pentobarbital has been researched along with Cough in 13 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to determine the possible involvement of GABA-ergic mechanisms in the modulation of the cough reflex, the effects of GABA antagonists on the pentobarbital-induced depression of respiration and cough were examined in a comparative study in rats." | 7.67 | Effects of GABA antagonists on the pentobarbital-induced depression of respiration and cough in rats. ( Kamei, J; Kasuya, Y; Ogawa, M, 1989) |
| "We studied the oral actions of antihistamines from six chemical classes, namely: the ethanolamines (ENA, diphenhydramine and clemastine); ethylenediamines (EDA, pyrilamine and tripelennamine); piperidines (PPD, terfenadine and astemizole); piperazines (PPZ, hydroxyzine and cetirizine); phenothiazines (PTZ, promethazine), and the alkylamines (ALA, chlorpheniramine and bromopheniramine) on cough reflexes, pentobarbital-induced sedation and minute ventilation in the conscious guinea pig." | 3.70 | Antitussive action of antihistamines is independent of sedative and ventilation activity in the guinea pig. ( Bolser, DC; Hey, JA; McLeod, RL; Mingo, G; O'Reilly, S; Ruck, LA, 1998) |
| " Chemical lesions to the medullary midline region (0-4 mm rostral to the obex) produced by localized injections of the neurotoxin kainic acid regularly abolished the cough reflexes evoked from the tracheobronchial and laryngopharyngeal regions and in most cases also the expiration reflex induced from the glottal area." | 3.70 | Effects of medullary midline lesions on cough and other airway reflexes in anaesthetized cats. ( Baráni, H; Bosel'ová, L; Jakus, J; Poliacek, I; Stránsky, A, 1998) |
| "In order to determine the possible involvement of GABA-ergic mechanisms in the modulation of the cough reflex, the effects of GABA antagonists on the pentobarbital-induced depression of respiration and cough were examined in a comparative study in rats." | 3.67 | Effects of GABA antagonists on the pentobarbital-induced depression of respiration and cough in rats. ( Kamei, J; Kasuya, Y; Ogawa, M, 1989) |
| "In order to understand the relationship between the cough and respiratory centers in the brain stem, we investigated the effects of respiratory stimulants, pentylenetetrazol (PTZ) and nikethamide (NK), and a respiratory depressant, pentobarbital (PB)on the cough reflex." | 3.66 | [Effects of respiratory drugs on the cough reflex]. ( Hosokawa, T; Kitagawa, H; Misawa, M; Yanaura, S, 1982) |
| "Cough was induced by mechanical stimulation of the tracheobronchial airways." | 1.43 | Changes in vagal afferent drive alter tracheobronchial coughing in anesthetized cats. ( Babalova, L; Jakus, J; Kotmanova, Z; Poliacek, I; Simera, M; Veternik, M, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (69.23) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Simera, M | 1 |
| Poliacek, I | 2 |
| Veternik, M | 1 |
| Babalova, L | 1 |
| Kotmanova, Z | 1 |
| Jakus, J | 2 |
| MAY, AJ | 1 |
| WIDDICOMBE, JG | 1 |
| KARBAAT, J | 1 |
| Yanaura, S | 2 |
| Kitagawa, H | 1 |
| Hosokawa, T | 2 |
| Misawa, M | 1 |
| Sanderson, PM | 1 |
| McLeod, RL | 1 |
| Mingo, G | 1 |
| O'Reilly, S | 1 |
| Ruck, LA | 1 |
| Bolser, DC | 1 |
| Hey, JA | 1 |
| Stránsky, A | 1 |
| Baráni, H | 1 |
| Bosel'ová, L | 1 |
| Nishimura, T | 1 |
| Iwase, H | 1 |
| Kamei, J | 1 |
| Ogawa, M | 1 |
| Kasuya, Y | 1 |
| Tatár, M | 1 |
| Korpás, J | 1 |
| Polácek, H | 1 |
| Záhradný, V | 1 |
| Bucher, UM | 1 |
| Dure-Smith, P | 1 |
| Freundlich, IM | 1 |
| Kasé, Y | 1 |
| Wakita, Y | 1 |
| Kito, G | 1 |
| Miyata, T | 1 |
| Yuizono, T | 1 |
| Kataoka, M | 1 |
13 other studies available for pentobarbital and Cough
| Article | Year |
|---|---|
Changes in vagal afferent drive alter tracheobronchial coughing in anesthetized cats.
Topics: Afferent Pathways; Anesthesia; Animals; Cats; Cold Temperature; Cough; Female; Hypnotics and Sedativ | 2016 |
Depression of the cough reflex by pentobarbitone and some opium derivatives.
Topics: Barbiturates; Cough; Depressive Disorder; Humans; Opium; Pentobarbital; Reflex; Respiration | 1954 |
[A case of death following intake of calcidrine syrup].
Topics: Cough; Death; Humans; Iodides; Pentobarbital | 1961 |
[Effects of respiratory drugs on the cough reflex].
Topics: Animals; Cough; Dogs; Dose-Response Relationship, Drug; Male; Nikethamide; Pentobarbital; Pentylenet | 1982 |
A survey of pentobarbital sedation for children undergoing abdominal CT scans after oral contrast medium.
Topics: Adjuvants, Anesthesia; Administration, Oral; Airway Obstruction; Anesthesiology; Bronchial Spasm; Ch | 1997 |
Antitussive action of antihistamines is independent of sedative and ventilation activity in the guinea pig.
Topics: Administration, Oral; Amines; Animals; Antitussive Agents; Cough; Dose-Response Relationship, Drug; | 1998 |
Effects of medullary midline lesions on cough and other airway reflexes in anaesthetized cats.
Topics: Anesthetics, Intravenous; Animals; Blood Pressure; Cats; Chloralose; Cough; Evoked Potentials; Femal | 1998 |
[Pharmacological studies on the cough reflex].
Topics: Airway Resistance; Allyl Compounds; Animals; Antitussive Agents; Benzamides; Cats; Chloralose; Chlor | 1975 |
Effects of GABA antagonists on the pentobarbital-induced depression of respiration and cough in rats.
Topics: Animals; Bicuculline; Cough; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, | 1989 |
Changes induced by severe hypoxia in respiratory defence reflexes in anaesthetized cats.
Topics: Anesthesia, Intravenous; Animals; Apnea; Cats; Cough; Female; Hydrogen-Ion Concentration; Hypoxia; M | 1986 |
Respiratory changes following reflexogenic expiratory twitches.
Topics: Animals; Anthracenes; Benzoates; Codeine; Columbidae; Cough; Decerebrate State; Methadone; Nalorphin | 1973 |
Bronchography: the rational use of premedication and local anesthesia.
Topics: Anesthetics, Local; Atropine; Body Weight; Bronchography; Bronchoscopy; Cocaine; Codeine; Cough; Dib | 1971 |
Centrally-induced coughs in the cat.
Topics: Animals; Brain Stem; Cats; Codeine; Cough; Electric Stimulation; Laryngeal Nerves; Medulla Oblongata | 1970 |