pentobarbital and Chemical Dependence
pentobarbital has been researched along with Chemical Dependence in 165 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
") given for 12 hr in the presence, versus in the absence, of continuous pentobarbital anesthesia in nonhibernating ground squirrels (Citellus lateralis) and, in addition, in rats." | 7.68 | Morphine physical dependence in the hibernator: central nervous system mechanisms underlying the development of dependence remain functional during depression induced by pentobarbital anesthesia. ( Beaver, TA; Beckman, AL; Lewis, FA, 1993) |
") given for 12 hr in the presence, versus in the absence, of continuous pentobarbital anesthesia in nonhibernating ground squirrels (Citellus lateralis) and, in addition, in rats." | 3.68 | Morphine physical dependence in the hibernator: central nervous system mechanisms underlying the development of dependence remain functional during depression induced by pentobarbital anesthesia. ( Beaver, TA; Beckman, AL; Lewis, FA, 1993) |
" Pharmacodynamic measures included subjective (euphoria, subject liking, sedation, and symptoms) and behavioral (signs and observed liking) responses." | 2.67 | Single-dose pharmacodynamics of diazepam and pentobarbital in substance abusers. ( Jasinski, DR; Johnson, RE; Sullivan, JT, 1993) |
"Zolpidem has abuse potential, particularly among individuals with histories of drug abuse." | 1.35 | A therapeutic dose of zolpidem has limited abuse-like effects in drug-naïve females: a pilot study. ( Dunlap, S; Licata, SC; Lukas, SE; Penetar, DM, 2008) |
"Flunitrazepam was evaluated in several procedures that have been used extensively to study the behavioral effects and abuse potential of positive GABA(A) modulators." | 1.31 | Behavioral effects of flunitrazepam: reinforcing and discriminative stimulus effects in rhesus monkeys and prevention of withdrawal signs in pentobarbital-dependent rats. ( France, CP; Gerak, LR; Harris, LS; Nader, MA; Patrick, GA; Winger, G; Woods, JH; Woolverton, WL, 2001) |
"These studies were designed to examine the effect of chronic administration of pentobarbital on activity of adenylate cyclase (AC) and protein kinase C (PKC) in the rat brain by autoradiography." | 1.30 | Changes in [3H]forskolin binding to adenylate cyclase and [3H]phorbol dibutyrate binding to protein kinase C in pentobarbital tolerant/dependent rats. ( Ho, IK; Oh, S; Wellman, SE, 1998) |
"Pentobarbital dependence was assessed 24 h after abrupt withdrawal from pentobarbital." | 1.30 | Autoradiographic study of [3H]flunitrazepam binding sites in the subnuclei of the thalamus of rats rendered tolerant to and dependent on pentobarbital. ( Ho, IK; Ito, T; Suzuki, T; Wellman, SE, 1998) |
"The pentobarbital dependence was assessed 24 hr after abrupt withdrawal from pentobarbital." | 1.29 | Changes in [3H]flunitrazepam binding in the brain of rats made tolerant to and dependent upon pentobarbital. ( Ho, IK; Ito, T; Suzuki, T; Wellman, SE, 1995) |
"Aminorex is a cyclic phenylisopropylamine that has been marketed as an anorectic." | 1.29 | Evaluation of the abuse liability of aminorex. ( Harris, LS; Massey, BW; Patrick, GA; Winger, G; Woolverton, WL, 1994) |
" In the physical dependence test, nefiracetam and codeine phosphate were administered to rats mixed with food for 43 days in a gradually increasing dosage schedule, followed by feeding a drug-free normal diet to detect signs of withdrawal." | 1.29 | Drug dependence study of the new cognition-enhancing agent nefiracetam in rats. ( Akiyama, Y; Fujikawa, K; Takayama, S, 1994) |
"Enciprazine was selected for clinical investigations." | 1.28 | Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds. ( Engel, J; Fleischhauer, I; Jakovlev, V; Johanson, CE; Kleemann, A; Kutscher, B; Nickel, B; Rauer, H; Szelenyi, I; Werner, U, 1990) |
" In addition, the effect of ITI length on the dose-response curve for pentobarbital, phencyclidine, D-amphetamine, and cocaine were determined." | 1.28 | Titrating matching-to-sample performance: effects of drugs of abuse and intertrial interval. ( Kimball, KA; Wenger, GR, 1992) |
"The effect of three dosage schedules on the expression of a withdrawal syndrome indicative of physical dependence on pentobarbital was determined in male Sprague-Dawley rats." | 1.28 | Intensity of the withdrawal syndrome varies with duration of pentobarbital administration. ( Yutrzenka, GJ, 1989) |
" Animals were treated with Na pentobarbital according to the "maximally tolerable" dosing schedule described previously, twice a day for 35 days, and abruptly withdrawn." | 1.27 | Effects of individual variations in drug elimination kinetics for production of pentobarbital physical dependence. ( Hinman, DJ; Okamoto, M, 1983) |
"CGS-8216, a benzodiazepine antagonist, was administered to rats acutely dosed with diazepam, and to rats chronically dosed with diazepam or pentobarbital." | 1.27 | Benzodiazepine antagonist, CGS-8216, in diazepam- or pentobarbital-dependent and non-dependent rats. ( Martin, WR; McNicholas, LF, 1986) |
"Fischer 344 (F344), Lewis (LEW), spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats were chronically fed food containing pentobarbital on an escalating drug dosage schedule over a period of 47 days." | 1.27 | Genetic differences in the development of physical dependence on pentobarbital in four inbred strains of rats. ( George, FR; Koike, Y; Meisch, RA; Suzuki, T; Yanaura, S, 1987) |
" Groups of animals were treated with Na pentobarbital according to the "maximally tolerable" dosing schedule described previously, except that with different dose-frequency schedules, i." | 1.27 | Effect of dosing frequency on the development of physical dependence and tolerance to pentobarbital. ( Okamoto, M; Rao, S; Walewski, JL, 1986) |
" In naive animals, after the chronic administration of midazolam at 0." | 1.27 | [Drug dependence tests on a new anesthesia inducer, midazolam]. ( Hakkei, M; Kubota, A; Kuwahara, A; Nakamura, K, 1986) |
"Experienced polydrug abusers (N = 190) were asked to indicate previous drugs used as well as drug preferences." | 1.26 | Indicated preference for drugs of abuse. ( Kliner, DJ; Pickens, R, 1982) |
"For barbital, tolerance was exclusively functional." | 1.26 | Physical dependence to barbital compared to pentobarbital. II. Tolerance characteristics. ( Boisse, NR; Okamoto, M, 1978) |
"After "chronically equivalent" barbital and pentobarbital dosing for 5 weeks, treatments were abruptly stopped and the animals were carefully observed for signs of barbiturate withdrawal." | 1.26 | Physical dependence to barbital compared to pentobarbital. III. Withdrawal characteristics. ( Boisse, NR; Okamoto, M, 1978) |
" The rate of barbiturate elimination after chronically equivalent pentobarbital dosing was reduced by barbital substitution or by first-order pentobarbital dose reduction, with the result that withdrawal signs became mild and appeared later (3 days postdrug)." | 1.26 | Physical dependence to barbital compared to pentobarbital. IV. Influence of elimination kinetics. ( Boisse, NR; Okamoto, M, 1978) |
"The occurrence of convulsions, during periods of complete reduction of the maintenance drug, became less frequent the longer the dogs had been maintained on a constant dose of sodium pentobarbital." | 1.26 | A method for bioassay of physical dependence on sedative drugs in dog. ( Jones, BE; Martin, WR; Prada, JA, 1976) |
" Physical dependence was produced in 63 cats by 'maximally tolerable' dosing with sodium pentobarbital." | 1.26 | Withdrawal characteristics following chronic pentobarbital dosing. ( Boisse, NR; Okamoto, M; Rosenberg, HC, 1976) |
Research
Studies (165)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 130 (78.79) | 18.7374 |
1990's | 30 (18.18) | 18.2507 |
2000's | 5 (3.03) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Engel, J | 1 |
Fleischhauer, I | 1 |
Jakovlev, V | 1 |
Kleemann, A | 1 |
Kutscher, B | 1 |
Nickel, B | 1 |
Rauer, H | 1 |
Werner, U | 1 |
Szelenyi, I | 1 |
Johanson, CE | 2 |
Licata, SC | 1 |
Penetar, DM | 1 |
Dunlap, S | 1 |
Lukas, SE | 2 |
Gerak, LR | 2 |
FRASER, HF | 2 |
WIKLER, A | 3 |
ESSIG, CF | 1 |
ISBELL, H | 1 |
OSNOS, RJ | 1 |
HILL, HE | 5 |
HAERTZEN, CA | 7 |
WOLBACH, AB | 2 |
MINER, EJ | 2 |
BELLEVILLE, RE | 1 |
BERGER, H | 1 |
HAMBURGER, E | 2 |
RICE, J | 1 |
COHEN, L | 1 |
Meisch, RA | 4 |
Carroll, ME | 1 |
Griffiths, RR | 15 |
Ator, NA | 4 |
Lamb, RJ | 3 |
Brady, JV | 3 |
Nabeshima, T | 1 |
Ho, IK | 12 |
Jasinski, DR | 2 |
Henningfield, JE | 1 |
Hickey, JE | 1 |
Johnson, RE | 2 |
McLeod, DR | 1 |
Emmett-Oglesby, MW | 1 |
Spencer, DG | 1 |
Lewis, MW | 1 |
Lal, H | 1 |
Okamoto, M | 10 |
Roache, JD | 6 |
Mandel, P | 2 |
Glowa, JR | 1 |
Barrett, JE | 1 |
Hinman, DJ | 2 |
Crowley, TJ | 2 |
Hienz, RD | 1 |
Martin, WR | 5 |
McNicholas, LF | 5 |
Pickens, RW | 3 |
Heston, LL | 2 |
Healey, ML | 1 |
Bigelow, GE | 5 |
Liebson, I | 5 |
Cherian, S | 1 |
Valdman, AV | 1 |
Zvartau, EE | 2 |
Kliner, DJ | 1 |
Pickens, R | 2 |
Flint, BA | 2 |
Val'dman, AV | 1 |
Aaronson, LM | 1 |
Ross, FE | 1 |
Kaliszak, JE | 1 |
Nabeshima, A | 2 |
Saito, T | 2 |
Takahata, N | 2 |
Toki, S | 1 |
Suzuki, T | 7 |
Ito, T | 2 |
Wellman, SE | 3 |
Woolverton, WL | 3 |
Massey, BW | 1 |
Winger, G | 2 |
Patrick, GA | 4 |
Harris, LS | 2 |
Fujikawa, K | 1 |
Akiyama, Y | 1 |
Takayama, S | 1 |
Sannerud, CA | 1 |
Sullivan, JT | 2 |
Tseng, YT | 1 |
Miyaoka, T | 2 |
Evans, EB | 1 |
Balster, RL | 3 |
Beckman, AL | 1 |
Beaver, TA | 1 |
Lewis, FA | 1 |
Liu, RH | 1 |
Foster, G | 1 |
Cone, EJ | 1 |
Kumar, SD | 1 |
Yutrzenka, GJ | 5 |
Stone, T | 1 |
Anderson, S | 1 |
Oh, S | 2 |
Hoshi, K | 1 |
Mintzer, MZ | 1 |
Guarino, J | 1 |
Kirk, T | 1 |
Pickworth, WB | 1 |
Rohrer, MS | 1 |
Fant, RV | 1 |
Crabbe, JC | 2 |
Phillips, TJ | 2 |
Buck, KJ | 1 |
Cunningham, CL | 1 |
Belknap, JK | 1 |
Ryabinin, AE | 1 |
Wang, YM | 1 |
Bachtell, RK | 1 |
Kinney, AE | 1 |
Grubb, MC | 1 |
Mark, GP | 1 |
Nader, MA | 2 |
Woods, JH | 2 |
France, CP | 1 |
Smith, MA | 1 |
Stoops, WW | 1 |
Strickholm, A | 1 |
Chait, LD | 1 |
Bigelow, G | 2 |
Teggin, AF | 1 |
Bewley, TH | 2 |
Franks, RD | 1 |
Boisse, NR | 6 |
Peterson, GR | 1 |
Covault, HP | 1 |
Hostetler, RM | 1 |
Rosenberg, HC | 2 |
Rosen, R | 1 |
Grant, I | 2 |
Adams, KM | 2 |
Carlin, AS | 2 |
Rennick, PM | 1 |
Judd, LL | 1 |
Schooff, K | 1 |
Reed, R | 1 |
Stauss, FF | 1 |
Lefkowitz, SS | 1 |
Nemeth, D | 1 |
Weeks, JR | 1 |
Roth-Schechter, BF | 1 |
Altshuler, H | 1 |
Weaver, S | 1 |
Phillips, P | 1 |
Turnbull, MJ | 1 |
Watkins, JW | 1 |
Yamamoto, I | 2 |
Becker, KE | 1 |
Loh, HH | 2 |
Way, EL | 1 |
Jones, BE | 1 |
Prada, JA | 1 |
Ritzmann, RF | 1 |
Tabakoff, B | 2 |
Frederickson, RC | 1 |
Hewes, CR | 1 |
Aiken, JW | 1 |
Liebson, IA | 1 |
Thompson, T | 1 |
Roerig, DL | 1 |
Lewand, DL | 1 |
Mueller, MA | 1 |
Wang, RI | 1 |
Rasmussen, K | 1 |
Jensen, K | 1 |
Alexander, GJ | 1 |
Griffiths, R | 1 |
Banerjee, U | 2 |
Saunders, PA | 2 |
Kimura, T | 1 |
Cole-Harding, S | 1 |
de Wit, H | 2 |
Koike, Y | 5 |
Yanaura, S | 4 |
George, FR | 2 |
Wenger, GR | 1 |
Kimball, KA | 1 |
Vanover, KE | 1 |
Bodker, B | 1 |
Ambre, J | 1 |
Burkhart-Kasch, S | 1 |
Gwiazdon, CC | 1 |
Carney, JM | 1 |
Landrum, RW | 1 |
Cheng, MS | 1 |
Seale, TW | 1 |
Dawson, AH | 1 |
Whyte, IM | 1 |
Lemaire, GA | 1 |
Rosenberger, W | 2 |
Liljequist, S | 1 |
Culp, S | 1 |
Hayes, BA | 1 |
Guarino, JJ | 1 |
Kirk, WT | 1 |
McMillan, DE | 1 |
Wessinger, WD | 1 |
Otani, K | 1 |
Yoshii, T | 2 |
Kosse, K | 1 |
Goa, KL | 1 |
Heel, RC | 1 |
Pruitt, TA | 1 |
de la Garza, R | 1 |
Ito, Y | 1 |
Lim, DK | 1 |
Lamb, R | 1 |
Kaneto, H | 1 |
Hori, A | 1 |
Gmerek, DE | 1 |
Dykstra, LA | 1 |
Chida, Y | 1 |
Misawa, M | 1 |
Kuwahara, A | 2 |
Kubota, A | 2 |
Hakkei, M | 2 |
Nakamura, K | 2 |
Rao, S | 1 |
Walewski, JL | 1 |
Sellers, EM | 1 |
Basu, PK | 1 |
Kapur, BM | 1 |
Matuk, Y | 1 |
McCulloch, C | 1 |
Piascik, MT | 1 |
Raft, D | 1 |
Gomez, R | 1 |
Ewing, JA | 1 |
Kales, A | 1 |
Bixler, EO | 1 |
Tan, TL | 1 |
Scharf, MB | 1 |
Kales, JD | 1 |
Harwood, CT | 1 |
Zahn, MA | 1 |
Ball, JC | 1 |
Stynes, AJ | 1 |
Hydinger, M | 1 |
Kaufman, IC | 1 |
Distasio, C | 1 |
Nawrot, M | 1 |
Nurimoto, S | 1 |
Lamb, D | 1 |
Roberts, G | 1 |
Yanagita, T | 2 |
Takahashi, S | 1 |
Choulis, NH | 1 |
Inaba, DS | 1 |
Ray, GR | 1 |
Newmeyer, JA | 1 |
Whitehead, C | 1 |
Maronde, RF | 1 |
Silverman, M | 1 |
Sheerin, E | 1 |
Kullberg, MP | 1 |
Gorodetzky, CW | 1 |
Klein, B | 1 |
Sheehan, JE | 1 |
Grunberg, E | 1 |
Walberg, CB | 1 |
Zbinden, G | 1 |
Randall, LO | 1 |
Holtzman, SG | 1 |
Villarreal, JE | 1 |
Deneau, G | 1 |
Seevers, MH | 1 |
Gray, GR | 1 |
Smith, DE | 2 |
Wesson, DR | 2 |
Sheppard, CW | 1 |
Johns, MW | 1 |
Hepburn, M | 1 |
Goodyear, MD | 1 |
Chessick, RD | 1 |
Pescor, FT | 1 |
Ben-Arie, O | 1 |
Cancrini, L | 1 |
Scapicchio, PL | 1 |
Urbaitis, JC | 1 |
Glasson, B | 1 |
Jaffe, JH | 1 |
Sharpless, SK | 1 |
Clinical Trials (2)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
The Difference in Pharmacodynamic and Pharmacokinetic Profiles Between Tentin and Magisterial Dexamfetamine in Adults With Attention Deficit Hyperactivity Disorder, a Double Blinded Randomised Crossover-controlled Trial[NCT05621174] | 26 participants (Anticipated) | Interventional | 2023-04-14 | Recruiting | |||
Evaluation of an Eye Tracking Sensor to Detect Cannabis Impairment[NCT03994926] | Early Phase 1 | 3 participants (Actual) | Interventional | 2020-02-03 | Terminated (stopped due to COVID-19 Pandmic halted study) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Reviews
7 reviews available for pentobarbital and Chemical Dependence
Article | Year |
---|---|
Barbiturate tolerance and physical dependence: contribution of pharmacological factors.
Topics: Anesthesia; Animals; Barbital; Barbiturates; Cats; Central Nervous System Depressants; Drug Administ | 1984 |
Identifying genes for alcohol and drug sensitivity: recent progress and future directions.
Topics: Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Chromosome Mapping; Cocaine; Crosses, Genet | 1999 |
The behavioral effects of phencyclidine in animals.
Topics: Animals; Behavior, Animal; Dextroamphetamine; Drug Interactions; Drug Tolerance; Humans; Motor Activ | 1978 |
An experimental analysis of behavioral factors in drug dependence.
Topics: Administration, Oral; Alcoholism; Amphetamine; Animals; Behavior, Animal; Cannabis; Chlorpromazine; | 1975 |
Zopiclone. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy as an hypnotic.
Topics: Anti-Anxiety Agents; Anticonvulsants; Anxiety; Azabicyclo Compounds; Benzodiazepines; Biotransformat | 1986 |
Certain theoretical and practical considerations involved in evaluating the overall abuse potential of opiate agonists and antagonists.
Topics: Animals; Chlorpromazine; Codeine; Cyclazocine; Drug Combinations; Drug Evaluation; Drug Evaluation, | 1973 |
Pharmacology of benzodiazepines: laboratory and clinical correlations.
Topics: Aggression; Alcoholism; Animals; Anticonvulsants; Anxiety; Autonomic Nervous System; Avoidance Learn | 1967 |
Trials
13 trials available for pentobarbital and Chemical Dependence
Article | Year |
---|---|
Human progressive-ratio performance: maintenance by pentobarbital.
Topics: Adult; Conditioning, Operant; Humans; Male; Pentobarbital; Physical Exertion; Psychomotor Performanc | 1983 |
Differential effects of diazepam and pentobarbital on mood and behavior.
Topics: Adolescent; Adult; Diazepam; Dose-Response Relationship, Drug; Emotions; Hostility; Humans; Hypnotic | 1983 |
Single-dose pharmacodynamics of diazepam and pentobarbital in substance abusers.
Topics: Adult; Behavior; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Midd | 1993 |
Ethanol and pentobarbital: comparison of behavioral and subjective effects in sedative drug abusers.
Topics: Adult; Affect; Behavior; Breath Tests; Central Nervous System Depressants; Cross-Over Studies; Dose- | 1997 |
Effects of abused drugs on psychomotor performance.
Topics: Adult; Amphetamine; Central Nervous System Depressants; Central Nervous System Stimulants; Cognition | 1997 |
Human drug self-administration: double-blind comparison of pentobarbital, diazepam, chlorpromazine and placebo.
Topics: Adult; Chlorpromazine; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Adminis | 1979 |
Self-administration of pentobarbital in light and moderate alcohol drinkers.
Topics: Adult; Affect; Alcohol Drinking; Body Weight; Double-Blind Method; Female; Humans; Individuality; Ma | 1992 |
Rate of increase of plasma drug level influences subjective response in humans.
Topics: Adult; Affect; Arousal; Behavior; Blood Pressure; Cognition; Humans; Male; Pentobarbital; Psychomoto | 1992 |
Comparison of the behavioral effects and abuse liability of ethanol and pentobarbital in recreational sedative abusers.
Topics: Adult; Affect; Alcohol Drinking; Alcoholism; Arousal; Dose-Response Relationship, Drug; Double-Blind | 1989 |
Comparison of triazolam and pentobarbital: performance impairment, subjective effects and abuse liability.
Topics: Adult; Analysis of Variance; Anti-Anxiety Agents; Cognition; Dose-Response Relationship, Drug; Human | 1985 |
The pentobarbital test dose for depressant drug dependence.
Topics: Adolescent; Adult; Alcohol Drinking; Anti-Anxiety Agents; Bender-Gestalt Test; Drug Tolerance; Eye M | 1974 |
Subjective effects of narcotic antagonists cyclazocine and nalorphine on the Addiction Research Center Inventory (ARCI).
Topics: Academies and Institutes; Analgesics; Analysis of Variance; Anxiety; Azocines; Clinical Trials as To | 1970 |
Reaction time ("mental set") in control and chronic schizophrenic subjects and in postaddicts under placebo, LSD-25, morphine, pentobarbital and amphetamine.
Topics: Adult; Amphetamine; Clinical Trials as Topic; Female; Humans; Lysergic Acid Diethylamide; Male; Midd | 1965 |
Other Studies
145 other studies available for pentobarbital and Chemical Dependence
Article | Year |
---|---|
Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds.
Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Chemical Phenomena; Chemistry; Explorato | 1990 |
A therapeutic dose of zolpidem has limited abuse-like effects in drug-naïve females: a pilot study.
Topics: Adult; Antipsychotic Agents; Blood Pressure; Chlorpromazine; Female; Heart Rate; Humans; Hypnotics a | 2008 |
Selective changes in sensitivity to benzodiazepines, and not other positive GABA(A) modulators, in rats receiving flunitrazepam chronically.
Topics: Animals; Benzodiazepines; Binding Sites; Dose-Response Relationship, Drug; Drug Tolerance; Flunitraz | 2009 |
Degree of physical dependence induced by secobarbital or pentobarbital.
Topics: Barbiturates; Behavior, Addictive; Humans; Pentobarbital; Secobarbital; Substance-Related Disorders | 1958 |
The treatment of narcotics addiction.
Topics: Humans; Methadone; Narcotics; Opioid-Related Disorders; Pentobarbital; Psychotherapy; Rehabilitation | 1963 |
THE ADDICTION RESEARCH CENTER INVENTORY: STANDARDIZATION OF SCALES WHICH EVALUATE SUBJECTIVE EFFECTS OF MORPHINE, AMPHETAMINE, PENTOBARBITAL, ALCOHOL, LSD-25, PYRAHEXYL AND CHLORPROMAZINE.
Topics: Alcohols; Amphetamine; Amphetamines; Antidepressive Agents; Behavior, Addictive; Benzopyrans; Chlorp | 1963 |
THE ADDICTION RESEARCH CENTER INVENTORY: APPENDIX. I. ITEMS COMPRISING EMPIRICAL SCALES FOR SEVEN DRUGS. II. ITEMS WHICH DO NOT DIFFERENTIATE PLACEBO FROM ANY DRUG CONDITION.
Topics: Alcohols; Amphetamine; Amphetamines; Antidepressive Agents; Appendix; Behavior, Addictive; Chlorprom | 1963 |
DEVELOPMENT OF THE ADDICTION RESEARCH CENTER INVENTORY (ARCI): SELECTION OF ITEMS THAT ARE SENSITIVE TO THE EFFECTS OF VARIOUS DRUGS.
Topics: Amphetamine; Amphetamines; Behavior, Addictive; Chlorpromazine; Humans; Lysergic Acid Diethylamide; | 1963 |
ASSESSING SUBJECTIVE EFFECTS OF DRUGS: AN INDEX OF CARELESSNESS AND CONFUSION FOR USE WITH THE ADDICTION RESEARCH CENTER INVENTORY (ARCI).
Topics: Alcohols; Amphetamine; Amphetamines; Behavior, Addictive; Chlorpromazine; Confusion; Ethanol; Humans | 1963 |
TREATMENT OF NARCOTIC ADDICTS IN PRIVATE PRACTICE.
Topics: Chlordiazepoxide; Chlorpromazine; Drug Therapy; Family Practice; General Practice; Glucose; Hospital | 1964 |
BARBITURATE USE IN NARCOTIC ADDICTS.
Topics: Barbiturates; Codeine; Drug Tolerance; Ethchlorvynol; Glutethimide; Heroin; Hydromorphone; Hypnotics | 1964 |
IDENTIFICATION AND TREATMENT OF BARBITURATE ABUSERS.
Topics: Barbiturates; Diagnosis; Drug Therapy; Drug Tolerance; Pentobarbital; Substance Withdrawal Syndrome; | 1965 |
NARCOTIC DRUG ADDICTION: ONE YEAR'S EXPERIECES AT PILGRIM STATE HOSPITAL.
Topics: Drug Therapy; Hepatitis; Homosexuality; Hospitals, Psychiatric; Hospitals, State; Humans; Legislatio | 1965 |
Establishment of orally delivered drugs as reinforcers for rhesus monkeys: some relations to human drug dependence.
Topics: Administration, Oral; Animals; Behavior, Animal; Benzimidazoles; Drinking Behavior; Ethanol; Feeding | 1981 |
Benzodiazepines: drug discrimination and physiological dependence.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Bromazepam; Diazepam; Discrimination Lear | 1984 |
Acute and chronic effects of pentobarbital on 5-hydroxytryptamine in mouse brain.
Topics: Animals; Brain; Dopamine; Drug Tolerance; Fenclonine; Humans; Hydroxyindoleacetic Acid; Kinetics; Ma | 1981 |
Progress report of the NIDA Addiction Research Center, Baltimore, Maryland, 1982.
Topics: Animals; Behavior, Animal; Buprenorphine; Chlordiazepoxide; Dronabinol; Humans; Nicotine; Opioid-Rel | 1983 |
Bioassay of subjective effects associated with benzodiazepine withdrawal in animals: a novel direction in dependence research.
Topics: Animals; Benzodiazepinones; Biological Assay; Clonidine; Conditioning, Operant; Diazepam; Discrimina | 1984 |
Experimental assessment of the relative abuse liability of triazolam and pentobarbital.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Pentobarbital; Psychomot | 1984 |
[Molecular mechanism of tolerance to and dependence on barbiturates].
Topics: Animals; Barbiturates; Brain; Cells, Cultured; Chick Embryo; Drug Tolerance; Energy Metabolism; Huma | 1980 |
Drug history modifies the behavioral effects of pentobarbital.
Topics: Animals; Behavior, Animal; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Interactions; H | 1983 |
Effects of individual variations in drug elimination kinetics for production of pentobarbital physical dependence.
Topics: Animals; Cats; Central Nervous System; Depression, Chemical; Female; Half-Life; Humans; Kinetics; Ma | 1983 |
Substance abuse research in monkey social groups.
Topics: Animals; Humans; Macaca nemestrina; Macaca radiata; Male; Methadone; Methamphetamine; Morphine; Moto | 1983 |
Psychophysical profiles differentiate drugs of abuse.
Topics: Amobarbital; Animals; Auditory Threshold; Barbiturates; Behavior, Animal; Chlordiazepoxide; Diazepam | 1981 |
Benzodiazepine dependence studies in rodents.
Topics: Animals; Benzodiazepines; Disease Models, Animal; Humans; Pentobarbital; Rats; Self Administration; | 1980 |
Personality factors in human drug self-administration.
Topics: Adult; Depression; Female; Humans; Male; Middle Aged; MMPI; Pentobarbital; Personality; Self Adminis | 1981 |
Diazepam dose preference in humans.
Topics: Adult; Diazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Fem | 1983 |
Diazepam and pentobarbital dependence in the rat.
Topics: Animals; Diazepam; Female; Humans; Pentobarbital; Rats; Rats, Inbred Strains; Substance Withdrawal S | 1982 |
Systems of reinforcement and drug dependence.
Topics: Amphetamines; Animals; Cats; Chlordiazepoxide; Cocaine; Diazepam; Drug Tolerance; Escape Reaction; E | 1982 |
Indicated preference for drugs of abuse.
Topics: Adolescent; Adult; Amphetamines; Cannabis; Cocaine; Codeine; Diazepam; Ethanol; Female; Heroin; Huma | 1982 |
Assessment of tolerance to and physical dependence on pentobarbital, induced by multiple pellet implantation.
Topics: Animals; Anticonvulsants; Body Temperature; Drug Implants; Drug Tolerance; Humans; In Vitro Techniqu | 1980 |
[Action on the emotional-reinforcement systems of the brain as a means of pathogenetic therapy for alcoholism and drug addiction].
Topics: Amphetamine; Animals; Carbolines; Cocaine; Dioxanes; Drug Evaluation, Preclinical; Ethanol; Humans; | 1980 |
Continuous administration of barbital by pellet implantation.
Topics: Animals; Barbital; Barbiturates; Behavior, Animal; Body Temperature; Body Weight; Drug Implants; Dru | 1980 |
Comparison of ethanol and barbiturate physical dependence.
Topics: Alcoholism; Animals; Barbital; Barbiturates; Cats; Central Nervous System Depressants; Dose-Response | 1981 |
Strength of drug habits: for heroin, morphine, methadone, alcohol, barbiturates, pentobarbital, benzedrine, cocaine, and marijuana.
Topics: Adult; Alcoholism; Amphetamines; Barbiturates; Cannabis; Cocaine; Heroin Dependence; Humans; Male; M | 1980 |
Drug preference in humans: double-blind choice comparison of pentobarbital, diazepam and placebo.
Topics: Adult; Behavior; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Hu | 1980 |
[Changes in GABAA/benzodiazepine receptor complex function in the pentobarbital-dependent rat].
Topics: Animals; Binding Sites; Brain; Down-Regulation; Drug Tolerance; gamma-Aminobutyric Acid; In Vitro Te | 1995 |
[Changes in GABAA/benzodiazepine receptor complex function in the pentobarbital-dependent rat. II: Strain differences between Lewis and Wistar-Kyoto rats].
Topics: Animals; Bicuculline; Brain; Chlorine; Ethanol; Female; Flunitrazepam; GABA Antagonists; GABA Modula | 1995 |
Changes in [3H]flunitrazepam binding in the brain of rats made tolerant to and dependent upon pentobarbital.
Topics: Animals; Brain; Drug Tolerance; Flunitrazepam; Injections, Intraventricular; Male; Pentobarbital; Ra | 1995 |
Evaluation of the abuse liability of aminorex.
Topics: Aminorex; Animals; Arousal; Dextroamphetamine; Discrimination Learning; Female; Infusions, Intraveno | 1994 |
Drug dependence study of the new cognition-enhancing agent nefiracetam in rats.
Topics: Animals; Body Weight; Codeine; Male; Morphine; Pentobarbital; Psychotropic Drugs; Pyrrolidinones; Ra | 1994 |
Behavioral pharmacology of tandospirone in baboons: chronic administration and withdrawal, self-injection and drug discrimination.
Topics: Animals; Anti-Anxiety Agents; Arousal; Buspirone; Cocaine; Discrimination Learning; Dose-Response Re | 1993 |
Region-specific changes of GABAA receptors by tolerance to and dependence upon pentobarbital.
Topics: Animals; Body Temperature; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cereb | 1993 |
Inhaled 1,1,1-trichloroethane-produced physical dependence in mice: effects of drugs and vapors on withdrawal.
Topics: Administration, Inhalation; Animals; Chlorpromazine; Ethanol; Male; Mice; Midazolam; Pentobarbital; | 1993 |
Morphine physical dependence in the hibernator: central nervous system mechanisms underlying the development of dependence remain functional during depression induced by pentobarbital anesthesia.
Topics: Anesthesia; Animals; Central Nervous System; Central Nervous System Diseases; Depression, Chemical; | 1993 |
Behavioral effects of pentobarbital, lorazepam, ethanol and chlorpromazine substitution in pentobarbital-dependent baboons.
Topics: Animals; Behavior, Animal; Chlorpromazine; Ethanol; Lorazepam; Male; Papio; Pentobarbital; Substance | 1993 |
Selecting an appropriate isotopic internal standard for gas chromatography/mass spectrometry analysis of drugs of abuse--pentobarbital example.
Topics: Gas Chromatography-Mass Spectrometry; Isotopes; Pentobarbital; Reference Standards; Substance-Relate | 1995 |
Ro 15-4513 alteration of pentobarbital dependence.
Topics: Animals; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Drug Interactions; Male; Pentoba | 1996 |
Role of NMDA receptors in pentobarbital tolerance/dependence.
Topics: Animals; Autoradiography; Cerebral Ventricles; Dizocilpine Maleate; Drug Evaluation, Preclinical; Dr | 1997 |
Changes in [3H]forskolin binding to adenylate cyclase and [3H]phorbol dibutyrate binding to protein kinase C in pentobarbital tolerant/dependent rats.
Topics: Adenylyl Cyclases; Animals; Brain; Cerebral Ventricles; Colforsin; Drug Tolerance; Infusions, Parent | 1998 |
Autoradiographic study of [3H]flunitrazepam binding sites in the subnuclei of the thalamus of rats rendered tolerant to and dependent on pentobarbital.
Topics: Animals; Autoradiography; Binding Sites; Drug Tolerance; Flunitrazepam; GABA Modulators; Hypnotics a | 1998 |
Cocaine- and alcohol-mediated expression of inducible transcription factors is blocked by pentobarbital anesthesia.
Topics: Anesthetics; Animals; Bacterial Proteins; Behavior, Animal; Brain; Carrier Proteins; Cocaine; Drug I | 2000 |
Behavioral effects of flunitrazepam: reinforcing and discriminative stimulus effects in rhesus monkeys and prevention of withdrawal signs in pentobarbital-dependent rats.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Discrimination Learning; Female; Flunitrazepam; GABA | 2001 |
Sensitivity to the effects of sedative-hypnotics on motor performance: influence of task difficulty and chronic phenobarbital administration.
Topics: Amobarbital; Animals; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Dru | 2001 |
Drug interactions with nerve membrane components regulating ionic permeability: action of tetrodotoxin, procaine, pentobarbital, and ethanol.
Topics: Animals; Astacoidea; Axons; Cell Membrane Permeability; Electric Conductivity; Ethanol; Humans; Hydr | 1979 |
Experimental studies of sedative self-administration by humans.
Topics: Adult; Drug Tolerance; Female; Half-Life; Humans; Hypnotics and Sedatives; Male; Middle Aged; Pentob | 1978 |
Withdrawal treatment for barbiturate dependence.
Topics: Barbiturates; Drug Administration Schedule; Female; Humans; Male; Pentobarbital; Substance Withdrawa | 1979 |
The overtranquilized patient.
Topics: Humans; Pentobarbital; Phenobarbital; Psychotherapy; Substance Withdrawal Syndrome; Substance-Relate | 1979 |
Physical dependence to barbital compared to pentobarbital. I. "Chronically equivalent" dosing method.
Topics: Animals; Barbital; Barbiturates; Cats; Dose-Response Relationship, Drug; Drug Administration Schedul | 1978 |
Physical dependence to barbital compared to pentobarbital. II. Tolerance characteristics.
Topics: Animals; Barbital; Barbiturates; Cats; Drug Tolerance; Humans; Pentobarbital; Substance-Related Diso | 1978 |
Physical dependence to barbital compared to pentobarbital. III. Withdrawal characteristics.
Topics: Animals; Barbital; Barbiturates; Cats; Humans; Pentobarbital; Substance Withdrawal Syndrome; Substan | 1978 |
Physical dependence to barbital compared to pentobarbital. IV. Influence of elimination kinetics.
Topics: Animals; Barbital; Barbiturates; Cats; Humans; Kinetics; Pentobarbital; Peritoneal Dialysis; Substan | 1978 |
Acute inhibition of microsomal drug metabolism by propoxyphene in narcotic tolerant/dependent mice.
Topics: Animals; Dextropropoxyphene; Drug Tolerance; Humans; Male; Methadone; Mice; Microsomes, Liver; Mixed | 1978 |
Characteristics of functional tolerance during barbiturate physical dependency production.
Topics: Animals; Barbital; Barbiturates; Cats; Central Nervous System Depressants; Dose-Response Relationshi | 1978 |
Organic impairment in polydrug users: risk factors.
Topics: Adult; Age Factors; Brain; Educational Status; Female; Follow-Up Studies; Heroin Dependence; Humans; | 1978 |
The prediction of neuropsychological impairment in polydrug abusers.
Topics: Adult; Alcoholism; Cannabis; Dextroamphetamine; Humans; Illicit Drugs; Life Style; Mental Disorders; | 1978 |
Immunosuppression of rosette-forming cells.
Topics: Amphetamine; Animals; Body Weight; Caffeine; Erythrocytes; Humans; Immunity; Immunologic Techniques; | 1976 |
Environmental influences affecting the voluntary intake of drugs: an overview.
Topics: Administration, Oral; Animals; Drinking Behavior; Haplorhini; Humans; Injections, Intravenous; Pento | 1975 |
[Barbiturate dependence at the cellular level].
Topics: Animals; Astrocytes; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Humans; Models, | 1975 |
Intragastric self-administration of psychoactive drugs by the rhesus monkey.
Topics: Animals; Dextroamphetamine; Disease Models, Animal; Ethanol; Haplorhini; Humans; Macaca mulatta; Met | 1975 |
Human sedative self-administration: effects of interingestion interval and dose.
Topics: Adult; Behavior; Diazepam; Drug Administration Schedule; Ethanol; Humans; Hypnotics and Sedatives; M | 1976 |
Acute tolerance to barbiturate in the rat.
Topics: Animals; Barbital; Barbiturates; Brain; Disease Models, Animal; Drug Tolerance; Female; Hexobarbital | 1976 |
Enhancement of pentobarbital effect by continuous administration of morphine in the mouse.
Topics: Animals; Body Temperature; Brain; Drug Synergism; Ethylmorphine-N-Demethylase; Humans; Liver; Male; | 1976 |
A method for bioassay of physical dependence on sedative drugs in dog.
Topics: Animals; Dogs; Drug Evaluation, Preclinical; Humans; Hypnotics and Sedatives; Methaqualone; Pentobar | 1976 |
Body temperature in mice: a quantitative measure of alcohol tolerance and physical dependence.
Topics: Animals; Behavior, Animal; Body Temperature; Diet; Drug Tolerance; Ethanol; Humans; Male; Mice; Mice | 1976 |
Correlation between the in vivo and an in vitro expression of opiate withdrawal precipitated by naloxone: their antagonism by l-(-)-delta9-tetrahydrocannabinol.
Topics: Acetylcholine; Animals; Chlorpromazine; Codeine; Dose-Response Relationship, Drug; Dronabinol; Femal | 1976 |
Effects of response requirement upon human sedative self-administration and drug-seeking behavior.
Topics: Adult; Behavior; Diazepam; Drug Tolerance; Humans; Hypnotics and Sedatives; Male; Pentobarbital; Rew | 1976 |
Withdrawal characteristics following chronic pentobarbital dosing.
Topics: Animals; Cats; Humans; Pentobarbital; Substance Withdrawal Syndrome; Substance-Related Disorders | 1976 |
Comparison of radioimmunoassay with thin-layer chromatographic and gas-liquid chromatographic methods of barbiturate detection in human urine.
Topics: Adult; Amobarbital; Barbiturates; Chromatography, Gas; Chromatography, Thin Layer; Evaluation Studie | 1975 |
[Letter: Mebumal (Nembutal) injected by a drug addict].
Topics: Abscess; Humans; Injections, Intravenous; Pentobarbital; Self Medication; Substance-Related Disorder | 1975 |
[Letter: Mebumal (Nembutal) injections and drug abuse].
Topics: Denmark; Humans; Injections, Intravenous; Pentobarbital; Substance-Related Disorders | 1975 |
A model for the rapid development of dispositional and functional tolerance to barbiturates.
Topics: Animals; Barbiturates; Drug Tolerance; Half-Life; Humans; Male; Mice; Mice, Inbred ICR; Microsomes, | 1975 |
Screening for drug abuse: use of NaCl to increase drug recovery from papers coated with ion-exchange resin.
Topics: Amphetamine; Chlorpromazine; Chromatography, Paper; Humans; Ion Exchange Resins; Methadone; Morphine | 1975 |
Experimental human drug self-administration: methodology and application to the study of sedative abuse.
Topics: Adult; Behavior; Diazepam; Environment; Humans; Male; Pentobarbital; Substance-Related Disorders; To | 1975 |
Conditioned avoidance behavior in pretrained rats intermittently treated with addictive drugs.
Topics: Amphetamine; Animals; Avoidance Learning; Body Weight; Conditioning, Operant; Dose-Response Relation | 1975 |
Effects of pentobarbital tolerance and dependence on convulsant and GABAA receptor antagonist binding.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Co | 1992 |
Sex differences in physical dependence on pentobarbital in four inbred strains of rats.
Topics: Animals; Female; Male; Pentobarbital; Postural Balance; Rats; Rats, Inbred F344; Rats, Inbred SHR; R | 1992 |
Titrating matching-to-sample performance: effects of drugs of abuse and intertrial interval.
Topics: Amphetamine; Animals; Cocaine; Columbidae; Male; Pentobarbital; Phencyclidine; Reaction Time; Reinfo | 1992 |
Evaluation of the discriminative stimulus and reinforcing effects of sertraline in rhesus monkeys.
Topics: 1-Naphthylamine; Amphetamine; Animals; Cocaine; Female; Macaca mulatta; Male; Pentobarbital; Reinfor | 1992 |
Locomotor responses of FAST and SLOW mice to several alcohols and drugs of abuse.
Topics: Alcohols; Animals; Caffeine; Dextroamphetamine; Diazepam; Mice; Mice, Inbred Strains; Motor Activity | 1992 |
Establishment of chronic intravenous drug self-administration in the C57BL/6J mouse.
Topics: Animals; Cocaine; Disease Models, Animal; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Inb | 1991 |
Compound analgesics.
Topics: Acetaminophen; Adult; Drug Combinations; Drug Overdose; Female; Humans; Pentobarbital; Substance-Rel | 1990 |
Reinforcing effects of a pentobarbital-ethanol combination relative to each drug alone.
Topics: Administration, Oral; Animals; Behavior, Animal; Drug Combinations; Drug Interactions; Ethanol; Maca | 1990 |
Substitution of temazepam and midazolam in pentobarbital-dependent rats.
Topics: Animals; Anti-Anxiety Agents; Arousal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred St | 1989 |
The effect of ethanol on 35S-TBPS binding to mouse brain membranes in the presence of chloride.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo | 1989 |
Intensity of the withdrawal syndrome varies with duration of pentobarbital administration.
Topics: Animals; Male; Pentobarbital; Random Allocation; Rats; Rats, Inbred Strains; Substance Withdrawal Sy | 1989 |
Assessment of the abuse potential of methocarbamol in primates.
Topics: Animals; Appetitive Behavior; Cocaine; Discrimination Learning; Dose-Response Relationship, Drug; Ma | 1989 |
Interaction of the discriminative stimulus effects of phencyclidine with those of (+)-N-allylnormetazocine, pentobarbital and d-amphetamine.
Topics: Amphetamines; Animals; Columbidae; Discrimination Learning; Drug Interactions; Pentobarbital; Phenaz | 1989 |
Induction of physical dependence on pentobarbital by new infusion method in the rat.
Topics: Animals; Behavior, Animal; Drug Tolerance; Female; Infusion Pumps; Infusions, Intravenous; Male; Pen | 1989 |
Dependence on phenobarbital but not pentobarbital using drug-adulterated food.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Food Contamination; Male; M | 1989 |
Physical dependence of benzodiazepines in the rat and dog.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Dogs; Dose-Response Relationship, Drug; Kidney Tubule | 1986 |
Discriminative stimulus properties of intragastrically administered d-amphetamine and pentobarbital in rhesus monkeys.
Topics: Animals; Anti-Anxiety Agents; Appetite Depressants; Bupropion; Dextroamphetamine; Discrimination Lea | 1987 |
Binding characteristics of t-[35S]butylbicyclophosphorothionate in discrete brain regions of rats made tolerant to and dependent on pentobarbital.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Com | 1989 |
Progress report from the Division of Behavioral Biology, the Johns Hopkins University School of Medicine.
Topics: Animals; Drug Tolerance; Humans; Male; Maryland; Papio; Pentobarbital; Research; Self Administration | 1986 |
Benzodiazepine antagonist, CGS-8216, in diazepam- or pentobarbital-dependent and non-dependent rats.
Topics: Animals; Arousal; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Pentobarbital; Pyr | 1986 |
[Pharmacological interactions between dependence-liable drugs].
Topics: Amphetamine; Animals; Cocaine; Drug Interactions; Drug Tolerance; Ethanol; Male; Mice; Morphine; Pen | 1988 |
Kappa opioids in rhesus monkeys. III. Dependence associated with chronic administration.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; B | 1987 |
Cross-physical dependence of several drugs in methaqualone-dependent rats.
Topics: Animals; Barbital; Diazepam; Ethanol; Male; Methaqualone; Pentobarbital; Postural Balance; Psychomot | 1988 |
Genetic differences in the development of physical dependence on pentobarbital in four inbred strains of rats.
Topics: Animals; Behavior, Animal; Body Weight; Female; Genetics, Behavioral; Pentobarbital; Rats; Rats, Inb | 1987 |
[Drug dependence test on a cerebral insufficiency improver, aniracetam].
Topics: Animals; Brain; Cocaine; Drug Evaluation, Preclinical; Macaca fascicularis; Male; Memory; Methamphet | 1987 |
Effect of dosing frequency on the development of physical dependence and tolerance to pentobarbital.
Topics: Animals; Cats; Central Nervous System; Drug Administration Schedule; Drug Tolerance; Female; Half-Li | 1986 |
[Drug dependence tests on a new anesthesia inducer, midazolam].
Topics: Animals; Injections, Intravenous; Macaca fascicularis; Male; Midazolam; Pentobarbital; Self Administ | 1986 |
Treatment of the barbiturate abstinence syndrome.
Topics: Barbiturates; Drug Administration Schedule; Drug Tolerance; Humans; Pentobarbital; Phenobarbital; Su | 1986 |
Abuse liability of triazolam: experimental measurements in animals and humans.
Topics: Animals; Diazepam; Drug Tolerance; Humans; Male; Papio; Pentobarbital; Psychomotor Performance; Self | 1987 |
Suitability of corneal grafts from donors treated with chemical agents.
Topics: Animals; Cornea; Corneal Transplantation; Ethanol; Graft Rejection; Guinea Pigs; Humans; Morphine; P | 1985 |
Continuous intraperitoneal infusion of pentobarbital: a model of barbiturate dependence in the rat.
Topics: Animals; Barbiturates; Disease Models, Animal; Humans; Injections, Intraperitoneal; Male; Motor Acti | 1985 |
Effect of pentobarbital dependence on adenylate cyclase activity and calmodulin levels in rat cerebral cortex.
Topics: Adenylyl Cyclases; Animals; Calcium; Calmodulin; Cerebral Cortex; Colforsin; Diterpenes; Dopamine; F | 1985 |
Sex differences in the induction of physical dependence on pentobarbital in the rat.
Topics: Animals; Body Weight; Circadian Rhythm; Female; Male; Motor Activity; Pentobarbital; Postural Balanc | 1985 |
Chronic hypnotic-drug use. Ineffectiveness, drug-withdrawal insomnia, and dependence.
Topics: Adult; Age Factors; Aged; Amobarbital; Chloral Hydrate; Chronic Disease; Dreams; Drug Therapy, Combi | 1974 |
Radioimmunoassay: its application to drugs of abuse.
Topics: Amphetamine; Animals; Antibody Formation; Antigen-Antibody Complex; Antigen-Antibody Reactions; Barb | 1974 |
Patterns and causes of drug addiction among Puerto Rican females.
Topics: Adolescent; Adult; Cannabis; Child; Criminal Psychology; Drug Prescriptions; Employment; Female; Her | 1974 |
Ethanol, methamphetamine, pentobarbital, morphine, and monkey social behavior.
Topics: Aggression; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Ethanol; Female; Humans; In | 1974 |
Programmed self-administration of potentially addictive drugs in young rats and its effects on learning.
Topics: Amphetamine; Animals; Avoidance Learning; Behavior, Animal; Drug Tolerance; Ethanol; Extinction, Psy | 1974 |
Methaqualone.
Topics: Adult; Drug and Narcotic Control; Humans; Japan; Methaqualone; Pentobarbital; Substance Withdrawal S | 1973 |
A simple method for evaluating physical dependence liability in rats.
Topics: Aminopyrine; Animals; Azepines; Body Weight; Codeine; Cyproheptadine; Dextropropoxyphene; Humans; Ma | 1973 |
Starch and talc emboli in drug addicts' lungs.
Topics: Acetaminophen; Adult; Alcohols; Amobarbital; Animals; Barbiturates; Female; Foreign-Body Reaction; H | 1972 |
Dependence liability of several sedative-hypnotic agents evaluated in monkeys.
Topics: Animals; Anthracenes; Barbiturates; Benzazepines; Catheterization; Chlordiazepoxide; Chloroform; Chl | 1973 |
Separation and quantitation of mixtures of the most commonly abused drugs.
Topics: Amobarbital; Cannabis; Chromatography, Thin Layer; Dextroamphetamine; Ephedrine; Humans; Indicators | 1973 |
Methaqualone abuse. "Luding out".
Topics: Adult; California; Cannabis; Counseling; Female; Heroin Dependence; Humans; Male; Methaqualone; Pent | 1973 |
Letter: Prescribing hypnotic and anti-anxiety drugs.
Topics: Chlordiazepoxide; Diazepam; Drug Prescriptions; Humans; Hypnotics and Sedatives; Meprobamate; Pentob | 1973 |
A programme which led to reduction in night sedation in a major hospital.
Topics: Attitude of Health Personnel; Attitude to Health; Australia; Drug Prescriptions; Drug-Related Side E | 1973 |
Studies on the use of XAD-2 resin for detection of abused drugs in urine.
Topics: Amobarbital; Amphetamine; Aspirin; Caffeine; Carbon Radioisotopes; Chromatography, Ion Exchange; Chr | 1974 |
Use of fluorescamine ("Fluram") to detect amphetamine in urine by thin-layer chromatography.
Topics: Amphetamine; Benzofurans; Chromatography, Ion Exchange; Chromatography, Thin Layer; Drug Stability; | 1974 |
Correlation of the "EMIT" urine barbiturate assay with a spectrophotometric serum barbiturate assay in suspected overdose.
Topics: Amobarbital; Barbiturates; Evaluation Studies as Topic; Humans; Methods; Pentobarbital; Phenobarbita | 1974 |
Morphine dependence and body temperature in rhesus monkeys.
Topics: Animals; Body Temperature; Chlorpromazine; Drug Synergism; Female; Haplorhini; Humans; Ketones; Male | 1969 |
Self-administration of psychoactive substances by the monkey.
Topics: Animals; Behavior, Animal; Caffeine; Catheterization; Chlorpromazine; Cocaine; Codeine; Dextroamphet | 1969 |
Outpatient barbiturate withdrawal using phenobarbital.
Topics: Administration, Oral; Adolescent; Adult; Ambulatory Care; Amobarbital; Barbiturates; Community Healt | 1972 |
Use of hypnotic drugs by hospital patients.
Topics: Adult; Aged; Amobarbital; Antipyrine; Barbiturates; Diphenhydramine; Female; Hospitalization; Humans | 1971 |
A new method for treatment of barbiturate dependence.
Topics: Barbiturates; Chlordiazepoxide; Diazepam; Heroin; Humans; Meprobamate; Pentobarbital; Phenobarbital; | 1970 |
Physical dependence on heroin and pentobarbitone.
Topics: Adult; Heroin; Humans; Male; Pentobarbital; Substance Withdrawal Syndrome; Substance-Related Disorde | 1968 |
Diagnosis and treatment of drug dependence of the barbiturate type.
Topics: Adult; Barbiturates; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Pentobarbital; Psyc | 1968 |
[Preliminary observations on the prophylaxis and therapy of toxicomaniac behavior among young people in Rome].
Topics: Adolescent; Adult; Cannabis; Female; Follow-Up Studies; Humans; Male; Methaqualone; Neurotic Disorde | 1968 |
Barbiturate dependence.
Topics: Barbiturates; Humans; Pentobarbital; Substance Withdrawal Syndrome; Substance-Related Disorders; Tim | 1969 |
[Services and perspectives of metabolic research on certain exogenous substances endowed with pharmacological activity].
Topics: Animals; Carbon Tetrachloride Poisoning; Humans; Microsomes; Pentobarbital; Pharmacology; Phenobarbi | 1965 |
The rapid development of physical dependence on barbiturates.
Topics: Animals; Cats; Denervation; Humans; Pentobarbital; Pentylenetetrazole; Seizures; Substance Withdrawa | 1965 |