pentobarbital has been researched along with Acute Kidney Injury in 14 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Posttreatment with pentobarbital decreased blood BUN, Cre, GOT, GPT, CPK levels, decreased the markers of kidney injury, and suppressed the release of NF-kappaB and iNOS after rhabdomyolysis." | 7.75 | Pentobarbital reduces rhabdomyolysis-induced acute renal failure in conscious rats. ( Hsu, BG; Lee, CJ; Lee, RP; Subeq, YM; Wu, WT; Yang, FL, 2009) |
| "Leonurine (LEO) is a special alkaloid extracted from Chinese motherwort (Leonurus japonicus Houtt), which has an anti-inflammatory effect and reduces oxidative stress." | 5.72 | Leonurine Preconditioning Attenuates Ischemic Acute Kidney Injury in Rats by Promoting Nrf2 Nuclear Translocation and Suppressing TLR4/NF-κB Pathway. ( Chen, A; Han, L; Liu, L; Wang, F, 2022) |
| " Posttreatment with pentobarbital decreased blood BUN, Cre, GOT, GPT, CPK levels, decreased the markers of kidney injury, and suppressed the release of NF-kappaB and iNOS after rhabdomyolysis." | 3.75 | Pentobarbital reduces rhabdomyolysis-induced acute renal failure in conscious rats. ( Hsu, BG; Lee, CJ; Lee, RP; Subeq, YM; Wu, WT; Yang, FL, 2009) |
| " We believed that this represented an adverse effect that was probably related to the study drug and the study was stopped." | 2.68 | Propylene glycol toxicity following continuous etomidate infusion for the control of refractory cerebral edema. ( Aranda, M; Giannotta, SL; Levy, ML; Zelman, V, 1995) |
| "Leonurine (LEO) is a special alkaloid extracted from Chinese motherwort (Leonurus japonicus Houtt), which has an anti-inflammatory effect and reduces oxidative stress." | 1.72 | Leonurine Preconditioning Attenuates Ischemic Acute Kidney Injury in Rats by Promoting Nrf2 Nuclear Translocation and Suppressing TLR4/NF-κB Pathway. ( Chen, A; Han, L; Liu, L; Wang, F, 2022) |
| "Therefore, we conclude that no acute renal failure is induced during intrarenal NE infusion in conscious rats; this is probably due to protective neurogenic mechanisms which are relatively inactivated during pentobarbital anesthesia." | 1.27 | Evaluation of renal function during intrarenal norepinephrine infusion in conscious rats. ( Kasbergen, CM; Kleinjans, JC; Smits, JF; Struyker-Boudier, HA; van Essen, H, 1984) |
| "Pentobarbital specimens were obtained simultaneously from arterial blood entering and leaving the dialysis machine at five 1-h intervals." | 1.27 | Hemodialysis clearance of pentobarbital during continuous infusion. ( Bell, R; Blouin, R; Porter, W; Record, K; Wermeling, D, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (50.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Han, L | 1 |
| Chen, A | 1 |
| Liu, L | 1 |
| Wang, F | 1 |
| Nieto Piñar, Y | 1 |
| Sala Carazo, M | 1 |
| Barceló Martín, B | 1 |
| Hensler, DM | 1 |
| McConnell, DP | 1 |
| Levasseur-Franklin, KE | 1 |
| Greathouse, KM | 1 |
| Subeq, YM | 1 |
| Wu, WT | 1 |
| Lee, CJ | 1 |
| Lee, RP | 1 |
| Yang, FL | 1 |
| Hsu, BG | 1 |
| Byrav, P | 1 |
| Medhi, B | 1 |
| Kaur, H | 1 |
| Prakash, A | 1 |
| Kleinjans, JC | 1 |
| Smits, JF | 1 |
| Kasbergen, CM | 1 |
| van Essen, H | 1 |
| Struyker-Boudier, HA | 1 |
| Osborn, JL | 1 |
| Kopp, UC | 1 |
| DiBona, GF | 1 |
| Finn, WF | 1 |
| Levy, ML | 1 |
| Aranda, M | 1 |
| Zelman, V | 1 |
| Giannotta, SL | 1 |
| Lochhead, KM | 1 |
| Kharasch, ED | 1 |
| Zager, RA | 1 |
| Wermeling, D | 1 |
| Record, K | 1 |
| Bell, R | 1 |
| Porter, W | 1 |
| Blouin, R | 1 |
| Larson, CP | 1 |
| Mazze, RI | 1 |
| Cooperman, LH | 1 |
| Wollman, H | 1 |
| Bullock, JD | 1 |
| Albert, DM | 1 |
| Klatte, EC | 1 |
| Brooks, AL | 1 |
| Rhamy, RK | 1 |
1 review available for pentobarbital and Acute Kidney Injury
| Article | Year |
|---|---|
Effects of anesthetics on cerebral, renal, and splanchnic circulations: recent developments.
Topics: Abdomen; Acute Kidney Injury; Anesthesia, Spinal; Anesthetics; Animals; Brain; Cerebrovascular Circu | 1974 |
1 trial available for pentobarbital and Acute Kidney Injury
| Article | Year |
|---|---|
Propylene glycol toxicity following continuous etomidate infusion for the control of refractory cerebral edema.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Anesthetics, Intravenous; Brain; Brain Edema; Drug Adm | 1995 |
12 other studies available for pentobarbital and Acute Kidney Injury
| Article | Year |
|---|---|
Leonurine Preconditioning Attenuates Ischemic Acute Kidney Injury in Rats by Promoting Nrf2 Nuclear Translocation and Suppressing TLR4/NF-κB Pathway.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Nucleus; Gallic Acid; In | 2022 |
[Use of continuous venovenous hemodiafiltration in a case of severe pentobarbital poisoning].
Topics: Acute Kidney Injury; Continuous Renal Replacement Therapy; Humans; Pentobarbital | 2023 |
Pentobarbital Removal During Continuous Venovenous Hemofiltration: Case Report and Review of the Literature.
Topics: Acute Kidney Injury; Adult; Brain Injuries, Traumatic; Female; Hemofiltration; Humans; Metabolic Cle | 2018 |
Pentobarbital reduces rhabdomyolysis-induced acute renal failure in conscious rats.
Topics: Acute Kidney Injury; Animals; Cognition; Disease Models, Animal; Follow-Up Studies; GABA Modulators; | 2009 |
Pentobarbital in the treatment of rhabdomyolysis-induced acute renal failure?
Topics: Acute Kidney Injury; Animals; GABA Modulators; Pentobarbital; Rats; Rhabdomyolysis | 2010 |
Evaluation of renal function during intrarenal norepinephrine infusion in conscious rats.
Topics: Acute Kidney Injury; Anesthesia, General; Animals; Consciousness; Glomerular Filtration Rate; Kidney | 1984 |
Ischemic acute renal failure: newer implications of stopped pipes.
Topics: Acute Kidney Injury; Animals; Humans; Ischemia; Kidney; Kidney Tubules, Proximal; Pentobarbital; Rat | 1981 |
Nephron heterogeneity in polyuric acute renal failure.
Topics: Acute Kidney Injury; Animals; Ischemia; Kidney; Kidney Tubules, Proximal; Male; Pentobarbital; Polyu | 1981 |
Anesthetic effects on the glycerol model of rhabdomyolysis-induced acute renal failure in rats.
Topics: Acute Kidney Injury; Anesthetics, Inhalation; Animals; Creatine Kinase; Creatinine; Desflurane; Glyc | 1998 |
Hemodialysis clearance of pentobarbital during continuous infusion.
Topics: Acute Kidney Injury; Adult; Humans; Infusions, Parenteral; Male; Pentobarbital; Renal Dialysis | 1985 |
Generalized oxalosis with retinal involvement following methoxyflurane anesthesia.
Topics: Acute Kidney Injury; Anesthesia, General; Biopsy; Calcium; Humans; Kidney; Male; Metabolic Diseases; | 1974 |
Toxicity of intra-arterial barbiturates and tranquilizing drugs.
Topics: Acute Kidney Injury; Animals; Calcinosis; Humans; Hydroxyzine; Injections, Intra-Arterial; Necrosis; | 1969 |