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pentobarbital and Aura

pentobarbital has been researched along with Aura in 33 studies

Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.

Research Excerpts

ExcerptRelevanceReference
" The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs), mossy fibre sprouting and hippocampal neurodegeneration in rats."7.75Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy. ( Lebrun, I; Luongo, R; Oliveira, DA; Sandoval, MR, 2009)
"Pentobarbital (PB) was used for comparison."5.28Anticonvulsive activity of a barbiturate derivative HB-7 in a model of allylglycine-induced epilepsy in cats. ( Georgiev, V; Getova, D; Ivanova, V; Moyanova, S, 1990)
" The maximal electroshock test (MES) and pentylenetertrazole (PTZ)-induced seizures in male mice were used to evaluate anticonvulsant activities of eudesmin, and sedative effects of eudesmin were evaluated by pentobarbital sodium-induced sleeping time (PST) and locomotor activity in mice."3.81Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats. ( He, J; Lei, JP; Liao, DG; Liu, F; Liu, H; Luo, K; Song, Z; Yang, L; Zhang, TY; Zhuang, K, 2015)
" The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs), mossy fibre sprouting and hippocampal neurodegeneration in rats."3.75Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy. ( Lebrun, I; Luongo, R; Oliveira, DA; Sandoval, MR, 2009)
" The muscarinic convulsant pilocarpine was used to elicit status epilepticus (SE) in adult female Sprague Dawley rats."3.75A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures. ( Friedman, D; Harden, CL; Maclusky, NJ; Malthankar-Phatak, GH; McCloskey, DP; Pearce, P; Scharfman, HE, 2009)
"2) Effective, seizures ceased but recurred with a decreased dose of PTB."2.68[Clinical study of pentobarbital treatment for status convulsivus in 14 children]. ( Kobayashi, K; Sato, M; Watanabe, T, 1996)
"Seizures were detected in 19% (n = 110) of patients who underwent cEEG monitoring; the seizures were exclusively nonconvulsive in 92% (n = 101) of these patients."2.42Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. ( Claassen, J; Emerson, RG; Hirsch, LJ; Kowalski, RG; Mayer, SA, 2004)
"Sequelae and risk for recurrence of SE are primarily related to the underlying cause."2.39Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. ( Mitchell, WG, 1996)
" In order to use these effectively, the critical care nurse must be aware of the indications and controversies surrounding their use, the patho-physiologic conditions that impact on the disposition, and appropriate dosing and monitoring of these agents in the critical care setting."2.38Anticonvulsants: pharmacotherapeutic issues in the critically ill patient. ( Dupuis, RE; Miranda-Massari, J, 1991)
" Plasma concentrations of total phenytoin, unbound phenytoin, and the major metabolite of phenytoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin, were measured, and pharmacokinetic variables obtained before and after barbiturate therapy were compared."1.29Effect of barbiturate therapy on phenytoin pharmacokinetics. ( Abe, J; Asada, A; Fujimori, M; Kaji, A; Nishi, S; Oda, Y; Yoshida, N, 1993)
"Loreclezole was also shown to inhibit 'low Ca2+' and 'low Mg2+' epileptogenesis at similar concentrations to those active on inhibition."1.28In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus. ( Ashton, D; Willems, R, 1992)
"Pentobarbital (PB) was used for comparison."1.28Anticonvulsive activity of a barbiturate derivative HB-7 in a model of allylglycine-induced epilepsy in cats. ( Georgiev, V; Getova, D; Ivanova, V; Moyanova, S, 1990)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199012 (36.36)18.7374
1990's11 (33.33)18.2507
2000's8 (24.24)29.6817
2010's1 (3.03)24.3611
2020's1 (3.03)2.80

Authors

AuthorsStudies
Bodor, GS1
Rands, AJ1
Liu, H1
Song, Z1
Liao, DG1
Zhang, TY1
Liu, F1
Zhuang, K1
Luo, K1
Yang, L1
He, J1
Lei, JP1
Luongo, R1
Oliveira, DA1
Lebrun, I1
Sandoval, MR1
Scharfman, HE1
Malthankar-Phatak, GH1
Friedman, D1
Pearce, P1
McCloskey, DP1
Harden, CL1
Maclusky, NJ1
Yee, AS1
Longacher, JM1
Staley, KJ1
Khazipov, R1
Holmes, GL1
SHIMIZU, K1
REFSUM, S1
GIBBS, FA1
PLOTNIKOFF, NP1
Claassen, J1
Mayer, SA1
Kowalski, RG1
Emerson, RG1
Hirsch, LJ1
Quilichini, PP1
Chiron, C1
Ben-Ari, Y1
Gozlan, H1
Jugovac, I1
Imas, O1
Hudetz, AG1
Lemos, T2
Cavalheiro, EA2
Yoshida, N1
Oda, Y1
Nishi, S1
Abe, J1
Kaji, A1
Asada, A1
Fujimori, M1
Mitchell, WG1
Kobayashi, K1
Watanabe, T1
Sato, M1
Lazar, LM1
Milrod, LM1
Solomon, GE1
Labar, DR1
Kasture, VS1
Chopde, CT1
Deshmukh, VK1
González Macías, J1
De Castro del Pozo, S1
Blom, S1
Heijbel, J1
Ashton, D1
Willems, R1
Popoli, P1
Pezzola, A1
Sagratella, S1
Zeng, YC1
Scotti de Carolis, A1
Dupuis, RE1
Miranda-Massari, J1
Getova, D2
Moyanova, S2
Georgiev, V1
Ivanova, V1
Miller, JW1
Ferrendelli, JA1
Wu, LW1
Wei, J1
Guo, DH1
Feng, YK1
Koga, K1
Miura, I1
Vourc'h, G1
Arfel, G1
Besson, JM1
Jelínek, JM1
Hohenauer, L1
Servít, Z1
Strejcková, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective Trial of Nonconvulsive Electrographic Seizure Detection by Nurses in the Adult Neuro ICU Using a Panel of Quantitative EEG Trends[NCT02082873]20 participants (Actual)Observational2015-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for pentobarbital and Aura

ArticleYear
Detection of electrographic seizures with continuous EEG monitoring in critically ill patients.
    Neurology, 2004, May-25, Volume: 62, Issue:10

    Topics: Adult; Aged; Anticonvulsants; Brain Diseases; Child; Child, Preschool; Cohort Studies; Coma; Conscio

2004
Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment.
    Epilepsia, 1996, Volume: 37 Suppl 1

    Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Benzodiazepines; Central Nervous System Disea

1996
Anticonvulsants: pharmacotherapeutic issues in the critically ill patient.
    AACN clinical issues in critical care nursing, 1991, Volume: 2, Issue:4

    Topics: Anticonvulsants; Benzodiazepines; Brain Injuries; Carbamazepine; Central Nervous System Diseases; Ep

1991

Trials

1 trial available for pentobarbital and Aura

ArticleYear
[Clinical study of pentobarbital treatment for status convulsivus in 14 children].
    No to hattatsu = Brain and development, 1996, Volume: 28, Issue:6

    Topics: Child; Child, Preschool; Encephalitis; Epilepsy; Female; Humans; Hypnotics and Sedatives; Infant; Ma

1996

Other Studies

29 other studies available for pentobarbital and Aura

ArticleYear
Quantitative LC-MS/MS Method for the Simultaneous Measurement of Six Antiepileptics and Pentobarbital in Human Serum.
    Methods in molecular biology (Clifton, N.J.), 2024, Volume: 2737

    Topics: Anticonvulsants; Chromatography, Liquid; Drug Monitoring; Epilepsy; Humans; Levetiracetam; Pentobarb

2024
DIAGNOSTIC acid in epilepsy. Nembutal-induced sleep improves E. E. G.
    What's new, 1951, Volume: 156

    Topics: Barbital; Electroencephalography; Epilepsy; Pentobarbital; Sleep

1951
Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats.
    Phytotherapy research : PTR, 2015, Volume: 29, Issue:7

    Topics: Acorus; Animals; Anticonvulsants; Brain; Caspase 3; Disease Models, Animal; Electroshock; Epilepsy;

2015
Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy.
    Brain research bulletin, 2009, Jun-30, Volume: 79, Issue:5

    Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Count; Cell Death; Diazepam; Electroencephalogr

2009
A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures.
    Endocrinology, 2009, Volume: 150, Issue:9

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Estrous Cycle; Female; Pentobarbital; Pi

2009
Convulsant and anticonvulsant effects on spontaneous CA3 population bursts.
    Journal of neurophysiology, 2003, Volume: 89, Issue:1

    Topics: Acetazolamide; Action Potentials; Animals; Anticonvulsants; Convulsants; Epilepsy; Hippocampus; Mode

2003
Synchronization of kainate-induced epileptic activity via GABAergic inhibition in the superfused rat hippocampus in vivo.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Jun-15, Volume: 23, Issue:12

    Topics: Action Potentials; Animals; Diffusion Chambers, Culture; Disease Models, Animal; Electroencephalogra

2003
Effect on the electrical activity of the brain of intra-arterially and intra-cerebrally injected convulsant and sedative drugs (metrazol and nembutal).
    Electroencephalography and clinical neurophysiology, 1952, Volume: 4, Issue:2

    Topics: Barbiturates; Brain; Convulsants; Electroencephalography; Epilepsy; Humans; Hypnotics and Sedatives;

1952
EFFECT OF PSYCHOACTIVE DRUGS ON ESCAPE FROM AUDIOGENIC SEIZURES.
    Archives internationales de pharmacodynamie et de therapie, 1963, Oct-01, Volume: 145

    Topics: Behavior, Animal; Chlorpromazine; Epilepsy; Imipramine; Mice; Pentobarbital; Perphenazine; Pharmacol

1963
Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels.
    Epilepsia, 2006, Volume: 47, Issue:4

    Topics: Animals; Animals, Newborn; Anticonvulsants; Chloride Channels; Dioxolanes; Disease Models, Animal; D

2006
Supraspinal anesthesia: behavioral and electroencephalographic effects of intracerebroventricularly infused pentobarbital, propofol, fentanyl, and midazolam.
    Anesthesiology, 2006, Volume: 105, Issue:4

    Topics: Anesthetics, Intravenous; Animals; Behavior, Animal; Brain; Consciousness; Data Interpretation, Stat

2006
Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats.
    Experimental brain research, 1995, Volume: 102, Issue:3

    Topics: Animals; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy; Hippocampus; Histocytochemistr

1995
Effect of barbiturate therapy on phenytoin pharmacokinetics.
    Critical care medicine, 1993, Volume: 21, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Critical Illness; Epilepsy; Female; Humans; Intracranial Pressure; M

1993
Status epilepticus and the late development of spontaneous seizures in the pilocarpine model of epilepsy.
    Epilepsy research. Supplement, 1996, Volume: 12

    Topics: Animals; Anticonvulsants; Brain Mapping; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy

1996
Asynchronous pentobarbital-induced burst suppression with corpus callosum hemorrhage.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 1999, Volume: 110, Issue:6

    Topics: Cerebral Hemorrhage; Child; Corpus Callosum; Electroencephalography; Epilepsy; Female; Humans; Pento

1999
Anticonvulsive activity of Albizzia lebbeck, Hibiscus rosa sinesis and Butea monosperma in experimental animals.
    Journal of ethnopharmacology, 2000, Volume: 71, Issue:1-2

    Topics: Amphetamine; Animals; Anticonvulsants; Behavior, Animal; Brain Chemistry; Central Nervous System Sti

2000
[Metabolism of phenylbutazone in the liver (author's transl)].
    Medizinische Klinik, 1976, Sep-03, Volume: 71, Issue:36

    Topics: Alcoholism; Cholestasis; Diabetes Mellitus; Enzyme Induction; Epilepsy; Ethanol; Half-Life; Hepatiti

1976
Benign epilepsy of children with centro-temporal EEG foci. Discharge rate during sleep.
    Epilepsia, 1975, Volume: 16, Issue:1

    Topics: Adolescent; Brain; Child; Child, Preschool; Chlorpromazine; Electroencephalography; Epilepsy; Female

1975
In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus.
    Epilepsy research, 1992, Volume: 11, Issue:2

    Topics: Animals; Anticonvulsants; Calcium; Electric Stimulation; Epilepsy; Etomidate; gamma-Aminobutyric Aci

1992
Cromakalim (BRL 34915) counteracts the epileptiform activity elicited by diltiazem and verapamil in rats.
    British journal of pharmacology, 1991, Volume: 104, Issue:4

    Topics: Animals; Anticonvulsants; Benzopyrans; Cromakalim; Diltiazem; Electric Stimulation; Electroencephalo

1991
Anticonvulsive activity of a barbiturate derivative HB-7 in a model of allylglycine-induced epilepsy in cats.
    Acta physiologica et pharmacologica Bulgarica, 1990, Volume: 16, Issue:3

    Topics: Allylglycine; Animals; Anticonvulsants; Cats; Electroencephalography; Epilepsy; Pentobarbital; Photi

1990
Characterization of GABAergic seizure regulation in the midline thalamus.
    Neuropharmacology, 1990, Volume: 29, Issue:7

    Topics: Animals; Baclofen; Bicuculline; Electroencephalography; Epilepsy; Female; Flurazepam; gamma-Aminobut

1990
[Clinical observation of sleep EEG induced by pentobarbital in epileptic patients].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1987, Volume: 9, Issue:2

    Topics: Electroencephalography; Epilepsy; Humans; Pentobarbital; Sleep

1987
A measurement of cerebral glucose uptake rate by 31P MRS.
    Biochemical and biophysical research communications, 1988, Dec-30, Volume: 157, Issue:3

    Topics: Analgesia; Animals; Bicuculline; Blood Pressure; Brain; Deoxy Sugars; Deoxyglucose; Epilepsy; Glucos

1988
Anticonvulsive effect of 2-hydroxylamine-5-ethyl-5-sec-pentyl barbituric acid (HB-7) in two experimental models of epilepsy.
    Methods and findings in experimental and clinical pharmacology, 1988, Volume: 10, Issue:4

    Topics: Animals; Anticonvulsants; Cats; Electroencephalography; Epilepsy; Penicillins; Pentobarbital

1988
[Effects of some anesthetics on the cerebral electric activity].
    Actualites neurophysiologiques, 1972, Volume: 9, Issue:0

    Topics: Analgesics; Anesthetics; Animals; Brain; Cats; Electroencephalography; Epilepsy; Evoked Potentials;

1972
The effect of some androgenic steroids on anesthesia.
    Acta biologica et medica Germanica, 1968, Volume: 20, Issue:4

    Topics: Anesthesia, Intravenous; Animals; Castration; Epilepsy; Female; Male; Methandrostenolone; Methyltest

1968
[Fever convulsions].
    Deutsche medizinische Wochenschrift (1946), 1972, Oct-20, Volume: 97, Issue:42

    Topics: Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Fever; Humans; Long-Term Care;

1972
Thalamocortical relations and the genesis of epileptic electrographic phenomena in the forebrain of the turtle.
    Experimental neurology, 1972, Volume: 35, Issue:1

    Topics: Animals; Biological Evolution; Cerebral Cortex; Electroencephalography; Epilepsy; Frontal Lobe; Neur

1972