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pentobarbital and Aging

pentobarbital has been researched along with Aging in 65 studies

Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The purpose of this study was to determine the relative roles of viral-induced interferon (IFN) and viral infection of the liver in mouse cytomegalovirus (MCMV)-induced depression of cytochrome P-450 (cyt P-450) levels and enhancement of pentobarbital-induced sleeping time (PEN-ST)."7.67Increased susceptibility to pentobarbital following mouse cytomegalovirus infection: relative roles of viral-induced interferon and viral infection of the liver. ( Catignani, JC; Ménache, MG; Selgrade, MK, 1989)
"We recently showed that the glottis is actively closed throughout post-hyperventilation, hypocapnic central apnea in lambs."3.69Prolonged active glottic closure after barbiturate-induced respiratory arrest in lambs. ( Dalle, D; Diaz, V; Kianicka, I; Leroux, JF; Praud, JP, 1996)
"The purpose of this study was to determine the relative roles of viral-induced interferon (IFN) and viral infection of the liver in mouse cytomegalovirus (MCMV)-induced depression of cytochrome P-450 (cyt P-450) levels and enhancement of pentobarbital-induced sleeping time (PEN-ST)."3.67Increased susceptibility to pentobarbital following mouse cytomegalovirus infection: relative roles of viral-induced interferon and viral infection of the liver. ( Catignani, JC; Ménache, MG; Selgrade, MK, 1989)
"The effects of lead acetate and aging on temporally-spaced responding (differential reinforcement of low rate or DRL-20 seconds) were studied."3.66Effects of lead on temporally-spaced responding in rats. ( Dietz, DD; Grant, LD; Kimmel, CA; McMillan, DE, 1978)
"Pentobarbital-treated rats received i."1.31Evidence suggesting that the potentiating action of neuropeptide Y on luteinizing hormone (LH)-releasing hormone-induced LH release remains unaltered in aged female rats. ( Sahu, A, 2000)
" The response to a TRH challenge (10 micrograms/kg) was unaffected by the low dosage of SRIF14 infusion (0."1.28Somatostatin inhibition of thyrotropin-releasing hormone- and growth hormone-releasing factor-induced growth hormone secretion in young and adult anesthetized chickens. ( Harvey, S; Scanes, CG, 1989)
"The diazepam stimuli were dose-dependent in each group."1.27A comparison of diazepam stimuli in aged and adult rats. ( Amrick, CL; Bennett, DA, 1987)
" Increases in pharmacologic effect that occur with aging may be caused by alterations in pharmacokinetic parameters or changes at the site of drug action."1.27Pharmacodynamics and pharmacokinetics of ethanol, diazepam and pentobarbital in young and aged rats. ( Cooper, RL; Guthrie, S; Linnoila, M; Thurman, R, 1987)
"The pentobarbital sleeping time was significantly prolonged following the ozone exposure in both the mice and rats when compared with an air control."1.27Age-dependent inhibition of pentobarbital sleeping time by ozone in mice and rats. ( Calabrese, EJ; Canada, AT; Leonard, D, 1986)
"The 5-hydroxytryptophan-induced rise was prevented by the serotonergic antagonist cyproheptadine but not by the dopaminergic antagonist haloperidol."1.26Maturation of central nervous system control of growth hormone secretion in rats. ( Kuhn, CM; Schanberg, SM, 1981)
" In all cases, data on plasma levels were subjected to pharmacokinetic analyses."1.26Carbamazepine pharmacokinetics in young, adult and pregnant rats. Relation to pharmacological effects. ( Assael, BM; Bossi, L; Garattini, S; Gerna, M; Gomeni, R; Morselli, PL, 1976)
"6 Animals withdrawn following chronic administration of a number of drugs, barbitone, barbitone/bemegride mixture, Mandrax (methaqualone: diphenhydramine; 10: 1), chlordiazepoxide, nitrazepam, chlorpromazine or ethanol, exhibited a significant tolerance to intracerebroventricularly administered pentobarbitone."1.25A study of the factors affecting the sleeping time following intracerebroventricular administration of pentobarbitone sodium: effect of prior administration of centrally active drugs. ( Stevenson, IH; Turnbull, MJ, 1974)

Research

Studies (65)

TimeframeStudies, this research(%)All Research%
pre-199043 (66.15)18.7374
1990's13 (20.00)18.2507
2000's7 (10.77)29.6817
2010's2 (3.08)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ota, Y1
Ago, Y1
Tanaka, T1
Hasebe, S1
Toratani, Y1
Onaka, Y1
Hashimoto, H1
Takuma, K1
Matsuda, T1
Tong, LM1
Yoon, SY1
Andrews-Zwilling, Y1
Yang, A1
Lin, V1
Lei, H1
Huang, Y1
Fu, Y1
Guo, L1
Zhang, J1
Chen, Y1
Wang, X1
Zeng, T1
Tian, S1
Ma, Y1
Yamazaki, H1
Okazaki, M1
Takeda, R1
Haji, A1
Vera, ER1
Battell, ML1
Bhanot, S1
McNeill, JH1
Ma, A1
Guo, H1
Chaudhary, V1
Hansen, R1
Lindgren, H1
Fulton, A1
DESBARATS-SCHONBAUM, ML1
BIRMINGHAM, MK1
JILEK, L3
TROJAN, S3
TRABUCCHI, E1
CHIESARA, E2
KATO, R2
VASSANELLI, P1
FRONTINO, G1
Sato, T1
Kuninaka, A1
Yoshino, H1
Ui, M1
Saito, K1
Goto, M1
Fukuda, H1
Sherman, MP1
Lehrer, RI1
Nass, TE1
Terasawa, E1
Dierschke, DJ1
Goy, RW1
Wise, PM1
Ratner, A1
Kuhn, CM1
Schanberg, SM1
Golda, V1
Petr, R1
Cermák, F1
Malec, R1
Ando, M1
Kleeberg, U1
Klinger, W1
Lee, S1
Panerai, AE1
Bellabarba, D1
Friesen, HG1
Mayevsky, A1
Shaya, B1
Schwartz, JB1
Shen, C1
Garcia, J1
Capili, H1
Sniezek, M1
Griffith, WH1
Murchison, DA1
Tsuchiya, T1
Aguayo, LG1
Alarcón, JM1
Praud, JP1
Kianicka, I1
Diaz, V1
Leroux, JF1
Dalle, D1
Alasmi, MM1
Pickens, WL1
Hoath, SB1
Anzalone, CR1
Lu, JK1
LaPolt, PS2
Sahu, A1
Chern, BY1
Chen, YH1
Hong, LS1
Blokland, A1
Honig, W1
Jolles, J1
Bruguerolle, B1
Mesdjian, E1
Valli, M1
Blanc, MC1
Jadot, G1
Bouyard, P1
Glatt, AF1
Talaat, HN1
Koella, WP1
Kohnen, R1
Lienert, GA1
Schmidt, FI1
Messiha, FS1
Osuide, G1
Wambebe, C1
Dietz, DD1
McMillan, DE1
Grant, LD1
Kimmel, CA1
Assael, BM1
Bossi, L1
Garattini, S1
Gerna, M1
Gomeni, R1
Morselli, PL1
Drake, WT1
Creighan, M1
Sims, DE1
Otis, TS1
Mody, I1
Ruano, D1
Cano, J1
Machado, A1
Vitorica, J1
Backofen, JE1
Koehler, RC1
Harris, AP1
Rogers, MC1
Traystman, RJ1
Jones, MD1
Keir, WJ1
Deitrich, RA1
Concas, A1
Pepitoni, S1
Atsoggiu, T1
Toffano, G1
Biggio, G1
Catignani, JC1
Ménache, MG1
Selgrade, MK1
Scanes, CG1
Harvey, S1
Paramonova, GI1
Sonntag, WE1
Gough, MA1
Meyers, MB1
Komiskey, HL1
Amrick, CL1
Bennett, DA1
Lee, JC1
McGrath, CJ1
Leighton, AT1
Wilson, MH1
Guthrie, S1
Cooper, RL1
Thurman, R1
Linnoila, M1
Canada, AT1
Calabrese, EJ1
Leonard, D1
Stevenson, IH1
Turnbull, MJ1
Mellström, A1
Effendi, H1
Versprille, A1
Wise, ME1
Cairns, RB1
Scholz, SD1
Galatulas, I1
Martini, M1
Pomarelli, P1
Piccinini, F1
Fujii, T1
Imai, M1
Morohashi, C1
Wakahara, E1
Watanabe, M1
Koyama, R1
Takanaka, A1
Randall, HM1
Toth, LA1
Kayahan, S1
Aksu, Y1

Other Studies

65 other studies available for pentobarbital and Aging

ArticleYear
Anxiolytic-like effects of restraint during the dark cycle in adolescent mice.
    Behavioural brain research, 2015, May-01, Volume: 284

    Topics: Aging; Animals; Anxiety; Brain; Conditioning, Psychological; Corticosterone; Darkness; Exploratory B

2015
Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Feb-17, Volume: 36, Issue:7

    Topics: Aging; Animals; Apolipoprotein E4; Female; GABA Agonists; gamma-Aminobutyric Acid; Gene Knock-In Tec

2016
Differential effects of ageing on the EEG during pentobarbital and ketamine anaesthesia.
    European journal of anaesthesiology, 2008, Volume: 25, Issue:10

    Topics: Adjuvants, Anesthesia; Aging; Anesthesia; Anesthetics, Dissociative; Animals; Electroencephalography

2008
Hypercapnic and hypoxic ventilatory responses in long-term streptozotocin-diabetic rats during conscious and pentobarbital-induced anesthetic states.
    Life sciences, 2002, Nov-22, Volume: 72, Issue:1

    Topics: Aging; Anesthetics; Animals; Blood Glucose; Body Weight; Consciousness; Diabetes Mellitus, Experimen

2002
Effects of age and anesthetic on plasma glucose and insulin levels and insulin sensitivity in spontaneously hypertensive and Wistar rats.
    Canadian journal of physiology and pharmacology, 2002, Volume: 80, Issue:10

    Topics: Aging; Anesthetics; Animals; Area Under Curve; Blood Glucose; Glucose Tolerance Test; Insulin; Insul

2002
[Effect of radix Achyranthis bidentatae on memory and endurance].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 1998, Volume: 21, Issue:12

    Topics: Achyranthes; Aging; Animals; Drugs, Chinese Herbal; Female; Male; Memory Disorders; Mice; Pentobarbi

1998
Effects of telazol and nembutal on retinal responses.
    Documenta ophthalmologica. Advances in ophthalmology, 2003, Volume: 107, Issue:1

    Topics: Aging; Anesthetics, Dissociative; Animals; Animals, Newborn; Dark Adaptation; Drug Combinations; Ele

2003
Effects of age and of Krebs-cycle metabolites on the inhibition of mouse brain respiration by pentobarbital.
    Journal of gerontology, 1959, Volume: 14

    Topics: Aging; Brain; Cell Respiration; Citric Acid Cycle; Humans; Pentobarbital; Respiration

1959
[Influences on resistance of the body against oligemia and ischemia of the CNS during the course of ontogenesis].
    Ceskoslovenska pediatrie, 1963, Volume: 18

    Topics: Aging; Central Nervous System; Chlorpromazine; Hyperglycemia; Hypoxia; Ischemia; Pentobarbital

1963
[Differences in influencing the course of anoxia and hypoxia of the central nervous system in ontogenesis].
    Sbornik lekarsky, 1962, Volume: 64

    Topics: Aging; Brain; Central Nervous System; Chlorpromazine; Humans; Hypoglycemia; Hypoxia; Pentobarbital

1962
[VARIATIONS IN THE ENZYME ACTIVITY AND PHARMACOLOGIC EFFECTS IN RELATION TO AGE].
    Giornale di gerontologia. Supplemento, 1964, Volume: 23

    Topics: Aging; Aldosterone; Aspirin; Carisoprodol; Cholesterol; Cholinesterases; Dexamethasone; Meprobamate;

1964
VARIATION IN THE ACTIVITY OF LIVER MICROSOMAL DRUG-METABOLIZING ENZYMES IN RATS IN RELATION TO THE AGE.
    Biochemical pharmacology, 1964, Volume: 13

    Topics: Aging; Animals, Newborn; Carisoprodol; Diphosphates; Hexobarbital; Insecticides; Liver; Meprobamate;

1964
[The effect of chlorpromazine and pentobarbital on the survival of spinal reflexes and activity of the respiration center in rats after decapitation in the course of ontogenesis].
    Sbornik lekarsky, 1961, Volume: 63

    Topics: Aging; Animals; Chlorpromazine; Decapitation; Medulla Oblongata; Pentobarbital; Rats; Reflex; Respir

1961
Plasma cyclic nucleotides in spontaneously hypertensive rats: hyperresponse to acute hot stress.
    Japanese journal of pharmacology, 1984, Volume: 34, Issue:2

    Topics: Aging; Animals; Autonomic Nervous System; Blood Pressure; Cyclic AMP; Cyclic GMP; Hot Temperature; H

1984
Effects of pentobarbital on [3H]diazepam binding in the cerebral cortex, cerebellum and spinal cord of developing rats.
    Japanese journal of pharmacology, 1984, Volume: 36, Issue:2

    Topics: Aging; Animals; Anti-Anxiety Agents; Cerebellum; Cerebral Cortex; Diazepam; Female; In Vitro Techniq

1984
Superoxide generation by neonatal and adult rabbit alveolar macrophages.
    Journal of leukocyte biology, 1984, Volume: 36, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Bordetella Infections; Cytochalasins; Female; Kinetics; Macrophage

1984
Developmental changes in luteinizing hormone secretion in the female guinea pig. II. Positive feedback effects of ovarian steroids.
    Endocrinology, 1984, Volume: 115, Issue:1

    Topics: Aging; Animals; Estradiol; Feedback; Female; Guinea Pigs; Luteinizing Hormone; Pentobarbital; Proges

1984
LHRH-induced LH and FSH responses in the aged female rat.
    Journal of gerontology, 1980, Volume: 35, Issue:4

    Topics: Aging; Animals; Diestrus; Estrus; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormo

1980
Maturation of central nervous system control of growth hormone secretion in rats.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 217, Issue:1

    Topics: 5-Hydroxytryptophan; Aging; Animals; Central Nervous System; Clonidine; Female; Growth Hormone; Male

1981
Blood pressure in the normotensive and genetically hypertensive rats: age, sex and narcosis dependency.
    Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove, 1981, Volume: 24, Issue:3

    Topics: Aging; Animals; Blood Pressure; Female; Hypertension; Male; Pentobarbital; Rats; Rats, Inbred Strain

1981
Cadmium effect on microsomal drug-metabolizing enzyme activity in rat livers with respect to differences in age and sex.
    Environmental research, 1982, Volume: 27, Issue:2

    Topics: Aging; Animals; Cadmium; Cytochrome P-450 Enzyme System; Male; Microsomes, Liver; Mixed Function Oxy

1982
Age course and inducibility of dimethylnitrosamine N-demethylation in rat liver.
    Acta biologica et medica Germanica, 1982, Volume: 41, Issue:7-8

    Topics: Aging; Animals; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Enzyme

1982
Effect of endocrine modifications and pharmacological treatments on brain and pituitary concentrations of beta-endorphin.
    Endocrinology, 1980, Volume: 107, Issue:1

    Topics: Adrenalectomy; Aging; Animals; Brain; Castration; Endorphins; Female; Male; Morphine; Naloxone; Pent

1980
Factors affecting the development of hyperbaric oxygen toxicity in the awake rat brain.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1980, Volume: 49, Issue:4

    Topics: Aging; Animals; Brain; Diazepam; Electroencephalography; Hyperbaric Oxygenation; Male; NAD; Pentobar

1980
Influence of autonomic blockade and aging on AV conduction and responses to verapamil in the beagle.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1995, Volume: 50, Issue:2

    Topics: Aging; Animals; Atrioventricular Node; Atropine; Autonomic Nervous System; Blood Pressure; Dogs; Dos

1995
Enhancement of GABA-activated membrane currents in aged Fischer 344 rat basal forebrain neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:3 Pt 2

    Topics: Action Potentials; Aging; Animals; Bicuculline; Drug Synergism; gamma-Aminobutyric Acid; Ion Channel

1995
[Effects of cutaneous mechanical stimulation on plasma corticosterone, luteinizing hormone (LH), and testosterone levels in anesthetized male rats].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1994, Volume: 69, Issue:2

    Topics: Aging; Anesthesia; Animals; Corticosterone; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Mal

1994
Modulation of the developing rat sympathetic GABAA receptor by Zn++, benzodiazepines, barbiturates and ethanol.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3

    Topics: Aging; Animals; Barbiturates; Benzodiazepines; Bicuculline; Diazepam; Ethanol; GABA-A Receptor Antag

1993
Prolonged active glottic closure after barbiturate-induced respiratory arrest in lambs.
    Respiration physiology, 1996, Volume: 104, Issue:2-3

    Topics: Abdominal Muscles; Aging; Animals; Animals, Newborn; Apnea; Electrodes, Implanted; Electromyography;

1996
Effect of tactile stimulation on serum lactate in the newborn rat.
    Pediatric research, 1997, Volume: 41, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Blood Glucose; Capsaicin; Carbon Dioxide; Epidermal Growth Factor;

1997
Influences of age and reproductive status on ovarian ovulatory responsiveness to gonadotropin stimulation.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1998, Volume: 217, Issue:4

    Topics: Aging; Animals; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Estrus; Female; Luteinizin

1998
Evidence suggesting that the potentiating action of neuropeptide Y on luteinizing hormone (LH)-releasing hormone-induced LH release remains unaltered in aged female rats.
    Journal of neuroendocrinology, 2000, Volume: 12, Issue:6

    Topics: Aging; Animals; Drug Synergism; Estradiol; Female; Gonadotropin-Releasing Hormone; Luteinizing Hormo

2000
Ovarian steroidogenic responsiveness to exogenous gonadotropin stimulation in young and middle-aged female rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, Volume: 224, Issue:4

    Topics: Aging; Animals; Body Weight; Cholesterol Side-Chain Cleavage Enzyme; Chorionic Gonadotropin; Dose-Re

2000
Long-term consequences of repeated pentobarbital anaesthesia on choice reaction time performance in ageing rats.
    British journal of anaesthesia, 2001, Volume: 87, Issue:5

    Topics: Adjuvants, Anesthesia; Aging; Animals; Behavior, Animal; Drug Administration Schedule; Hypnotics and

2001
[The effects of age and sex on the acute toxicity of two barbiturate anesthetics in rats].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1977, Volume: 171, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Female; Male; Pentobarbital; Rats; Sex Factors; Thiopental

1977
Testing of peripheral nerve function in chronic experiments in rats.
    Pharmacology & therapeutics. Part B: General & systematic pharmacology, 1979, Volume: 5, Issue:1-3

    Topics: Action Potentials; Aging; Animals; Electric Stimulation; Furazolidone; Male; Neural Conduction; Pent

1979
[Clinico-physiological sleep- and hangover-spectra from pentobarbital, promazin and their combination, as reflected by self-ratings of young and elderly subjects (author's transl)].
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1979, Volume: 12, Issue:3

    Topics: Adult; Aged; Aging; Drug Combinations; Humans; Pentobarbital; Promazine; Sleep

1979
Epididymal alcohol and aldehyde dehydrogenases in rodents.
    Proceedings of the Western Pharmacology Society, 1979, Volume: 22

    Topics: Aging; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Animals; Cricetinae; Disulfiram; Epididymi

1979
Antagonism of pentobarbitone sleep by dopamine in young chicks [proceedings].
    West African journal of pharmacology and drug research, 1977, Volume: 4, Issue:1

    Topics: Aging; Animals; Chickens; Dopamine; Male; Pentobarbital; Sleep

1977
Effects of lead on temporally-spaced responding in rats.
    Drug and chemical toxicology, 1978, Volume: 1, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationsh

1978
Carbamazepine pharmacokinetics in young, adult and pregnant rats. Relation to pharmacological effects.
    Archives internationales de pharmacodynamie et de therapie, 1976, Volume: 220, Issue:1

    Topics: Aging; Animals; Carbamazepine; Electroshock; Female; Kinetics; Male; Maternal-Fetal Exchange; Pentob

1976
Limitations of monastral blue as a vascular label: rapid rate of clearance is age-dependent, and interactions with anesthetics depress arterial blood pressure in rats.
    Microscopy research and technique, 1992, Nov-01, Volume: 23, Issue:3

    Topics: Aging; Anesthetics; Animals; Blood Pressure; Coloring Agents; Drug Interactions; Halothane; Indoles;

1992
Modulation of decay kinetics and frequency of GABAA receptor-mediated spontaneous inhibitory postsynaptic currents in hippocampal neurons.
    Neuroscience, 1992, Volume: 49, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Anesthetics, Local; Animal

1992
Pharmacologic characterization of GABAA/benzodiazepine receptor in rat hippocampus during aging.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:3

    Topics: Aging; Animals; Binding Sites; Cerebellum; Cerebral Cortex; Culture Techniques; Drug Interactions; F

1991
Efficacy of Cushing response during development in sheep.
    The American journal of physiology, 1991, Volume: 261, Issue:2 Pt 2

    Topics: Aging; Animals; Animals, Newborn; Blood Circulation; Blood Pressure; Brain; Cardiac Output; Cerebros

1991
Development of central nervous system sensitivity to ethanol and pentobarbital in short- and long-sleep mice.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:3

    Topics: Aging; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Ethanol; Female; Gas Chromatograph

1990
Aging reduces the GABA-dependent 36Cl- flux in rat brain membrane vesicles.
    Life sciences, 1988, Volume: 43, Issue:22

    Topics: Aging; Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocycl

1988
Increased susceptibility to pentobarbital following mouse cytomegalovirus infection: relative roles of viral-induced interferon and viral infection of the liver.
    Journal of biochemical toxicology, 1989,Winter, Volume: 4, Issue:4

    Topics: Aging; Animals; Antibodies; Cytochrome P-450 Enzyme System; Cytomegalovirus; Cytomegalovirus Infecti

1989
Somatostatin inhibition of thyrotropin-releasing hormone- and growth hormone-releasing factor-induced growth hormone secretion in young and adult anesthetized chickens.
    General and comparative endocrinology, 1989, Volume: 75, Issue:2

    Topics: Aging; Animals; Chickens; Dose-Response Relationship, Drug; Growth Hormone; Growth Hormone-Releasing

1989
[The relationship of the intensity of liver microsomal oxidation to individual longevity].
    Biulleten' eksperimental'noi biologii i meditsiny, 1989, Volume: 107, Issue:6

    Topics: Aging; Animals; Female; Longevity; Microsomes, Liver; Oxidation-Reduction; Pentobarbital; Rats; Rats

1989
Growth hormone releasing hormone induced release of growth hormone in aging male rats: dependence on pharmacological manipulation and endogenous somatostatin release.
    Neuroendocrinology, 1988, Volume: 47, Issue:6

    Topics: Aging; Animals; Ditiocarb; Growth Hormone; Growth Hormone-Releasing Hormone; Immunization, Passive;

1988
Aging: effect on the interaction of ethanol and pentobarbital with the benzodiazepine-GABA receptor-ionophore complex.
    Brain research, 1985, Sep-23, Volume: 343, Issue:2

    Topics: Aging; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Ethanol; Flunitr

1985
A comparison of diazepam stimuli in aged and adult rats.
    Psychopharmacology, 1987, Volume: 93, Issue:3

    Topics: Aging; Animals; Chlordiazepoxide; Diazepam; Discrimination Learning; Dose-Response Relationship, Dru

1987
Effects of surgical pentobarbital anesthesia on blood pressure, heart rate, and arterial blood pH and gas tension in turkeys.
    Laboratory animal science, 1988, Volume: 38, Issue:2

    Topics: Acid-Base Equilibrium; Aging; Anesthesia, Intravenous; Animals; Blood Pressure; Body Weight; Carbon

1988
Pharmacodynamics and pharmacokinetics of ethanol, diazepam and pentobarbital in young and aged rats.
    Pharmacology & toxicology, 1987, Volume: 61, Issue:5

    Topics: Aging; Animals; Brain Chemistry; Diazepam; Ethanol; Female; Pentobarbital; Rats; Sleep

1987
Age-dependent inhibition of pentobarbital sleeping time by ozone in mice and rats.
    Journal of gerontology, 1986, Volume: 41, Issue:5

    Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Female; Liver; Mice; Mice, Inbred DBA; Ozone; Pentob

1986
A study of the factors affecting the sleeping time following intracerebroventricular administration of pentobarbitone sodium: effect of prior administration of centrally active drugs.
    British journal of pharmacology, 1974, Volume: 50, Issue:4

    Topics: Aging; Amphetamine; Animals; Anti-Anxiety Agents; Barbiturates; Body Weight; Carbon Radioisotopes; C

1974
Postnatal excitability changes of the ankle monosynaptic reflexes in the cat.
    Acta physiologica Scandinavica, 1971, Volume: 82, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Ankle; Cats; Decerebrate State; Electric Stimulation; Laminectomy;

1971
The negative inotropic effect of barbiturates on the heart of newborn and adult guinea-pigs.
    Archives internationales de pharmacodynamie et de therapie, 1974, Volume: 209, Issue:1

    Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Barbiturates; Depression, Chemical; Dose-Res

1974
Fighting in mice: dyadic escalation and what is learned.
    Journal of comparative and physiological psychology, 1973, Volume: 85, Issue:3

    Topics: Aggression; Aging; Animals; Arousal; Behavior, Animal; Chlorpromazine; Dose-Response Relationship, D

1973
Effect of drugs on the calcium exchangeability in the pineal gland.
    Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 196

    Topics: Aging; Amphetamine; Animals; Biological Clocks; Calcium; Calcium Isotopes; Male; Pentobarbital; Pine

1972
Sex and age differences in the effects of barbiturates.
    Japanese journal of pharmacology, 1965, Volume: 15, Issue:2

    Topics: Aging; Animals; Female; Male; Pentobarbital; Phenobarbital; Rats; Sex

1965
Metabolism of drugs in old rats. II. Metabolism in vivo and effect of drugs in old rats.
    Japanese journal of pharmacology, 1968, Volume: 18, Issue:4

    Topics: Aging; Anesthesia; Animals; Carisoprodol; Female; Hexobarbital; Injections, Intraperitoneal; Insecti

1968
Effects of spontaneous ischemia on aerobic metabolism of cortical and medullary homogenates of dog kidney.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1970, Volume: 135, Issue:3

    Topics: Aging; Animals; Dogs; Female; Glutarates; Ischemia; Isocitrate Dehydrogenase; Kidney; Malate Dehydro

1970
The effect of penthobarbital on stimulation threshold in young and old subjects.
    Gerontologia, 1968, Volume: 14, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Basal Metabolism; Female; Homeostasis; Humans; Male; Middle Aged; Ox

1968