pentobarbital has been researched along with Cholestasis in 9 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The metabolism of meprobamate, pentobarbital and tolbutamide was assessed in subjects with intrahepatic recurrent cholestasis (3), cholestatic hepatitis (6), extrahepatic biliary obstruction (7) and normal controls (16)." | 3.65 | Alteration of drug metabolism during cholestasis in man. ( Carulli, N; Ferrari, A; Gallo, M; Manenti, F; Ponz de Leon, M; Salvioli, G, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kakis, G | 1 |
| Phillips, MJ | 1 |
| Yousef, IM | 1 |
| Younes, M | 1 |
| Schlichting, R | 1 |
| Siegers, CP | 1 |
| Ossenberg, FW | 1 |
| Marmo, E | 1 |
| Di Mezza, F | 1 |
| Brita, G | 1 |
| Grella, A | 1 |
| Alfano, C | 1 |
| González Macías, J | 1 |
| De Castro del Pozo, S | 1 |
| Carulli, N | 1 |
| Manenti, F | 1 |
| Ponz de Leon, M | 1 |
| Ferrari, A | 1 |
| Salvioli, G | 1 |
| Gallo, M | 1 |
| Bomzon, A | 1 |
| Monies-Chass, I | 1 |
| Kamenetz, L | 1 |
| Blendis, L | 1 |
| Buxton, BH | 1 |
| Witschi, H | 1 |
| Plaa, GL | 1 |
| Stacher, G | 1 |
9 other studies available for pentobarbital and Cholestasis
| Article | Year |
|---|---|
The respective roles of membrane cholesterol and of sodium potassium adenosine triphosphatase in the pathogenesis of lithocholate-induced cholestasis.
Topics: Animals; Bile; Bile Ducts, Intrahepatic; Cell Membrane; Cholestasis; Cholesterol; Lipids; Lithocholi | 1980 |
Glutathione S-transferase activities in rat liver: effect of some factors influencing the metabolism of xenobiotics.
Topics: Animals; Blood Glucose; Cholestasis; Cytosol; Diabetes Mellitus, Experimental; Ethanol; Glutathione | 1980 |
[Pharmacokinetics of pentobarbital in liver damage].
Topics: Animals; Biotransformation; Cholestasis; Humans; Liver Cirrhosis; Microsomes, Liver; Pentobarbital; | 1977 |
Drug induction and experimental cholestasis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Cholestasis; Cytochrome P-450 | 1976 |
[Metabolism of phenylbutazone in the liver (author's transl)].
Topics: Alcoholism; Cholestasis; Diabetes Mellitus; Enzyme Induction; Epilepsy; Ethanol; Half-Life; Hepatiti | 1976 |
Alteration of drug metabolism during cholestasis in man.
Topics: Adolescent; Adult; Aged; Cholestasis; Female; Half-Life; Hepatitis; Humans; Liver; Male; Meprobamate | 1975 |
Anesthesia and pressor responsiveness in chronic bile-duct-ligated dogs.
Topics: Anesthesia; Angiotensin II; Animals; Bile Ducts; Blood Pressure; Cholestasis; Dogs; Fentanyl; Haloth | 1990 |
Biochemical changes provoked in rat liver by cholestatic doses of -naphthylisothiocyanate.
Topics: Aminopyrine N-Demethylase; Animals; Bile Ducts; Carbon Isotopes; Carbon Tetrachloride; Cholestasis; | 1973 |
Intrahepatic cholostasis following combined diazepam-barbiturate therapy in patients with tetanus.
Topics: Adult; Aged; Anti-Bacterial Agents; Chlorpromazine; Cholestasis; Diazepam; Drug Combinations; Female | 1973 |