pentobarbital has been researched along with Brain Swelling in 39 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The authors anecdotally observed that patients in a pentobarbital coma have a CSR that can mimic pathological conditions." | 7.70 | The ciliospinal reflex in pentobarbital coma. ( Andrefsky, JC; Chyatte, D; Frank, JI, 1999) |
| "Global cerebrovenous oxygenation was evaluated before and after intravenous administration of pentobarbital sodium for the management of refractory intracranial hypertension in 151 comatose patients who had acute traumatic brain swelling." | 7.69 | Adverse effects of pentobarbital on cerebral venous oxygenation of comatose patients with acute traumatic brain swelling: relationship to outcome. ( Cruz, J, 1996) |
| "To evaluate the impact of anesthetics on the evolution of a cerebral injury, 33 rabbits were subjected to a cryogenic brain lesion, followed by 10 h of anesthesia with 1 MAC halothane or isoflurane (n = 11 each) or with an equipotent dose of pentobarbital (n = 11)." | 7.67 | A comparison of the effects of halothane, isoflurane, and pentobarbital anesthesia on intracranial pressure and cerebral edema formation following brain injury in rabbits. ( Kaieda, R; Todd, MM; Warner, DS; Weeks, JB, 1989) |
| "We observed that cerebral hyperemia follows an initial rise in brain water content, rather than in the cerebrospinal fluid concentration of glutamine." | 3.71 | Cerebral hyperemia and nitric oxide synthase in rats with ammonia-induced brain edema. ( Blei, AT; Gottstein, J; Larsen, FS, 2001) |
| " The authors anecdotally observed that patients in a pentobarbital coma have a CSR that can mimic pathological conditions." | 3.70 | The ciliospinal reflex in pentobarbital coma. ( Andrefsky, JC; Chyatte, D; Frank, JI, 1999) |
| "Global cerebrovenous oxygenation was evaluated before and after intravenous administration of pentobarbital sodium for the management of refractory intracranial hypertension in 151 comatose patients who had acute traumatic brain swelling." | 3.69 | Adverse effects of pentobarbital on cerebral venous oxygenation of comatose patients with acute traumatic brain swelling: relationship to outcome. ( Cruz, J, 1996) |
| "To evaluate the impact of anesthetics on the evolution of a cerebral injury, 33 rabbits were subjected to a cryogenic brain lesion, followed by 10 h of anesthesia with 1 MAC halothane or isoflurane (n = 11 each) or with an equipotent dose of pentobarbital (n = 11)." | 3.67 | A comparison of the effects of halothane, isoflurane, and pentobarbital anesthesia on intracranial pressure and cerebral edema formation following brain injury in rabbits. ( Kaieda, R; Todd, MM; Warner, DS; Weeks, JB, 1989) |
| " We believed that this represented an adverse effect that was probably related to the study drug and the study was stopped." | 2.68 | Propylene glycol toxicity following continuous etomidate infusion for the control of refractory cerebral edema. ( Aranda, M; Giannotta, SL; Levy, ML; Zelman, V, 1995) |
| "No patient died from isolated cerebral edema." | 1.35 | Results of a protocol for the management of patients with fulminant liver failure. ( Curry, SC; Gerkin, R; Leibowitz, AI; Little, E; Manch, R; Ramos, A; Raschke, RA; Rempe, S; Wong, M, 2008) |
| "The use of pharmacologic coma (PC) to treat status epilepticus (SE) is not always successful, and there are no guidelines for the duration of PC in an attempt to achieve seizure control." | 1.32 | Now we lay them down to sleep: ethical issues with the use of pharmacologic coma for adult status epilepticus. ( Bramstedt, KA; Morris, HH; Tanner, A, 2004) |
| "Pentobarbital prevented the increase in ODC mRNA, whereas the glutamate antagonist MK-801 had no effect on the elevation of ODC gene expression after ischemia." | 1.28 | Modulation of ornithine decarboxylase mRNA following transient ischemia in the gerbil brain. ( Carney, JM; Dempsey, RJ; Kindy, MS, 1991) |
| " The course of concentration under maintenance dosage was extremely variable, mainly due to interindividual and intraindividual variations in clearance." | 1.27 | [Thiopental kinetics in high-dose use]. ( Jensen, U; Murr, R; Peter, K; Schmiedeck, P; Taeger, K, 1986) |
| "Focal cerebral ischemia initiates multiple detrimental effects in the brain." | 1.27 | Indomethacin-mediated improvement following middle cerebral artery occlusion in cats. Effects of anesthesia. ( Dempsey, RJ; Donaldson, DL; Meyer, KL; Roy, MW, 1985) |
| "Experimental vasogenic cerebral edema was created in rabbits with a cold-induced left occipital cortical lesions." | 1.26 | Acute therapeutic modalities for experimental vasogenic edema. ( Harbaugh, RD; James, HE; Laurin, R; Marshall, LF; Shapiro, HM, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (71.79) | 18.7374 |
| 1990's | 6 (15.38) | 18.2507 |
| 2000's | 4 (10.26) | 29.6817 |
| 2010's | 1 (2.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mansour, N | 1 |
| deSouza, RM | 1 |
| Sikorski, C | 1 |
| Kahana, M | 1 |
| Frim, D | 1 |
| Raschke, RA | 1 |
| Curry, SC | 1 |
| Rempe, S | 1 |
| Gerkin, R | 1 |
| Little, E | 1 |
| Manch, R | 1 |
| Wong, M | 1 |
| Ramos, A | 1 |
| Leibowitz, AI | 1 |
| Bramstedt, KA | 1 |
| Morris, HH | 1 |
| Tanner, A | 1 |
| Ritz, MF | 1 |
| Schmidt, P | 1 |
| Mendelowitsch, A | 1 |
| Kassell, NF | 1 |
| Peerless, SJ | 1 |
| Drake, CG | 1 |
| Boarini, DJ | 1 |
| Adams, HP | 1 |
| Yoshida, S | 1 |
| Inoh, S | 1 |
| Asano, T | 1 |
| Sano, K | 1 |
| Shimasaki, H | 1 |
| Ueta, N | 1 |
| Schwartz, ML | 1 |
| Tator, CH | 1 |
| Rowed, DW | 1 |
| Reid, SR | 1 |
| Meguro, K | 1 |
| Andrews, DF | 1 |
| Piatt, JH | 1 |
| Schiff, SJ | 1 |
| James, HE | 5 |
| Cornell, W | 1 |
| del Bigio, M | 1 |
| Werner, R | 2 |
| Kolata, GB | 1 |
| Millson, CH | 1 |
| Shapiro, HM | 2 |
| Laurin, R | 2 |
| Algren, JT | 1 |
| Roe, EJ | 1 |
| Frewen, TC | 1 |
| Swedlow, DB | 1 |
| Watcha, M | 1 |
| Raphaely, RC | 1 |
| Godinez, RI | 1 |
| Heiser, MS | 1 |
| Kettrick, RG | 1 |
| Bruce, DA | 1 |
| Camp, PE | 1 |
| Harbaugh, RD | 2 |
| Marshall, LF | 2 |
| Bricolo, AP | 1 |
| Glick, RP | 1 |
| Levy, ML | 1 |
| Aranda, M | 1 |
| Zelman, V | 1 |
| Giannotta, SL | 1 |
| Cruz, J | 1 |
| Lam, AM | 1 |
| Coplin, WM | 1 |
| Andrefsky, JC | 1 |
| Frank, JI | 1 |
| Chyatte, D | 1 |
| Larsen, FS | 1 |
| Gottstein, J | 1 |
| Blei, AT | 1 |
| Venes, JL | 1 |
| Michenfelder, JD | 1 |
| Milde, JH | 1 |
| Sundt, TM | 1 |
| Smith, AL | 1 |
| Marque, JJ | 1 |
| Hayakawa, T | 1 |
| Waltz, AG | 1 |
| Dempsey, RJ | 2 |
| Carney, JM | 1 |
| Kindy, MS | 1 |
| Gaab, MR | 1 |
| Poch, B | 1 |
| Heller, V | 1 |
| Schettini, A | 1 |
| Lippman, RH | 1 |
| Walsh, EK | 1 |
| Kaieda, R | 1 |
| Todd, MM | 1 |
| Weeks, JB | 1 |
| Warner, DS | 1 |
| Edgehouse, NL | 1 |
| Dorman, RV | 1 |
| Dvorák, J | 1 |
| Trojan, S | 1 |
| St'astný, F | 1 |
| Taeger, K | 1 |
| Murr, R | 1 |
| Schmiedeck, P | 1 |
| Jensen, U | 1 |
| Peter, K | 1 |
| Roy, MW | 1 |
| Meyer, KL | 1 |
| Donaldson, DL | 1 |
| Clasen, RA | 1 |
| Pandolfi, S | 1 |
| Casey, D | 1 |
| Tomlin, PJ | 1 |
| Angel, A | 1 |
| Berridge, DA | 1 |
| Unwin, J | 1 |
| Yamamoto, S | 1 |
| Hayashi, M | 1 |
| Yamamoto, T | 1 |
| Komai, Y | 1 |
| Kobayashi, K | 1 |
| Hiraiwa, N | 1 |
| Nakazawa, S | 1 |
1 trial available for pentobarbital and Brain Swelling
| Article | Year |
|---|---|
Propylene glycol toxicity following continuous etomidate infusion for the control of refractory cerebral edema.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Anesthetics, Intravenous; Brain; Brain Edema; Drug Adm | 1995 |
38 other studies available for pentobarbital and Brain Swelling
| Article | Year |
|---|---|
Role of barbiturate coma in the management of focally induced, severe cerebral edema in children.
Topics: Brain Edema; Brain Neoplasms; Cerebral Hemorrhage; Child; Child, Preschool; Coma; Drug Administratio | 2013 |
Results of a protocol for the management of patients with fulminant liver failure.
Topics: Adolescent; Adult; Brain Edema; Female; Hemostatics; Hospital Mortality; Humans; Hypnotics and Sedat | 2008 |
Now we lay them down to sleep: ethical issues with the use of pharmacologic coma for adult status epilepticus.
Topics: Adult; Anticonvulsants; Brain; Brain Edema; Coma; Drug Therapy; Fatal Outcome; Female; Humans; Hypno | 2004 |
Effects of isoflurane on glutamate and taurine releases, brain swelling and injury during transient ischemia and reperfusion.
Topics: Anesthetics; Animals; Brain Edema; Glutamic Acid; Ischemic Attack, Transient; Isoflurane; Male; Neur | 2006 |
Treatment of ischemic deficits from cerebral vasospasm with high dose barbiturate therapy.
Topics: Adolescent; Adult; Aged; Barbiturates; Brain Edema; Cerebral Infarction; Dextrans; Female; Humans; H | 1980 |
Brain free fatty acids, edema, and mortality in gerbils subjected to transient, bilateral ischemia, and effect of barbiturate anesthesia.
Topics: Anesthesia, General; Animals; Arachidonic Acid; Arachidonic Acids; Body Water; Brain; Brain Edema; F | 1983 |
The University of Toronto head injury treatment study: a prospective, randomized comparison of pentobarbital and mannitol.
Topics: Adult; Brain Edema; Cerebral Hemorrhage; Hematoma; Humans; Intracranial Pressure; Mannitol; Pentobar | 1984 |
High dose barbiturate therapy in neurosurgery and intensive care.
Topics: Barbiturates; Brain; Brain Diseases; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Criti | 1984 |
Dimethyl sulfoxide in brain edema and intracranial pressure.
Topics: Animals; Blood Pressure; Brain Edema; Dimethyl Sulfoxide; Intracranial Pressure; Pentobarbital; Rabb | 1983 |
Reye's syndrome: a medical mystery.
Topics: Brain Edema; Fatty Liver; Humans; Intracranial Pressure; Mannitol; Mitochondria, Liver; Pentobarbita | 1980 |
Combination therapy in brain edema.
Topics: Acetazolamide; Animals; Brain Chemistry; Brain Edema; Dexamethasone; Diuretics; Drug Therapy, Combin | 1980 |
Intracranial hypertension and brain oedema in albino rabbits. Part 3: Effect of acute simultaneous diuretic and barbiturate therapy.
Topics: Animals; Body Water; Brain Chemistry; Brain Edema; Drug Combinations; Electroencephalography; Furose | 1982 |
Barbiturate-augmented neurointensive care of intracranial hypertension in meningitis.
Topics: Adolescent; Brain Edema; Humans; Intracranial Pressure; Male; Meningitis, Pneumococcal; Penicillins; | 1983 |
Outcome in severe Reye syndrome with early pentobarbital coma and hypothermia.
Topics: Brain Edema; Child; Coma; Humans; Hypothermia, Induced; Intracranial Pressure; Outcome and Process A | 1982 |
Comparison of the effects of DMSO and pentobarbitone on experimental brain oedema.
Topics: Animals; Blood Pressure; Brain Chemistry; Brain Edema; Central Venous Pressure; Dimethyl Sulfoxide; | 1982 |
Barbiturate effects on acute experimental intracranial hypertension.
Topics: Animals; Blood Pressure; Brain Edema; Cats; Cerebrovascular Circulation; Electroencephalography; Fem | 1981 |
Adverse effects of pentobarbital on cerebral venous oxygenation of comatose patients with acute traumatic brain swelling: relationship to outcome.
Topics: Adolescent; Adult; Aged; Brain Edema; Brain Injuries; Cerebral Veins; Coma; Female; Humans; Male; Mi | 1996 |
Pentobarbital and venous oxygenation.
Topics: Acute Disease; Brain Edema; Brain Injuries; Cerebral Veins; Coma; Humans; Oxygen; Pentobarbital | 1997 |
The ciliospinal reflex in pentobarbital coma.
Topics: Adult; Blood Pressure; Brain Edema; Coma; Electroencephalography; GABA Modulators; Heart Rate; Human | 1999 |
Cerebral hyperemia and nitric oxide synthase in rats with ammonia-induced brain edema.
Topics: Ammonia; Anesthesia, General; Animals; Arteries; Body Water; Brain; Brain Edema; Cerebrovascular Cir | 2001 |
Use of iatrogenic barbiturate coma.
Topics: Adult; Brain Edema; Brain Injuries; Coma; Humans; Iatrogenic Disease; Intracranial Pressure; Pentoba | 1979 |
Acute therapeutic modalities for experimental vasogenic edema.
Topics: Acetazolamide; Acute Disease; Animals; Brain Edema; Cerebrovascular Disorders; Cold Temperature; Dex | 1979 |
Cerebral protection by barbiturate anesthesia. Use after middle cerebral artery occlusion in Java monkeys.
Topics: Anesthesia, Inhalation; Animals; Brain Edema; Brain Injuries; Cerebral Arterial Diseases; Cerebrovas | 1976 |
Anesthetics and cerebral edema.
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics; Animals; Brain; Brain Edema; Dogs; Dro | 1976 |
Changes of epidural pressures after experimental occlusion of one middle cerebral artery in cats.
Topics: Animals; Brain; Brain Edema; Cats; Cerebral Arteries; Halothane; Infarction; Intracranial Pressure; | 1975 |
Modulation of ornithine decarboxylase mRNA following transient ischemia in the gerbil brain.
Topics: Animals; Blotting, Northern; Brain; Brain Edema; Gerbillinae; Ischemic Attack, Transient; Male; Orni | 1991 |
Oxygen tension, oxygen metabolism, and microcirculation in vasogenic brain edema.
Topics: Animals; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Cold Temperature; Ketamine; Male; | 1990 |
Attenuation of decompressive hypoperfusion and cerebral edema by superoxide dismutase.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Body Water; Brain; Brain Edema; Carbon Dioxide; Cerebr | 1989 |
A comparison of the effects of halothane, isoflurane, and pentobarbital anesthesia on intracranial pressure and cerebral edema formation following brain injury in rabbits.
Topics: Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Brain Edema; Brain Injuries; C | 1989 |
Ischemia-induced development of cerebral edema in awake and anesthetized gerbils.
Topics: Anesthetics; Animals; Brain; Brain Edema; Brain Ischemia; Gerbillinae; Male; Pentobarbital | 1987 |
[The effect of pentobarbital and pargyline on the development of acute experimental intracranial hypertension in chick embryos].
Topics: Acute Disease; Animals; Asphyxia; Brain Edema; Chick Embryo; Intracranial Pressure; Pargyline; Pento | 1987 |
[Thiopental kinetics in high-dose use].
Topics: Adult; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Dose-Response Relationship, Drug; Female; H | 1986 |
Indomethacin-mediated improvement following middle cerebral artery occlusion in cats. Effects of anesthesia.
Topics: Animals; Brain Edema; Brain Ischemia; Cats; Cerebral Arteries; Cerebrovascular Circulation; Evoked P | 1985 |
Furosemide and pentobarbital in cryogenic cerebral injury and edema.
Topics: Animals; Brain; Brain Edema; Cerebral Hemorrhage; Drug Synergism; Erythrocytes; Freezing; Furosemide | 1974 |
Death in outpatient dental anaesthetic practice.
Topics: Adolescent; Adult; Aged; Anesthesia, Dental; Anesthesia, General; Anesthesia, Local; Anesthetics; An | 1974 |
The effect of anaesthetic agents on primary cortical evoked responses.
Topics: Animals; Blood Pressure; Brain Edema; Carbon Dioxide; Cerebral Cortex; Electric Stimulation; Electro | 1973 |
[Acute intracranial hypertension].
Topics: Adult; Aged; Betamethasone; Blood Pressure; Brain Edema; Cerebrospinal Fluid; Chlorpromazine; Electr | 1971 |
[Biochemical study of cerebral edema; with special reference to dynamic metabolism of proteolipid protein].
Topics: Animals; Brain Edema; Carbon Isotopes; Cats; Cold Temperature; Freezing; In Vitro Techniques; Inject | 1971 |