pentobarbital has been researched along with Ataxia in 24 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Four groups of rats received chlordiazepoxide (CDP): a) intermittently, experiencing hypothermia and rotarod performance (RR) deficit after test doses (contingency); b) chronically, experiencing hypothermia and RR deficit after test doses; c) intermittently, RR preceding test doses and with protection against hypothermia afforded by exposure to heat lamps (nonexperienced, noncontingency); and d) chronically, RR preceding test doses and with protection against hypothermia." | 7.68 | Cellular and learned tolerances to chlordiazepoxide hypothermia and ataxia. ( MacKenzie-Taylor, DR; Rech, RH, 1993) |
| "Pentobarbital was administered to 4 groups of rats: 1) intermittently before testing on the rotarod (RR) (experienced, EXP), 2) chronically (CHR) before testing on the RR (EXP), 3) intermittently (INT) after being tested on the RR (NONEXP), and 4) chronically (CHR) after being tested on the RR (NONEXP)." | 5.28 | Cellular and learned tolerance to pentobarbital ataxia. ( MacKenzie-Taylor, DR; Rech, RH, 1991) |
| " and intracerebroventricular pentobarbital-induced sedation and alcohol-induced ataxia models." | 3.76 | Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H. ( Bagad, AS; Bahekar, PC; Chidrewar, GU; Mandhane, SN; Mehetre, SV; Pawar, CA; Rajamannar, T; Rao, CT; Shah, JH, 2010) |
| " Acute nitrendipine significantly increased the latency of seizures in response to the partial benzodiazepine inverse agonist FG7142 during barbiturate withdrawal, but there was no effect on the seizure incidence in response to bicuculline." | 3.69 | Dihydropyridine-sensitive calcium channels and barbiturate tolerance and withdrawal. ( Brown, J; Butterworth, AR; Little, HJ; Rabbani, M, 1994) |
| "Four groups of rats received chlordiazepoxide (CDP): a) intermittently, experiencing hypothermia and rotarod performance (RR) deficit after test doses (contingency); b) chronically, experiencing hypothermia and RR deficit after test doses; c) intermittently, RR preceding test doses and with protection against hypothermia afforded by exposure to heat lamps (nonexperienced, noncontingency); and d) chronically, RR preceding test doses and with protection against hypothermia." | 3.68 | Cellular and learned tolerances to chlordiazepoxide hypothermia and ataxia. ( MacKenzie-Taylor, DR; Rech, RH, 1993) |
| "The ataxia was significantly more pronounced earlier in males than in females, although the sex difference became insignificant 18 d after dosing." | 1.28 | Role of socialization, stress and sex of chickens on response to anesthesia and on response to an organophosphate neurotoxicant. ( Ehrich, M; Gross, WB; Odom, A, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (45.83) | 18.7374 |
| 1990's | 8 (33.33) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Linden, AM | 1 |
| Aller, MI | 1 |
| Leppä, E | 1 |
| Rosenberg, PH | 1 |
| Wisden, W | 1 |
| Korpi, ER | 1 |
| Mandhane, SN | 1 |
| Shah, JH | 1 |
| Bahekar, PC | 1 |
| Mehetre, SV | 1 |
| Pawar, CA | 1 |
| Bagad, AS | 1 |
| Chidrewar, GU | 1 |
| Rao, CT | 1 |
| Rajamannar, T | 1 |
| ITOH, H | 1 |
| HORIGUCHI, Y | 1 |
| YAMAGUCHI, T | 1 |
| YAMASAWA, S | 1 |
| SAKUMA, A | 1 |
| YAJIMA, M | 1 |
| Maas, JW | 1 |
| Vogt, SK | 1 |
| Chan, GC | 1 |
| Pineda, VV | 1 |
| Storm, DR | 1 |
| Muglia, LJ | 1 |
| Hefner, K | 1 |
| Holmes, A | 2 |
| Boyce-Rustay, JM | 1 |
| Cameron, HA | 1 |
| Griffiths, RR | 1 |
| Bigelow, GE | 1 |
| Liebson, I | 1 |
| Ikeda, H | 1 |
| Rabbani, M | 1 |
| Brown, J | 1 |
| Butterworth, AR | 1 |
| Little, HJ | 1 |
| MacKenzie-Taylor, DR | 2 |
| Rech, RH | 2 |
| Kim, CK | 1 |
| Kalynchuk, LE | 1 |
| Pinel, JP | 1 |
| Kippin, TE | 1 |
| Vatine, JJ | 1 |
| Ratner, A | 1 |
| Dvorkin, M | 1 |
| Seltzer, Z | 1 |
| Vanover, KE | 1 |
| Maeda, H | 1 |
| Hayes, AW | 1 |
| Presley, DB | 1 |
| Neville, JA | 1 |
| Odom, A | 1 |
| Gross, WB | 1 |
| Ehrich, M | 1 |
| Sklow, B | 1 |
| Sinnamon, HM | 1 |
| Brittain, RT | 1 |
| Goldberg, SR | 1 |
| Hoffmeister, F | 1 |
| Schlichting, UU | 1 |
| Wuttke, W | 1 |
| Bradshaw, EG | 1 |
| Pleuvry, BJ | 1 |
| Bhargava, UC | 1 |
| Westfall, BA | 1 |
| Siehr, DJ | 1 |
| Daly, RJ | 1 |
| Kane, FJ | 1 |
| Stark, P | 1 |
| Henderson, JK | 1 |
24 other studies available for pentobarbital and Ataxia
| Article | Year |
|---|---|
K+ channel TASK-1 knockout mice show enhanced sensitivities to ataxic and hypnotic effects of GABA(A) receptor ligands.
Topics: Animals; Anti-Anxiety Agents; Ataxia; Benzodiazepines; Brain; Diazepam; Female; Flurazepam; Hypnotic | 2008 |
Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H.
Topics: Acetates; Alcohols; Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ataxia; Cetirizin | 2010 |
EXAMINATIONS ON INTRAPERITONEAL INJECTION.
Topics: Acetylcholine; Animals; Apomorphine; Ataxia; Atropine; Blood Chemical Analysis; Carbon Tetrachloride | 1963 |
Calcium-stimulated adenylyl cyclases are critical modulators of neuronal ethanol sensitivity.
Topics: Adenylyl Cyclases; Analysis of Variance; Animals; Ataxia; Behavior, Animal; Blotting, Western; Calci | 2005 |
An investigation of the behavioral actions of ethanol across adolescence in mice.
Topics: Age Factors; Alcohol Drinking; Analysis of Variance; Animals; Ataxia; Behavior, Animal; Central Nerv | 2007 |
Chronic swim stress alters sensitivity to acute behavioral effects of ethanol in mice.
Topics: Alcohol Drinking; Animals; Ataxia; Behavior, Animal; Body Temperature; Central Nervous System Depres | 2007 |
Human preference comparison of pentobarbital, diazepam, and placebo.
Topics: Ataxia; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hypnotics and Sedat | 1981 |
[Pharmacological studies on the functional development of the central nervous system in first generation rats born to phenytoin-treated mothers (author's transl)].
Topics: Animals; Animals, Newborn; Ataxia; Birth Rate; Brain; Catalepsy; Diazepam; Eye; Feeding Behavior; Fe | 1982 |
Dihydropyridine-sensitive calcium channels and barbiturate tolerance and withdrawal.
Topics: Anesthesia, General; Animals; Ataxia; Barbiturates; Bicuculline; Calcium Channels; Carbolines; Dihyd | 1994 |
Cellular and learned tolerances to chlordiazepoxide hypothermia and ataxia.
Topics: Animals; Ataxia; Body Temperature; Chlordiazepoxide; Drug Tolerance; Hypothermia; Learning; Male; Pe | 1993 |
Tolerance to the anticonvulsant and ataxic effects of pentobarbital: effect of an ascending-dose regimen.
Topics: Animals; Anticonvulsants; Ataxia; Dose-Response Relationship, Drug; Drug Tolerance; Kindling, Neurol | 1995 |
A novel computerized system for analyzing motor and social behavior in groups of animals.
Topics: Animals; Ataxia; GABA Modulators; Male; Microcomputers; Motor Activity; Pentobarbital; Rats; Social | 1998 |
Interaction of ethanol with excitatory amino acid receptor antagonists in mice.
Topics: Animals; Ataxia; Behavior, Animal; Benzodiazepines; Central Nervous System Depressants; Chlordiazepo | 1999 |
Effects of psychotropic drugs upon the hypothalamic rage response in cats.
Topics: Anger; Animals; Ataxia; Cats; Chlorpromazine; Diazepam; Haloperidol; Hypothalamus; Hypothalamus, Mid | 1976 |
Acute toxicity of penitrem A in dogs.
Topics: Animals; Ataxia; Blood Cell Count; Diarrhea; Dogs; Enzymes; Female; Liver; Male; Mycotoxins; Pentoba | 1976 |
Role of socialization, stress and sex of chickens on response to anesthesia and on response to an organophosphate neurotoxicant.
Topics: Anesthesia; Animals; Ataxia; Chickens; Female; Male; Noise; Pentobarbital; Plasticizers; Poultry Dis | 1992 |
Cellular and learned tolerance to pentobarbital ataxia.
Topics: Animals; Ataxia; Brain; Drug Tolerance; Extinction, Psychological; Learning; Male; Pentobarbital; Po | 1991 |
Initiation and execution of locomotion elicited by diencephalic stimulation: regional differences in response to nembutal.
Topics: Animals; Ataxia; Behavior, Animal; Diencephalon; Electric Stimulation; Gait; Hypothalamus, Middle; I | 1990 |
The intracerebral effects of noradrenaline and its modification by drugs in the mouse.
Topics: Amitriptyline; Animals; Antidepressive Agents; Ataxia; Atropine; Body Temperature; Brain; Central Ne | 1966 |
A comparison of pentobarbital and cocaine self-administration in rhesus monkeys: effects of dose and fixed-ratio parameter.
Topics: Animals; Ataxia; Cocaine; Conditioning, Classical; Female; Haplorhini; Male; Pentobarbital; Self Sti | 1971 |
Respiratory and hypnotic effects of nitrazepam, diazepam and pentobarbitone and their solvents in the rabbit and the mouse.
Topics: Animals; Ataxia; Benzazepines; Diazepam; Female; Hypnotics and Sedatives; Injections, Intraperitonea | 1971 |
Preliminary pharmacology of ellagic acid from Juglans nigra (black walnut).
Topics: Animals; Anticonvulsants; Ataxia; Benzopyrans; Blood Pressure; Duodenum; Electroshock; Female; Heart | 1968 |
Two severe reactions to benzodiazepine compounds.
Topics: Adult; Alcoholism; Ataxia; Chlordiazepoxide; Diazepam; Drug Synergism; Humans; Male; Middle Aged; Mu | 1965 |
Differentiation of classes of neurosedatives using rats with septal lesions.
Topics: Amobarbital; Animals; Ataxia; Behavior, Animal; Cerebral Ventricles; Chlordiazepoxide; Chlorpromazin | 1966 |