pentobarbital has been researched along with Brain Neoplasms in 11 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Malignant gliomas are common and aggressive brain tumors in adults." | 5.35 | Anesthetic pentobarbital inhibits proliferation and migration of malignant glioma cells. ( Huang, Y; Li, Y; Ou, Y; Qiu, P; Shu, M; Xie, J; Yan, G; Zhu, W, 2009) |
| " Local coupling of blood flow and metabolism was studied under different types of anesthesia (barbiturate, halothane), following experimental tumor implantation, and during penicillin seizures or spreading depression." | 3.66 | A double tracer autoradiographic technique for simultaneous measurement of cerebral blood flow and cerebral metabolism in rats. ( Hossmann, KA; Mies, G; Niebuhr, I, 1981) |
| "Malignant gliomas are common and aggressive brain tumors in adults." | 1.35 | Anesthetic pentobarbital inhibits proliferation and migration of malignant glioma cells. ( Huang, Y; Li, Y; Ou, Y; Qiu, P; Shu, M; Xie, J; Yan, G; Zhu, W, 2009) |
| "Pentobarbital has recently been shown to be a cerebral radioprotectant in the rodent and primate models of single fraction radiation injury." | 1.28 | The cerebral radioprotective effect of alternative barbiturates to pentobarbital. ( DeLaney, T; Oldfield, EH; Olson, JJ; Orr, K; Shelley, C, 1992) |
| "Pentobarbital acts as a cerebral radioprotectant, but the selectivity of its protection for the central nervous system has not been demonstrated." | 1.28 | Enhancement of the efficacy of x-irradiation by pentobarbital in a rodent brain-tumor model. ( Delaney, T; Friedman, R; Oldfield, EH; Olson, JJ; Orr, K, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mansour, N | 1 |
| deSouza, RM | 1 |
| Sikorski, C | 1 |
| Kahana, M | 1 |
| Frim, D | 1 |
| Xie, J | 1 |
| Li, Y | 1 |
| Huang, Y | 1 |
| Qiu, P | 1 |
| Shu, M | 1 |
| Zhu, W | 1 |
| Ou, Y | 1 |
| Yan, G | 1 |
| OROSZ, E | 1 |
| SUZUKI, K | 1 |
| KOREY, SR | 1 |
| TERRY, RD | 1 |
| Astrup, J | 1 |
| Rosenørn, J | 1 |
| Cold, GE | 1 |
| Bendtsen, A | 1 |
| Møller Sørensen, P | 1 |
| Mies, G | 1 |
| Niebuhr, I | 1 |
| Hossmann, KA | 1 |
| Steen, RG | 1 |
| Kitagishi, K | 1 |
| Morgan, K | 1 |
| Kimler, BF | 1 |
| Liu, C | 1 |
| Evans, RG | 1 |
| Morantz, RA | 1 |
| Olson, JJ | 2 |
| Shelley, C | 1 |
| Orr, K | 2 |
| DeLaney, T | 2 |
| Oldfield, EH | 2 |
| Friedman, R | 1 |
| Shapiro, HM | 1 |
| Wyte, SR | 1 |
| Loeser, J | 1 |
11 other studies available for pentobarbital and Brain Neoplasms
| Article | Year |
|---|---|
Role of barbiturate coma in the management of focally induced, severe cerebral edema in children.
Topics: Brain Edema; Brain Neoplasms; Cerebral Hemorrhage; Child; Child, Preschool; Coma; Drug Administratio | 2013 |
Anesthetic pentobarbital inhibits proliferation and migration of malignant glioma cells.
Topics: Animals; Brain Neoplasms; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Movement; Cell Survival; | 2009 |
[SIGNIFICANCE OF GENERAL ANESTHESIA IN NEUROSURGERY].
Topics: Anesthesia; Anesthesia, Endotracheal; Anesthesia, General; Brain Neoplasms; Cerebral Angiography; Ce | 1964 |
STUDIES ON PROTEIN SYNTHESIS IN BRAIN MICROSOMAL SYSTEM.
Topics: Amino Acids; Biomedical Research; Brain; Brain Diseases; Brain Neoplasms; Dementia; Electrons; Ether | 1964 |
Minimum cerebral blood flow and metabolism during craniotomy. Effect of thiopental loading.
Topics: Adult; Aged; Anesthesia, General; Anesthesia, Inhalation; Blood Pressure; Brain; Brain Neoplasms; Ce | 1984 |
A double tracer autoradiographic technique for simultaneous measurement of cerebral blood flow and cerebral metabolism in rats.
Topics: Animals; Antipyrine; Autoradiography; Brain; Brain Neoplasms; Cerebrovascular Circulation; Cortical | 1981 |
In vivo measurement of tumor blood oxygenation by near-infrared spectroscopy: immediate effects of pentobarbital overdose or carmustine treatment.
Topics: Animals; Brain Neoplasms; Carmustine; Cerebrovascular Circulation; Gliosarcoma; Hemoglobins; Oxygen; | 1994 |
Effect of pentobarbital on normal brain protection and on the response of 9L rat brain tumor to radiation therapy.
Topics: Animals; Brain; Brain Neoplasms; Dose-Response Relationship, Radiation; Glioma; Ketamine; Male; Pent | 1993 |
The cerebral radioprotective effect of alternative barbiturates to pentobarbital.
Topics: Animals; Barbiturates; Brain Neoplasms; Male; Methohexital; Pentobarbital; Phenobarbital; Radiation | 1992 |
Enhancement of the efficacy of x-irradiation by pentobarbital in a rodent brain-tumor model.
Topics: Animals; Brain; Brain Neoplasms; Disease Models, Animal; Glioma; Male; Pentobarbital; Radiation-Prot | 1990 |
Barbiturate-augmented hypothermia for reduction of persistent intracranial hypertension.
Topics: Adolescent; Blood Pressure; Brain Diseases; Brain Neoplasms; Child; Child, Preschool; Coma; Cranioce | 1974 |