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pentobarbital and Cough

pentobarbital has been researched along with Cough in 13 studies

Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.

Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.

Research Excerpts

ExcerptRelevanceReference
"In order to determine the possible involvement of GABA-ergic mechanisms in the modulation of the cough reflex, the effects of GABA antagonists on the pentobarbital-induced depression of respiration and cough were examined in a comparative study in rats."7.67Effects of GABA antagonists on the pentobarbital-induced depression of respiration and cough in rats. ( Kamei, J; Kasuya, Y; Ogawa, M, 1989)
"We studied the oral actions of antihistamines from six chemical classes, namely: the ethanolamines (ENA, diphenhydramine and clemastine); ethylenediamines (EDA, pyrilamine and tripelennamine); piperidines (PPD, terfenadine and astemizole); piperazines (PPZ, hydroxyzine and cetirizine); phenothiazines (PTZ, promethazine), and the alkylamines (ALA, chlorpheniramine and bromopheniramine) on cough reflexes, pentobarbital-induced sedation and minute ventilation in the conscious guinea pig."3.70Antitussive action of antihistamines is independent of sedative and ventilation activity in the guinea pig. ( Bolser, DC; Hey, JA; McLeod, RL; Mingo, G; O'Reilly, S; Ruck, LA, 1998)
" Chemical lesions to the medullary midline region (0-4 mm rostral to the obex) produced by localized injections of the neurotoxin kainic acid regularly abolished the cough reflexes evoked from the tracheobronchial and laryngopharyngeal regions and in most cases also the expiration reflex induced from the glottal area."3.70Effects of medullary midline lesions on cough and other airway reflexes in anaesthetized cats. ( Baráni, H; Bosel'ová, L; Jakus, J; Poliacek, I; Stránsky, A, 1998)
"In order to determine the possible involvement of GABA-ergic mechanisms in the modulation of the cough reflex, the effects of GABA antagonists on the pentobarbital-induced depression of respiration and cough were examined in a comparative study in rats."3.67Effects of GABA antagonists on the pentobarbital-induced depression of respiration and cough in rats. ( Kamei, J; Kasuya, Y; Ogawa, M, 1989)
"In order to understand the relationship between the cough and respiratory centers in the brain stem, we investigated the effects of respiratory stimulants, pentylenetetrazol (PTZ) and nikethamide (NK), and a respiratory depressant, pentobarbital (PB)on the cough reflex."3.66[Effects of respiratory drugs on the cough reflex]. ( Hosokawa, T; Kitagawa, H; Misawa, M; Yanaura, S, 1982)
"Cough was induced by mechanical stimulation of the tracheobronchial airways."1.43Changes in vagal afferent drive alter tracheobronchial coughing in anesthetized cats. ( Babalova, L; Jakus, J; Kotmanova, Z; Poliacek, I; Simera, M; Veternik, M, 2016)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19909 (69.23)18.7374
1990's3 (23.08)18.2507
2000's0 (0.00)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Simera, M1
Poliacek, I2
Veternik, M1
Babalova, L1
Kotmanova, Z1
Jakus, J2
MAY, AJ1
WIDDICOMBE, JG1
KARBAAT, J1
Yanaura, S2
Kitagawa, H1
Hosokawa, T2
Misawa, M1
Sanderson, PM1
McLeod, RL1
Mingo, G1
O'Reilly, S1
Ruck, LA1
Bolser, DC1
Hey, JA1
Stránsky, A1
Baráni, H1
Bosel'ová, L1
Nishimura, T1
Iwase, H1
Kamei, J1
Ogawa, M1
Kasuya, Y1
Tatár, M1
Korpás, J1
Polácek, H1
Záhradný, V1
Bucher, UM1
Dure-Smith, P1
Freundlich, IM1
Kasé, Y1
Wakita, Y1
Kito, G1
Miyata, T1
Yuizono, T1
Kataoka, M1

Other Studies

13 other studies available for pentobarbital and Cough

ArticleYear
Changes in vagal afferent drive alter tracheobronchial coughing in anesthetized cats.
    Respiratory physiology & neurobiology, 2016, Volume: 230

    Topics: Afferent Pathways; Anesthesia; Animals; Cats; Cold Temperature; Cough; Female; Hypnotics and Sedativ

2016
Depression of the cough reflex by pentobarbitone and some opium derivatives.
    British journal of pharmacology and chemotherapy, 1954, Volume: 9, Issue:3

    Topics: Barbiturates; Cough; Depressive Disorder; Humans; Opium; Pentobarbital; Reflex; Respiration

1954
[A case of death following intake of calcidrine syrup].
    Nederlands militair geneeskundig tijdschrift, 1961, Volume: 14

    Topics: Cough; Death; Humans; Iodides; Pentobarbital

1961
[Effects of respiratory drugs on the cough reflex].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1982, Volume: 80, Issue:1

    Topics: Animals; Cough; Dogs; Dose-Response Relationship, Drug; Male; Nikethamide; Pentobarbital; Pentylenet

1982
A survey of pentobarbital sedation for children undergoing abdominal CT scans after oral contrast medium.
    Paediatric anaesthesia, 1997, Volume: 7, Issue:4

    Topics: Adjuvants, Anesthesia; Administration, Oral; Airway Obstruction; Anesthesiology; Bronchial Spasm; Ch

1997
Antitussive action of antihistamines is independent of sedative and ventilation activity in the guinea pig.
    Pharmacology, 1998, Volume: 57, Issue:2

    Topics: Administration, Oral; Amines; Animals; Antitussive Agents; Cough; Dose-Response Relationship, Drug;

1998
Effects of medullary midline lesions on cough and other airway reflexes in anaesthetized cats.
    Physiological research, 1998, Volume: 47, Issue:3

    Topics: Anesthetics, Intravenous; Animals; Blood Pressure; Cats; Chloralose; Cough; Evoked Potentials; Femal

1998
[Pharmacological studies on the cough reflex].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1975, Volume: 71, Issue:2

    Topics: Airway Resistance; Allyl Compounds; Animals; Antitussive Agents; Benzamides; Cats; Chloralose; Chlor

1975
Effects of GABA antagonists on the pentobarbital-induced depression of respiration and cough in rats.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:1

    Topics: Animals; Bicuculline; Cough; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors,

1989
Changes induced by severe hypoxia in respiratory defence reflexes in anaesthetized cats.
    Respiration; international review of thoracic diseases, 1986, Volume: 49, Issue:2

    Topics: Anesthesia, Intravenous; Animals; Apnea; Cats; Cough; Female; Hydrogen-Ion Concentration; Hypoxia; M

1986
Respiratory changes following reflexogenic expiratory twitches.
    Agents and actions, 1973, Volume: 3, Issue:2

    Topics: Animals; Anthracenes; Benzoates; Codeine; Columbidae; Cough; Decerebrate State; Methadone; Nalorphin

1973
Bronchography: the rational use of premedication and local anesthesia.
    Journal of the Canadian Association of Radiologists, 1971, Volume: 22, Issue:3

    Topics: Anesthetics, Local; Atropine; Body Weight; Bronchography; Bronchoscopy; Cocaine; Codeine; Cough; Dib

1971
Centrally-induced coughs in the cat.
    Life sciences, 1970, Jan-01, Volume: 9, Issue:1

    Topics: Animals; Brain Stem; Cats; Codeine; Cough; Electric Stimulation; Laryngeal Nerves; Medulla Oblongata

1970