiopental coma to manage severe increased intracranial pressure in seven patients was associated with a 37% reduction of lactate, 59% reduction of glutamate, and 66% reduction in aspartate in the extracellular space of the brain." | 2.68 | Lactate and excitatory amino acids measured by microdialysis are decreased by pentobarbital coma in head-injured patients. ( Cormio, M; Goodman, JC; Gopinath, SP; Robertson, CS; Valadka, AB, 1996) |
| " Additional pharmacokinetic investigations are recommended to optimise pharmacological outcomes in patients with severe head injury." | 2.40 | Pharmacokinetic alterations after severe head injury. Clinical relevance. ( Boucher, BA; Hanes, SD, 1998) |
| "Pentobarbital has been used in the majority of the clinical studies." | 2.38 | Management of elevated intracranial pressure. ( LeBlanc, KL; Woster, PS, 1990) |
| "In summary, barbiturate coma can be a useful treatment modality for acutely reducing ICP in selected patients." | 1.30 | Cerebral hemodynamic effects of pentobarbital coma in head-injured patients. ( Cormio, M; Gopinath, SP; Robertson, CS; Valadka, A, 1999) |
| "Global cerebral ischemia was produced by a 10 min occlusion of both common carotid arteries 24 hr after the permanent electrocauterization of bilateral vertebral arteries." | 1.29 | The effect of VA-045 on disturbance in consciousness in experimental animal models. ( Araki, H; Imagawa, Y; Ogawa, S; Okuyama, S; Otomo, S; Saito, Y; Sakagawa, T; Shima, K; Yamada, S, 1993) |
| "In the present two cases of brain death a large amount of barbiturate remained in the brain, even when the blood concentration was not detectable, possibly because the blood flow was stagnant in the brain." | 1.29 | Influence of antemortem medication on the determination of brain death. ( Nakajima, Y; Osawa, M; Saito, T; Takeichi, S; Yukawa, N, 1995) |
| "Pentobarbital plasma levels were determined in 16 critical care patients receiving a dose of approximately 30 mg/kg/day and suffering from severe head injury." | 1.27 | Monitoring of pentobarbital plasma levels in critical care patients suffering from increased intracranial pressure. ( Dennhardt, R; Heinemeyer, G; Roots, I, 1986) |
| "Pentobarbital disposition was assessed in 10 adults with severe nonpenetrating head injury after an intravenous loading dose of sodium pentobarbital, 10 mg/kg, infused over 1 hour, followed by a continuous infusion at 0." | 1.27 | Pharmacokinetics of high-dose pentobarbital in severe head trauma. ( Bayliff, CD; Hardy, BG; Schwartz, ML, 1985) |
| "Clomipramine which has a stimulating effect on oxygen metabolism should be kept in reserve for the chronic phase of prolonged coma." | 1.26 | [Prolonged traumatic and vascular coma: prognostic and therapeutic indications based on hemodynamic and metabolic studies]. ( Baldy-Moulinier, M; Escuret, E; Frèrebeau, P; Passouant, P; Roquefeuil, B, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (50.00) | 18.7374 |
| 1990's | 9 (40.91) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Echegoyen, J | 1 |
| Armstrong, C | 1 |
| Morgan, RJ | 1 |
| Soltesz, I | 1 |
| Chun, TH | 1 |
| Amanullah, S | 1 |
| Karishma-Bahl, D | 1 |
| Machan, JT | 1 |
| Andrada, ER | 1 |
| Lewander, WJ | 1 |
| Artru, F | 1 |
| Guerin, JM | 1 |
| Latarjet, J | 1 |
| Deleuze, R | 1 |
| Magnuson, B | 1 |
| Hatton, J | 1 |
| Zweng, TN | 1 |
| Young, B | 1 |
| Okuyama, S | 1 |
| Imagawa, Y | 1 |
| Ogawa, S | 1 |
| Saito, Y | 1 |
| Araki, H | 1 |
| Otomo, S | 1 |
| Sakagawa, T | 1 |
| Yamada, S | 1 |
| Shima, K | 1 |
| Saito, T | 1 |
| Takeichi, S | 1 |
| Nakajima, Y | 1 |
| Yukawa, N | 1 |
| Osawa, M | 1 |
| Goodman, JC | 1 |
| Valadka, AB | 1 |
| Gopinath, SP | 2 |
| Cormio, M | 2 |
| Robertson, CS | 2 |
| Boucher, BA | 1 |
| Hanes, SD | 1 |
| Miyazato, H | 1 |
| Skinner, RD | 1 |
| Cobb, M | 1 |
| Andersen, B | 1 |
| Garcia-Rill, E | 1 |
| Valadka, A | 1 |
| Baldy-Moulinier, M | 1 |
| Roquefeuil, B | 1 |
| Escuret, E | 1 |
| Frèrebeau, P | 1 |
| Passouant, P | 1 |
| Woster, PS | 1 |
| LeBlanc, KL | 1 |
| Nishihara, K | 1 |
| Kohda, Y | 1 |
| Tsutsumi, H | 1 |
| Sasaki, M | 1 |
| Aruga, T | 1 |
| Toyooka, H | 1 |
| Mii, K | 1 |
| Fried, RC | 1 |
| Dickerson, RN | 1 |
| Guenter, PA | 1 |
| Stein, TP | 1 |
| Gennarelli, TA | 1 |
| Dempsey, DT | 1 |
| Buzby, GP | 1 |
| Mullen, JL | 1 |
| Gilkison, C | 1 |
| Ploessl, J | 1 |
| Kasoff, SS | 1 |
| Lansen, TA | 1 |
| Holder, D | 1 |
| Filippo, JS | 1 |
| Heinemeyer, G | 1 |
| Roots, I | 1 |
| Dennhardt, R | 1 |
| Fruin, AH | 1 |
| Taylon, C | 1 |
| Pettis, MS | 1 |
| Bayliff, CD | 1 |
| Schwartz, ML | 1 |
| Hardy, BG | 1 |
| Shapiro, HM | 1 |
| Wyte, SR | 1 |
| Loeser, J | 1 |
| Oka, M | 1 |
| Yoshioka, K | 1 |
| Fujita, I | 1 |
| Aoyama, H | 1 |
| Hamada, T | 1 |
4 reviews available for pentobarbital and Craniocerebral Trauma
| Article | Year |
|---|---|
Pentobarbital coma in neurosurgical patients: nutrition considerations.
Topics: Coma; Craniocerebral Trauma; Humans; Nutritional Physiological Phenomena; Pentobarbital | 1994 |
The use of barbiturates in the control of intracranial hypertension. Brain Trauma Foundation.
Topics: Barbiturates; Craniocerebral Trauma; Humans; Intracranial Pressure; MEDLINE; Pentobarbital; Pseudotu | 1996 |
Pharmacokinetic alterations after severe head injury. Clinical relevance.
Topics: Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Blood-Brain Barrier; Cranioce | 1998 |
Management of elevated intracranial pressure.
Topics: Adrenal Cortex Hormones; Barbiturates; Craniocerebral Trauma; Diuretics; Humans; Pentobarbital; Pseu | 1990 |
1 trial available for pentobarbital and Craniocerebral Trauma
| Article | Year |
|---|---|
Lactate and excitatory amino acids measured by microdialysis are decreased by pentobarbital coma in head-injured patients.
Topics: Adolescent; Adult; Brain Chemistry; Coma; Craniocerebral Trauma; Excitatory Amino Acids; Female; Hum | 1996 |
17 other studies available for pentobarbital and Craniocerebral Trauma
| Article | Year |
|---|---|
Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Craniocerebral Trauma; Disease Models, Animal; Electroen | 2009 |
Comparison of methohexital and pentobarbital as sedative agents for pediatric emergency department patients for computed tomography.
Topics: Child, Preschool; Craniocerebral Trauma; Emergency Service, Hospital; Female; Humans; Hypnotics and | 2009 |
[Treatment of head injury coma with prolonged pentobarbital anaesthesia (author's transl)].
Topics: Adolescent; Adult; Anesthesia; Coma; Craniocerebral Trauma; Humans; Pentobarbital; Time Factors | 1981 |
The effect of VA-045 on disturbance in consciousness in experimental animal models.
Topics: Animals; Avoidance Learning; Brain; Brain Ischemia; Consciousness; Craniocerebral Trauma; Disease Mo | 1993 |
Influence of antemortem medication on the determination of brain death.
Topics: Adolescent; Brain; Brain Death; Child, Preschool; Coma; Craniocerebral Trauma; Diagnosis, Differenti | 1995 |
Midlatency auditory-evoked potentials in the rat: effects of interventions that modulate arousal.
Topics: Anesthetics; Animals; Arousal; Craniocerebral Trauma; Ethanol; Evoked Potentials, Auditory; Halothan | 1999 |
Cerebral hemodynamic effects of pentobarbital coma in head-injured patients.
Topics: Adult; Cerebrovascular Circulation; Coma; Craniocerebral Trauma; Female; Hemodynamics; Humans; Hypno | 1999 |
[Prolonged traumatic and vascular coma: prognostic and therapeutic indications based on hemodynamic and metabolic studies].
Topics: Blood Gas Analysis; Brain; Carbon Dioxide; Cerebrovascular Circulation; Cerebrovascular Disorders; C | 1976 |
Development of an optimum dosage regimen for pentobarbital in patients with severe head injury.
Topics: Adolescent; Adult; Algorithms; Craniocerebral Trauma; Drug Administration Schedule; Female; Half-Lif | 1987 |
Barbiturate therapy reduces nitrogen excretion in acute head injury.
Topics: Adolescent; Adult; Craniocerebral Trauma; Energy Intake; Energy Metabolism; Female; Humans; Male; Me | 1989 |
The impact of computers on patient care and research: the pentobarbital coma experience.
Topics: Computers; Craniocerebral Trauma; Humans; Intensive Care Units; Intracranial Pressure; Monitoring, P | 1986 |
Aggressive physiologic monitoring of pediatric head trauma patients with elevated intracranial pressure.
Topics: Accidental Falls; Accidents, Traffic; Catheterization, Swan-Ganz; Child; Craniocerebral Trauma; Dopa | 1988 |
Monitoring of pentobarbital plasma levels in critical care patients suffering from increased intracranial pressure.
Topics: Adult; Aged; Child; Child, Preschool; Craniocerebral Trauma; Critical Care; Drug Interactions; Femal | 1986 |
Caloric requirements in patients with severe head injuries.
Topics: Craniocerebral Trauma; Energy Intake; Energy Metabolism; Humans; Intracranial Pressure; Pentobarbita | 1986 |
Pharmacokinetics of high-dose pentobarbital in severe head trauma.
Topics: Adolescent; Adult; Aged; Chromatography, Gas; Craniocerebral Trauma; Female; Half-Life; Humans; Infu | 1985 |
Barbiturate-augmented hypothermia for reduction of persistent intracranial hypertension.
Topics: Adolescent; Blood Pressure; Brain Diseases; Brain Neoplasms; Child; Child, Preschool; Coma; Cranioce | 1974 |
[Absorption of ultrasonic sound pulse in the brain--observations by continuous measurement of the absorption coefficient].
Topics: Absorption; Animals; Body Temperature; Brain; Craniocerebral Trauma; Dogs; Fluorescence; Methods; Pe | 1968 |