pentobarbital has been researched along with Alzheimer Disease in 4 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pentobarbital treatment reduced 2-DG accumulation in all brain areas examined and these reductions were not influenced by the nBM lesions." | 1.27 | Deoxyglucose uptake and choline acetyltransferase activity in cerebral cortex following lesions of the nucleus basalis magnocellularis. ( Fibiger, HC; Lamarca, MV, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Quiroga, C | 1 |
| Chaparro, RE | 1 |
| Karlnoski, R | 1 |
| Erasso, D | 1 |
| Gordon, M | 1 |
| Morgan, D | 1 |
| Bosco, G | 1 |
| Rubini, A | 1 |
| Parmagnani, A | 1 |
| Paoli, A | 1 |
| Mangar, D | 1 |
| Camporesi, EM | 1 |
| Run, X | 1 |
| Liang, Z | 1 |
| Zhang, L | 1 |
| Iqbal, K | 1 |
| Grundke-Iqbal, I | 1 |
| Gong, CX | 1 |
| Lamarca, MV | 1 |
| Fibiger, HC | 1 |
| Panegyres, PK | 1 |
4 other studies available for pentobarbital and Alzheimer Disease
| Article | Year |
|---|---|
Effects of repetitive exposure to anesthetics and analgesics in the Tg2576 mouse Alzheimer's model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analgesics; Anesthetics; A | 2014 |
Anesthesia induces phosphorylation of tau.
Topics: Adjuvants, Anesthesia; Alzheimer Disease; Anesthetics, Inhalation; Animals; Cognition Disorders; Eth | 2009 |
Deoxyglucose uptake and choline acetyltransferase activity in cerebral cortex following lesions of the nucleus basalis magnocellularis.
Topics: Alzheimer Disease; Animals; Basal Ganglia; Brain Diseases; Cerebral Cortex; Choline O-Acetyltransfer | 1984 |
The effects of excitotoxicity on the expression of the amyloid precursor protein gene in the brain and its modulation by neuroprotective agents.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzofurans; Brain; Dizocilpine Maleate; | 1998 |