pentobarbital has been researched along with Chemical and Drug Induced Liver Injury in 34 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prior administration of aminoacetonitrile (AAN) or imidazole but not isoxazole to rats, was able partially to prevent thioacetamide (TAC)-induced liver necrosis at 24 h." | 7.66 | Prevention of thioacetamide-induced liver necrosis by prior aminoacetonitrile or imidazole administration. ( Castro, JA; De Fenos, OM; De Ferreyra, EC, 1982) |
| " The prolongation of narcolepsy induced by pentobarbital was shortened significantly by the extract." | 3.76 | The effectiveness of ethanolic extract of Amaranthus tricolor L.: A natural hepatoprotective agent. ( Al-Dosari, MS, 2010) |
| "Prior administration of aminoacetonitrile (AAN) or imidazole but not isoxazole to rats, was able partially to prevent thioacetamide (TAC)-induced liver necrosis at 24 h." | 3.66 | Prevention of thioacetamide-induced liver necrosis by prior aminoacetonitrile or imidazole administration. ( Castro, JA; De Fenos, OM; De Ferreyra, EC, 1982) |
| " Impairment of xenobiotic biotransformation was confirmed by elevated pentobarbital sleeping time in animals under the same CCl4 dosing regimen." | 1.28 | Enhanced neurotoxicity of 3,3'-iminodipropionitrile following carbon tetrachloride pretreatment in the rat. ( Crofton, KM; Llorens, J, 1991) |
| " These permit the elaboration of dose-response lines for the substances in question, the calculation of median effective doses and the statistical analysis of differences in liver-damaging potency." | 1.26 | Quantitative aspects in the assessment of liver injury. ( Plaa, GL, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (64.71) | 18.7374 |
| 1990's | 5 (14.71) | 18.2507 |
| 2000's | 2 (5.88) | 29.6817 |
| 2010's | 5 (14.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Alqasoumi, S | 1 |
| Al-Dosari, MS | 1 |
| Ali, BH | 1 |
| Mousa, HM | 1 |
| El-Mougy, S | 1 |
| KURZ, H | 1 |
| Davis, ME | 1 |
| Mehendale, HM | 1 |
| De Ferreyra, EC | 2 |
| De Fenos, OM | 3 |
| Castro, JA | 4 |
| Gilani, AH | 3 |
| Janbaz, KH | 4 |
| Gilani, AU | 1 |
| Karan, M | 1 |
| Vasisht, K | 1 |
| Handa, SS | 1 |
| Chiba, T | 1 |
| Horiuchi, M | 1 |
| Akashi, Y | 1 |
| Andersen, ME | 1 |
| French, JE | 1 |
| Gargas, ML | 1 |
| Jones, RA | 1 |
| Jenkins, LJ | 1 |
| Nishie, K | 3 |
| Donatelli, L | 1 |
| Marmo, E | 1 |
| Ferreyra, EC | 1 |
| de Castro, CR | 1 |
| Diaz Gómez, MI | 1 |
| Gram, TE | 1 |
| Reagan, RL | 1 |
| Guarino, AM | 1 |
| Plaa, GL | 2 |
| Llorens, J | 1 |
| Crofton, KM | 1 |
| Goel, SK | 1 |
| Rao, GS | 1 |
| Pandya, KP | 1 |
| Takeda, T | 1 |
| Enomoto, M | 1 |
| Makita, T | 1 |
| Norred, WP | 2 |
| Pensabene, JW | 1 |
| Ruckebusch, Y | 1 |
| Grivel, ML | 1 |
| Kolenda, KD | 1 |
| Haacke, H | 1 |
| Johnsen, K | 1 |
| Wasserman, A | 1 |
| Keyl, AC | 1 |
| Indacochea-Redmond, N | 1 |
| Witschi, H | 1 |
| Hollwich, F | 1 |
| Dieckhues, B | 1 |
| Eriksson, M | 1 |
| Rubin, E | 1 |
| Bacchin, P | 1 |
| Gang, H | 1 |
| Lieber, CS | 1 |
| Cignoli, EV | 1 |
| Peters, JM | 1 |
| Boyd, EM | 1 |
2 reviews available for pentobarbital and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
[Current status of hepatic and biliary drug therapy. Part I].
Topics: Biliary Tract Diseases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chol | 1976 |
32 other studies available for pentobarbital and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Carbon tetrachloride-induced hepatotoxicity: Protective effect of 'Rocket' Eruca sativa L. in rats.
Topics: Animals; Antioxidants; Bilirubin; Biomarkers; Brassicaceae; Carbon Tetrachloride; Carbon Tetrachlori | 2010 |
The effectiveness of ethanolic extract of Amaranthus tricolor L.: A natural hepatoprotective agent.
Topics: Amaranthus; Animals; Antioxidants; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2010 |
The effect of a water extract and anthocyanins of hibiscus sabdariffa L on paracetamol-induced hepatoxicity in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Anthocyanins; Antioxidants; Chemical and Drug Induced | 2003 |
[THE PERMEATION OF POISONS INTO THE LIVER].
Topics: Aminopyrine; Animals; Antipyrine; Barbiturates; Chemical and Drug Induced Liver Injury; Ethylamines; | 1964 |
Functional and biochemical correlates of chlordecone exposure and its enhancement of CCl4 hepatotoxicity.
Topics: Animals; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlordecone; Drug Inter | 1980 |
Prevention of thioacetamide-induced liver necrosis by prior aminoacetonitrile or imidazole administration.
Topics: Acetamides; Acetonitriles; Aminoacetonitrile; Animals; Chemical and Drug Induced Liver Injury; Imida | 1982 |
Effect of different chemicals on thioacetamine-induced liver necrosis.
Topics: Acetamides; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Liver; | 1980 |
Preventive and curative effects of Artemisia absinthium on acetaminophen and CCl4-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Che | 1995 |
Studies on protective effect of Cyperus scariosus extract on acetaminophen and CCl4-induced hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Car | 1995 |
Hepatoprotective effects of artemisia scoparia against carbon tetrachloride: an environmental contaminant.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dose-Response Relat | 1994 |
Antihepatotoxic activity of Swertia chirata on carbon tetrachloride induced hepatotoxicity in rats.
Topics: Animals; Butanols; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorofor | 1999 |
Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Ber | 2000 |
[Effect of thiol compounds on experimental liver damage (III). Effect of tiopronin (2-mercaptopropionylglycine) and glutathione on drug metabolizing activity (author's transl)].
Topics: Amino Acids, Sulfur; Aminopyrine; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Chemical | 1979 |
Saturable metabolism and the acute toxicity of 1,1-dichloroethylene.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dichloroethylenes; Hydrocarbons, Chlorinated; Letha | 1979 |
A comparison of ascorbic acid excretion with other indicators of nitrosamine hepatotoxicity.
Topics: Animals; Ascorbic Acid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Liver; | 1978 |
Studies on the role of protein syntheis in cell injury by toxic agents: I. Effect of cycloheximide administration on several factors modulating carbon tetrachloride-induced liver necrosis.
Topics: Animals; Body Temperature; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cycloheximi | 1977 |
Quantitative aspects in the assessment of liver injury.
Topics: 1-Propanol; Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Che | 1976 |
Enhanced neurotoxicity of 3,3'-iminodipropionitrile following carbon tetrachloride pretreatment in the rat.
Topics: Analysis of Variance; Animals; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver In | 1991 |
Hepatotoxic effects elicited by n-hexane or n-heptane.
Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Glucose-6-Phosphatase; Heptanes; Hexanes; L | 1988 |
Gross and microscopic characteristics of liver lesions induced by direct injection of pentobarbital sodium into rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 1987 |
Effect of short-term administration of N-nitroso compounds on liver histology and on pentobarbital-induced sleeping time in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Lipid Metabolism; Liver; Liv | 1974 |
[Hepatic insufficiency and neurotropic medicinal activity].
Topics: Animals; Chemical and Drug Induced Liver Injury; Dogs; Drug Synergism; Female; Hexobarbital; Ipronia | 1966 |
Proceedings: Studies on the interference of 14C-pentobarbital, 14C-diphenylhydantoin and 3H-digitoxin with ethanol in the isolated perfused guinea-pig liver.
Topics: Animals; Bile; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme | 1974 |
Phototoxicity and differential hepatotoxicity as biological indicators of nitrosamine activity.
Topics: Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Liver; Male; Mice; Microscopy | 1972 |
Effects of inhibitors of protein and ribonucleic acid synthesis on naphthyliso-thiocyanate-induced hyperbilirubinemia, sulfobromophthalein retention and prolongation of pentobarbital hypnosis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cycloheximide; Dactinomycin; Depression, Chemical; | 1974 |
[Ocular light perception and metabolic activity of the liver (author's transl)].
Topics: Animals; Bilirubin; Blindness; Cataract; Cataract Extraction; Chemical and Drug Induced Liver Injury | 1974 |
Salicylate-induced foetal damage during late pregnancy in mice. The modifying effect of repeated administration and dosage.
Topics: Abnormalities, Drug-Induced; Animals; Chemical and Drug Induced Liver Injury; Female; Fetal Death; F | 1970 |
Induction and inhibition of hepatic microsomal and mitochondrial enzymes by ethanol.
Topics: Acyltransferases; Alcoholism; Aniline Compounds; Animals; Benzopyrenes; Centrifugation; Chemical and | 1970 |
Effect of inhibitors of drug metabolizing enzymes on carbon tetrachloride hepatotoxicity.
Topics: Aminopyrine; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemi | 1971 |
Resistance to pentobarbital in rats fed a cachexigenic diet.
Topics: Animals; Biotin; Cachexia; Chemical and Drug Induced Liver Injury; Diet; Female; Pentobarbital; Rats | 1966 |