pentobarbital has been researched along with Consciousness, Loss of in 18 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thiopental is an anesthetic used for controlling high intracranial pressure (ICP) caused by brain surgery, brain trauma, and severe stroke." | 7.75 | Thiopental exaggerates ischemic brain damage and neurological deficits after experimental stroke in spontaneously hypertensive rats. ( Duan, WM; Duan, YF; Liu, C; Zhao, LR; Zhao, YF, 2009) |
| " Time to achieve recumbency, LORR, quiescent electromyograph, isoelectric electrocorticograph, heart rate and apnea were recorded." | 3.83 | Assessment of Carbon Dioxide, Carbon Dioxide/Oxygen, Isoflurane and Pentobarbital Killing Methods in Adult Female Sprague-Dawley Rats. ( Chisholm, JM; Pang, DS, 2016) |
| "Thiopental is an anesthetic used for controlling high intracranial pressure (ICP) caused by brain surgery, brain trauma, and severe stroke." | 3.75 | Thiopental exaggerates ischemic brain damage and neurological deficits after experimental stroke in spontaneously hypertensive rats. ( Duan, WM; Duan, YF; Liu, C; Zhao, LR; Zhao, YF, 2009) |
| "The molecular agents that induce loss of consciousness during anesthesia are classically believed to act by binding to cognate transmembrane receptors widely distributed in the CNS and critically suppressing local processing and network connectivity." | 1.43 | Brainstem node for loss of consciousness due to GABA(A) receptor-active anesthetics. ( Devor, M; Minert, A, 2016) |
| "5 to 5 g/L) have been recommended, but few reports describe dose-response testing, the time to loss of consciousness, or the reliability of euthanasia." | 1.35 | Evaluation and refinement of euthanasia methods for Xenopus laevis. ( Green, SL; McClure, DE; Torreilles, SL, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (38.89) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Mukai, A | 1 |
| Irifune, M | 1 |
| Shimizu, Y | 1 |
| Doi, M | 1 |
| Kikuchi, Y | 1 |
| Katayama, S | 1 |
| Oue, K | 1 |
| Yoshida, M | 1 |
| Ago, Y | 1 |
| Okada, Y | 1 |
| Morioka, N | 1 |
| Nakata, Y | 1 |
| Sakai, N | 1 |
| de Souza Dyer, C | 1 |
| Brice, AK | 1 |
| Marx, JO | 1 |
| Martin, JE | 1 |
| McKeegan, DEF | 1 |
| Magee, DL | 1 |
| Armour, N | 1 |
| Pritchard, DG | 1 |
| Minert, A | 1 |
| Devor, M | 2 |
| Chisholm, JM | 1 |
| Pang, DS | 1 |
| Duan, YF | 1 |
| Liu, C | 1 |
| Zhao, YF | 1 |
| Duan, WM | 1 |
| Zhao, LR | 1 |
| Torreilles, SL | 1 |
| McClure, DE | 1 |
| Green, SL | 1 |
| Chiou, RJ | 1 |
| Kuo, CC | 1 |
| Liang, KC | 1 |
| Yen, CT | 1 |
| Miyamoto, M | 1 |
| Fukuda, N | 1 |
| Narumi, S | 1 |
| Nagai, Y | 1 |
| Saji, Y | 1 |
| Nagawa, Y | 1 |
| Sieber, FE | 1 |
| Brown, PR | 1 |
| Wu, Y | 1 |
| Koehler, RC | 1 |
| Traystman, RJ | 1 |
| Haberham, ZL | 1 |
| van den Brom, WE | 1 |
| Venker-van Haagen, AJ | 1 |
| Baumans, V | 1 |
| de Groot, HN | 1 |
| Hellebrekers, LJ | 1 |
| Zalkind, V | 1 |
| Davis, H | 1 |
| Plevová, J | 1 |
| Formánek, J | 1 |
| Holoubková, E | 1 |
| Tikal, K | 1 |
| Fell, RH | 1 |
| Gunning, AJ | 1 |
| Bardhan, KD | 1 |
| Triger, DR | 1 |
| Tabatabai, M | 1 |
| Ovassapian, A | 1 |
| Shahidi, HA | 1 |
| Farivar, S | 1 |
| Sawa, M | 1 |
| Izumi, T | 1 |
| Dale, RA | 1 |
18 other studies available for pentobarbital and Consciousness, Loss of
| Article | Year |
|---|---|
N-methyl-d-aspartate receptors and glycinergic transmission, respectively, mediate muscle relaxation and immobility of pentobarbital in mice.
Topics: Animals; Dizocilpine Maleate; gamma-Aminobutyric Acid; Mecamylamine; Mice; Pentobarbital; Receptors, | 2023 |
Intraperitoneal Administration of Ethanol as a Means of Euthanasia for Neonatal Mice (
Topics: Animal Welfare; Animals; Animals, Newborn; Ethanol; Euthanasia, Animal; Injections, Intraperitoneal; | 2017 |
Pathological consequences of low atmospheric pressure stunning in broiler chickens.
Topics: Abattoirs; Animal Husbandry; Animals; Atmospheric Pressure; Chickens; Decompression; Euthanasia, Ani | 2020 |
Brainstem node for loss of consciousness due to GABA(A) receptor-active anesthetics.
Topics: Anesthetics; Animals; Brain Stem; GABA Modulators; Hypnotics and Sedatives; Male; Neural Pathways; P | 2016 |
Assessment of Carbon Dioxide, Carbon Dioxide/Oxygen, Isoflurane and Pentobarbital Killing Methods in Adult Female Sprague-Dawley Rats.
Topics: Adjuvants, Anesthesia; Animals; Apnea; Bradycardia; Carbon Dioxide; Electrocardiography; Electrocort | 2016 |
Thiopental exaggerates ischemic brain damage and neurological deficits after experimental stroke in spontaneously hypertensive rats.
Topics: Anesthetics, Intravenous; Animals; Brain; Brain Ischemia; Chloral Hydrate; Disease Models, Animal; D | 2009 |
Evaluation and refinement of euthanasia methods for Xenopus laevis.
Topics: Aminobenzoates; Animals; Benzocaine; Euthanasia, Animal; Pentobarbital; Phenytoin; Time Factors; Unc | 2009 |
State-dependent amygdala stimulation-induced cardiovascular effects in rats.
Topics: Amygdala; Anesthetics, General; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Chl | 2009 |
Gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide citrate (DN-1417): a novel TRH analog with potent effects on the central nervous system.
Topics: Animals; Arousal; Behavior, Animal; Central Nervous System Agents; Hypothermia, Induced; Male; Mice; | 1981 |
Cerebral blood flow responsivity to CO2 in anesthetized chronically diabetic dogs.
Topics: Animals; Blood Glucose; Carbon Dioxide; Cerebrovascular Circulation; Diabetes Mellitus, Experimental | 1993 |
EEG evaluation of reflex testing as assessment of depth of pentobarbital anaesthesia in the rat.
Topics: Analgesics, Opioid; Anesthesia; Anesthetics, Intravenous; Animals; Buprenorphine; Butyrophenones; El | 1999 |
Reversible analgesia, atonia, and loss of consciousness on bilateral intracerebral microinjection of pentobarbital.
Topics: Adjuvants, Anesthesia; Analgesia; Anesthesia; Animals; Brain; Injections, Intraventricular; Male; Mi | 2001 |
Leverpress escape behavior in a clinically unconscious rat.
Topics: Anesthesia, General; Animals; Conditioning, Operant; Electroshock; Male; Pentobarbital; Rats; Uncons | 1979 |
An attempt to predict the duration of pentobarbital narcosis on the basis of exploratory activity, defecation rate and body weight of rats.
Topics: Anesthesia, General; Animals; Body Weight; Defecation; Exploratory Behavior; Male; Pentobarbital; Ra | 1977 |
Severe hypothermia as a result of barbiturate overdose complicated by cardiac arrest.
Topics: Adult; Anuria; Electric Countershock; Electrocardiography; Extracorporeal Circulation; Female; Heart | 1968 |
Elimination of panting by decerebration and determination of core temperature threshold for panting in conscious and anesthetized cats.
Topics: Anesthesia; Animals; Body Temperature; Body Temperature Regulation; Cats; Decerebrate State; Hot Tem | 1974 |
[Neuronal activities during disturbance of consciousness caused by various chemicals].
Topics: Animals; Cats; Cerebral Cortex; Electric Stimulation; Electroencephalography; Ethyl Ethers; Evoked P | 1971 |
Effects of sampling procedures on the contents of some intermediate metabolities of glycolysis in rat tissues.
Topics: Animals; Brain; Decerebrate State; Epinephrine; Ethyl Ethers; Freezing; Glycolysis; Hexosephosphates | 1965 |