pentobarbital and Coma
pentobarbital has been researched along with Coma in 58 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neurosurgical patients in pentobarbital coma are a complex nutrition support population." | 8.79 | Pentobarbital coma in neurosurgical patients: nutrition considerations. ( Hatton, J; Magnuson, B; Young, B; Zweng, TN, 1994) |
| " Pentobarbital coma is often instituted following the failure of osmotic interventions and sedation to control intracranial pressure (ICP)." | 8.31 | Pentobarbital coma for management of intracranial hypertension following traumatic brain injury: Lack of early response to treatment portends poor outcomes. ( Bonnin, SS; Chapple, KM; Huang, DD; Kelley, CJ; Rudy, RF; Snyder, LA; Stansbury, BM; Weinberg, JA, 2023) |
| "We present a rare case of pentobarbital infusion causing propylene glycol-induced lactic acidosis, during refractory status epilepticus treatment in a 66-year-old man without seizure history." | 7.88 | Pentobarbital-induced lactic acidosis following status epilepticus barbiturate coma. ( Ghazala, S; Golden, TR; Solnicky, V; Wadeea, R, 2018) |
| "To identify predictors of mortality and long-term outcomes in survivors after pentobarbital coma (PBC) in patients failing current treatment standards for severe traumatic brain injuries (TBI)." | 7.76 | Pentobarbital coma for refractory intra-cranial hypertension after severe traumatic brain injury: mortality predictions and one-year outcomes in 55 patients. ( Cotton, BA; Hansen, EN; James, RF; Landman, MP; Marshall, GT; May, AK; Morris, JA; O'Neill, PJ, 2010) |
| "A retrospective, observational evaluation of patients (>14 y of age) who received a therapeutic pentobarbital coma in combination with EN was conducted." | 7.74 | Evaluation of feeding intolerance in patients with pentobarbital-induced coma. ( Beynnon, BJ; Commichau, C; Crookes, BA; Frock, KM; Marden, BT; Rebuck, JA; Stevens, AM; Then, JE, 2008) |
| " The authors anecdotally observed that patients in a pentobarbital coma have a CSR that can mimic pathological conditions." | 7.70 | The ciliospinal reflex in pentobarbital coma. ( Andrefsky, JC; Chyatte, D; Frank, JI, 1999) |
| "The scores indicated the intensity of interventions used in pentobarbital coma and the use of resources." | 7.69 | Therapeutic Intervention Scoring System used in the care of patients in pentobarbital-induced coma to determine nurse-patient ratios. ( Bucholz, RD; Gomez, CR; Malkoff, MD; Myles, GL; Perry, AG, 1996) |
| "Global cerebrovenous oxygenation was evaluated before and after intravenous administration of pentobarbital sodium for the management of refractory intracranial hypertension in 151 comatose patients who had acute traumatic brain swelling." | 7.69 | Adverse effects of pentobarbital on cerebral venous oxygenation of comatose patients with acute traumatic brain swelling: relationship to outcome. ( Cruz, J, 1996) |
| "Pentobarbital coma (PBC) is a treatment for patients with refractory status epilepticus, but there are currently few guidelines for choosing when to initiate or continue this therapy." | 7.68 | Prognostic factors of pentobarbital therapy for refractory generalized status epilepticus. ( Lowenstein, DH; Yaffe, K, 1993) |
| "Controversy exists regarding the optimal means for monitoring the patient receiving pentobarbital therapy during medical coma." | 7.68 | Electroencephalographic activity and serum and cerebrospinal fluid pentobarbital levels in determining the therapeutic end point during barbiturate coma. ( Jimenez, F; Rosenwasser, RH; Winer, JW, 1991) |
| "Dose-response curves for the incidence of coma after intraperitoneal injections of various doses of valproic acid (VP) and octanoic acid (OA) showed that, mole for mole, valproic acid was less toxic than octanoic acid." | 7.67 | Valproic acid induction of coma in rats: synergism with NH4+ and pentobarbital. ( Lyftogt, C; Zieve, L, 1989) |
| "The effect of pentobarbital therapy was studied prospectively in 31 nearly drowned children in a flaccid state of coma." | 7.67 | Pentobarbital therapy does not improve neurologic outcome in nearly drowned, flaccid-comatose children. ( Maggi, JC; Nussbaum, E, 1988) |
| "We sought to determine whether pentobarbital (PB) coma compromises the use of evoked potentials (EPs) in the assessment of brain dysfunction and of the prognosis of severely head-injured patients." | 7.66 | Effects of therapeutic pentobarbital coma on multimodality evoked potentials recorded from severely head-injured patients. ( Becker, DP; Enas, GG; Greenberg, RP; Newlon, PG, 1983) |
| "Forty-five patients in deep coma resulting from head injury were treated with pentobarbital in doses adjusted to maintain serum barbiturate levels between 15 and 25 mg/l and short burst suppression phases on EEG." | 7.66 | [Treatment of head injury coma with prolonged pentobarbital anaesthesia (author's transl)]. ( Artru, F; Deleuze, R; Guerin, JM; Latarjet, J, 1981) |
| "Specifically, induction of thiopental coma to manage severe increased intracranial pressure in seven patients was associated with a 37% reduction of lactate, 59% reduction of glutamate, and 66% reduction in aspartate in the extracellular space of the brain." | 6.68 | Lactate and excitatory amino acids measured by microdialysis are decreased by pentobarbital coma in head-injured patients. ( Cormio, M; Goodman, JC; Gopinath, SP; Robertson, CS; Valadka, AB, 1996) |
| "A seven-year-old child with generalized status epilepticus who was placed in a barbiturate coma was monitored with the bispectral index monitor in addition to the standard full channel electroencephalogram." | 5.32 | Use of an anesthesia cerebral monitor bispectral index to assess burst-suppression in pentobarbital coma. ( Gill, K; Horowitz, IN; Jaggi, P; Schwabe, MJ, 2003) |
| " The potential for serious complications of pentobarbital therapy among neonates highlights the need for careful dosing in this age group." | 5.31 | Neurologic outcomes of pediatric epileptic patients with pentobarbital coma. ( Kim, JS; Kim, SJ; Lee, DY, 2001) |
| "In summary, barbiturate coma can be a useful treatment modality for acutely reducing ICP in selected patients." | 5.30 | Cerebral hemodynamic effects of pentobarbital coma in head-injured patients. ( Cormio, M; Gopinath, SP; Robertson, CS; Valadka, A, 1999) |
| "Neurosurgical patients in pentobarbital coma are a complex nutrition support population." | 4.79 | Pentobarbital coma in neurosurgical patients: nutrition considerations. ( Hatton, J; Magnuson, B; Young, B; Zweng, TN, 1994) |
| " Pentobarbital coma is often instituted following the failure of osmotic interventions and sedation to control intracranial pressure (ICP)." | 4.31 | Pentobarbital coma for management of intracranial hypertension following traumatic brain injury: Lack of early response to treatment portends poor outcomes. ( Bonnin, SS; Chapple, KM; Huang, DD; Kelley, CJ; Rudy, RF; Snyder, LA; Stansbury, BM; Weinberg, JA, 2023) |
| "We present a rare case of pentobarbital infusion causing propylene glycol-induced lactic acidosis, during refractory status epilepticus treatment in a 66-year-old man without seizure history." | 3.88 | Pentobarbital-induced lactic acidosis following status epilepticus barbiturate coma. ( Ghazala, S; Golden, TR; Solnicky, V; Wadeea, R, 2018) |
| "To identify predictors of mortality and long-term outcomes in survivors after pentobarbital coma (PBC) in patients failing current treatment standards for severe traumatic brain injuries (TBI)." | 3.76 | Pentobarbital coma for refractory intra-cranial hypertension after severe traumatic brain injury: mortality predictions and one-year outcomes in 55 patients. ( Cotton, BA; Hansen, EN; James, RF; Landman, MP; Marshall, GT; May, AK; Morris, JA; O'Neill, PJ, 2010) |
| " Thus, because oxygen consumption by the brain represents approximately 20 per cent of the body's oxygen needs, and pentobarbital's primary action is as a central nervous system depressant, the induction of pentobarbital coma was instituted to reduce cerebral oxygen consumption." | 3.75 | The use of barbiturate coma as salvage therapy in a postoperative Jehovah's Witness patient with life-threatening anemia. ( Badami, CD; Deitch, EA; Wang, SW, 2009) |
| "A retrospective, observational evaluation of patients (>14 y of age) who received a therapeutic pentobarbital coma in combination with EN was conducted." | 3.74 | Evaluation of feeding intolerance in patients with pentobarbital-induced coma. ( Beynnon, BJ; Commichau, C; Crookes, BA; Frock, KM; Marden, BT; Rebuck, JA; Stevens, AM; Then, JE, 2008) |
| " The authors anecdotally observed that patients in a pentobarbital coma have a CSR that can mimic pathological conditions." | 3.70 | The ciliospinal reflex in pentobarbital coma. ( Andrefsky, JC; Chyatte, D; Frank, JI, 1999) |
| "Global cerebrovenous oxygenation was evaluated before and after intravenous administration of pentobarbital sodium for the management of refractory intracranial hypertension in 151 comatose patients who had acute traumatic brain swelling." | 3.69 | Adverse effects of pentobarbital on cerebral venous oxygenation of comatose patients with acute traumatic brain swelling: relationship to outcome. ( Cruz, J, 1996) |
| "The scores indicated the intensity of interventions used in pentobarbital coma and the use of resources." | 3.69 | Therapeutic Intervention Scoring System used in the care of patients in pentobarbital-induced coma to determine nurse-patient ratios. ( Bucholz, RD; Gomez, CR; Malkoff, MD; Myles, GL; Perry, AG, 1996) |
| "Pentobarbital coma (PBC) is a treatment for patients with refractory status epilepticus, but there are currently few guidelines for choosing when to initiate or continue this therapy." | 3.68 | Prognostic factors of pentobarbital therapy for refractory generalized status epilepticus. ( Lowenstein, DH; Yaffe, K, 1993) |
| " Propofol was used for surgical anesthesia because recovery in normal animals from an intravenous infusion was found to be nearly complete within 2 h of cessation and absolutely complete by 4 h." | 3.68 | Early assessment of neurologic deficits in the fluid percussion model of brain injury. ( Einhaus, SL; Hilton, DL; Meric, AL; Park, MR; Robertson, JT; Schweitzer, JB; White, RP, 1993) |
| "Controversy exists regarding the optimal means for monitoring the patient receiving pentobarbital therapy during medical coma." | 3.68 | Electroencephalographic activity and serum and cerebrospinal fluid pentobarbital levels in determining the therapeutic end point during barbiturate coma. ( Jimenez, F; Rosenwasser, RH; Winer, JW, 1991) |
| "Dose-response curves for the incidence of coma after intraperitoneal injections of various doses of valproic acid (VP) and octanoic acid (OA) showed that, mole for mole, valproic acid was less toxic than octanoic acid." | 3.67 | Valproic acid induction of coma in rats: synergism with NH4+ and pentobarbital. ( Lyftogt, C; Zieve, L, 1989) |
| "The effect of pentobarbital therapy was studied prospectively in 31 nearly drowned children in a flaccid state of coma." | 3.67 | Pentobarbital therapy does not improve neurologic outcome in nearly drowned, flaccid-comatose children. ( Maggi, JC; Nussbaum, E, 1988) |
| " These patients were successfully managed using pentobarbital-induced coma to ameliorate intracranial pressure elevation." | 3.67 | Treatment of sagittal sinus thrombosis associated with cerebral hemorrhage and intracranial hypertension. ( Borel, CO; Feldman, E; Goldberg, AL; Hanley, DF; Rosenbaum, AE, 1988) |
| "The present studies evaluated the effect of phenobarbital, pentobarbital, and thiopental at concentrations comparable to those attained during therapeutic barbiturate-induced coma, on in vitro mitogen-induced lymphocyte activation." | 3.66 | Barbiturate inhibition of lymphocyte function. Differing effects of various barbiturates used to induce coma. ( Frenkel, E; Hill, SA; Kikuchi, K; Lipsky, P; Neuwelt, EA, 1982) |
| "We sought to determine whether pentobarbital (PB) coma compromises the use of evoked potentials (EPs) in the assessment of brain dysfunction and of the prognosis of severely head-injured patients." | 3.66 | Effects of therapeutic pentobarbital coma on multimodality evoked potentials recorded from severely head-injured patients. ( Becker, DP; Enas, GG; Greenberg, RP; Newlon, PG, 1983) |
| "Forty-five patients in deep coma resulting from head injury were treated with pentobarbital in doses adjusted to maintain serum barbiturate levels between 15 and 25 mg/l and short burst suppression phases on EEG." | 3.66 | [Treatment of head injury coma with prolonged pentobarbital anaesthesia (author's transl)]. ( Artru, F; Deleuze, R; Guerin, JM; Latarjet, J, 1981) |
| "Specifically, induction of thiopental coma to manage severe increased intracranial pressure in seven patients was associated with a 37% reduction of lactate, 59% reduction of glutamate, and 66% reduction in aspartate in the extracellular space of the brain." | 2.68 | Lactate and excitatory amino acids measured by microdialysis are decreased by pentobarbital coma in head-injured patients. ( Cormio, M; Goodman, JC; Gopinath, SP; Robertson, CS; Valadka, AB, 1996) |
| "Pentobarbital is a short-acting barbiturate with anticonvulsant and sedative-hypnotic properties." | 2.44 | Liquid Chromatography-Tandem Mass Spectrometry for Quantitation of Serum Pentobarbital. ( Kyle, PB; Yahya, HA, 2024) |
| "Among patients with seizures, 89% (n = 98) were in intensive care units at the time of monitoring." | 2.42 | Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. ( Claassen, J; Emerson, RG; Hirsch, LJ; Kowalski, RG; Mayer, SA, 2004) |
| "The diagnosis of brain death and the implications of pentobarbital intoxication during a brain death examination are discussed." | 1.35 | Head injuries, pentobarbital, and the determination of death. ( McCutcheon, JR; Molina, DK; Rulon, JJ, 2009) |
| "The use of pharmacologic coma (PC) to treat status epilepticus (SE) is not always successful, and there are no guidelines for the duration of PC in an attempt to achieve seizure control." | 1.32 | Now we lay them down to sleep: ethical issues with the use of pharmacologic coma for adult status epilepticus. ( Bramstedt, KA; Morris, HH; Tanner, A, 2004) |
| "A seven-year-old child with generalized status epilepticus who was placed in a barbiturate coma was monitored with the bispectral index monitor in addition to the standard full channel electroencephalogram." | 1.32 | Use of an anesthesia cerebral monitor bispectral index to assess burst-suppression in pentobarbital coma. ( Gill, K; Horowitz, IN; Jaggi, P; Schwabe, MJ, 2003) |
| " The potential for serious complications of pentobarbital therapy among neonates highlights the need for careful dosing in this age group." | 1.31 | Neurologic outcomes of pediatric epileptic patients with pentobarbital coma. ( Kim, JS; Kim, SJ; Lee, DY, 2001) |
| "Pentobarbital coma is indicated in status epilepticus, refractory to other anticonvulsants, and in certain neurologic conditions in order to decrease brain metabolism." | 1.30 | Atypical triphasic waves associated with the use of pentobarbital. ( Lancman, ME; Lansen, T; Mahmood, K; Marks, S, 1997) |
| "In summary, barbiturate coma can be a useful treatment modality for acutely reducing ICP in selected patients." | 1.30 | Cerebral hemodynamic effects of pentobarbital coma in head-injured patients. ( Cormio, M; Gopinath, SP; Robertson, CS; Valadka, A, 1999) |
| "In the present two cases of brain death a large amount of barbiturate remained in the brain, even when the blood concentration was not detectable, possibly because the blood flow was stagnant in the brain." | 1.29 | Influence of antemortem medication on the determination of brain death. ( Nakajima, Y; Osawa, M; Saito, T; Takeichi, S; Yukawa, N, 1995) |
| "In the comatose patient the auditory brain stem response may be one of the few indices of CNS function available." | 1.27 | Resistance of the auditory brain stem response to high barbiturate levels. ( Frewen, TC; Marsh, RR; Potsic, WP; Sutton, LN, 1984) |
| "Clomipramine which has a stimulating effect on oxygen metabolism should be kept in reserve for the chronic phase of prolonged coma." | 1.26 | [Prolonged traumatic and vascular coma: prognostic and therapeutic indications based on hemodynamic and metabolic studies]. ( Baldy-Moulinier, M; Escuret, E; Frèrebeau, P; Passouant, P; Roquefeuil, B, 1976) |
Research
Studies (58)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (46.55) | 18.7374 |
| 1990's | 15 (25.86) | 18.2507 |
| 2000's | 7 (12.07) | 29.6817 |
| 2010's | 6 (10.34) | 24.3611 |
| 2020's | 3 (5.17) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Koh, S | 1 |
| Kim, TJ | 1 |
| Lim, TS | 1 |
| Lee, JS | 1 |
| Kim, BG | 1 |
| Park, SA | 1 |
| Huh, K | 1 |
| Choi, JY | 1 |
| Stansbury, BM | 1 |
| Kelley, CJ | 1 |
| Rudy, RF | 1 |
| Bonnin, SS | 1 |
| Chapple, KM | 1 |
| Snyder, LA | 1 |
| Weinberg, JA | 1 |
| Huang, DD | 1 |
| Yahya, HA | 1 |
| Kyle, PB | 1 |
| Kanawaku, Y | 1 |
| Hirakawa, K | 1 |
| Koike, K | 1 |
| Kanetake, J | 1 |
| Ohno, Y | 1 |
| Golden, TR | 1 |
| Solnicky, V | 1 |
| Wadeea, R | 1 |
| Ghazala, S | 1 |
| Mansour, N | 1 |
| deSouza, RM | 1 |
| Sikorski, C | 1 |
| Kahana, M | 1 |
| Frim, D | 1 |
| Molina, DK | 1 |
| McCutcheon, JR | 1 |
| Rulon, JJ | 1 |
| Wang, SW | 1 |
| Badami, CD | 1 |
| Deitch, EA | 1 |
| Marshall, GT | 1 |
| James, RF | 1 |
| Landman, MP | 1 |
| O'Neill, PJ | 1 |
| Cotton, BA | 1 |
| Hansen, EN | 1 |
| Morris, JA | 1 |
| May, AK | 1 |
| Kontogiorgi, M | 1 |
| Opsimoulis, P | 1 |
| Diamanti-Kandarakis, E | 1 |
| Karabinis, A | 1 |
| Bischoff, K | 1 |
| Jaeger, R | 1 |
| Ebel, JG | 1 |
| Jaggi, P | 1 |
| Schwabe, MJ | 1 |
| Gill, K | 1 |
| Horowitz, IN | 1 |
| NAKAJIMA, S | 1 |
| Claassen, J | 1 |
| Mayer, SA | 1 |
| Kowalski, RG | 1 |
| Emerson, RG | 1 |
| Hirsch, LJ | 1 |
| Bramstedt, KA | 1 |
| Morris, HH | 1 |
| Tanner, A | 1 |
| Stevens, AM | 1 |
| Then, JE | 1 |
| Frock, KM | 1 |
| Crookes, BA | 1 |
| Commichau, C | 1 |
| Marden, BT | 1 |
| Beynnon, BJ | 1 |
| Rebuck, JA | 1 |
| Takeda, M | 1 |
| Yoshimura, H | 1 |
| Tsukamoto, H | 1 |
| Marsh, RR | 1 |
| Frewen, TC | 2 |
| Sutton, LN | 2 |
| Potsic, WP | 1 |
| Bowers, SA | 1 |
| Newlon, PG | 1 |
| Greenberg, RP | 1 |
| Enas, GG | 1 |
| Becker, DP | 1 |
| Neuwelt, EA | 1 |
| Kikuchi, K | 1 |
| Hill, SA | 1 |
| Lipsky, P | 1 |
| Frenkel, E | 1 |
| Swedlow, DB | 1 |
| Watcha, M | 1 |
| Raphaely, RC | 1 |
| Godinez, RI | 1 |
| Heiser, MS | 1 |
| Kettrick, RG | 1 |
| Bruce, DA | 2 |
| Selman, WR | 1 |
| Spetzler, RF | 1 |
| Roski, RA | 1 |
| Roessmann, U | 1 |
| Crumrine, R | 1 |
| Macko, R | 1 |
| Frewen, T | 1 |
| Marsh, R | 1 |
| Jaggi, J | 1 |
| Artru, F | 2 |
| Guerin, JM | 2 |
| Chacornac, R | 1 |
| Deleuze, R | 2 |
| Latarjet, J | 1 |
| Dean, JM | 1 |
| McComb, JG | 1 |
| Mirski, MA | 1 |
| Williams, MA | 1 |
| Hanley, DF | 2 |
| Lee, MW | 1 |
| Deppe, SA | 1 |
| Sipperly, ME | 1 |
| Barrette, RR | 1 |
| Thompson, DR | 1 |
| Magnuson, B | 1 |
| Hatton, J | 1 |
| Zweng, TN | 1 |
| Young, B | 1 |
| Hiraga, Y | 1 |
| Nakata, N | 1 |
| Jin, H | 1 |
| Ito, S | 1 |
| Sato, R | 1 |
| Yoshida, A | 1 |
| Mori, T | 1 |
| Ozeki, M | 1 |
| Ikeda, Y | 1 |
| Hilton, DL | 1 |
| Einhaus, SL | 1 |
| Meric, AL | 1 |
| White, RP | 1 |
| Schweitzer, JB | 1 |
| Park, MR | 1 |
| Robertson, JT | 1 |
| Yaffe, K | 1 |
| Lowenstein, DH | 1 |
| Saito, T | 1 |
| Takeichi, S | 1 |
| Nakajima, Y | 1 |
| Yukawa, N | 1 |
| Osawa, M | 1 |
| Myles, GL | 1 |
| Malkoff, MD | 1 |
| Perry, AG | 1 |
| Bucholz, RD | 1 |
| Gomez, CR | 1 |
| Cruz, J | 1 |
| Goodman, JC | 1 |
| Valadka, AB | 1 |
| Gopinath, SP | 2 |
| Cormio, M | 2 |
| Robertson, CS | 2 |
| Lancman, ME | 1 |
| Marks, S | 1 |
| Mahmood, K | 1 |
| Lansen, T | 1 |
| Lam, AM | 1 |
| Coplin, WM | 1 |
| Andrefsky, JC | 1 |
| Frank, JI | 1 |
| Chyatte, D | 1 |
| Valadka, A | 1 |
| Kim, SJ | 1 |
| Lee, DY | 1 |
| Kim, JS | 1 |
| Venes, JL | 1 |
| Baldy-Moulinier, M | 1 |
| Roquefeuil, B | 1 |
| Escuret, E | 1 |
| Frèrebeau, P | 1 |
| Passouant, P | 1 |
| Winer, JW | 1 |
| Rosenwasser, RH | 1 |
| Jimenez, F | 1 |
| Zieve, L | 1 |
| Lyftogt, C | 1 |
| Pittman, T | 1 |
| Bucholz, R | 1 |
| Williams, D | 1 |
| Eisenberg, HM | 1 |
| Frankowski, RF | 1 |
| Contant, CF | 1 |
| Marshall, LF | 1 |
| Walker, MD | 1 |
| Nussbaum, E | 1 |
| Maggi, JC | 1 |
| Feldman, E | 1 |
| Borel, CO | 1 |
| Rosenbaum, AE | 1 |
| Goldberg, AL | 1 |
| Vedrinne, J | 1 |
| Dô, JP | 1 |
| Bevegård, S | 1 |
| Thorstrand, C | 1 |
| Shapiro, HM | 1 |
| Wyte, SR | 1 |
| Loeser, J | 1 |
| Nordzell, B | 1 |
| Fournier, E | 1 |
| Kaloyanova, F | 1 |
| Treich, I | 1 |
| Capelle, N | 1 |
| Mantz, JM | 1 |
| Tempe, JD | 1 |
| Jaeger, A | 1 |
| Kurtz, D | 1 |
| Lobstein, A | 1 |
| Mack, G | 1 |
| Bird, TD | 1 |
| Plum, F | 1 |
| Lous, P | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Trial of Nonconvulsive Electrographic Seizure Detection by Nurses in the Adult Neuro ICU Using a Panel of Quantitative EEG Trends[NCT02082873] | 20 participants (Actual) | Observational | 2015-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
2 reviews available for pentobarbital and Coma
| Article | Year |
|---|---|
Detection of electrographic seizures with continuous EEG monitoring in critically ill patients.
Topics: Adult; Aged; Anticonvulsants; Brain Diseases; Child; Child, Preschool; Cohort Studies; Coma; Conscio | 2004 |
Pentobarbital coma in neurosurgical patients: nutrition considerations.
Topics: Coma; Craniocerebral Trauma; Humans; Nutritional Physiological Phenomena; Pentobarbital | 1994 |
Trials
2 trials available for pentobarbital and Coma
| Article | Year |
|---|---|
Lactate and excitatory amino acids measured by microdialysis are decreased by pentobarbital coma in head-injured patients.
Topics: Adolescent; Adult; Brain Chemistry; Coma; Craniocerebral Trauma; Excitatory Amino Acids; Female; Hum | 1996 |
High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury.
Topics: Adolescent; Adult; Clinical Trials as Topic; Coma; Humans; Intracranial Pressure; Middle Aged; Model | 1988 |
Other Studies
54 other studies available for pentobarbital and Coma
| Article | Year |
|---|---|
Pentobarbital coma therapy for super-refractory status epilepticus and in-hospital mortality: an observational study.
Topics: Coma; Hospital Mortality; Humans; Pentobarbital; Retrospective Studies; Sepsis; Status Epilepticus | 2021 |
Pentobarbital coma for management of intracranial hypertension following traumatic brain injury: Lack of early response to treatment portends poor outcomes.
Topics: Adult; Brain Injuries; Brain Injuries, Traumatic; Coma; Female; Glasgow Coma Scale; Humans; Intracra | 2023 |
Liquid Chromatography-Tandem Mass Spectrometry for Quantitation of Serum Pentobarbital.
Topics: Brain Injuries, Traumatic; Chromatography, High Pressure Liquid; Chromatography, Liquid; Coma; Human | 2024 |
Pattern recognition analysis of proton nuclear magnetic resonance spectra of postmortem cerebrospinal fluid from rats with drug-induced seizure or coma.
Topics: Animals; Cerebrospinal Fluid; Coma; Convulsants; Discriminant Analysis; Hypnotics and Sedatives; Mag | 2017 |
Pentobarbital-induced lactic acidosis following status epilepticus barbiturate coma.
Topics: Acidosis, Lactic; Aged; Coma; Humans; Hypnotics and Sedatives; Male; Pentobarbital; Status Epileptic | 2018 |
Role of barbiturate coma in the management of focally induced, severe cerebral edema in children.
Topics: Brain Edema; Brain Neoplasms; Cerebral Hemorrhage; Child; Child, Preschool; Coma; Drug Administratio | 2013 |
Head injuries, pentobarbital, and the determination of death.
Topics: Accidents, Traffic; Adolescent; Adult; Brain Death; Coma; Female; Forensic Pathology; Head Injuries, | 2009 |
The use of barbiturate coma as salvage therapy in a postoperative Jehovah's Witness patient with life-threatening anemia.
Topics: Anemia; Coma; Humans; Hypnotics and Sedatives; Intestinal Perforation; Jehovah's Witnesses; Jejunal | 2009 |
Pentobarbital coma for refractory intra-cranial hypertension after severe traumatic brain injury: mortality predictions and one-year outcomes in 55 patients.
Topics: Adolescent; Adult; Brain Injuries; Child; Child, Preschool; Cohort Studies; Coma; Confidence Interva | 2010 |
Cerebral salt wasting syndrome in traumatic brain injury following therapeutic barbiturate coma.
Topics: Brain Injuries; Coma; Humans; Hypnotics and Sedatives; Hyponatremia; Inappropriate ADH Syndrome; Int | 2011 |
An unusual case of relay pentobarbital toxicosis in a dog.
Topics: Adipose Tissue; Animals; Anticonvulsants; Coma; Dog Diseases; Dogs; Female; Gas Chromatography-Mass | 2011 |
Use of an anesthesia cerebral monitor bispectral index to assess burst-suppression in pentobarbital coma.
Topics: Anesthesia; Child; Coma; Electroencephalography; Humans; Male; Monitoring, Physiologic; Pentobarbita | 2003 |
EFFECTS OF CHEMICAL INJECTION INTO THE RETICULAR FORMATION OF RATS.
Topics: Chlorides; Citrates; Coma; Fear; Injections; Nikethamide; Pentobarbital; Potassium; Procaine; Rats; | 1964 |
Now we lay them down to sleep: ethical issues with the use of pharmacologic coma for adult status epilepticus.
Topics: Adult; Anticonvulsants; Brain; Brain Edema; Coma; Drug Therapy; Fatal Outcome; Female; Humans; Hypno | 2004 |
Evaluation of feeding intolerance in patients with pentobarbital-induced coma.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Brain Injuries; Coma; Cr | 2008 |
[Metabolism of drugs. LIV. On the pharmacological action of carbamate N-glucuronides].
Topics: Animals; Carbamates; Coma; Glucuronates; Male; Meprobamate; Mice; Pentobarbital; Rats; Seizures; Ure | 1966 |
Resistance of the auditory brain stem response to high barbiturate levels.
Topics: Animals; Brain Stem; Cats; Coma; Evoked Potentials, Auditory; Pentobarbital | 1984 |
New, last-ditch therapy for malignant cerebral hypertension.
Topics: Adult; Brain Injuries; Coma; Humans; Hypertension; Intracranial Pressure; Male; Neurologic Examinati | 1983 |
Effects of therapeutic pentobarbital coma on multimodality evoked potentials recorded from severely head-injured patients.
Topics: Adult; Brain; Brain Injuries; Brain Stem; Coma; Evoked Potentials; Evoked Potentials, Auditory; Evok | 1983 |
Barbiturate inhibition of lymphocyte function. Differing effects of various barbiturates used to induce coma.
Topics: Barbiturates; Blood Proteins; Cell Division; Coma; Humans; Lymphocyte Activation; Lymphocytes; Mitog | 1982 |
Outcome in severe Reye syndrome with early pentobarbital coma and hypothermia.
Topics: Brain Edema; Child; Coma; Humans; Hypothermia, Induced; Intracranial Pressure; Outcome and Process A | 1982 |
Barbiturate coma in focal cerebral ischemia. Relationship of protection to timing of therapy.
Topics: Animals; Brain; Coma; Intracranial Pressure; Ischemic Attack, Transient; Male; Neurologic Examinatio | 1982 |
The effects of deep barbiturate coma on multimodality evoked potentials.
Topics: Animals; Barbiturates; Brain Stem; Cats; Coma; Electroencephalography; Evoked Potentials; Evoked Pot | 1982 |
[Practical aspects of the treatment of traumatic coma with prolonged barbiturate anesthesia].
Topics: Anesthesia, General; Brain Injuries; Coma; Humans; Intracranial Pressure; Pentobarbital | 1982 |
[Treatment of head injury coma with prolonged pentobarbital anaesthesia (author's transl)].
Topics: Adolescent; Adult; Anesthesia; Coma; Craniocerebral Trauma; Humans; Pentobarbital; Time Factors | 1981 |
Intracranial pressure monitoring in severe pediatric near-drowning.
Topics: Child; Coma; Drowning; Humans; Intracranial Pressure; Monitoring, Physiologic; Pentobarbital; Progno | 1981 |
Prolonged pentobarbital and phenobarbital coma for refractory generalized status epilepticus.
Topics: Adolescent; Coma; Electrocardiography; Humans; Male; Pentobarbital; Phenobarbital; Status Epilepticu | 1995 |
The efficacy of barbiturate coma in the management of uncontrolled intracranial hypertension following neurosurgical trauma.
Topics: Adolescent; Adult; Brain Injuries; Chi-Square Distribution; Child; Coma; Female; Glasgow Coma Scale; | 1994 |
Effect of the rice bran-derived phytosterol cycloartenol ferulic acid ester on the central nervous system.
Topics: Amnesia; Animals; Anticonvulsants; Avoidance Learning; Blood Pressure; Body Temperature; Cats; Centr | 1993 |
Early assessment of neurologic deficits in the fluid percussion model of brain injury.
Topics: Anesthesia; Animals; Behavior, Animal; Blood Pressure; Brain Injuries; Brain Stem; Cats; Cerebral He | 1993 |
Prognostic factors of pentobarbital therapy for refractory generalized status epilepticus.
Topics: Adult; Aged; Coma; Electroencephalography; Female; Follow-Up Studies; Humans; Male; Pentobarbital; P | 1993 |
Influence of antemortem medication on the determination of brain death.
Topics: Adolescent; Brain; Brain Death; Child, Preschool; Coma; Craniocerebral Trauma; Diagnosis, Differenti | 1995 |
Therapeutic Intervention Scoring System used in the care of patients in pentobarbital-induced coma to determine nurse-patient ratios.
Topics: Adult; Cerebrovascular Disorders; Coma; Female; Humans; Hypnotics and Sedatives; Intracranial Pressu | 1996 |
Adverse effects of pentobarbital on cerebral venous oxygenation of comatose patients with acute traumatic brain swelling: relationship to outcome.
Topics: Adolescent; Adult; Aged; Brain Edema; Brain Injuries; Cerebral Veins; Coma; Female; Humans; Male; Mi | 1996 |
Atypical triphasic waves associated with the use of pentobarbital.
Topics: Brain; Coma; Electroencephalography; Female; Humans; Infant; Middle Aged; Pentobarbital | 1997 |
Pentobarbital and venous oxygenation.
Topics: Acute Disease; Brain Edema; Brain Injuries; Cerebral Veins; Coma; Humans; Oxygen; Pentobarbital | 1997 |
The ciliospinal reflex in pentobarbital coma.
Topics: Adult; Blood Pressure; Brain Edema; Coma; Electroencephalography; GABA Modulators; Heart Rate; Human | 1999 |
Cerebral hemodynamic effects of pentobarbital coma in head-injured patients.
Topics: Adult; Cerebrovascular Circulation; Coma; Craniocerebral Trauma; Female; Hemodynamics; Humans; Hypno | 1999 |
Neurologic outcomes of pediatric epileptic patients with pentobarbital coma.
Topics: Adolescent; Child; Coma; Female; Humans; Hypnotics and Sedatives; Infant; Infant, Newborn; Male; Pen | 2001 |
Use of iatrogenic barbiturate coma.
Topics: Adult; Brain Edema; Brain Injuries; Coma; Humans; Iatrogenic Disease; Intracranial Pressure; Pentoba | 1979 |
[Prolonged traumatic and vascular coma: prognostic and therapeutic indications based on hemodynamic and metabolic studies].
Topics: Blood Gas Analysis; Brain; Carbon Dioxide; Cerebrovascular Circulation; Cerebrovascular Disorders; C | 1976 |
Electroencephalographic activity and serum and cerebrospinal fluid pentobarbital levels in determining the therapeutic end point during barbiturate coma.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Child; Coma; Electroencephalography; Female; Human | 1991 |
Valproic acid induction of coma in rats: synergism with NH4+ and pentobarbital.
Topics: Ammonium Chloride; Animals; Anticonvulsants; Caprylates; Coma; Dose-Response Relationship, Drug; Dru | 1989 |
Efficacy of barbiturates in the treatment of resistant intracranial hypertension in severely head-injured children.
Topics: Adolescent; Brain Injuries; Child; Child, Preschool; Coma; Humans; Infant; Pentobarbital; Pseudotumo | 1989 |
Pentobarbital therapy does not improve neurologic outcome in nearly drowned, flaccid-comatose children.
Topics: Brain Damage, Chronic; Child; Child, Preschool; Coma; Combined Modality Therapy; Drowning; Humans; H | 1988 |
Treatment of sagittal sinus thrombosis associated with cerebral hemorrhage and intracranial hypertension.
Topics: Adult; Cerebral Hemorrhage; Cerebrospinal Fluid; Coma; Disseminated Intravascular Coagulation; Drain | 1988 |
[Acute poisoning by short-acting barbiturates. Current clinical and medico-legal aspects].
Topics: Adolescent; Adult; Autopsy; Barbiturates; Coma; Female; Forensic Medicine; Humans; Hypertension; Mal | 1969 |
Central hemodynamics in severe poisoning by hypnotic drugs. Coma depth and body temperature.
Topics: Adult; Aged; Amitriptyline; Blood Pressure; Body Temperature; Cardiac Output; Central Venous Pressur | 1972 |
Barbiturate-augmented hypothermia for reduction of persistent intracranial hypertension.
Topics: Adolescent; Blood Pressure; Brain Diseases; Brain Neoplasms; Child; Child, Preschool; Coma; Cranioce | 1974 |
[Ischemic contracture after sleeping pill coma].
Topics: Barbiturates; Coma; Hand; Humans; Ischemia; Muscle Contraction; Pentobarbital | 1971 |
[Application of gas chromatography to the identification and determination of barbiturate derivatives in the blood during acute poisoning].
Topics: Amobarbital; Barbiturates; Chemistry, Clinical; Chromatography, Gas; Coma; Humans; Methods; Methylat | 1970 |
[24-hour cerebral electric silence during a massive poisoning with 10g of pentobarbital. Hemodialysis cure].
Topics: Brain Death; Coma; Electroencephalography; Electroretinography; Female; Fluoroscopy; Humans; Middle | 1971 |
Recovery from barbiturate overdose coma with a prolonged isoelectric electroencephalogram.
Topics: Adult; Coma; Electroencephalography; Headache; Humans; Hypertension; Hypotension; Male; Pentobarbita | 1968 |
Elimination of barbiturates.
Topics: Adult; Amobarbital; Barbiturates; Coma; Female; Humans; Pentobarbital; Phenobarbital; Thiopental | 1966 |