pentobarbital has been researched along with Acute Brain Injuries in 46 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The objectives of the present study were to assess the effectiveness of pentobarbital and thiopental in terms of controlling refractory intracranial hypertension in patients with severe traumatic brain injury, and to evaluate the adverse effects of treatment." | 9.13 | Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial. ( Abadal, JM; Brell, M; Frontera, G; Homar, J; Ibáñez, J; Llompart-Pou, JA; Pérez-Bárcena, J; Raurich, JM, 2008) |
| " Pentobarbital coma is often instituted following the failure of osmotic interventions and sedation to control intracranial pressure (ICP)." | 8.31 | Pentobarbital coma for management of intracranial hypertension following traumatic brain injury: Lack of early response to treatment portends poor outcomes. ( Bonnin, SS; Chapple, KM; Huang, DD; Kelley, CJ; Rudy, RF; Snyder, LA; Stansbury, BM; Weinberg, JA, 2023) |
| "To identify predictors of mortality and long-term outcomes in survivors after pentobarbital coma (PBC) in patients failing current treatment standards for severe traumatic brain injuries (TBI)." | 7.76 | Pentobarbital coma for refractory intra-cranial hypertension after severe traumatic brain injury: mortality predictions and one-year outcomes in 55 patients. ( Cotton, BA; Hansen, EN; James, RF; Landman, MP; Marshall, GT; May, AK; Morris, JA; O'Neill, PJ, 2010) |
| "There is considerable debate regarding the appropriateness of feeding patients by the enteral route in conjunction with pentobarbital coma therapy." | 7.74 | Evaluation of feeding intolerance in patients with pentobarbital-induced coma. ( Beynnon, BJ; Commichau, C; Crookes, BA; Frock, KM; Marden, BT; Rebuck, JA; Stevens, AM; Then, JE, 2008) |
| "Global cerebrovenous oxygenation was evaluated before and after intravenous administration of pentobarbital sodium for the management of refractory intracranial hypertension in 151 comatose patients who had acute traumatic brain swelling." | 7.69 | Adverse effects of pentobarbital on cerebral venous oxygenation of comatose patients with acute traumatic brain swelling: relationship to outcome. ( Cruz, J, 1996) |
| "Controversy exists regarding the optimal means for monitoring the patient receiving pentobarbital therapy during medical coma." | 7.68 | Electroencephalographic activity and serum and cerebrospinal fluid pentobarbital levels in determining the therapeutic end point during barbiturate coma. ( Jimenez, F; Rosenwasser, RH; Winer, JW, 1991) |
| "To evaluate the impact of anesthetics on the evolution of a cerebral injury, 33 rabbits were subjected to a cryogenic brain lesion, followed by 10 h of anesthesia with 1 MAC halothane or isoflurane (n = 11 each) or with an equipotent dose of pentobarbital (n = 11)." | 7.67 | A comparison of the effects of halothane, isoflurane, and pentobarbital anesthesia on intracranial pressure and cerebral edema formation following brain injury in rabbits. ( Kaieda, R; Todd, MM; Warner, DS; Weeks, JB, 1989) |
| "We sought to determine whether pentobarbital (PB) coma compromises the use of evoked potentials (EPs) in the assessment of brain dysfunction and of the prognosis of severely head-injured patients." | 7.66 | Effects of therapeutic pentobarbital coma on multimodality evoked potentials recorded from severely head-injured patients. ( Becker, DP; Enas, GG; Greenberg, RP; Newlon, PG, 1983) |
| " The objectives of the present study were to assess the effectiveness of pentobarbital and thiopental in terms of controlling refractory intracranial hypertension in patients with severe traumatic brain injury, and to evaluate the adverse effects of treatment." | 5.13 | Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial. ( Abadal, JM; Brell, M; Frontera, G; Homar, J; Ibáñez, J; Llompart-Pou, JA; Pérez-Bárcena, J; Raurich, JM, 2008) |
| " Pentobarbital coma is often instituted following the failure of osmotic interventions and sedation to control intracranial pressure (ICP)." | 4.31 | Pentobarbital coma for management of intracranial hypertension following traumatic brain injury: Lack of early response to treatment portends poor outcomes. ( Bonnin, SS; Chapple, KM; Huang, DD; Kelley, CJ; Rudy, RF; Snyder, LA; Stansbury, BM; Weinberg, JA, 2023) |
| "To identify predictors of mortality and long-term outcomes in survivors after pentobarbital coma (PBC) in patients failing current treatment standards for severe traumatic brain injuries (TBI)." | 3.76 | Pentobarbital coma for refractory intra-cranial hypertension after severe traumatic brain injury: mortality predictions and one-year outcomes in 55 patients. ( Cotton, BA; Hansen, EN; James, RF; Landman, MP; Marshall, GT; May, AK; Morris, JA; O'Neill, PJ, 2010) |
| "There is considerable debate regarding the appropriateness of feeding patients by the enteral route in conjunction with pentobarbital coma therapy." | 3.74 | Evaluation of feeding intolerance in patients with pentobarbital-induced coma. ( Beynnon, BJ; Commichau, C; Crookes, BA; Frock, KM; Marden, BT; Rebuck, JA; Stevens, AM; Then, JE, 2008) |
| "Global cerebrovenous oxygenation was evaluated before and after intravenous administration of pentobarbital sodium for the management of refractory intracranial hypertension in 151 comatose patients who had acute traumatic brain swelling." | 3.69 | Adverse effects of pentobarbital on cerebral venous oxygenation of comatose patients with acute traumatic brain swelling: relationship to outcome. ( Cruz, J, 1996) |
| " Propofol was used for surgical anesthesia because recovery in normal animals from an intravenous infusion was found to be nearly complete within 2 h of cessation and absolutely complete by 4 h." | 3.68 | Early assessment of neurologic deficits in the fluid percussion model of brain injury. ( Einhaus, SL; Hilton, DL; Meric, AL; Park, MR; Robertson, JT; Schweitzer, JB; White, RP, 1993) |
| "Controversy exists regarding the optimal means for monitoring the patient receiving pentobarbital therapy during medical coma." | 3.68 | Electroencephalographic activity and serum and cerebrospinal fluid pentobarbital levels in determining the therapeutic end point during barbiturate coma. ( Jimenez, F; Rosenwasser, RH; Winer, JW, 1991) |
| "To evaluate the impact of anesthetics on the evolution of a cerebral injury, 33 rabbits were subjected to a cryogenic brain lesion, followed by 10 h of anesthesia with 1 MAC halothane or isoflurane (n = 11 each) or with an equipotent dose of pentobarbital (n = 11)." | 3.67 | A comparison of the effects of halothane, isoflurane, and pentobarbital anesthesia on intracranial pressure and cerebral edema formation following brain injury in rabbits. ( Kaieda, R; Todd, MM; Warner, DS; Weeks, JB, 1989) |
| "Survival rates following incomplete brain ischemia induced during pentobarbital anesthesia were significantly higher in mice with a minor brain injury, inflicted one week before, than in those given a sham operation." | 3.67 | Effects of pentobarbital and ketamine on brain injury-induced anti-ischemic activity. ( Endoh, H; Fujiwara, N; Ohama, E; Shimoji, K; Taga, K; Takahata, Y, 1987) |
| "We sought to determine whether pentobarbital (PB) coma compromises the use of evoked potentials (EPs) in the assessment of brain dysfunction and of the prognosis of severely head-injured patients." | 3.66 | Effects of therapeutic pentobarbital coma on multimodality evoked potentials recorded from severely head-injured patients. ( Becker, DP; Enas, GG; Greenberg, RP; Newlon, PG, 1983) |
| "Pentobarbital was started as soon as possible after the head injury, regardless of the intracranial pressure (ICP), and was continued for a prescribed period of time." | 2.66 | Failure of prophylactic barbiturate coma in the treatment of severe head injury. ( Becker, DP; Choi, SC; Keenan, R; Marmarou, A; Miller, JD; Newlon, PG; Ward, JD; Wood, C, 1985) |
| " In order to use these effectively, the critical care nurse must be aware of the indications and controversies surrounding their use, the patho-physiologic conditions that impact on the disposition, and appropriate dosing and monitoring of these agents in the critical care setting." | 2.38 | Anticonvulsants: pharmacotherapeutic issues in the critically ill patient. ( Dupuis, RE; Miranda-Massari, J, 1991) |
| " The purpose of this study was to evaluate pharmacokinetic (PK) parameters of vancomycin in patients with acute brain injury undergoing temperature modulation." | 1.42 | Vancomycin pharmacokinetic parameters in patients with acute brain injury undergoing controlled normothermia, therapeutic hypothermia, or pentobarbital infusion. ( Jordan, JD; Morbitzer, KA; Rhoney, DH, 2015) |
| "Pentobarbital was unable to significantly modulate mitochondrial function in traumatized rats, whereas it exerted this effect in all control animals." | 1.33 | Pentobarbital fails to reduce cerebral oxygen consumption early after non-hemorrhagic closed head injury in rats. ( Borgers, M; De Visscher, G; Flameng, W; Jorens, P; Reneman, RS; Rooker, S; Van Rossem, K; Verlooy, J, 2005) |
| "Rats treated with isoflurane had the best cognitive recovery (p < 0." | 1.33 | Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats. ( Alexander, H; Clark, RS; Dixon, CE; Jenkins, L; Kochanek, PM; Statler, KD; Vagni, V, 2006) |
| "03 L/kg and a terminal half-life of 19." | 1.27 | Pentobarbital pharmacokinetics in patients with severe head injury. ( Blouin, RA; Porter, WH; Rapp, RP; Tibbs, PA; Wermeling, DP, 1987) |
| " Pentobarbital elimination half-life was not significantly different from control values." | 1.26 | High-dose pentobarbital pharmacokinetics in hypothermic brain-injured children. ( Cupit, GC; Rocci, ML; Schaible, DH; Swedlow, DB, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (43.48) | 18.7374 |
| 1990's | 14 (30.43) | 18.2507 |
| 2000's | 5 (10.87) | 29.6817 |
| 2010's | 6 (13.04) | 24.3611 |
| 2020's | 1 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Stansbury, BM | 1 |
| Kelley, CJ | 1 |
| Rudy, RF | 1 |
| Bonnin, SS | 1 |
| Chapple, KM | 1 |
| Snyder, LA | 1 |
| Weinberg, JA | 1 |
| Huang, DD | 1 |
| Shore, PM | 1 |
| Wakai, A | 1 |
| McCabe, A | 1 |
| Roberts, I | 1 |
| Schierhout, G | 1 |
| Morbitzer, KA | 1 |
| Jordan, JD | 1 |
| Rhoney, DH | 2 |
| Pérez-Bárcena, J | 1 |
| Llompart-Pou, JA | 1 |
| Homar, J | 1 |
| Abadal, JM | 1 |
| Raurich, JM | 1 |
| Frontera, G | 1 |
| Brell, M | 1 |
| Ibáñez, J | 2 |
| Marshall, GT | 1 |
| James, RF | 1 |
| Landman, MP | 1 |
| O'Neill, PJ | 1 |
| Cotton, BA | 1 |
| Hansen, EN | 1 |
| Morris, JA | 1 |
| May, AK | 1 |
| Kontogiorgi, M | 1 |
| Opsimoulis, P | 1 |
| Diamanti-Kandarakis, E | 1 |
| Karabinis, A | 1 |
| Mellion, SA | 1 |
| Bennett, KS | 1 |
| Ellsworth, GL | 1 |
| Moore, K | 1 |
| Riva-Cambrin, J | 1 |
| Metzger, RR | 1 |
| Bratton, SL | 1 |
| Parker, D | 1 |
| Formea, CM | 1 |
| Yap, C | 1 |
| Coplin, WM | 2 |
| HALSWICK, R | 1 |
| De Visscher, G | 1 |
| Rooker, S | 1 |
| Jorens, P | 1 |
| Verlooy, J | 1 |
| Borgers, M | 1 |
| Reneman, RS | 1 |
| Van Rossem, K | 1 |
| Flameng, W | 1 |
| Statler, KD | 1 |
| Alexander, H | 1 |
| Vagni, V | 1 |
| Dixon, CE | 1 |
| Clark, RS | 1 |
| Jenkins, L | 1 |
| Kochanek, PM | 1 |
| Stevens, AM | 1 |
| Then, JE | 1 |
| Frock, KM | 1 |
| Crookes, BA | 1 |
| Commichau, C | 1 |
| Marden, BT | 1 |
| Beynnon, BJ | 1 |
| Rebuck, JA | 1 |
| Bowers, SA | 1 |
| Rea, GL | 1 |
| Rockswold, GL | 1 |
| Newlon, PG | 2 |
| Greenberg, RP | 1 |
| Enas, GG | 1 |
| Becker, DP | 2 |
| Traeger, SM | 1 |
| Henning, RJ | 1 |
| Dobkin, W | 1 |
| Giannotta, S | 1 |
| Weil, MH | 1 |
| Weiss, M | 1 |
| Schaible, DH | 1 |
| Cupit, GC | 1 |
| Swedlow, DB | 1 |
| Rocci, ML | 1 |
| Artru, F | 1 |
| Guerin, JM | 1 |
| Chacornac, R | 1 |
| Deleuze, R | 1 |
| Hoppe, E | 1 |
| Christensen, L | 1 |
| Christensen, KN | 1 |
| Clubb, RJ | 1 |
| Maxwell, RE | 1 |
| Chou, SN | 1 |
| Amir, S | 1 |
| Robinson, B | 1 |
| Woodside, B | 1 |
| Lee, MW | 1 |
| Deppe, SA | 1 |
| Sipperly, ME | 1 |
| Barrette, RR | 1 |
| Thompson, DR | 1 |
| Hilton, DL | 1 |
| Einhaus, SL | 1 |
| Meric, AL | 1 |
| White, RP | 1 |
| Schweitzer, JB | 1 |
| Park, MR | 1 |
| Robertson, JT | 1 |
| Cruz, J | 1 |
| Lam, AM | 2 |
| Nara, I | 1 |
| Shiogai, T | 1 |
| Hara, M | 1 |
| Saito, I | 1 |
| McKinley, BA | 1 |
| Parmley, CL | 1 |
| Venes, JL | 1 |
| Marshall, LF | 1 |
| Smith, RW | 1 |
| Shapiro, HM | 1 |
| Michenfelder, JD | 1 |
| Milde, JH | 1 |
| Sundt, TM | 1 |
| Shapira, Y | 1 |
| Pavlin, EG | 1 |
| Archer, DP | 2 |
| Priddy, RE | 1 |
| Tang, TK | 1 |
| Sabourin, MA | 1 |
| Samanani, N | 1 |
| Dupuis, RE | 1 |
| Miranda-Massari, J | 1 |
| Winer, JW | 1 |
| Rosenwasser, RH | 1 |
| Jimenez, F | 1 |
| Teba, L | 1 |
| Weber, S | 1 |
| Elphinstone, MG | 1 |
| Pappius, HM | 1 |
| Gaab, MR | 1 |
| Poch, B | 1 |
| Heller, V | 1 |
| Pittman, T | 1 |
| Bucholz, R | 1 |
| Williams, D | 1 |
| Kaieda, R | 1 |
| Todd, MM | 1 |
| Weeks, JB | 1 |
| Warner, DS | 1 |
| Wermeling, DP | 1 |
| Blouin, RA | 1 |
| Porter, WH | 1 |
| Rapp, RP | 1 |
| Tibbs, PA | 1 |
| Shimoji, K | 2 |
| Takahata, Y | 2 |
| Fujiwara, N | 1 |
| Endoh, H | 1 |
| Taga, K | 1 |
| Ohama, E | 1 |
| Ward, JD | 1 |
| Miller, JD | 1 |
| Choi, SC | 1 |
| Marmarou, A | 1 |
| Wood, C | 1 |
| Keenan, R | 1 |
| Beattie, CW | 1 |
| Chernov, HI | 1 |
| Bernard, PS | 1 |
| Glenny, FH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension.[NCT00622570] | Phase 3 | 44 participants (Actual) | Interventional | 2002-05-31 | Terminated (stopped due to Slowly recruitment rate. Intermediate analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pentobarbital and Acute Brain Injuries
| Article | Year |
|---|---|
Mannitol for acute traumatic brain injury.
Topics: Acute Disease; Brain Injuries; Diuretics, Osmotic; Humans; Intracranial Hypertension; Intracranial P | 2013 |
Anticonvulsants: pharmacotherapeutic issues in the critically ill patient.
Topics: Anticonvulsants; Benzodiazepines; Brain Injuries; Carbamazepine; Central Nervous System Diseases; Ep | 1991 |
2 trials available for pentobarbital and Acute Brain Injuries
| Article | Year |
|---|---|
Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Brain Injuries; Cohort Studies; Female; Humans; Intracranial Hypertension; | 2008 |
Failure of prophylactic barbiturate coma in the treatment of severe head injury.
Topics: Adolescent; Adult; Brain; Brain Injuries; Clinical Trials as Topic; Evoked Potentials; Female; Human | 1985 |
42 other studies available for pentobarbital and Acute Brain Injuries
| Article | Year |
|---|---|
Pentobarbital coma for management of intracranial hypertension following traumatic brain injury: Lack of early response to treatment portends poor outcomes.
Topics: Adult; Brain Injuries; Brain Injuries, Traumatic; Coma; Female; Glasgow Coma Scale; Humans; Intracra | 2023 |
Pentobarbital for refractory intracranial hypertension: time to "go retro"?
Topics: Brain Injuries; Female; GABA Modulators; Humans; Intracranial Hypertension; Male; Pentobarbital | 2013 |
Vancomycin pharmacokinetic parameters in patients with acute brain injury undergoing controlled normothermia, therapeutic hypothermia, or pentobarbital infusion.
Topics: Adult; Body Temperature; Brain Injuries; Female; Humans; Hypnotics and Sedatives; Hypothermia, Induc | 2015 |
Pentobarbital coma for refractory intra-cranial hypertension after severe traumatic brain injury: mortality predictions and one-year outcomes in 55 patients.
Topics: Adolescent; Adult; Brain Injuries; Child; Child, Preschool; Cohort Studies; Coma; Confidence Interva | 2010 |
Cerebral salt wasting syndrome in traumatic brain injury following therapeutic barbiturate coma.
Topics: Brain Injuries; Coma; Humans; Hypnotics and Sedatives; Hyponatremia; Inappropriate ADH Syndrome; Int | 2011 |
High-dose barbiturates for refractory intracranial hypertension in children with severe traumatic brain injury.
Topics: Adolescent; Brain Injuries; Child; Child, Preschool; Drug Administration Schedule; Drug Monitoring; | 2013 |
Tolerability of bolus versus continuous gastric feeding in brain-injured patients.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Ulcer | 2002 |
[On the influence of megaphen, nembutal and novocain on spontaneous EEG and bioelectrical response to light stimuli in brain-injured rabbits].
Topics: Animals; Brain; Brain Injuries; Chlorpromazine; Electroencephalography; Electrophysiological Phenome | 1960 |
Pentobarbital fails to reduce cerebral oxygen consumption early after non-hemorrhagic closed head injury in rats.
Topics: Animals; Brain Injuries; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Down- | 2005 |
Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats.
Topics: Anesthetics; Animals; Brain; Brain Injuries; Cell Survival; Cognition Disorders; Diazepam; Disease M | 2006 |
Evaluation of feeding intolerance in patients with pentobarbital-induced coma.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Brain Injuries; Coma; Cr | 2008 |
[The use of barbiturates in severe cranio-cerebral injuries].
Topics: Accidents; Brain Injuries; Emergencies; Humans; Intracranial Pressure; Pentobarbital | 1984 |
New, last-ditch therapy for malignant cerebral hypertension.
Topics: Adult; Brain Injuries; Coma; Humans; Hypertension; Intracranial Pressure; Male; Neurologic Examinati | 1983 |
Barbiturate therapy in uncontrolled intracranial hypertension.
Topics: Adolescent; Adult; Brain Injuries; Child; Humans; Intracranial Pressure; Middle Aged; Pentobarbital; | 1983 |
Effects of therapeutic pentobarbital coma on multimodality evoked potentials recorded from severely head-injured patients.
Topics: Adult; Brain; Brain Injuries; Brain Stem; Coma; Evoked Potentials; Evoked Potentials, Auditory; Evok | 1983 |
Hemodynamic effects of pentobarbital therapy for intracranial hypertension.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Cerebrovascular Circulation; Hemodynamics; Humans; | 1983 |
High-dose pentobarbital pharmacokinetics in hypothermic brain-injured children.
Topics: Adolescent; Brain Injuries; Child; Child, Preschool; Half-Life; Humans; Hypothermia, Induced; Infant | 1982 |
[Practical aspects of the treatment of traumatic coma with prolonged barbiturate anesthesia].
Topics: Anesthesia, General; Brain Injuries; Coma; Humans; Intracranial Pressure; Pentobarbital | 1982 |
The clinical outcome of patients with severe head injuries, treated with highdose dexamethasone, hyperventilation and barbiturates.
Topics: Adolescent; Adult; Age Factors; Aged; Brain Injuries; Child; Child, Preschool; Chlorpromazine; Dexam | 1981 |
Experimental brain injury in the dog. The pharmacological effects of pentobarbital and sodium nitroprusside.
Topics: Animals; Blood Pressure; Brain Injuries; Dogs; Female; Ferricyanides; Intracranial Pressure; Male; N | 1980 |
Induction of Fos protein in the piriform cortex after brain injury in pentobarbital-anaesthetized rats: lack of effect of lactation.
Topics: Anesthesia; Animals; Brain Injuries; Cerebral Cortex; Dizocilpine Maleate; Female; Lactation; Male; | 1994 |
The efficacy of barbiturate coma in the management of uncontrolled intracranial hypertension following neurosurgical trauma.
Topics: Adolescent; Adult; Brain Injuries; Chi-Square Distribution; Child; Coma; Female; Glasgow Coma Scale; | 1994 |
Early assessment of neurologic deficits in the fluid percussion model of brain injury.
Topics: Anesthesia; Animals; Behavior, Animal; Blood Pressure; Brain Injuries; Brain Stem; Cats; Cerebral He | 1993 |
Adverse effects of pentobarbital on cerebral venous oxygenation of comatose patients with acute traumatic brain swelling: relationship to outcome.
Topics: Adolescent; Adult; Aged; Brain Edema; Brain Injuries; Cerebral Veins; Coma; Female; Humans; Male; Mi | 1996 |
Pentobarbital and venous oxygenation.
Topics: Acute Disease; Brain Edema; Brain Injuries; Cerebral Veins; Coma; Humans; Oxygen; Pentobarbital | 1997 |
Comparative effects of hypothermia, barbiturate, and osmotherapy for cerebral oxygen metabolism, intracranial pressure, and cerebral perfusion pressure in patients with severe head injury.
Topics: Adolescent; Adult; Barbiturates; Blood Pressure; Brain; Brain Injuries; Child; Dose-Response Relatio | 1998 |
Effects of injury and therapy on brain parenchyma pO2, pCO2, pH and ICP following severe closed head injury.
Topics: Acid-Base Equilibrium; Adolescent; Adult; Brain; Brain Injuries; Brain Ischemia; Carbon Dioxide; Cra | 1998 |
Use of iatrogenic barbiturate coma.
Topics: Adult; Brain Edema; Brain Injuries; Coma; Humans; Iatrogenic Disease; Intracranial Pressure; Pentoba | 1979 |
The outcome with aggressive treatment in severe head injuries. Part II: acute and chronic barbiturate administration in the management of head injury.
Topics: Adult; Brain Injuries; Humans; Intracranial Pressure; Pentobarbital; Prognosis | 1979 |
Cerebral protection by barbiturate anesthesia. Use after middle cerebral artery occlusion in Java monkeys.
Topics: Anesthesia, Inhalation; Animals; Brain Edema; Brain Injuries; Cerebral Arterial Diseases; Cerebrovas | 1976 |
The evidence that a serotonergic mechanism plays an important role in cryogenic brain injury: are the results conclusive?
Topics: Animals; Brain Injuries; Cold Temperature; Pentobarbital; Rats; Serotonin | 1992 |
The influence of cryogenic brain injury on the pharmacodynamics of pentobarbital. Evidence for a serotonergic mechanism.
Topics: Animals; Brain Injuries; Fenclonine; Freezing; Infusions, Intravenous; Male; Pentobarbital; Rats; Ra | 1991 |
Electroencephalographic activity and serum and cerebrospinal fluid pentobarbital levels in determining the therapeutic end point during barbiturate coma.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Child; Coma; Electroencephalography; Female; Human | 1991 |
Intensive management of severe head injury.
Topics: Brain Injuries; Critical Care; Humans; Intracranial Pressure; Pentobarbital | 1991 |
The effect of pentobarbital and isoflurane on glucose metabolism in thermally injured rat brain.
Topics: Animals; Autoradiography; Brain Injuries; Disease Models, Animal; Freezing; Glucose; Isoflurane; Mal | 1990 |
Oxygen tension, oxygen metabolism, and microcirculation in vasogenic brain edema.
Topics: Animals; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Cold Temperature; Ketamine; Male; | 1990 |
Efficacy of barbiturates in the treatment of resistant intracranial hypertension in severely head-injured children.
Topics: Adolescent; Brain Injuries; Child; Child, Preschool; Coma; Humans; Infant; Pentobarbital; Pseudotumo | 1989 |
A comparison of the effects of halothane, isoflurane, and pentobarbital anesthesia on intracranial pressure and cerebral edema formation following brain injury in rabbits.
Topics: Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Brain Edema; Brain Injuries; C | 1989 |
Pentobarbital pharmacokinetics in patients with severe head injury.
Topics: Adolescent; Adult; Brain Injuries; Female; Humans; Infusions, Intravenous; Intracranial Pressure; Ki | 1987 |
Effects of pentobarbital and ketamine on brain injury-induced anti-ischemic activity.
Topics: Anesthesia; Animals; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Ketamine; Male; Mi | 1987 |
Brain injury improves survival of mice following brain ischemia.
Topics: Anesthesia, General; Animals; Brain Injuries; Brain Ischemia; Mice; Pentobarbital | 1986 |
Pharmacological alteration of hyper-reactivity in rats with septal and hypothalamic lesions.
Topics: Aminopyrine; Analgesics; Animals; Behavior, Animal; Brain; Brain Injuries; Cerebral Ventricles; Chlo | 1969 |