Page last updated: 2024-11-02

pentobarbital and Ache

pentobarbital has been researched along with Ache in 102 studies

Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.

Research Excerpts

ExcerptRelevanceReference
"To investigate the effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways."7.76Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats. ( Gao, G; Luo, F; Wang, JY; Wang, N; Zhang, Y, 2010)
"Naloxone, per se, was ineffective."5.26Caerulein and morphine in a model of visceral pain. Effects on the hypotensive response to renal pelvis distension in the rat. ( Brasch, H; Zetler, G, 1982)
" In this study, we examined 3 commonly used euthanasia methods in mice: intraperitoneal injection of pentobarbital-phenytoin solution, CO2 inhalation, and isoflurane anesthesia followed by CO2 inhalation."3.85Physiologic, Behavioral, and Histologic Responses to Various Euthanasia Methods in C57BL/6NTac Male Mice. ( Boivin, GP; Bottomley, MA; Goss, L; Grobe, N; Schiml, PA, 2017)
"Formalin-induced acute inflammatory pain was established by intraplantar injection of 1% formalin without anesthesia or with anesthesia using the clinical anesthetics sevoflurane, propofol, or pentobarbital sodium."3.81Differential effects of general anesthetics on anxiety-like behavior in formalin-induced pain: involvement of ERK activation in the anterior cingulate cortex. ( Dai, RP; Li, CQ; Luo, C; Luo, W; Xu, JM; Zhang, YL; Zhou, FH, 2015)
"To investigate the effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways."3.76Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats. ( Gao, G; Luo, F; Wang, JY; Wang, N; Zhang, Y, 2010)
" The extract at given doses significantly and dose dependently reduced the frequency of acetic acid induced writhing in mice, prolonged the tail flicking latency in mice, reduced Carrageenan-induced paw edema volume in rat, delayed the onset as well as reduced the frequency of castor oil induced diarrhoeal episodes in mice, decreased gastrointestinal motility as assessed by the charcoal motility test in mice and prolonged pentobarbitone induced sleeping time in mice."3.73Preliminary pharmacological studies on Piper chaba stem bark. ( Ahmed, M; Faiz Hossain, C; Shilpi, JA; Taufiq-Ur-Rahman, M, 2005)
" In the first series of experiments, RT and VPL responses to pinching with a small artery clamp were tested with the rats under pentobarbital, urethane, ketamine, or halothane anesthesia."3.72Reticular thalamic responses to nociceptive inputs in anesthetized rats. ( Shaw, FZ; Yen, CT, 2003)
"Acetic acid-induced abdominal writhing, the tail flick test and carrageenan-induced peritonitis were used to study the analgesic and anti-inflammatory activity of the crude ethanolic extract from Spiranthera odoratissima roots."3.72Analgesic and anti-inflammatory activity of the ethanolic extract from Spiranthera odoratissima A. St. Hillaire (Manacá) roots. ( Costa, EA; Matos, LG; Paula, JR; Pontes, IS; Tresvenzol, LM, 2004)
" In NRGC neurons that responded to both nociception (tail clamp) and transient hypertension elicited by phenylephrine (5 micrograms/kg, i."3.69Interaction between neuronal responses to nociception and hypertension in the nucleus reticularis gigantocellularis of the rat. ( Chan, JY; Chan, SH; Kuo, TB; Tsai, HF, 1994)
" Few studies exist quantifying adverse events during and after euthanasia."2.61An Objective Exploration of Euthanasia and Adverse Events. ( Marchitelli, B, 2019)
"When ketamine was used as the general anesthetic, self-mutilation was almost suppressed (13%) and consisted of superficial erosions."1.32Effects of anesthesia and nociceptive stimulation in an experimental model of brachial plexus avulsion. ( Rokyta, R; Vaculín, S, 2004)
"Decreased pain was correlated with increased motor activity for morphine and amphetamine, and with decreased activity for xylazine and acepromazine; dipyrone and indomethacin did not alter activity levels."1.31The formalin test in the mouse: a parametric analysis of scoring properties. ( Abbott, FV; Saddi, GM, 2000)
" Dogs euthanatized with pentobarbital alone had significantly longer times than did dogs euthanatized with pentobarbital in combination with any of the lidocaine concentrations."1.29Comparison of pentobarbital alone and pentobarbital in combination with lidocaine for euthanasia of dogs. ( Broadstone, R; Evans, AT; Hooks, TM; Johnston, SM; McNeil, JR; Stapleton, J, 1993)
" Dose-response curves were monophasic and linear over this range."1.28Propofol and barbiturate depression of spinal nociceptive neurotransmission. ( Gibbs, LM; Jewett, BA; Kendig, JJ; Tarasiuk, A, 1992)
"Pretreatment with pentobarbital 250 micrograms prevented the facilitation by naloxone of C fibre-evoked activity."1.27Effects of intrathecally administered pentobarbital and naloxone on the activity evoked in ascending axons of the rat spinal cord by stimulation of afferent A and C fibres. Further evidence for a tonic endorphinergic inhibition in nociception. ( Bernatzky, G; Doi, T; Jurna, I, 1983)
" The elimination-phase half-life of pentobarbital was 8."1.27Pharmacokinetics of pentobarbital in the dog. ( Atkinson, AJ; Frederiksen, MC; Henthorn, TK; Ruo, TI, 1983)
"When pentobarbital and morphine were administered in combination by i."1.27Interaction of pentobarbital and morphine in the tail-flick test performed on rats: synergism at the spinal and antagonism at the supraspinal level. ( Carlsson, KH; Jurna, I, 1986)
"Naloxone, per se, was ineffective."1.26Caerulein and morphine in a model of visceral pain. Effects on the hypotensive response to renal pelvis distension in the rat. ( Brasch, H; Zetler, G, 1982)

Research

Studies (102)

TimeframeStudies, this research(%)All Research%
pre-199053 (51.96)18.7374
1990's18 (17.65)18.2507
2000's21 (20.59)29.6817
2010's7 (6.86)24.3611
2020's3 (2.94)2.80

Authors

AuthorsStudies
Davis, JA1
Bopp, AC1
Henwood, MK1
Bean, P1
Grau, JW2
Laferriere, CA1
Pang, DS1
Reimer, JN1
Schuster, CJ1
Knight, CG1
Pang, DSJ1
Leung, VSY1
Boivin, GP2
Bottomley, MA1
Schiml, PA1
Goss, L1
Grobe, N1
Duckett, S1
Dudley, ES1
Marchitelli, B1
Belmont, AP1
Nossair, F1
Brambilla, D1
Friedman, M1
Boswinkel, J1
Bradford, AB1
Kwiatkowski, JL1
Luo, C1
Zhang, YL1
Luo, W1
Zhou, FH1
Li, CQ1
Xu, JM1
Dai, RP1
Liu, L1
Tsuruoka, M1
Maeda, M1
Hayashi, B1
Wang, X1
Inoue, T1
Wang, N1
Zhang, Y1
Wang, JY1
Gao, G1
Luo, F1
Wang, B1
Samanani, N1
Roth, SH2
Archer, DP2
Yen, CT2
Shaw, FZ2
Devi, KP1
Sreepriya, M1
Devaki, T1
Balakrishna, K1
COLLINS, W1
HOLT, LB1
ROBESON, K1
ROYCE, PC1
SAYERS, G1
ALLEN, T1
GRAFF, TD1
PHILLIPS, OC1
NELSON, AT1
HARRIS, LC1
FOX, ET1
FRAZIER, TM1
WEATHERALL, JA1
CLIFFORD, DH1
ARORA, RB1
SHARMA, PL1
ARGENT, DE1
MITCHELL, CL2
STRAW, RN1
HILL, HE1
BELLEVILLE, RE1
WIKLER, A1
Vaculín, S1
Rokyta, R1
Nishikawa, T1
Takeda, M1
Tanimoto, T1
Matsumoto, S1
Matos, LG1
Pontes, IS1
Tresvenzol, LM1
Paula, JR1
Costa, EA1
Taufiq-Ur-Rahman, M1
Shilpi, JA2
Ahmed, M1
Faiz Hossain, C1
Gradl, G1
Gaida, S1
Finke, B1
Lindenblatt, N1
Gierer, P1
Menger, MD1
Mittlmeier, T1
Vollmar, B1
Craft, RM1
Leitl, MD1
Uddin, SJ1
Rahman, MT1
Ferdous, M1
Rouf, R1
Sarker, SD1
Kumar, A1
Kulkarni, SK1
Kubota, I1
Tsuboi, Y1
Shoda, E1
Kondo, M1
Masuda, Y1
Kitagawa, J1
Oi, Y1
Iwata, K1
Washburn, SN1
Patton, BC1
Ferguson, AR1
Hudson, KL1
Svendsen, O1
Kok, L1
Lauritzen, B1
Chen, YF1
Li, N1
Jiao, YL1
Wei, P1
Zhang, QY1
Rahman, K1
Zheng, HC1
Qin, LP1
Hori, Y1
Lee, KH1
Chung, JM1
Endo, K1
Willis, WD1
Terman, GW1
Shavit, Y1
Lewis, JW1
Cannon, JT1
Liebeskind, JC2
Kissin, I2
Jebeles, JA1
Bernatzky, G1
Doi, T1
Jurna, I2
Frederiksen, MC1
Henthorn, TK1
Ruo, TI1
Atkinson, AJ1
Jensen, TS1
Smith, DF1
Moskovets, ON1
Brasch, H1
Zetler, G1
Tomemori, N1
Komatsu, T1
Shingu, K1
Urabe, N1
Seo, N1
Mori, K1
Willow, M1
Carmody, J1
Carroll, P1
Follett, KA1
Dirks, B1
Tsai, HF1
Kuo, TB1
Chan, JY1
Chan, SH1
Goto, T2
Marota, JJ1
Crosby, G1
Evans, AT1
Broadstone, R1
Stapleton, J1
Hooks, TM1
Johnston, SM1
McNeil, JR1
McGaraughty, S1
Reinis, S1
Tsoukatos, J1
Sapsed-Byrne, S1
Holdcroft, A1
Ridout, D1
Abbott, FV2
Guy, ER1
Takahashi, H1
Yanagida, H1
Roychowdhury, SM1
Heinricher, MM2
Vatine, JJ1
Ratner, A1
Rosen, D1
Seltzer, Z1
Aikawa, N1
Ohmori, K1
Hiruma-Lima, CA1
Gracioso, JS1
Bighetti, EJ1
Germonsén Robineou, L1
Souza Brito, AR1
Saddi, GM1
Gurgel, LA1
Santos, FA1
Rao, VS1
Rollin, BE1
Chen, RF1
Martin, BR1
Dewey, WL1
Chau-Pham, T1
Prnage, AJ1
Geller, EB1
Durlofsky, L1
Cowan, A1
Harakal, C1
Adler, MW1
Passatore, M1
Haigler, HJ1
Emmers, R1
Jewett, BA1
Gibbs, LM1
Tarasiuk, A1
Kendig, JJ1
Olivéras, JL1
Montagne-Clavel, J1
Martin, G1
Iwasaki, H2
Collins, JG3
Namiki, A1
Yamasawa, Y1
Omote, K1
Omote, T1
Matsumoto, M1
Haws, CM1
Fields, HL1
Ren, K1
Saito, Y1
Tang, J1
Wang, QA1
Mao, LM1
Han, JS1
Baumeister, AA1
Hebert, G1
Nagy, M1
Hawkins, M1
Maier, SF1
Stein, C1
Morgan, MM1
Fleischmann, A1
Urca, G1
Wixson, SK1
White, WJ1
Hughes, HC1
Marshall, WK1
Lang, CM1
Kajander, KC1
Giesler, GJ1
Pomeranz, B2
Nguyen, P1
Peets, JM1
Dykstra, LA1
Woods, JH1
Carlsson, KH1
Mason, JO1
Vinik, HR1
McDanal, J1
Bradley, EL1
Pendse, VK1
Madan, BR1
Krauthamer, GM1
Whitaker, AH1
Slater, P1
Van Alstine, RS1
Fisher, SJ1
Moertel, CG1
Ahmann, DL1
Taylor, WF1
Schwartau, N1
Sherman, AD1
Gebhart, GF1
Ryhänen, P1
Hollmén, A1
Hinkula, A1
Pakonen, ML1
Pihlajaniemi, H1
Kerkelä, A1
Mima, T1
Uchiyama, S1
Onchi, Y1
Lambelin, G1
Roba, J1
Gillet, C1
Buu-Hoï, NP1
Mizuguchi, T1
Nakazato, K1
Suzuki, H1
Akita, H1
Mietani, M1
Jacobs, BL1
Farel, PB1
Koppel, AC1
Adams-Koppel, E1
Shanbhag, SM1
Kulkarni, HJ1
Gaitonde, BB1
Hahn, L1
Baldy-Moulinier, M1
Ingvar, DH1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Subanesthetic Sevoflurane for Treatment-Resistant Depression: A Proof-of-Concept Trial[NCT05008939]15 participants (Anticipated)Interventional2021-08-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for pentobarbital and Ache

ArticleYear
Review of Intraperitoneal Injection of Sodium Pentobarbital as a Method of Euthanasia in Laboratory Rodents.
    Journal of the American Association for Laboratory Animal Science : JAALAS, 2020, 05-01, Volume: 59, Issue:3

    Topics: Anesthetics, Inhalation; Animal Welfare; Animals; Animals, Laboratory; Biomedical Research; Euthanas

2020
An Objective Exploration of Euthanasia and Adverse Events.
    The Veterinary clinics of North America. Small animal practice, 2019, Volume: 49, Issue:3

    Topics: Animals; Euthanasia, Animal; Hypnotics and Sedatives; Pain; Pentobarbital

2019

Trials

3 trials available for pentobarbital and Ache

ArticleYear
Nociception after intraperitoneal injection of a sodium pentobarbitone formulation with and without lidocaine in rats quantified by expression of neuronal c-fos in the spinal cord--a preliminary study.
    Laboratory animals, 2007, Volume: 41, Issue:2

    Topics: Anesthetics, Local; Animals; Hypnotics and Sedatives; Lidocaine; Male; Neurons; Pain; Pain Measureme

2007
Relief of pain by oral medications. A controlled evaluation of analgesic combinations.
    JAMA, 1974, Jul-01, Volume: 229, Issue:1

    Topics: Administration, Oral; Analgesics; Aspirin; Azepines; Caffeine; Clinical Trials as Topic; Codeine; De

1974
[Effects of sedatives on postoperative pain].
    Masui. The Japanese journal of anesthesiology, 1971, Volume: 20, Issue:8

    Topics: Blood Pressure; Chlorpromazine; Clinical Trials as Topic; Humans; Hypnotics and Sedatives; Injection

1971

Other Studies

97 other studies available for pentobarbital and Ache

ArticleYear
General Anesthesia Blocks Pain-Induced Hemorrhage and Locomotor Deficits After Spinal Cord Injury in Rats.
    Journal of neurotrauma, 2023, Volume: 40, Issue:23-24

    Topics: Anesthesia, General; Anesthetics; Animals; Contusions; Hemorrhage; Humans; Isoflurane; Pain; Pentoba

2023
Intraperitoneal injection of sodium pentobarbital has the potential to elicit pain in adult rats (Rattus norvegicus).
    PloS one, 2020, Volume: 15, Issue:9

    Topics: Animals; Behavior, Animal; Female; Hypnotics and Sedatives; Injections, Intraperitoneal; Liver; Male

2020
Physiologic, Behavioral, and Histologic Responses to Various Euthanasia Methods in C57BL/6NTac Male Mice.
    Journal of the American Association for Laboratory Animal Science : JAALAS, 2017, Jan-01, Volume: 56, Issue:1

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Carbon Dioxide; Euthanasia, Animal; Hypnotics and Seda

2017
Knowing, Anticipating, Even Facilitating but Still not Intending: Another Challenge to Double Effect Reasoning.
    Journal of bioethical inquiry, 2018, Volume: 15, Issue:1

    Topics: Advance Directives; Beneficence; Cause of Death; Decision Making; Ethics, Medical; Health Services A

2018
Evaluation of a Commercially Available Euthanasia Solution as a Voluntarily Ingested Euthanasia Agent in Laboratory Mice.
    Journal of the American Association for Laboratory Animal Science : JAALAS, 2018, 01-01, Volume: 57, Issue:1

    Topics: Administration, Oral; Animals; Euthanasia, Animal; Female; Laboratory Animal Science; Male; Mice; Pa

2018
Safety of deep sedation in young children with sickle cell disease: a retrospective cohort study.
    The Journal of pediatrics, 2015, Volume: 166, Issue:5

    Topics: Acute Chest Syndrome; Adjuvants, Anesthesia; Anemia, Sickle Cell; Child; Child, Preschool; Deep Seda

2015
Differential effects of general anesthetics on anxiety-like behavior in formalin-induced pain: involvement of ERK activation in the anterior cingulate cortex.
    Psychopharmacology, 2015, Volume: 232, Issue:24

    Topics: Anesthetics, Inhalation; Animals; Anxiety; Behavior, Animal; Extracellular Signal-Regulated MAP Kina

2015
Descending modulation of visceral nociceptive transmission from the locus coeruleus/subcoeruleus in the rat.
    Brain research bulletin, 2008, Aug-15, Volume: 76, Issue:6

    Topics: Animals; Colon; Electric Stimulation; Electrophysiology; Evoked Potentials; Hypnotics and Sedatives;

2008
Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats.
    Neuroscience bulletin, 2010, Volume: 26, Issue:3

    Topics: Action Potentials; Anesthesia; Anesthetics; Animals; Brain; Gyrus Cinguli; Lasers; Male; Microelectr

2010
Spinal carbonic anhydrase contributes to nociceptive reflex enhancement by midazolam, pentobarbital, and propofol.
    Anesthesiology, 2003, Volume: 98, Issue:4

    Topics: Acetazolamide; Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Ethoxzolamide; Hypnotics

2003
Reticular thalamic responses to nociceptive inputs in anesthetized rats.
    Brain research, 2003, Apr-11, Volume: 968, Issue:2

    Topics: Action Potentials; Afferent Pathways; Anesthesia; Anesthetics, Dissociative; Anesthetics, Inhalation

2003
Antinociceptive and hypnotic effects of Premna tomentosa L. (Verbenaceae) in experimental animals.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 75, Issue:2

    Topics: Acetic Acid; Analgesics; Animals; Aspirin; Hypnotics and Sedatives; Male; Motor Activity; Pain; Pain

2003
Tubocurarine and nembutal anesthesia.
    American journal of ophthalmology, 1958, Volume: 46, Issue:4

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Corneal Transplantation; Curare; Pain; Pentobarbita

1958
Blood ACTH: effects of ether, pentobarbital, epinephrine and pain.
    Endocrinology, 1958, Volume: 63, Issue:6

    Topics: Adrenocorticotropic Hormone; Epinephrine; Ether; Ethers; Pain; Pentamidine; Pentobarbital

1958
The intraperitoneal use of procaine hydrochloride with morphine-pentobarbital anesthesia.
    Journal of the American Veterinary Medical Association, 1959, Aug-15, Volume: 135, Issue:4

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Animals; Animals, Newborn; Morphine; Pain; Pain Man

1959
Post-tonsillectomy analgesia: a double-blind study comparing pentobarbital, codeine and a placebo.
    Southern medical journal, 1961, Volume: 54

    Topics: Analgesia; Codeine; Double-Blind Method; Humans; Pain; Pain Management; Pentobarbital; Placebos; Pos

1961
Anaesthesia in new-born animals.
    British journal of pharmacology and chemotherapy, 1960, Volume: 15

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Animals; Animals, Newborn; Ethers; Pain; Pain Manag

1960
Effect of preanesthetic medication with promazine and promethazine on pentobarbital anesthesia and subsequent hypothermia in the cat.
    Journal of the American Veterinary Medical Association, 1960, Aug-15, Volume: 137

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Animals; Cats; Hypothermia; Hypothermia, Induced; P

1960
Mean auricularrate and ventricular response rate in auricular flutter in 200 dogs under sodium-pentobarbitone anaesthesia.
    The Indian journal of medical research, 1962, Volume: 50

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Animals; Atrial Flutter; Dogs; Pain; Pain Managemen

1962
ANAESTHESIA AND ANALGESIA IN DOMICILIARY MIDWIFERY.
    The Practitioner, 1964, Volume: 192

    Topics: Analgesia; Anesthesia; Anesthesia, Conduction; Anesthesia, General; Anesthesia, Inhalation; Anesthes

1964
A COMPARISON OF DRUG EFFECTS UPON THE JAW JERK RESPONSE TO ELECTRICAL STIMULATION OF THE TOOTH PULP IN DOGS AND CATS.
    The Journal of pharmacology and experimental therapeutics, 1964, Volume: 146

    Topics: Animals; Cats; Chlorpromazine; Dental Pulp; Dogs; Electric Stimulation; Morphine; Pain; Pentobarbita

1964
THE EFFECTS OF MORPHINE, PENTOBARBITAL, PENTAZOCINE AND NALORPHINE ON BIOELECTRICAL POTENTIALS EVOKED IN THE BRAIN STEM OF THE CAT BY ELECTRICAL STIMULATION OF THE TOOTH PULP.
    The Journal of pharmacology and experimental therapeutics, 1964, Volume: 146

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Brain; Brain Stem; Cats; Dental Pulp; Electric S

1964
Studies on anxiety associated with anticipation of pain. II. Comparative effects of pentobarbital and morphine.
    A.M.A. archives of neurology and psychiatry, 1955, Volume: 73, Issue:6

    Topics: Anxiety; Barbiturates; Humans; Morphine; Pain; Pentobarbital

1955
Effects of anesthesia and nociceptive stimulation in an experimental model of brachial plexus avulsion.
    Physiological research, 2004, Volume: 53, Issue:2

    Topics: Anesthesia; Animals; Brachial Plexus; Ketamine; Male; Models, Animal; Nociceptors; Pain; Pentobarbit

2004
Convergence of nociceptive information from temporomandibular joint and tooth pulp afferents on C1 spinal neurons in the rat.
    Life sciences, 2004, Aug-06, Volume: 75, Issue:12

    Topics: Animals; Dental Pulp; Electric Stimulation; Electromyography; Histological Techniques; Male; Neurons

2004
Analgesic and anti-inflammatory activity of the ethanolic extract from Spiranthera odoratissima A. St. Hillaire (Manacá) roots.
    Phytotherapy research : PTR, 2004, Volume: 18, Issue:12

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Migrati

2004
Preliminary pharmacological studies on Piper chaba stem bark.
    Journal of ethnopharmacology, 2005, Jun-03, Volume: 99, Issue:2

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidiarrheals; Carrageenan; Central

2005
Supernatant of traumatized muscle induces inflammation and pain, but not microcirculatory perfusion failure and apoptotic cell death.
    Shock (Augusta, Ga.), 2005, Volume: 24, Issue:3

    Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Death; Edema; Hemodynamics; In Situ

2005
Potentiation of morphine antinociception by pentobarbital in female vs. male rats.
    Pain, 2006, Volume: 121, Issue:1-2

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Analysis of Variance; Animals; Castration; Disease Models

2006
Assessment of neuropharmacological activities of Pandanus foetidus (Pandanaceae) in mice.
    Die Pharmazie, 2006, Volume: 61, Issue:4

    Topics: Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Hypnotics and Sedatives;

2006
Protective effect of BR-16A, a polyherbal preparation against social isolation stress: possible GABAergic mechanism.
    Phytotherapy research : PTR, 2006, Volume: 20, Issue:7

    Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; GABA Ago

2006
Modulation of neuronal activity in CNS pain pathways following propofol administration in rats: Fos and EEG analysis.
    Experimental brain research, 2007, Volume: 179, Issue:2

    Topics: Anesthesia; Anesthetics, Intravenous; Anesthetics, Local; Animals; Central Nervous System; Conscious

2007
Exposure to intermittent nociceptive stimulation under pentobarbital anesthesia disrupts spinal cord function in rats.
    Psychopharmacology, 2007, Volume: 192, Issue:2

    Topics: Animals; Behavior, Animal; Conditioning, Operant; Electroshock; Hindlimb; Hypnotics and Sedatives; M

2007
Antinociceptive activity of petroleum ether fraction from the MeOH extracts of Paederia scandens in mice.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2008, Volume: 15, Issue:6-7

    Topics: Acetic Acid; Alkanes; Analgesics; Animals; Capsaicin; Formaldehyde; Hot Temperature; Methanol; Mice;

2008
The effects of small doses of barbiturate on the activity of primate nociceptive tract cells.
    Brain research, 1984, Jul-30, Volume: 307, Issue:1-2

    Topics: Anesthesia, General; Animals; Cerebral Decortication; Decerebrate State; Halothane; Nerve Fibers; Ni

1984
Intrinsic mechanisms of pain inhibition: activation by stress.
    Science (New York, N.Y.), 1984, Dec-14, Volume: 226, Issue:4680

    Topics: Adaptation, Physiological; Adrenalectomy; Anesthesia; Animals; Brain Stem; Conditioning, Psychologic

1984
Halothane antagonizes effect of morphine on the motor reaction threshold in rats.
    Anesthesiology, 1984, Volume: 61, Issue:6

    Topics: Animals; Constriction; Dose-Response Relationship, Drug; Halothane; Morphine; Motor Activity; Pain;

1984
Effects of intrathecally administered pentobarbital and naloxone on the activity evoked in ascending axons of the rat spinal cord by stimulation of afferent A and C fibres. Further evidence for a tonic endorphinergic inhibition in nociception.
    Naunyn-Schmiedeberg's archives of pharmacology, 1983, Volume: 323, Issue:3

    Topics: Afferent Pathways; Animals; Axons; Electric Stimulation; Endorphins; Evoked Potentials; Female; Inje

1983
Pharmacokinetics of pentobarbital in the dog.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 225, Issue:2

    Topics: Anesthesia, Intravenous; Animals; Blood Volume; Dogs; Female; Hematocrit; Kinetics; Male; Pain; Pent

1983
Stimulation of spinal dopaminergic receptors: differential effects on tail reflexes in rats.
    Neuropharmacology, 1983, Volume: 22, Issue:4

    Topics: Animals; Apomorphine; Dopamine; Male; Pain; Pentobarbital; Rats; Rats, Inbred Strains; Reaction Time

1983
[Effect of auricular electroacupuncture on the motor manifestations of nociceptive reactions].
    Biulleten' eksperimental'noi biologii i meditsiny, 1980, Volume: 89, Issue:4

    Topics: Acupuncture Therapy; Animals; Cats; Ear, External; Electric Stimulation Therapy; Electromyography; M

1980
Caerulein and morphine in a model of visceral pain. Effects on the hypotensive response to renal pelvis distension in the rat.
    Naunyn-Schmiedeberg's archives of pharmacology, 1982, Volume: 319, Issue:2

    Topics: Animals; Blood Pressure; Ceruletide; Disease Models, Animal; Kidney Pelvis; Male; Morphine; Naloxone

1982
Activation of the supraspinal pain inhibition system by ketamine hydrochloride.
    Acta anaesthesiologica Scandinavica, 1981, Volume: 25, Issue:4

    Topics: Animals; Bradykinin; Cats; Decerebrate State; Female; Ketamine; Male; Pain; Pentobarbital; Spinal Co

1981
The effects of swimming in mice on pain perception and sleeping time in response to hypnotic drugs.
    Life sciences, 1980, Jan-21, Volume: 26, Issue:3

    Topics: Animals; Ethanol; Female; Mice; Morphine; Naloxone; Pain; Pentobarbital; Sleep; Stress, Physiologica

1980
Responses of neurons in ventrolateral orbital cortex to noxious visceral stimulation in the rat.
    Brain research, 1995, Jan-16, Volume: 669, Issue:2

    Topics: Animals; Cerebral Cortex; Electric Stimulation; Male; Nerve Fibers; Neurons; Nociceptors; Pain; Pent

1995
Interaction between neuronal responses to nociception and hypertension in the nucleus reticularis gigantocellularis of the rat.
    Neuroscience letters, 1994, Jan-03, Volume: 165, Issue:1-2

    Topics: Anesthesia; Animals; Basal Ganglia; Blood Pressure; Evoked Potentials; Hypertension; Male; Neurons;

1994
Pentobarbitone, but not propofol, produces pre-emptive analgesia in the rat formalin model.
    British journal of anaesthesia, 1994, Volume: 72, Issue:6

    Topics: Analgesics; Anesthesia, Intravenous; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde

1994
Comparison of pentobarbital alone and pentobarbital in combination with lidocaine for euthanasia of dogs.
    Journal of the American Veterinary Medical Association, 1993, Sep-01, Volume: 203, Issue:5

    Topics: Animals; Dogs; Drug Combinations; Drug Synergism; Electrocardiography; Euthanasia; Female; Injection

1993
A correlogram analysis of the activity in the rostral ventromedial medulla of awake rats and in rats anesthetized with ketamine or pentobarbital following the administration of morphine.
    Experimental brain research, 1995, Volume: 106, Issue:2

    Topics: Action Potentials; Analgesics, Opioid; Animals; Data Interpretation, Statistical; Drug Combinations;

1995
The influence of colonic temperature changes in anaesthetised rats on tail skin temperatures and repeated testing of tail-flick latencies.
    Pain, 1995, Volume: 63, Issue:2

    Topics: Analysis of Variance; Anesthesia; Animals; Behavior, Animal; Body Temperature; Colon; Female; Pain;

1995
Effects of morphine, pentobarbital and amphetamine on formalin-induced behaviours in infant rats: sedation versus specific suppression of pain.
    Pain, 1995, Volume: 62, Issue:3

    Topics: Amphetamine; Animals; Animals, Newborn; Behavior, Animal; Female; Formaldehyde; Hypnotics and Sedati

1995
Is pentobarbital analgesic in the rat formalin test?
    Anesthesiology, 1997, Volume: 86, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; Hypnotics and Sedatives; Pain; Pentobarbita

1997
Effects of iontophoretically applied serotonin on three classes of physiologically characterized putative pain modulating neurons in the rostral ventromedial medulla of lightly anesthetized rats.
    Neuroscience letters, 1997, Apr-25, Volume: 226, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia, General; Animals; Evoked Potentials; Iontophores

1997
Differential sensory-motor effects of pentobarbital in intact rats genetically selected for high vs. low neuropathic pain-related behaviour.
    Pain, 1998, Volume: 75, Issue:2-3

    Topics: Animals; Behavior, Animal; Male; Motor Activity; Pain; Pain Measurement; Pentobarbital; Rats; Rats,

1998
Acetazolamide and amiloride inhibit pentobarbital-induced facilitation of nocifensive reflexes.
    Anesthesiology, 1999, Volume: 90, Issue:4

    Topics: Acetazolamide; Amiloride; Animals; GABA Modulators; Male; NG-Nitroarginine Methyl Ester; Pain; Pento

1999
Effect of zaldaride maleate, an antidiarrheal compound, on visceral pain reflex induced by small intestinal distention in anesthetized rats.
    Japanese journal of pharmacology, 1999, Volume: 81, Issue:4

    Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Animals, Newborn; Antidiarrheals; Atropine; Benzi

1999
The juice of fresh leaves of Boerhaavia diffusa L. (Nyctaginaceae) markedly reduces pain in mice.
    Journal of ethnopharmacology, 2000, Volume: 71, Issue:1-2

    Topics: Acetates; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Carrageenan; Edema; Hot Temperature

2000
The formalin test in the mouse: a parametric analysis of scoring properties.
    Pain, 2000, Dec-15, Volume: 89, Issue:1

    Topics: Acepromazine; Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Amphetamine; Analgesics, Opioid; Ani

2000
Effects of human placental extract on chemical and thermal nociception in mice.
    European journal of pain (London, England), 2000, Volume: 4, Issue:4

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Hot Temperature;

2000
An ethicist's commentary on the producer who is unwilling to euthanize sick pigs.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2001, Volume: 42, Issue:1

    Topics: Animal Husbandry; Animals; Ethics, Professional; Euthanasia; Pain; Pentobarbital; Swine; Swine Disea

2001
Dynamic changes of touch- and laser heat-evoked field potentials of primary somatosensory cortex in awake and pentobarbital-anesthetized rats.
    Brain research, 2001, Aug-24, Volume: 911, Issue:2

    Topics: Adjuvants, Anesthesia; Animals; Behavior, Animal; Electroencephalography; Evoked Potentials, Somatos

2001
Interactions of thyrotropin releasing hormone and morphine sulfate in rodents.
    Life sciences, 1977, Feb-15, Volume: 20, Issue:4

    Topics: Analgesics; Animals; Apomorphine; Behavior, Animal; Body Weight; Chlorpromazine; Dronabinol; Humans;

1977
The effect of pentobarbital on the antinociceptive action of morphine in morphine-tolerant and non-tolerant rats.
    Life sciences, 1979, Jul-09, Volume: 25, Issue:2

    Topics: Animals; Drug Tolerance; Humans; Male; Morphine; Morphine Dependence; Pain; Pentobarbital; Rats; Sen

1979
Physiological characterization of efferent cervical sympathetic fibers influenced by changes of illumination.
    Experimental neurology, 1976, Volume: 53, Issue:1

    Topics: Animals; Asphyxia; Blood Pressure; Body Temperature; Cats; Cervical Plexus; Evoked Potentials; Light

1976
Morphine: ability to block neuronal activity evoked by a nociceptive stimulus.
    Life sciences, 1976, Sep-15, Volume: 19, Issue:6

    Topics: Action Potentials; Animals; Brain Stem; Chlorpromazine; Levorphanol; Male; Methadone; Morphine; Nalo

1976
Thalamic mechanisms that process a temporal pulse code for pain.
    Brain research, 1976, Feb-27, Volume: 103, Issue:3

    Topics: Action Potentials; Animals; Electric Stimulation; Electrocoagulation; Morphine; Nerve Degeneration;

1976
Propofol and barbiturate depression of spinal nociceptive neurotransmission.
    Anesthesiology, 1992, Volume: 77, Issue:6

    Topics: Animals; Animals, Newborn; Depression, Chemical; Hyperalgesia; In Vitro Techniques; Pain; Pentobarbi

1992
Drastic changes of ventromedial medulla neuronal properties induced by barbiturate anesthesia. I. Comparison of the single-unit types in the same awake and pentobarbital-treated rats.
    Brain research, 1991, Nov-01, Volume: 563, Issue:1-2

    Topics: Anesthesia; Animals; Electric Stimulation; Electroencephalography; Hot Temperature; Medulla Oblongat

1991
[Comparison of the effect of propofol and that of pentobarbital on behavioral responses to somatic and visceral stimuli in rats].
    Masui. The Japanese journal of anesthesiology, 1991, Volume: 40, Issue:9

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Male; Pain; Pentobarbital; Propofol; Ra

1991
Alpha-adrenergic receptor agonists, but not antagonists, alter the tail-flick latency when microinjected into the rostral ventromedial medulla of the lightly anesthetized rat.
    Brain research, 1990, Nov-19, Volume: 533, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Male; Medulla Oblongata; Microinje

1990
Plasticity of some spinal dorsal horn neurons as revealed by pentobarbital-induced disinhibition.
    Brain research, 1990, Aug-20, Volume: 525, Issue:2

    Topics: Animals; Cats; Female; Hot Temperature; Neuronal Plasticity; Neurons; Pain; Pentobarbital; Physical

1990
Analgesia from electrical stimulation of the hypothalamic arcuate nucleus in pentobarbital-anesthetized rats.
    Brain research, 1990, Sep-03, Volume: 526, Issue:2

    Topics: Analgesia; Animals; Arcuate Nucleus of Hypothalamus; Brain Mapping; Electric Stimulation; Female; Na

1990
Pentobarbital attenuates the antinociceptive effect of intranigral morphine.
    Neuropharmacology, 1989, Volume: 28, Issue:2

    Topics: Animals; Drug Interactions; Male; Morphine; Pain; Pentobarbital; Rats; Rats, Inbred Strains; Referen

1989
Determinants of the nature of environmentally induced hypoalgesia.
    Behavioral neuroscience, 1989, Volume: 103, Issue:1

    Topics: Analgesia; Animals; Electroshock; Endorphins; Male; Naltrexone; Pain; Pentobarbital; Rats; Rats, Inb

1989
Barbiturate-induced inhibition of a spinal nociceptive reflex: role of GABA mechanisms and descending modulation.
    Brain research, 1987, Mar-31, Volume: 407, Issue:2

    Topics: Analgesics; Animals; Depression, Chemical; gamma-Aminobutyric Acid; Male; Pain; Pentobarbital; Rats;

1987
Different endogenous analgesia systems are activated by noxious stimulation of different body regions.
    Brain research, 1988, Jul-05, Volume: 455, Issue:1

    Topics: Analgesia; Animals; Brain; Male; Mice; Mice, Inbred ICR; Nociceptors; Organ Specificity; Pain; Pento

1988
The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on noxious stimulus perception in adult male rats.
    Laboratory animal science, 1987, Volume: 37, Issue:6

    Topics: Anesthesia; Anesthetics; Animals; Diazepam; Droperidol; Drug Combinations; Fentanyl; Ketamine; Male;

1987
Responses of neurons in the lateral cervical nucleus of the cat to noxious cutaneous stimulation.
    Journal of neurophysiology, 1987, Volume: 57, Issue:6

    Topics: Animals; Cats; Decerebrate State; Evoked Potentials, Somatosensory; Methohexital; Nociceptors; Pain;

1987
Intrathecal diazepam suppresses nociceptive reflexes and potentiates electroacupuncture effects in pentobarbital-anesthetized rats.
    Neuroscience letters, 1987, Jun-26, Volume: 77, Issue:3

    Topics: Acupuncture Therapy; Anesthesia, Intravenous; Animals; Diazepam; Drug Synergism; Humans; Injections,

1987
A descriptive study of spinal dorsal horn neurons in the physiologically intact, awake, drug-free cat.
    Brain research, 1987, Jul-21, Volume: 416, Issue:1

    Topics: Action Potentials; Anesthesia; Animals; Cats; Female; Male; Membrane Potentials; Neurons, Afferent;

1987
Studies in suppression of nocifensive reflexes measured with tail flick electromyograms and using intrathecal drugs in barbiturate anesthetized rats.
    Brain research, 1987, Jul-28, Volume: 416, Issue:2

    Topics: Anesthesia; Animals; Conditioning, Classical; Electric Stimulation; Electromyography; Injections, Sp

1987
A tail withdrawal procedure for assessing analgesic activity in rhesus monkeys.
    Journal of pharmacological methods, 1986, Volume: 15, Issue:3

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Female; Haloperidol; Hot Temperature; Male; M

1986
Interaction of pentobarbital and morphine in the tail-flick test performed on rats: synergism at the spinal and antagonism at the supraspinal level.
    Neuroscience letters, 1986, Nov-21, Volume: 71, Issue:3

    Topics: Animals; Central Nervous System; Drug Interactions; Female; Injections, Intraperitoneal; Injections,

1986
Barbiturates inhibit stress-induced analgesia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1987, Volume: 34, Issue:2

    Topics: Animals; Male; Naloxone; Pain; Pain Measurement; Pentobarbital; Rats; Rats, Inbred Strains; Sensory

1987
Some pharmacological actions of cyclizine, chlorcyclizine and homchlorcyclizine.
    Indian journal of physiology and pharmacology, 1969, Volume: 13, Issue:1

    Topics: Acetylcholine; Animals; Anura; Central Nervous System; Conditioning, Psychological; Cyclizine; Diaph

1969
Cortical synchronization evoked by noxious bradykinin stimulation under barbiturate anesthesia.
    Brain research, 1974, Nov-08, Volume: 80, Issue:1

    Topics: Anesthesia, Intravenous; Animals; Bradykinin; Cats; Cerebral Cortex; Cortical Synchronization; Elect

1974
Effect of 6-hydroxydopamine on some actions of tremorine and oxotremorine.
    European journal of pharmacology, 1974, Volume: 25, Issue:2

    Topics: Amines; Animals; Body Temperature; Brain Chemistry; Catecholamines; Dopamine; Dose-Response Relation

1974
Use of sedation-analgesia in general dentistry.
    Journal of the Canadian Dental Association, 1973, Volume: 39, Issue:7

    Topics: Analgesia; Anesthesia, Dental; Diazepam; Humans; Meperidine; Nitrous Oxide; Pain; Pentobarbital; Sco

1973
Pain-induced alteration of glutamate in periaqueductal central gray and its reversal by morphine.
    Life sciences, 1974, Nov-15, Volume: 15, Issue:10

    Topics: Animals; Chlorpromazine; Glutamates; Hypothalamus; Male; Mice; Morphine; Naloxone; Nociceptors; Pain

1974
Patient's views on general anaesthesia.
    Annales chirurgiae et gynaecologiae Fenniae, 1973, Volume: 62, Issue:5

    Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Inhalation; Attitude; Cognition; Diazepam;

1973
Pharmacology of a new analgesic, antipyretic, and anti-inflammatory agent, 4-allyloxy-3-chlorophenylacetic acid.
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:5

    Topics: Aminopyrine; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Carrageenan; Codeine

1970
[Effect of sedatives on pain threshold].
    Masui. The Japanese journal of anesthesiology, 1971, Volume: 20, Issue:10

    Topics: Adult; Diazepam; Female; Humans; Hypnotics and Sedatives; Meperidine; Pain; Pentazocine; Pentobarbit

1971
Motivated behaviors produced by increased arousal in the presence of goal objects.
    Physiology & behavior, 1971, Volume: 6, Issue:5

    Topics: Aggression; Animal Nutritional Physiological Phenomena; Animals; Arousal; Behavior, Animal; Consumma

1971
A method of intravenous medication.
    Sda Dentist, 1969,Spring, Volume: 2, Issue:3

    Topics: Anxiety; Humans; Injections, Intravenous; Meperidine; Pain; Pentobarbital; Preanesthetic Medication;

1969
Pharmacological actions of berberine on the central nervous system.
    Japanese journal of pharmacology, 1970, Volume: 20, Issue:4

    Topics: Alkaloids; Amphetamine; Analgesics; Animals; Anticonvulsants; Cats; Central Nervous System; Drug Syn

1970
Continuous paracervical block anaesthesia.
    Acta obstetricia et gynecologica Scandinavica, 1969, Volume: 48, Issue:S3

    Topics: Adolescent; Adult; Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthetics, Local; Catheterizat

1969
EEG frequency content related to regional blood flow of cerebral cortex in cat.
    Experimental brain research, 1968, Volume: 5, Issue:1

    Topics: Animals; Cats; Cerebral Cortex; Cerebrovascular Circulation; Electroencephalography; Fentanyl; Krypt

1968