Page last updated: 2024-11-02

pentobarbital and Chemical Dependence

pentobarbital has been researched along with Chemical Dependence in 165 studies

Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.

Research Excerpts

ExcerptRelevanceReference
") given for 12 hr in the presence, versus in the absence, of continuous pentobarbital anesthesia in nonhibernating ground squirrels (Citellus lateralis) and, in addition, in rats."7.68Morphine physical dependence in the hibernator: central nervous system mechanisms underlying the development of dependence remain functional during depression induced by pentobarbital anesthesia. ( Beaver, TA; Beckman, AL; Lewis, FA, 1993)
") given for 12 hr in the presence, versus in the absence, of continuous pentobarbital anesthesia in nonhibernating ground squirrels (Citellus lateralis) and, in addition, in rats."3.68Morphine physical dependence in the hibernator: central nervous system mechanisms underlying the development of dependence remain functional during depression induced by pentobarbital anesthesia. ( Beaver, TA; Beckman, AL; Lewis, FA, 1993)
" Pharmacodynamic measures included subjective (euphoria, subject liking, sedation, and symptoms) and behavioral (signs and observed liking) responses."2.67Single-dose pharmacodynamics of diazepam and pentobarbital in substance abusers. ( Jasinski, DR; Johnson, RE; Sullivan, JT, 1993)
"Zolpidem has abuse potential, particularly among individuals with histories of drug abuse."1.35A therapeutic dose of zolpidem has limited abuse-like effects in drug-naïve females: a pilot study. ( Dunlap, S; Licata, SC; Lukas, SE; Penetar, DM, 2008)
"Flunitrazepam was evaluated in several procedures that have been used extensively to study the behavioral effects and abuse potential of positive GABA(A) modulators."1.31Behavioral effects of flunitrazepam: reinforcing and discriminative stimulus effects in rhesus monkeys and prevention of withdrawal signs in pentobarbital-dependent rats. ( France, CP; Gerak, LR; Harris, LS; Nader, MA; Patrick, GA; Winger, G; Woods, JH; Woolverton, WL, 2001)
"These studies were designed to examine the effect of chronic administration of pentobarbital on activity of adenylate cyclase (AC) and protein kinase C (PKC) in the rat brain by autoradiography."1.30Changes in [3H]forskolin binding to adenylate cyclase and [3H]phorbol dibutyrate binding to protein kinase C in pentobarbital tolerant/dependent rats. ( Ho, IK; Oh, S; Wellman, SE, 1998)
"Pentobarbital dependence was assessed 24 h after abrupt withdrawal from pentobarbital."1.30Autoradiographic study of [3H]flunitrazepam binding sites in the subnuclei of the thalamus of rats rendered tolerant to and dependent on pentobarbital. ( Ho, IK; Ito, T; Suzuki, T; Wellman, SE, 1998)
"The pentobarbital dependence was assessed 24 hr after abrupt withdrawal from pentobarbital."1.29Changes in [3H]flunitrazepam binding in the brain of rats made tolerant to and dependent upon pentobarbital. ( Ho, IK; Ito, T; Suzuki, T; Wellman, SE, 1995)
"Aminorex is a cyclic phenylisopropylamine that has been marketed as an anorectic."1.29Evaluation of the abuse liability of aminorex. ( Harris, LS; Massey, BW; Patrick, GA; Winger, G; Woolverton, WL, 1994)
" In the physical dependence test, nefiracetam and codeine phosphate were administered to rats mixed with food for 43 days in a gradually increasing dosage schedule, followed by feeding a drug-free normal diet to detect signs of withdrawal."1.29Drug dependence study of the new cognition-enhancing agent nefiracetam in rats. ( Akiyama, Y; Fujikawa, K; Takayama, S, 1994)
"Enciprazine was selected for clinical investigations."1.28Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds. ( Engel, J; Fleischhauer, I; Jakovlev, V; Johanson, CE; Kleemann, A; Kutscher, B; Nickel, B; Rauer, H; Szelenyi, I; Werner, U, 1990)
" In addition, the effect of ITI length on the dose-response curve for pentobarbital, phencyclidine, D-amphetamine, and cocaine were determined."1.28Titrating matching-to-sample performance: effects of drugs of abuse and intertrial interval. ( Kimball, KA; Wenger, GR, 1992)
"The effect of three dosage schedules on the expression of a withdrawal syndrome indicative of physical dependence on pentobarbital was determined in male Sprague-Dawley rats."1.28Intensity of the withdrawal syndrome varies with duration of pentobarbital administration. ( Yutrzenka, GJ, 1989)
" Animals were treated with Na pentobarbital according to the "maximally tolerable" dosing schedule described previously, twice a day for 35 days, and abruptly withdrawn."1.27Effects of individual variations in drug elimination kinetics for production of pentobarbital physical dependence. ( Hinman, DJ; Okamoto, M, 1983)
"CGS-8216, a benzodiazepine antagonist, was administered to rats acutely dosed with diazepam, and to rats chronically dosed with diazepam or pentobarbital."1.27Benzodiazepine antagonist, CGS-8216, in diazepam- or pentobarbital-dependent and non-dependent rats. ( Martin, WR; McNicholas, LF, 1986)
"Fischer 344 (F344), Lewis (LEW), spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats were chronically fed food containing pentobarbital on an escalating drug dosage schedule over a period of 47 days."1.27Genetic differences in the development of physical dependence on pentobarbital in four inbred strains of rats. ( George, FR; Koike, Y; Meisch, RA; Suzuki, T; Yanaura, S, 1987)
" Groups of animals were treated with Na pentobarbital according to the "maximally tolerable" dosing schedule described previously, except that with different dose-frequency schedules, i."1.27Effect of dosing frequency on the development of physical dependence and tolerance to pentobarbital. ( Okamoto, M; Rao, S; Walewski, JL, 1986)
" In naive animals, after the chronic administration of midazolam at 0."1.27[Drug dependence tests on a new anesthesia inducer, midazolam]. ( Hakkei, M; Kubota, A; Kuwahara, A; Nakamura, K, 1986)
"Experienced polydrug abusers (N = 190) were asked to indicate previous drugs used as well as drug preferences."1.26Indicated preference for drugs of abuse. ( Kliner, DJ; Pickens, R, 1982)
"For barbital, tolerance was exclusively functional."1.26Physical dependence to barbital compared to pentobarbital. II. Tolerance characteristics. ( Boisse, NR; Okamoto, M, 1978)
"After "chronically equivalent" barbital and pentobarbital dosing for 5 weeks, treatments were abruptly stopped and the animals were carefully observed for signs of barbiturate withdrawal."1.26Physical dependence to barbital compared to pentobarbital. III. Withdrawal characteristics. ( Boisse, NR; Okamoto, M, 1978)
" The rate of barbiturate elimination after chronically equivalent pentobarbital dosing was reduced by barbital substitution or by first-order pentobarbital dose reduction, with the result that withdrawal signs became mild and appeared later (3 days postdrug)."1.26Physical dependence to barbital compared to pentobarbital. IV. Influence of elimination kinetics. ( Boisse, NR; Okamoto, M, 1978)
"The occurrence of convulsions, during periods of complete reduction of the maintenance drug, became less frequent the longer the dogs had been maintained on a constant dose of sodium pentobarbital."1.26A method for bioassay of physical dependence on sedative drugs in dog. ( Jones, BE; Martin, WR; Prada, JA, 1976)
" Physical dependence was produced in 63 cats by 'maximally tolerable' dosing with sodium pentobarbital."1.26Withdrawal characteristics following chronic pentobarbital dosing. ( Boisse, NR; Okamoto, M; Rosenberg, HC, 1976)

Research

Studies (165)

TimeframeStudies, this research(%)All Research%
pre-1990130 (78.79)18.7374
1990's30 (18.18)18.2507
2000's5 (3.03)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Engel, J1
Fleischhauer, I1
Jakovlev, V1
Kleemann, A1
Kutscher, B1
Nickel, B1
Rauer, H1
Werner, U1
Szelenyi, I1
Johanson, CE2
Licata, SC1
Penetar, DM1
Dunlap, S1
Lukas, SE2
Gerak, LR2
FRASER, HF2
WIKLER, A3
ESSIG, CF1
ISBELL, H1
OSNOS, RJ1
HILL, HE5
HAERTZEN, CA7
WOLBACH, AB2
MINER, EJ2
BELLEVILLE, RE1
BERGER, H1
HAMBURGER, E2
RICE, J1
COHEN, L1
Meisch, RA4
Carroll, ME1
Griffiths, RR15
Ator, NA4
Lamb, RJ3
Brady, JV3
Nabeshima, T1
Ho, IK12
Jasinski, DR2
Henningfield, JE1
Hickey, JE1
Johnson, RE2
McLeod, DR1
Emmett-Oglesby, MW1
Spencer, DG1
Lewis, MW1
Lal, H1
Okamoto, M10
Roache, JD6
Mandel, P2
Glowa, JR1
Barrett, JE1
Hinman, DJ2
Crowley, TJ2
Hienz, RD1
Martin, WR5
McNicholas, LF5
Pickens, RW3
Heston, LL2
Healey, ML1
Bigelow, GE5
Liebson, I5
Cherian, S1
Valdman, AV1
Zvartau, EE2
Kliner, DJ1
Pickens, R2
Flint, BA2
Val'dman, AV1
Aaronson, LM1
Ross, FE1
Kaliszak, JE1
Nabeshima, A2
Saito, T2
Takahata, N2
Toki, S1
Suzuki, T7
Ito, T2
Wellman, SE3
Woolverton, WL3
Massey, BW1
Winger, G2
Patrick, GA4
Harris, LS2
Fujikawa, K1
Akiyama, Y1
Takayama, S1
Sannerud, CA1
Sullivan, JT2
Tseng, YT1
Miyaoka, T2
Evans, EB1
Balster, RL3
Beckman, AL1
Beaver, TA1
Lewis, FA1
Liu, RH1
Foster, G1
Cone, EJ1
Kumar, SD1
Yutrzenka, GJ5
Stone, T1
Anderson, S1
Oh, S2
Hoshi, K1
Mintzer, MZ1
Guarino, J1
Kirk, T1
Pickworth, WB1
Rohrer, MS1
Fant, RV1
Crabbe, JC2
Phillips, TJ2
Buck, KJ1
Cunningham, CL1
Belknap, JK1
Ryabinin, AE1
Wang, YM1
Bachtell, RK1
Kinney, AE1
Grubb, MC1
Mark, GP1
Nader, MA2
Woods, JH2
France, CP1
Smith, MA1
Stoops, WW1
Strickholm, A1
Chait, LD1
Bigelow, G2
Teggin, AF1
Bewley, TH2
Franks, RD1
Boisse, NR6
Peterson, GR1
Covault, HP1
Hostetler, RM1
Rosenberg, HC2
Rosen, R1
Grant, I2
Adams, KM2
Carlin, AS2
Rennick, PM1
Judd, LL1
Schooff, K1
Reed, R1
Stauss, FF1
Lefkowitz, SS1
Nemeth, D1
Weeks, JR1
Roth-Schechter, BF1
Altshuler, H1
Weaver, S1
Phillips, P1
Turnbull, MJ1
Watkins, JW1
Yamamoto, I2
Becker, KE1
Loh, HH2
Way, EL1
Jones, BE1
Prada, JA1
Ritzmann, RF1
Tabakoff, B2
Frederickson, RC1
Hewes, CR1
Aiken, JW1
Liebson, IA1
Thompson, T1
Roerig, DL1
Lewand, DL1
Mueller, MA1
Wang, RI1
Rasmussen, K1
Jensen, K1
Alexander, GJ1
Griffiths, R1
Banerjee, U2
Saunders, PA2
Kimura, T1
Cole-Harding, S1
de Wit, H2
Koike, Y5
Yanaura, S4
George, FR2
Wenger, GR1
Kimball, KA1
Vanover, KE1
Bodker, B1
Ambre, J1
Burkhart-Kasch, S1
Gwiazdon, CC1
Carney, JM1
Landrum, RW1
Cheng, MS1
Seale, TW1
Dawson, AH1
Whyte, IM1
Lemaire, GA1
Rosenberger, W2
Liljequist, S1
Culp, S1
Hayes, BA1
Guarino, JJ1
Kirk, WT1
McMillan, DE1
Wessinger, WD1
Otani, K1
Yoshii, T2
Kosse, K1
Goa, KL1
Heel, RC1
Pruitt, TA1
de la Garza, R1
Ito, Y1
Lim, DK1
Lamb, R1
Kaneto, H1
Hori, A1
Gmerek, DE1
Dykstra, LA1
Chida, Y1
Misawa, M1
Kuwahara, A2
Kubota, A2
Hakkei, M2
Nakamura, K2
Rao, S1
Walewski, JL1
Sellers, EM1
Basu, PK1
Kapur, BM1
Matuk, Y1
McCulloch, C1
Piascik, MT1
Raft, D1
Gomez, R1
Ewing, JA1
Kales, A1
Bixler, EO1
Tan, TL1
Scharf, MB1
Kales, JD1
Harwood, CT1
Zahn, MA1
Ball, JC1
Stynes, AJ1
Hydinger, M1
Kaufman, IC1
Distasio, C1
Nawrot, M1
Nurimoto, S1
Lamb, D1
Roberts, G1
Yanagita, T2
Takahashi, S1
Choulis, NH1
Inaba, DS1
Ray, GR1
Newmeyer, JA1
Whitehead, C1
Maronde, RF1
Silverman, M1
Sheerin, E1
Kullberg, MP1
Gorodetzky, CW1
Klein, B1
Sheehan, JE1
Grunberg, E1
Walberg, CB1
Zbinden, G1
Randall, LO1
Holtzman, SG1
Villarreal, JE1
Deneau, G1
Seevers, MH1
Gray, GR1
Smith, DE2
Wesson, DR2
Sheppard, CW1
Johns, MW1
Hepburn, M1
Goodyear, MD1
Chessick, RD1
Pescor, FT1
Ben-Arie, O1
Cancrini, L1
Scapicchio, PL1
Urbaitis, JC1
Glasson, B1
Jaffe, JH1
Sharpless, SK1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Difference in Pharmacodynamic and Pharmacokinetic Profiles Between Tentin and Magisterial Dexamfetamine in Adults With Attention Deficit Hyperactivity Disorder, a Double Blinded Randomised Crossover-controlled Trial[NCT05621174]26 participants (Anticipated)Interventional2023-04-14Recruiting
Evaluation of an Eye Tracking Sensor to Detect Cannabis Impairment[NCT03994926]Early Phase 13 participants (Actual)Interventional2020-02-03Terminated (stopped due to COVID-19 Pandmic halted study)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for pentobarbital and Chemical Dependence

ArticleYear
Barbiturate tolerance and physical dependence: contribution of pharmacological factors.
    NIDA research monograph, 1984, Volume: 54

    Topics: Anesthesia; Animals; Barbital; Barbiturates; Cats; Central Nervous System Depressants; Drug Administ

1984
Identifying genes for alcohol and drug sensitivity: recent progress and future directions.
    Trends in neurosciences, 1999, Volume: 22, Issue:4

    Topics: Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Chromosome Mapping; Cocaine; Crosses, Genet

1999
The behavioral effects of phencyclidine in animals.
    NIDA research monograph, 1978, Issue:21

    Topics: Animals; Behavior, Animal; Dextroamphetamine; Drug Interactions; Drug Tolerance; Humans; Motor Activ

1978
An experimental analysis of behavioral factors in drug dependence.
    Federation proceedings, 1975, Volume: 34, Issue:9

    Topics: Administration, Oral; Alcoholism; Amphetamine; Animals; Behavior, Animal; Cannabis; Chlorpromazine;

1975
Zopiclone. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy as an hypnotic.
    Drugs, 1986, Volume: 32, Issue:1

    Topics: Anti-Anxiety Agents; Anticonvulsants; Anxiety; Azabicyclo Compounds; Benzodiazepines; Biotransformat

1986
Certain theoretical and practical considerations involved in evaluating the overall abuse potential of opiate agonists and antagonists.
    Advances in biochemical psychopharmacology, 1973, Volume: 8, Issue:0

    Topics: Animals; Chlorpromazine; Codeine; Cyclazocine; Drug Combinations; Drug Evaluation; Drug Evaluation,

1973
Pharmacology of benzodiazepines: laboratory and clinical correlations.
    Advances in pharmacology, 1967, Volume: 5

    Topics: Aggression; Alcoholism; Animals; Anticonvulsants; Anxiety; Autonomic Nervous System; Avoidance Learn

1967

Trials

13 trials available for pentobarbital and Chemical Dependence

ArticleYear
Human progressive-ratio performance: maintenance by pentobarbital.
    Psychopharmacology, 1983, Volume: 79, Issue:1

    Topics: Adult; Conditioning, Operant; Humans; Male; Pentobarbital; Physical Exertion; Psychomotor Performanc

1983
Differential effects of diazepam and pentobarbital on mood and behavior.
    Archives of general psychiatry, 1983, Volume: 40, Issue:8

    Topics: Adolescent; Adult; Diazepam; Dose-Response Relationship, Drug; Emotions; Hostility; Humans; Hypnotic

1983
Single-dose pharmacodynamics of diazepam and pentobarbital in substance abusers.
    Clinical pharmacology and therapeutics, 1993, Volume: 54, Issue:6

    Topics: Adult; Behavior; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Midd

1993
Ethanol and pentobarbital: comparison of behavioral and subjective effects in sedative drug abusers.
    Experimental and clinical psychopharmacology, 1997, Volume: 5, Issue:3

    Topics: Adult; Affect; Behavior; Breath Tests; Central Nervous System Depressants; Cross-Over Studies; Dose-

1997
Effects of abused drugs on psychomotor performance.
    Experimental and clinical psychopharmacology, 1997, Volume: 5, Issue:3

    Topics: Adult; Amphetamine; Central Nervous System Depressants; Central Nervous System Stimulants; Cognition

1997
Human drug self-administration: double-blind comparison of pentobarbital, diazepam, chlorpromazine and placebo.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 210, Issue:2

    Topics: Adult; Chlorpromazine; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Adminis

1979
Self-administration of pentobarbital in light and moderate alcohol drinkers.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:2

    Topics: Adult; Affect; Alcohol Drinking; Body Weight; Double-Blind Method; Female; Humans; Individuality; Ma

1992
Rate of increase of plasma drug level influences subjective response in humans.
    Psychopharmacology, 1992, Volume: 107, Issue:2-3

    Topics: Adult; Affect; Arousal; Behavior; Blood Pressure; Cognition; Humans; Male; Pentobarbital; Psychomoto

1992
Comparison of the behavioral effects and abuse liability of ethanol and pentobarbital in recreational sedative abusers.
    NIDA research monograph, 1989, Volume: 95

    Topics: Adult; Affect; Alcohol Drinking; Alcoholism; Arousal; Dose-Response Relationship, Drug; Double-Blind

1989
Comparison of triazolam and pentobarbital: performance impairment, subjective effects and abuse liability.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 234, Issue:1

    Topics: Adult; Analysis of Variance; Anti-Anxiety Agents; Cognition; Dose-Response Relationship, Drug; Human

1985
The pentobarbital test dose for depressant drug dependence.
    The Journal of nervous and mental disease, 1974, Volume: 159, Issue:5

    Topics: Adolescent; Adult; Alcohol Drinking; Anti-Anxiety Agents; Bender-Gestalt Test; Drug Tolerance; Eye M

1974
Subjective effects of narcotic antagonists cyclazocine and nalorphine on the Addiction Research Center Inventory (ARCI).
    Psychopharmacologia, 1970, Volume: 18, Issue:4

    Topics: Academies and Institutes; Analgesics; Analysis of Variance; Anxiety; Azocines; Clinical Trials as To

1970
Reaction time ("mental set") in control and chronic schizophrenic subjects and in postaddicts under placebo, LSD-25, morphine, pentobarbital and amphetamine.
    Psychopharmacologia, 1965, May-21, Volume: 7, Issue:6

    Topics: Adult; Amphetamine; Clinical Trials as Topic; Female; Humans; Lysergic Acid Diethylamide; Male; Midd

1965

Other Studies

145 other studies available for pentobarbital and Chemical Dependence

ArticleYear
Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:11

    Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Chemical Phenomena; Chemistry; Explorato

1990
A therapeutic dose of zolpidem has limited abuse-like effects in drug-naïve females: a pilot study.
    European journal of pharmacology, 2008, Nov-19, Volume: 598, Issue:1-3

    Topics: Adult; Antipsychotic Agents; Blood Pressure; Chlorpromazine; Female; Heart Rate; Humans; Hypnotics a

2008
Selective changes in sensitivity to benzodiazepines, and not other positive GABA(A) modulators, in rats receiving flunitrazepam chronically.
    Psychopharmacology, 2009, Volume: 204, Issue:4

    Topics: Animals; Benzodiazepines; Binding Sites; Dose-Response Relationship, Drug; Drug Tolerance; Flunitraz

2009
Degree of physical dependence induced by secobarbital or pentobarbital.
    Journal of the American Medical Association, 1958, Jan-11, Volume: 166, Issue:2

    Topics: Barbiturates; Behavior, Addictive; Humans; Pentobarbital; Secobarbital; Substance-Related Disorders

1958
The treatment of narcotics addiction.
    New York state journal of medicine, 1963, Apr-15, Volume: 63

    Topics: Humans; Methadone; Narcotics; Opioid-Related Disorders; Pentobarbital; Psychotherapy; Rehabilitation

1963
THE ADDICTION RESEARCH CENTER INVENTORY: STANDARDIZATION OF SCALES WHICH EVALUATE SUBJECTIVE EFFECTS OF MORPHINE, AMPHETAMINE, PENTOBARBITAL, ALCOHOL, LSD-25, PYRAHEXYL AND CHLORPROMAZINE.
    Psychopharmacologia, 1963, May-15, Volume: 4

    Topics: Alcohols; Amphetamine; Amphetamines; Antidepressive Agents; Behavior, Addictive; Benzopyrans; Chlorp

1963
THE ADDICTION RESEARCH CENTER INVENTORY: APPENDIX. I. ITEMS COMPRISING EMPIRICAL SCALES FOR SEVEN DRUGS. II. ITEMS WHICH DO NOT DIFFERENTIATE PLACEBO FROM ANY DRUG CONDITION.
    Psychopharmacologia, 1963, May-15, Volume: 4

    Topics: Alcohols; Amphetamine; Amphetamines; Antidepressive Agents; Appendix; Behavior, Addictive; Chlorprom

1963
DEVELOPMENT OF THE ADDICTION RESEARCH CENTER INVENTORY (ARCI): SELECTION OF ITEMS THAT ARE SENSITIVE TO THE EFFECTS OF VARIOUS DRUGS.
    Psychopharmacologia, 1963, May-15, Volume: 4

    Topics: Amphetamine; Amphetamines; Behavior, Addictive; Chlorpromazine; Humans; Lysergic Acid Diethylamide;

1963
ASSESSING SUBJECTIVE EFFECTS OF DRUGS: AN INDEX OF CARELESSNESS AND CONFUSION FOR USE WITH THE ADDICTION RESEARCH CENTER INVENTORY (ARCI).
    Journal of clinical psychology, 1963, Volume: 19

    Topics: Alcohols; Amphetamine; Amphetamines; Behavior, Addictive; Chlorpromazine; Confusion; Ethanol; Humans

1963
TREATMENT OF NARCOTIC ADDICTS IN PRIVATE PRACTICE.
    Archives of internal medicine, 1964, Volume: 114

    Topics: Chlordiazepoxide; Chlorpromazine; Drug Therapy; Family Practice; General Practice; Glucose; Hospital

1964
BARBITURATE USE IN NARCOTIC ADDICTS.
    JAMA, 1964, Aug-03, Volume: 189

    Topics: Barbiturates; Codeine; Drug Tolerance; Ethchlorvynol; Glutethimide; Heroin; Hydromorphone; Hypnotics

1964
IDENTIFICATION AND TREATMENT OF BARBITURATE ABUSERS.
    JAMA, 1965, Aug-02, Volume: 193

    Topics: Barbiturates; Diagnosis; Drug Therapy; Drug Tolerance; Pentobarbital; Substance Withdrawal Syndrome;

1965
NARCOTIC DRUG ADDICTION: ONE YEAR'S EXPERIECES AT PILGRIM STATE HOSPITAL.
    The Psychiatric quarterly, 1965, Volume: 39

    Topics: Drug Therapy; Hepatitis; Homosexuality; Hospitals, Psychiatric; Hospitals, State; Humans; Legislatio

1965
Establishment of orally delivered drugs as reinforcers for rhesus monkeys: some relations to human drug dependence.
    NIDA research monograph, 1981, Volume: 37

    Topics: Administration, Oral; Animals; Behavior, Animal; Benzimidazoles; Drinking Behavior; Ethanol; Feeding

1981
Benzodiazepines: drug discrimination and physiological dependence.
    NIDA research monograph, 1984, Volume: 49

    Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Bromazepam; Diazepam; Discrimination Lear

1984
Acute and chronic effects of pentobarbital on 5-hydroxytryptamine in mouse brain.
    Progress in neuro-psychopharmacology, 1981, Volume: 5, Issue:4

    Topics: Animals; Brain; Dopamine; Drug Tolerance; Fenclonine; Humans; Hydroxyindoleacetic Acid; Kinetics; Ma

1981
Progress report of the NIDA Addiction Research Center, Baltimore, Maryland, 1982.
    NIDA research monograph, 1983, Volume: 43

    Topics: Animals; Behavior, Animal; Buprenorphine; Chlordiazepoxide; Dronabinol; Humans; Nicotine; Opioid-Rel

1983
Bioassay of subjective effects associated with benzodiazepine withdrawal in animals: a novel direction in dependence research.
    NIDA research monograph, 1984, Volume: 49

    Topics: Animals; Benzodiazepinones; Biological Assay; Clonidine; Conditioning, Operant; Diazepam; Discrimina

1984
Experimental assessment of the relative abuse liability of triazolam and pentobarbital.
    NIDA research monograph, 1984, Volume: 55

    Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Pentobarbital; Psychomot

1984
[Molecular mechanism of tolerance to and dependence on barbiturates].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1980, Volume: 174, Issue:3

    Topics: Animals; Barbiturates; Brain; Cells, Cultured; Chick Embryo; Drug Tolerance; Energy Metabolism; Huma

1980
Drug history modifies the behavioral effects of pentobarbital.
    Science (New York, N.Y.), 1983, Apr-15, Volume: 220, Issue:4594

    Topics: Animals; Behavior, Animal; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Interactions; H

1983
Effects of individual variations in drug elimination kinetics for production of pentobarbital physical dependence.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:1

    Topics: Animals; Cats; Central Nervous System; Depression, Chemical; Female; Half-Life; Humans; Kinetics; Ma

1983
Substance abuse research in monkey social groups.
    Progress in clinical and biological research, 1983, Volume: 131

    Topics: Animals; Humans; Macaca nemestrina; Macaca radiata; Male; Methadone; Methamphetamine; Morphine; Moto

1983
Psychophysical profiles differentiate drugs of abuse.
    NIDA research monograph, 1981, Volume: 34

    Topics: Amobarbital; Animals; Auditory Threshold; Barbiturates; Behavior, Animal; Chlordiazepoxide; Diazepam

1981
Benzodiazepine dependence studies in rodents.
    NIDA research monograph, 1980, Issue:33

    Topics: Animals; Benzodiazepines; Disease Models, Animal; Humans; Pentobarbital; Rats; Self Administration;

1980
Personality factors in human drug self-administration.
    NIDA research monograph, 1981, Volume: 37

    Topics: Adult; Depression; Female; Humans; Male; Middle Aged; MMPI; Pentobarbital; Personality; Self Adminis

1981
Diazepam dose preference in humans.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:3

    Topics: Adult; Diazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Fem

1983
Diazepam and pentobarbital dependence in the rat.
    Life sciences, 1982, Aug-23, Volume: 31, Issue:8

    Topics: Animals; Diazepam; Female; Humans; Pentobarbital; Rats; Rats, Inbred Strains; Substance Withdrawal S

1982
Systems of reinforcement and drug dependence.
    Drug and alcohol dependence, 1982, Volume: 10, Issue:4

    Topics: Amphetamines; Animals; Cats; Chlordiazepoxide; Cocaine; Diazepam; Drug Tolerance; Escape Reaction; E

1982
Indicated preference for drugs of abuse.
    The International journal of the addictions, 1982, Volume: 17, Issue:3

    Topics: Adolescent; Adult; Amphetamines; Cannabis; Cocaine; Codeine; Diazepam; Ethanol; Female; Heroin; Huma

1982
Assessment of tolerance to and physical dependence on pentobarbital, induced by multiple pellet implantation.
    European journal of pharmacology, 1980, Aug-08, Volume: 65, Issue:4

    Topics: Animals; Anticonvulsants; Body Temperature; Drug Implants; Drug Tolerance; Humans; In Vitro Techniqu

1980
[Action on the emotional-reinforcement systems of the brain as a means of pathogenetic therapy for alcoholism and drug addiction].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1980, Volume: 80, Issue:7

    Topics: Amphetamine; Animals; Carbolines; Cocaine; Dioxanes; Drug Evaluation, Preclinical; Ethanol; Humans;

1980
Continuous administration of barbital by pellet implantation.
    Journal of pharmacological methods, 1980, Volume: 4, Issue:2

    Topics: Animals; Barbital; Barbiturates; Behavior, Animal; Body Temperature; Body Weight; Drug Implants; Dru

1980
Comparison of ethanol and barbiturate physical dependence.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 218, Issue:3

    Topics: Alcoholism; Animals; Barbital; Barbiturates; Cats; Central Nervous System Depressants; Dose-Response

1981
Strength of drug habits: for heroin, morphine, methadone, alcohol, barbiturates, pentobarbital, benzedrine, cocaine, and marijuana.
    Drug and alcohol dependence, 1980, Volume: 5, Issue:6

    Topics: Adult; Alcoholism; Amphetamines; Barbiturates; Cannabis; Cocaine; Heroin Dependence; Humans; Male; M

1980
Drug preference in humans: double-blind choice comparison of pentobarbital, diazepam and placebo.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 215, Issue:3

    Topics: Adult; Behavior; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Hu

1980
[Changes in GABAA/benzodiazepine receptor complex function in the pentobarbital-dependent rat].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1995, Volume: 15, Issue:3

    Topics: Animals; Binding Sites; Brain; Down-Regulation; Drug Tolerance; gamma-Aminobutyric Acid; In Vitro Te

1995
[Changes in GABAA/benzodiazepine receptor complex function in the pentobarbital-dependent rat. II: Strain differences between Lewis and Wistar-Kyoto rats].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1995, Volume: 15, Issue:4

    Topics: Animals; Bicuculline; Brain; Chlorine; Ethanol; Female; Flunitrazepam; GABA Antagonists; GABA Modula

1995
Changes in [3H]flunitrazepam binding in the brain of rats made tolerant to and dependent upon pentobarbital.
    Life sciences, 1995, Volume: 57, Issue:5

    Topics: Animals; Brain; Drug Tolerance; Flunitrazepam; Injections, Intraventricular; Male; Pentobarbital; Ra

1995
Evaluation of the abuse liability of aminorex.
    Drug and alcohol dependence, 1994, Volume: 36, Issue:3

    Topics: Aminorex; Animals; Arousal; Dextroamphetamine; Discrimination Learning; Female; Infusions, Intraveno

1994
Drug dependence study of the new cognition-enhancing agent nefiracetam in rats.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:2A

    Topics: Animals; Body Weight; Codeine; Male; Morphine; Pentobarbital; Psychotropic Drugs; Pyrrolidinones; Ra

1994
Behavioral pharmacology of tandospirone in baboons: chronic administration and withdrawal, self-injection and drug discrimination.
    Drug and alcohol dependence, 1993, Volume: 32, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Arousal; Buspirone; Cocaine; Discrimination Learning; Dose-Response Re

1993
Region-specific changes of GABAA receptors by tolerance to and dependence upon pentobarbital.
    European journal of pharmacology, 1993, May-12, Volume: 236, Issue:1

    Topics: Animals; Body Temperature; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cereb

1993
Inhaled 1,1,1-trichloroethane-produced physical dependence in mice: effects of drugs and vapors on withdrawal.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:2

    Topics: Administration, Inhalation; Animals; Chlorpromazine; Ethanol; Male; Mice; Midazolam; Pentobarbital;

1993
Morphine physical dependence in the hibernator: central nervous system mechanisms underlying the development of dependence remain functional during depression induced by pentobarbital anesthesia.
    Life sciences, 1993, Volume: 52, Issue:13

    Topics: Anesthesia; Animals; Central Nervous System; Central Nervous System Diseases; Depression, Chemical;

1993
Behavioral effects of pentobarbital, lorazepam, ethanol and chlorpromazine substitution in pentobarbital-dependent baboons.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:1

    Topics: Animals; Behavior, Animal; Chlorpromazine; Ethanol; Lorazepam; Male; Papio; Pentobarbital; Substance

1993
Selecting an appropriate isotopic internal standard for gas chromatography/mass spectrometry analysis of drugs of abuse--pentobarbital example.
    Journal of forensic sciences, 1995, Volume: 40, Issue:6

    Topics: Gas Chromatography-Mass Spectrometry; Isotopes; Pentobarbital; Reference Standards; Substance-Relate

1995
Ro 15-4513 alteration of pentobarbital dependence.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 55, Issue:3

    Topics: Animals; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Drug Interactions; Male; Pentoba

1996
Role of NMDA receptors in pentobarbital tolerance/dependence.
    Neurochemical research, 1997, Volume: 22, Issue:7

    Topics: Animals; Autoradiography; Cerebral Ventricles; Dizocilpine Maleate; Drug Evaluation, Preclinical; Dr

1997
Changes in [3H]forskolin binding to adenylate cyclase and [3H]phorbol dibutyrate binding to protein kinase C in pentobarbital tolerant/dependent rats.
    Neurochemical research, 1998, Volume: 23, Issue:4

    Topics: Adenylyl Cyclases; Animals; Brain; Cerebral Ventricles; Colforsin; Drug Tolerance; Infusions, Parent

1998
Autoradiographic study of [3H]flunitrazepam binding sites in the subnuclei of the thalamus of rats rendered tolerant to and dependent on pentobarbital.
    European journal of pharmacology, 1998, Aug-07, Volume: 354, Issue:2-3

    Topics: Animals; Autoradiography; Binding Sites; Drug Tolerance; Flunitrazepam; GABA Modulators; Hypnotics a

1998
Cocaine- and alcohol-mediated expression of inducible transcription factors is blocked by pentobarbital anesthesia.
    Brain research, 2000, Sep-22, Volume: 877, Issue:2

    Topics: Anesthetics; Animals; Bacterial Proteins; Behavior, Animal; Brain; Carrier Proteins; Cocaine; Drug I

2000
Behavioral effects of flunitrazepam: reinforcing and discriminative stimulus effects in rhesus monkeys and prevention of withdrawal signs in pentobarbital-dependent rats.
    Drug and alcohol dependence, 2001, Jun-01, Volume: 63, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Discrimination Learning; Female; Flunitrazepam; GABA

2001
Sensitivity to the effects of sedative-hypnotics on motor performance: influence of task difficulty and chronic phenobarbital administration.
    Behavioural pharmacology, 2001, Volume: 12, Issue:2

    Topics: Amobarbital; Animals; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Dru

2001
Drug interactions with nerve membrane components regulating ionic permeability: action of tetrodotoxin, procaine, pentobarbital, and ethanol.
    Progress in clinical and biological research, 1979, Volume: 27

    Topics: Animals; Astacoidea; Axons; Cell Membrane Permeability; Electric Conductivity; Ethanol; Humans; Hydr

1979
Experimental studies of sedative self-administration by humans.
    NIDA research monograph, 1978, Issue:20

    Topics: Adult; Drug Tolerance; Female; Half-Life; Humans; Hypnotics and Sedatives; Male; Middle Aged; Pentob

1978
Withdrawal treatment for barbiturate dependence.
    The Practitioner, 1979, Volume: 223, Issue:1333

    Topics: Barbiturates; Drug Administration Schedule; Female; Humans; Male; Pentobarbital; Substance Withdrawa

1979
The overtranquilized patient.
    American family physician, 1979, Volume: 20, Issue:4

    Topics: Humans; Pentobarbital; Phenobarbital; Psychotherapy; Substance Withdrawal Syndrome; Substance-Relate

1979
Physical dependence to barbital compared to pentobarbital. I. "Chronically equivalent" dosing method.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 204, Issue:3

    Topics: Animals; Barbital; Barbiturates; Cats; Dose-Response Relationship, Drug; Drug Administration Schedul

1978
Physical dependence to barbital compared to pentobarbital. II. Tolerance characteristics.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 204, Issue:3

    Topics: Animals; Barbital; Barbiturates; Cats; Drug Tolerance; Humans; Pentobarbital; Substance-Related Diso

1978
Physical dependence to barbital compared to pentobarbital. III. Withdrawal characteristics.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 204, Issue:3

    Topics: Animals; Barbital; Barbiturates; Cats; Humans; Pentobarbital; Substance Withdrawal Syndrome; Substan

1978
Physical dependence to barbital compared to pentobarbital. IV. Influence of elimination kinetics.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 204, Issue:3

    Topics: Animals; Barbital; Barbiturates; Cats; Humans; Kinetics; Pentobarbital; Peritoneal Dialysis; Substan

1978
Acute inhibition of microsomal drug metabolism by propoxyphene in narcotic tolerant/dependent mice.
    Life sciences, 1978, Jun-19, Volume: 22, Issue:23

    Topics: Animals; Dextropropoxyphene; Drug Tolerance; Humans; Male; Methadone; Mice; Microsomes, Liver; Mixed

1978
Characteristics of functional tolerance during barbiturate physical dependency production.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 207, Issue:3

    Topics: Animals; Barbital; Barbiturates; Cats; Central Nervous System Depressants; Dose-Response Relationshi

1978
Organic impairment in polydrug users: risk factors.
    The American journal of psychiatry, 1978, Volume: 135, Issue:2

    Topics: Adult; Age Factors; Brain; Educational Status; Female; Follow-Up Studies; Heroin Dependence; Humans;

1978
The prediction of neuropsychological impairment in polydrug abusers.
    Addictive behaviors, 1978, Volume: 3, Issue:1

    Topics: Adult; Alcoholism; Cannabis; Dextroamphetamine; Humans; Illicit Drugs; Life Style; Mental Disorders;

1978
Immunosuppression of rosette-forming cells.
    Advances in experimental medicine and biology, 1976, Volume: 73 Pt B

    Topics: Amphetamine; Animals; Body Weight; Caffeine; Erythrocytes; Humans; Immunity; Immunologic Techniques;

1976
Environmental influences affecting the voluntary intake of drugs: an overview.
    Federation proceedings, 1975, Volume: 34, Issue:9

    Topics: Administration, Oral; Animals; Drinking Behavior; Haplorhini; Humans; Injections, Intravenous; Pento

1975
[Barbiturate dependence at the cellular level].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1975, Feb-03, Volume: 280, Issue:5

    Topics: Animals; Astrocytes; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Humans; Models,

1975
Intragastric self-administration of psychoactive drugs by the rhesus monkey.
    Life sciences, 1975, Sep-15, Volume: 17, Issue:6

    Topics: Animals; Dextroamphetamine; Disease Models, Animal; Ethanol; Haplorhini; Humans; Macaca mulatta; Met

1975
Human sedative self-administration: effects of interingestion interval and dose.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 197, Issue:3

    Topics: Adult; Behavior; Diazepam; Drug Administration Schedule; Ethanol; Humans; Hypnotics and Sedatives; M

1976
Acute tolerance to barbiturate in the rat.
    European journal of pharmacology, 1976, Volume: 36, Issue:1

    Topics: Animals; Barbital; Barbiturates; Brain; Disease Models, Animal; Drug Tolerance; Female; Hexobarbital

1976
Enhancement of pentobarbital effect by continuous administration of morphine in the mouse.
    Life sciences, 1976, Aug-01, Volume: 19, Issue:3

    Topics: Animals; Body Temperature; Brain; Drug Synergism; Ethylmorphine-N-Demethylase; Humans; Liver; Male;

1976
A method for bioassay of physical dependence on sedative drugs in dog.
    Psychopharmacology, 1976, May-05, Volume: 47, Issue:1

    Topics: Animals; Dogs; Drug Evaluation, Preclinical; Humans; Hypnotics and Sedatives; Methaqualone; Pentobar

1976
Body temperature in mice: a quantitative measure of alcohol tolerance and physical dependence.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 199, Issue:1

    Topics: Animals; Behavior, Animal; Body Temperature; Diet; Drug Tolerance; Ethanol; Humans; Male; Mice; Mice

1976
Correlation between the in vivo and an in vitro expression of opiate withdrawal precipitated by naloxone: their antagonism by l-(-)-delta9-tetrahydrocannabinol.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 199, Issue:2

    Topics: Acetylcholine; Animals; Chlorpromazine; Codeine; Dose-Response Relationship, Drug; Dronabinol; Femal

1976
Effects of response requirement upon human sedative self-administration and drug-seeking behavior.
    Pharmacology, biochemistry, and behavior, 1976, Volume: 5, Issue:6

    Topics: Adult; Behavior; Diazepam; Drug Tolerance; Humans; Hypnotics and Sedatives; Male; Pentobarbital; Rew

1976
Withdrawal characteristics following chronic pentobarbital dosing.
    European journal of pharmacology, 1976, Volume: 40, Issue:1

    Topics: Animals; Cats; Humans; Pentobarbital; Substance Withdrawal Syndrome; Substance-Related Disorders

1976
Comparison of radioimmunoassay with thin-layer chromatographic and gas-liquid chromatographic methods of barbiturate detection in human urine.
    Clinical chemistry, 1975, Volume: 21, Issue:6

    Topics: Adult; Amobarbital; Barbiturates; Chromatography, Gas; Chromatography, Thin Layer; Evaluation Studie

1975
[Letter: Mebumal (Nembutal) injected by a drug addict].
    Ugeskrift for laeger, 1975, Feb-03, Volume: 137, Issue:6

    Topics: Abscess; Humans; Injections, Intravenous; Pentobarbital; Self Medication; Substance-Related Disorder

1975
[Letter: Mebumal (Nembutal) injections and drug abuse].
    Ugeskrift for laeger, 1975, Mar-10, Volume: 137, Issue:11

    Topics: Denmark; Humans; Injections, Intravenous; Pentobarbital; Substance-Related Disorders

1975
A model for the rapid development of dispositional and functional tolerance to barbiturates.
    European journal of pharmacology, 1975, Volume: 30, Issue:2

    Topics: Animals; Barbiturates; Drug Tolerance; Half-Life; Humans; Male; Mice; Mice, Inbred ICR; Microsomes,

1975
Screening for drug abuse: use of NaCl to increase drug recovery from papers coated with ion-exchange resin.
    Clinical chemistry, 1975, Volume: 21, Issue:12

    Topics: Amphetamine; Chlorpromazine; Chromatography, Paper; Humans; Ion Exchange Resins; Methadone; Morphine

1975
Experimental human drug self-administration: methodology and application to the study of sedative abuse.
    Pharmacological reviews, 1975, Volume: 27, Issue:4

    Topics: Adult; Behavior; Diazepam; Environment; Humans; Male; Pentobarbital; Substance-Related Disorders; To

1975
Conditioned avoidance behavior in pretrained rats intermittently treated with addictive drugs.
    Physiology & behavior, 1975, Volume: 15, Issue:3

    Topics: Amphetamine; Animals; Avoidance Learning; Body Weight; Conditioning, Operant; Dose-Response Relation

1975
Effects of pentobarbital tolerance and dependence on convulsant and GABAA receptor antagonist binding.
    Life sciences, 1992, Volume: 50, Issue:22

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Co

1992
Sex differences in physical dependence on pentobarbital in four inbred strains of rats.
    General pharmacology, 1992, Volume: 23, Issue:3

    Topics: Animals; Female; Male; Pentobarbital; Postural Balance; Rats; Rats, Inbred F344; Rats, Inbred SHR; R

1992
Titrating matching-to-sample performance: effects of drugs of abuse and intertrial interval.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:2

    Topics: Amphetamine; Animals; Cocaine; Columbidae; Male; Pentobarbital; Phencyclidine; Reaction Time; Reinfo

1992
Evaluation of the discriminative stimulus and reinforcing effects of sertraline in rhesus monkeys.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:4

    Topics: 1-Naphthylamine; Amphetamine; Animals; Cocaine; Female; Macaca mulatta; Male; Pentobarbital; Reinfor

1992
Locomotor responses of FAST and SLOW mice to several alcohols and drugs of abuse.
    Annals of the New York Academy of Sciences, 1992, Jun-28, Volume: 654

    Topics: Alcohols; Animals; Caffeine; Dextroamphetamine; Diazepam; Mice; Mice, Inbred Strains; Motor Activity

1992
Establishment of chronic intravenous drug self-administration in the C57BL/6J mouse.
    Neuroreport, 1991, Volume: 2, Issue:8

    Topics: Animals; Cocaine; Disease Models, Animal; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Inb

1991
Compound analgesics.
    The Medical journal of Australia, 1990, Mar-19, Volume: 152, Issue:6

    Topics: Acetaminophen; Adult; Drug Combinations; Drug Overdose; Female; Humans; Pentobarbital; Substance-Rel

1990
Reinforcing effects of a pentobarbital-ethanol combination relative to each drug alone.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 35, Issue:2

    Topics: Administration, Oral; Animals; Behavior, Animal; Drug Combinations; Drug Interactions; Ethanol; Maca

1990
Substitution of temazepam and midazolam in pentobarbital-dependent rats.
    Physiology & behavior, 1989, Volume: 46, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Arousal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred St

1989
The effect of ethanol on 35S-TBPS binding to mouse brain membranes in the presence of chloride.
    Pharmacology & toxicology, 1989, Volume: 65, Issue:5

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo

1989
Intensity of the withdrawal syndrome varies with duration of pentobarbital administration.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 34, Issue:1

    Topics: Animals; Male; Pentobarbital; Random Allocation; Rats; Rats, Inbred Strains; Substance Withdrawal Sy

1989
Assessment of the abuse potential of methocarbamol in primates.
    NIDA research monograph, 1989, Volume: 95

    Topics: Animals; Appetitive Behavior; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Ma

1989
Interaction of the discriminative stimulus effects of phencyclidine with those of (+)-N-allylnormetazocine, pentobarbital and d-amphetamine.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:3

    Topics: Amphetamines; Animals; Columbidae; Discrimination Learning; Drug Interactions; Pentobarbital; Phenaz

1989
Induction of physical dependence on pentobarbital by new infusion method in the rat.
    Progress in neuro-psychopharmacology & biological psychiatry, 1989, Volume: 13, Issue:1-2

    Topics: Animals; Behavior, Animal; Drug Tolerance; Female; Infusion Pumps; Infusions, Intravenous; Male; Pen

1989
Dependence on phenobarbital but not pentobarbital using drug-adulterated food.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:4

    Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Food Contamination; Male; M

1989
Physical dependence of benzodiazepines in the rat and dog.
    NIDA research monograph, 1986, Volume: 67

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Dogs; Dose-Response Relationship, Drug; Kidney Tubule

1986
Discriminative stimulus properties of intragastrically administered d-amphetamine and pentobarbital in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Appetite Depressants; Bupropion; Dextroamphetamine; Discrimination Lea

1987
Binding characteristics of t-[35S]butylbicyclophosphorothionate in discrete brain regions of rats made tolerant to and dependent on pentobarbital.
    Journal of neurochemistry, 1989, Volume: 52, Issue:4

    Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Com

1989
Progress report from the Division of Behavioral Biology, the Johns Hopkins University School of Medicine.
    NIDA research monograph, 1986, Volume: 67

    Topics: Animals; Drug Tolerance; Humans; Male; Maryland; Papio; Pentobarbital; Research; Self Administration

1986
Benzodiazepine antagonist, CGS-8216, in diazepam- or pentobarbital-dependent and non-dependent rats.
    Drug and alcohol dependence, 1986, Volume: 17, Issue:4

    Topics: Animals; Arousal; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Pentobarbital; Pyr

1986
[Pharmacological interactions between dependence-liable drugs].
    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology, 1988, Volume: 8, Issue:3

    Topics: Amphetamine; Animals; Cocaine; Drug Interactions; Drug Tolerance; Ethanol; Male; Mice; Morphine; Pen

1988
Kappa opioids in rhesus monkeys. III. Dependence associated with chronic administration.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; B

1987
Cross-physical dependence of several drugs in methaqualone-dependent rats.
    Japanese journal of pharmacology, 1988, Volume: 46, Issue:4

    Topics: Animals; Barbital; Diazepam; Ethanol; Male; Methaqualone; Pentobarbital; Postural Balance; Psychomot

1988
Genetic differences in the development of physical dependence on pentobarbital in four inbred strains of rats.
    Japanese journal of pharmacology, 1987, Volume: 45, Issue:4

    Topics: Animals; Behavior, Animal; Body Weight; Female; Genetics, Behavioral; Pentobarbital; Rats; Rats, Inb

1987
[Drug dependence test on a cerebral insufficiency improver, aniracetam].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1987, Volume: 89, Issue:1

    Topics: Animals; Brain; Cocaine; Drug Evaluation, Preclinical; Macaca fascicularis; Male; Memory; Methamphet

1987
Effect of dosing frequency on the development of physical dependence and tolerance to pentobarbital.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:3

    Topics: Animals; Cats; Central Nervous System; Drug Administration Schedule; Drug Tolerance; Female; Half-Li

1986
[Drug dependence tests on a new anesthesia inducer, midazolam].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1986, Volume: 88, Issue:2

    Topics: Animals; Injections, Intravenous; Macaca fascicularis; Male; Midazolam; Pentobarbital; Self Administ

1986
Treatment of the barbiturate abstinence syndrome.
    The Medical journal of Australia, 1986, Nov-03, Volume: 145, Issue:9

    Topics: Barbiturates; Drug Administration Schedule; Drug Tolerance; Humans; Pentobarbital; Phenobarbital; Su

1986
Abuse liability of triazolam: experimental measurements in animals and humans.
    Psychopharmacology series, 1987, Volume: 3

    Topics: Animals; Diazepam; Drug Tolerance; Humans; Male; Papio; Pentobarbital; Psychomotor Performance; Self

1987
Suitability of corneal grafts from donors treated with chemical agents.
    Developments in ophthalmology, 1985, Volume: 11

    Topics: Animals; Cornea; Corneal Transplantation; Ethanol; Graft Rejection; Guinea Pigs; Humans; Morphine; P

1985
Continuous intraperitoneal infusion of pentobarbital: a model of barbiturate dependence in the rat.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:1

    Topics: Animals; Barbiturates; Disease Models, Animal; Humans; Injections, Intraperitoneal; Male; Motor Acti

1985
Effect of pentobarbital dependence on adenylate cyclase activity and calmodulin levels in rat cerebral cortex.
    Life sciences, 1985, Jul-08, Volume: 37, Issue:1

    Topics: Adenylyl Cyclases; Animals; Calcium; Calmodulin; Cerebral Cortex; Colforsin; Diterpenes; Dopamine; F

1985
Sex differences in the induction of physical dependence on pentobarbital in the rat.
    Japanese journal of pharmacology, 1985, Volume: 39, Issue:4

    Topics: Animals; Body Weight; Circadian Rhythm; Female; Male; Motor Activity; Pentobarbital; Postural Balanc

1985
Chronic hypnotic-drug use. Ineffectiveness, drug-withdrawal insomnia, and dependence.
    JAMA, 1974, Feb-04, Volume: 227, Issue:5

    Topics: Adult; Age Factors; Aged; Amobarbital; Chloral Hydrate; Chronic Disease; Dreams; Drug Therapy, Combi

1974
Radioimmunoassay: its application to drugs of abuse.
    Pharmacology, 1974, Volume: 11, Issue:1

    Topics: Amphetamine; Animals; Antibody Formation; Antigen-Antibody Complex; Antigen-Antibody Reactions; Barb

1974
Patterns and causes of drug addiction among Puerto Rican females.
    Addictive diseases, 1974, Volume: 1, Issue:2

    Topics: Adolescent; Adult; Cannabis; Child; Criminal Psychology; Drug Prescriptions; Employment; Female; Her

1974
Ethanol, methamphetamine, pentobarbital, morphine, and monkey social behavior.
    Archives of general psychiatry, 1974, Volume: 31, Issue:6

    Topics: Aggression; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Ethanol; Female; Humans; In

1974
Programmed self-administration of potentially addictive drugs in young rats and its effects on learning.
    Psychopharmacologia, 1974, Volume: 38, Issue:2

    Topics: Amphetamine; Animals; Avoidance Learning; Behavior, Animal; Drug Tolerance; Ethanol; Extinction, Psy

1974
Methaqualone.
    The American journal of nursing, 1973, Volume: 73, Issue:11

    Topics: Adult; Drug and Narcotic Control; Humans; Japan; Methaqualone; Pentobarbital; Substance Withdrawal S

1973
A simple method for evaluating physical dependence liability in rats.
    Japanese journal of pharmacology, 1973, Volume: 23, Issue:3

    Topics: Aminopyrine; Animals; Azepines; Body Weight; Codeine; Cyproheptadine; Dextropropoxyphene; Humans; Ma

1973
Starch and talc emboli in drug addicts' lungs.
    Journal of clinical pathology, 1972, Volume: 25, Issue:10

    Topics: Acetaminophen; Adult; Alcohols; Amobarbital; Animals; Barbiturates; Female; Foreign-Body Reaction; H

1972
Dependence liability of several sedative-hypnotic agents evaluated in monkeys.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 185, Issue:2

    Topics: Animals; Anthracenes; Barbiturates; Benzazepines; Catheterization; Chlordiazepoxide; Chloroform; Chl

1973
Separation and quantitation of mixtures of the most commonly abused drugs.
    Journal of pharmaceutical sciences, 1973, Volume: 62, Issue:1

    Topics: Amobarbital; Cannabis; Chromatography, Thin Layer; Dextroamphetamine; Ephedrine; Humans; Indicators

1973
Methaqualone abuse. "Luding out".
    JAMA, 1973, Jun-11, Volume: 224, Issue:11

    Topics: Adult; California; Cannabis; Counseling; Female; Heroin Dependence; Humans; Male; Methaqualone; Pent

1973
Letter: Prescribing hypnotic and anti-anxiety drugs.
    Annals of internal medicine, 1973, Volume: 79, Issue:3

    Topics: Chlordiazepoxide; Diazepam; Drug Prescriptions; Humans; Hypnotics and Sedatives; Meprobamate; Pentob

1973
A programme which led to reduction in night sedation in a major hospital.
    The Medical journal of Australia, 1973, Oct-06, Volume: 2, Issue:14

    Topics: Attitude of Health Personnel; Attitude to Health; Australia; Drug Prescriptions; Drug-Related Side E

1973
Studies on the use of XAD-2 resin for detection of abused drugs in urine.
    Clinical chemistry, 1974, Volume: 20, Issue:2

    Topics: Amobarbital; Amphetamine; Aspirin; Caffeine; Carbon Radioisotopes; Chromatography, Ion Exchange; Chr

1974
Use of fluorescamine ("Fluram") to detect amphetamine in urine by thin-layer chromatography.
    Clinical chemistry, 1974, Volume: 20, Issue:2

    Topics: Amphetamine; Benzofurans; Chromatography, Ion Exchange; Chromatography, Thin Layer; Drug Stability;

1974
Correlation of the "EMIT" urine barbiturate assay with a spectrophotometric serum barbiturate assay in suspected overdose.
    Clinical chemistry, 1974, Volume: 20, Issue:2

    Topics: Amobarbital; Barbiturates; Evaluation Studies as Topic; Humans; Methods; Pentobarbital; Phenobarbita

1974
Morphine dependence and body temperature in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1969, Volume: 166, Issue:1

    Topics: Animals; Body Temperature; Chlorpromazine; Drug Synergism; Female; Haplorhini; Humans; Ketones; Male

1969
Self-administration of psychoactive substances by the monkey.
    Psychopharmacologia, 1969, Volume: 16, Issue:1

    Topics: Animals; Behavior, Animal; Caffeine; Catheterization; Chlorpromazine; Cocaine; Codeine; Dextroamphet

1969
Outpatient barbiturate withdrawal using phenobarbital.
    The International journal of the addictions, 1972, Volume: 7, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Ambulatory Care; Amobarbital; Barbiturates; Community Healt

1972
Use of hypnotic drugs by hospital patients.
    The Medical journal of Australia, 1971, Dec-25, Volume: 2, Issue:26

    Topics: Adult; Aged; Amobarbital; Antipyrine; Barbiturates; Diphenhydramine; Female; Hospitalization; Humans

1971
A new method for treatment of barbiturate dependence.
    JAMA, 1970, Jul-13, Volume: 213, Issue:2

    Topics: Barbiturates; Chlordiazepoxide; Diazepam; Heroin; Humans; Meprobamate; Pentobarbital; Phenobarbital;

1970
Physical dependence on heroin and pentobarbitone.
    The Practitioner, 1968, Volume: 200, Issue:196

    Topics: Adult; Heroin; Humans; Male; Pentobarbital; Substance Withdrawal Syndrome; Substance-Related Disorde

1968
Diagnosis and treatment of drug dependence of the barbiturate type.
    The American journal of psychiatry, 1968, Volume: 125, Issue:6

    Topics: Adult; Barbiturates; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Pentobarbital; Psyc

1968
[Preliminary observations on the prophylaxis and therapy of toxicomaniac behavior among young people in Rome].
    Giornale di psichiatria e di neuropatologia, 1968, Volume: 96, Issue:4

    Topics: Adolescent; Adult; Cannabis; Female; Follow-Up Studies; Humans; Male; Methaqualone; Neurotic Disorde

1968
Barbiturate dependence.
    The American journal of psychiatry, 1969, Volume: 126, Issue:3

    Topics: Barbiturates; Humans; Pentobarbital; Substance Withdrawal Syndrome; Substance-Related Disorders; Tim

1969
[Services and perspectives of metabolic research on certain exogenous substances endowed with pharmacological activity].
    Bulletin de la Societe de chimie biologique, 1965, Volume: 47, Issue:5

    Topics: Animals; Carbon Tetrachloride Poisoning; Humans; Microsomes; Pentobarbital; Pharmacology; Phenobarbi

1965
The rapid development of physical dependence on barbiturates.
    The Journal of pharmacology and experimental therapeutics, 1965, Volume: 150, Issue:1

    Topics: Animals; Cats; Denervation; Humans; Pentobarbital; Pentylenetetrazole; Seizures; Substance Withdrawa

1965
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