pentobarbital has been researched along with Aura in 33 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs), mossy fibre sprouting and hippocampal neurodegeneration in rats." | 7.75 | Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy. ( Lebrun, I; Luongo, R; Oliveira, DA; Sandoval, MR, 2009) |
| "Pentobarbital (PB) was used for comparison." | 5.28 | Anticonvulsive activity of a barbiturate derivative HB-7 in a model of allylglycine-induced epilepsy in cats. ( Georgiev, V; Getova, D; Ivanova, V; Moyanova, S, 1990) |
| " The maximal electroshock test (MES) and pentylenetertrazole (PTZ)-induced seizures in male mice were used to evaluate anticonvulsant activities of eudesmin, and sedative effects of eudesmin were evaluated by pentobarbital sodium-induced sleeping time (PST) and locomotor activity in mice." | 3.81 | Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats. ( He, J; Lei, JP; Liao, DG; Liu, F; Liu, H; Luo, K; Song, Z; Yang, L; Zhang, TY; Zhuang, K, 2015) |
| " The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs), mossy fibre sprouting and hippocampal neurodegeneration in rats." | 3.75 | Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy. ( Lebrun, I; Luongo, R; Oliveira, DA; Sandoval, MR, 2009) |
| " The muscarinic convulsant pilocarpine was used to elicit status epilepticus (SE) in adult female Sprague Dawley rats." | 3.75 | A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures. ( Friedman, D; Harden, CL; Maclusky, NJ; Malthankar-Phatak, GH; McCloskey, DP; Pearce, P; Scharfman, HE, 2009) |
| "2) Effective, seizures ceased but recurred with a decreased dose of PTB." | 2.68 | [Clinical study of pentobarbital treatment for status convulsivus in 14 children]. ( Kobayashi, K; Sato, M; Watanabe, T, 1996) |
| "Seizures were detected in 19% (n = 110) of patients who underwent cEEG monitoring; the seizures were exclusively nonconvulsive in 92% (n = 101) of these patients." | 2.42 | Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. ( Claassen, J; Emerson, RG; Hirsch, LJ; Kowalski, RG; Mayer, SA, 2004) |
| "Sequelae and risk for recurrence of SE are primarily related to the underlying cause." | 2.39 | Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. ( Mitchell, WG, 1996) |
| " In order to use these effectively, the critical care nurse must be aware of the indications and controversies surrounding their use, the patho-physiologic conditions that impact on the disposition, and appropriate dosing and monitoring of these agents in the critical care setting." | 2.38 | Anticonvulsants: pharmacotherapeutic issues in the critically ill patient. ( Dupuis, RE; Miranda-Massari, J, 1991) |
| " Plasma concentrations of total phenytoin, unbound phenytoin, and the major metabolite of phenytoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin, were measured, and pharmacokinetic variables obtained before and after barbiturate therapy were compared." | 1.29 | Effect of barbiturate therapy on phenytoin pharmacokinetics. ( Abe, J; Asada, A; Fujimori, M; Kaji, A; Nishi, S; Oda, Y; Yoshida, N, 1993) |
| "Loreclezole was also shown to inhibit 'low Ca2+' and 'low Mg2+' epileptogenesis at similar concentrations to those active on inhibition." | 1.28 | In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus. ( Ashton, D; Willems, R, 1992) |
| "Pentobarbital (PB) was used for comparison." | 1.28 | Anticonvulsive activity of a barbiturate derivative HB-7 in a model of allylglycine-induced epilepsy in cats. ( Georgiev, V; Getova, D; Ivanova, V; Moyanova, S, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (36.36) | 18.7374 |
| 1990's | 11 (33.33) | 18.2507 |
| 2000's | 8 (24.24) | 29.6817 |
| 2010's | 1 (3.03) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Bodor, GS | 1 |
| Rands, AJ | 1 |
| Liu, H | 1 |
| Song, Z | 1 |
| Liao, DG | 1 |
| Zhang, TY | 1 |
| Liu, F | 1 |
| Zhuang, K | 1 |
| Luo, K | 1 |
| Yang, L | 1 |
| He, J | 1 |
| Lei, JP | 1 |
| Luongo, R | 1 |
| Oliveira, DA | 1 |
| Lebrun, I | 1 |
| Sandoval, MR | 1 |
| Scharfman, HE | 1 |
| Malthankar-Phatak, GH | 1 |
| Friedman, D | 1 |
| Pearce, P | 1 |
| McCloskey, DP | 1 |
| Harden, CL | 1 |
| Maclusky, NJ | 1 |
| Yee, AS | 1 |
| Longacher, JM | 1 |
| Staley, KJ | 1 |
| Khazipov, R | 1 |
| Holmes, GL | 1 |
| SHIMIZU, K | 1 |
| REFSUM, S | 1 |
| GIBBS, FA | 1 |
| PLOTNIKOFF, NP | 1 |
| Claassen, J | 1 |
| Mayer, SA | 1 |
| Kowalski, RG | 1 |
| Emerson, RG | 1 |
| Hirsch, LJ | 1 |
| Quilichini, PP | 1 |
| Chiron, C | 1 |
| Ben-Ari, Y | 1 |
| Gozlan, H | 1 |
| Jugovac, I | 1 |
| Imas, O | 1 |
| Hudetz, AG | 1 |
| Lemos, T | 2 |
| Cavalheiro, EA | 2 |
| Yoshida, N | 1 |
| Oda, Y | 1 |
| Nishi, S | 1 |
| Abe, J | 1 |
| Kaji, A | 1 |
| Asada, A | 1 |
| Fujimori, M | 1 |
| Mitchell, WG | 1 |
| Kobayashi, K | 1 |
| Watanabe, T | 1 |
| Sato, M | 1 |
| Lazar, LM | 1 |
| Milrod, LM | 1 |
| Solomon, GE | 1 |
| Labar, DR | 1 |
| Kasture, VS | 1 |
| Chopde, CT | 1 |
| Deshmukh, VK | 1 |
| González Macías, J | 1 |
| De Castro del Pozo, S | 1 |
| Blom, S | 1 |
| Heijbel, J | 1 |
| Ashton, D | 1 |
| Willems, R | 1 |
| Popoli, P | 1 |
| Pezzola, A | 1 |
| Sagratella, S | 1 |
| Zeng, YC | 1 |
| Scotti de Carolis, A | 1 |
| Dupuis, RE | 1 |
| Miranda-Massari, J | 1 |
| Getova, D | 2 |
| Moyanova, S | 2 |
| Georgiev, V | 1 |
| Ivanova, V | 1 |
| Miller, JW | 1 |
| Ferrendelli, JA | 1 |
| Wu, LW | 1 |
| Wei, J | 1 |
| Guo, DH | 1 |
| Feng, YK | 1 |
| Koga, K | 1 |
| Miura, I | 1 |
| Vourc'h, G | 1 |
| Arfel, G | 1 |
| Besson, JM | 1 |
| Jelínek, JM | 1 |
| Hohenauer, L | 1 |
| Servít, Z | 1 |
| Strejcková, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Trial of Nonconvulsive Electrographic Seizure Detection by Nurses in the Adult Neuro ICU Using a Panel of Quantitative EEG Trends[NCT02082873] | 20 participants (Actual) | Observational | 2015-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for pentobarbital and Aura
| Article | Year |
|---|---|
Detection of electrographic seizures with continuous EEG monitoring in critically ill patients.
Topics: Adult; Aged; Anticonvulsants; Brain Diseases; Child; Child, Preschool; Cohort Studies; Coma; Conscio | 2004 |
Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Benzodiazepines; Central Nervous System Disea | 1996 |
Anticonvulsants: pharmacotherapeutic issues in the critically ill patient.
Topics: Anticonvulsants; Benzodiazepines; Brain Injuries; Carbamazepine; Central Nervous System Diseases; Ep | 1991 |
1 trial available for pentobarbital and Aura
| Article | Year |
|---|---|
[Clinical study of pentobarbital treatment for status convulsivus in 14 children].
Topics: Child; Child, Preschool; Encephalitis; Epilepsy; Female; Humans; Hypnotics and Sedatives; Infant; Ma | 1996 |
29 other studies available for pentobarbital and Aura
| Article | Year |
|---|---|
Quantitative LC-MS/MS Method for the Simultaneous Measurement of Six Antiepileptics and Pentobarbital in Human Serum.
Topics: Anticonvulsants; Chromatography, Liquid; Drug Monitoring; Epilepsy; Humans; Levetiracetam; Pentobarb | 2024 |
DIAGNOSTIC acid in epilepsy. Nembutal-induced sleep improves E. E. G.
Topics: Barbital; Electroencephalography; Epilepsy; Pentobarbital; Sleep | 1951 |
Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats.
Topics: Acorus; Animals; Anticonvulsants; Brain; Caspase 3; Disease Models, Animal; Electroshock; Epilepsy; | 2015 |
Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Count; Cell Death; Diazepam; Electroencephalogr | 2009 |
A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Estrous Cycle; Female; Pentobarbital; Pi | 2009 |
Convulsant and anticonvulsant effects on spontaneous CA3 population bursts.
Topics: Acetazolamide; Action Potentials; Animals; Anticonvulsants; Convulsants; Epilepsy; Hippocampus; Mode | 2003 |
Synchronization of kainate-induced epileptic activity via GABAergic inhibition in the superfused rat hippocampus in vivo.
Topics: Action Potentials; Animals; Diffusion Chambers, Culture; Disease Models, Animal; Electroencephalogra | 2003 |
Effect on the electrical activity of the brain of intra-arterially and intra-cerebrally injected convulsant and sedative drugs (metrazol and nembutal).
Topics: Barbiturates; Brain; Convulsants; Electroencephalography; Epilepsy; Humans; Hypnotics and Sedatives; | 1952 |
EFFECT OF PSYCHOACTIVE DRUGS ON ESCAPE FROM AUDIOGENIC SEIZURES.
Topics: Behavior, Animal; Chlorpromazine; Epilepsy; Imipramine; Mice; Pentobarbital; Perphenazine; Pharmacol | 1963 |
Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels.
Topics: Animals; Animals, Newborn; Anticonvulsants; Chloride Channels; Dioxolanes; Disease Models, Animal; D | 2006 |
Supraspinal anesthesia: behavioral and electroencephalographic effects of intracerebroventricularly infused pentobarbital, propofol, fentanyl, and midazolam.
Topics: Anesthetics, Intravenous; Animals; Behavior, Animal; Brain; Consciousness; Data Interpretation, Stat | 2006 |
Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats.
Topics: Animals; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy; Hippocampus; Histocytochemistr | 1995 |
Effect of barbiturate therapy on phenytoin pharmacokinetics.
Topics: Adult; Aged; Aged, 80 and over; Critical Illness; Epilepsy; Female; Humans; Intracranial Pressure; M | 1993 |
Status epilepticus and the late development of spontaneous seizures in the pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Brain Mapping; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy | 1996 |
Asynchronous pentobarbital-induced burst suppression with corpus callosum hemorrhage.
Topics: Cerebral Hemorrhage; Child; Corpus Callosum; Electroencephalography; Epilepsy; Female; Humans; Pento | 1999 |
Anticonvulsive activity of Albizzia lebbeck, Hibiscus rosa sinesis and Butea monosperma in experimental animals.
Topics: Amphetamine; Animals; Anticonvulsants; Behavior, Animal; Brain Chemistry; Central Nervous System Sti | 2000 |
[Metabolism of phenylbutazone in the liver (author's transl)].
Topics: Alcoholism; Cholestasis; Diabetes Mellitus; Enzyme Induction; Epilepsy; Ethanol; Half-Life; Hepatiti | 1976 |
Benign epilepsy of children with centro-temporal EEG foci. Discharge rate during sleep.
Topics: Adolescent; Brain; Child; Child, Preschool; Chlorpromazine; Electroencephalography; Epilepsy; Female | 1975 |
In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus.
Topics: Animals; Anticonvulsants; Calcium; Electric Stimulation; Epilepsy; Etomidate; gamma-Aminobutyric Aci | 1992 |
Cromakalim (BRL 34915) counteracts the epileptiform activity elicited by diltiazem and verapamil in rats.
Topics: Animals; Anticonvulsants; Benzopyrans; Cromakalim; Diltiazem; Electric Stimulation; Electroencephalo | 1991 |
Anticonvulsive activity of a barbiturate derivative HB-7 in a model of allylglycine-induced epilepsy in cats.
Topics: Allylglycine; Animals; Anticonvulsants; Cats; Electroencephalography; Epilepsy; Pentobarbital; Photi | 1990 |
Characterization of GABAergic seizure regulation in the midline thalamus.
Topics: Animals; Baclofen; Bicuculline; Electroencephalography; Epilepsy; Female; Flurazepam; gamma-Aminobut | 1990 |
[Clinical observation of sleep EEG induced by pentobarbital in epileptic patients].
Topics: Electroencephalography; Epilepsy; Humans; Pentobarbital; Sleep | 1987 |
A measurement of cerebral glucose uptake rate by 31P MRS.
Topics: Analgesia; Animals; Bicuculline; Blood Pressure; Brain; Deoxy Sugars; Deoxyglucose; Epilepsy; Glucos | 1988 |
Anticonvulsive effect of 2-hydroxylamine-5-ethyl-5-sec-pentyl barbituric acid (HB-7) in two experimental models of epilepsy.
Topics: Animals; Anticonvulsants; Cats; Electroencephalography; Epilepsy; Penicillins; Pentobarbital | 1988 |
[Effects of some anesthetics on the cerebral electric activity].
Topics: Analgesics; Anesthetics; Animals; Brain; Cats; Electroencephalography; Epilepsy; Evoked Potentials; | 1972 |
The effect of some androgenic steroids on anesthesia.
Topics: Anesthesia, Intravenous; Animals; Castration; Epilepsy; Female; Male; Methandrostenolone; Methyltest | 1968 |
[Fever convulsions].
Topics: Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Fever; Humans; Long-Term Care; | 1972 |
Thalamocortical relations and the genesis of epileptic electrographic phenomena in the forebrain of the turtle.
Topics: Animals; Biological Evolution; Cerebral Cortex; Electroencephalography; Epilepsy; Frontal Lobe; Neur | 1972 |