pentobarbital has been researched along with Abnormality, Heart in 6 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Children with congenital heart disease are repeatedly exposed to sedatives and anesthetics that may affect brain development." | 2.87 | Comparison of Intranasal Dexmedetomidine and Oral Pentobarbital Sedation for Transthoracic Echocardiography in Infants and Toddlers: A Prospective, Randomized, Double-Blind Trial. ( Ding, L; Divanovic, A; Gunter, JB; Kreeger, RN; Lam, JE; Li, BL; Lin, EP; Loepke, AW; Mahmoud, M; Miller, JW; Paquin, JR; Spaeth, JP, 2018) |
| " Serial pharmacokinetic blood samples were obtained." | 1.37 | Population pharmacokinetics of pentobarbital in neonates, infants, and children after open heart surgery. ( Barrett, JS; Gastonguay, MR; Nicolson, SC; Zuppa, AF, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miller, JW | 1 |
| Ding, L | 1 |
| Gunter, JB | 1 |
| Lam, JE | 1 |
| Lin, EP | 1 |
| Paquin, JR | 1 |
| Li, BL | 1 |
| Spaeth, JP | 1 |
| Kreeger, RN | 1 |
| Divanovic, A | 1 |
| Mahmoud, M | 1 |
| Loepke, AW | 1 |
| Zuppa, AF | 1 |
| Nicolson, SC | 1 |
| Barrett, JS | 1 |
| Gastonguay, MR | 1 |
| Vinks, AA | 1 |
| Levine, MF | 1 |
| Hartley, EJ | 1 |
| Macpherson, BA | 1 |
| Burrows, FA | 1 |
| Lerman, J | 1 |
| Jaffe, RB | 1 |
| Kraft-Kinz, J | 1 |
| Finsterbusch, W | 1 |
| Friehs, G | 1 |
| Koch, G | 1 |
| List, WF | 1 |
| Klein, W | 1 |
| Sterz, H | 1 |
| Eide, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Qualitative Comparison of Two Sedation Techniques in Children Undergoing Transthoracic Echocardiography[NCT02250820] | Phase 1 | 280 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for pentobarbital and Abnormality, Heart
| Article | Year |
|---|---|
Comparison of Intranasal Dexmedetomidine and Oral Pentobarbital Sedation for Transthoracic Echocardiography in Infants and Toddlers: A Prospective, Randomized, Double-Blind Trial.
Topics: Administration, Intranasal; Child, Preschool; Dexmedetomidine; Double-Blind Method; Echocardiography | 2018 |
Oral midazolam premedication for children with congenital cyanotic heart disease undergoing cardiac surgery: a comparative study.
Topics: Administration, Oral; Administration, Rectal; Anxiety, Separation; Atropine; Awareness; Child; Child | 1993 |
4 other studies available for pentobarbital and Abnormality, Heart
| Article | Year |
|---|---|
Population pharmacokinetics of pentobarbital in neonates, infants, and children after open heart surgery.
Topics: Age Factors; Body Weight; Child, Preschool; Heart Defects, Congenital; Humans; Hypnotics and Sedativ | 2011 |
Important role of population pharmacokinetic/pharmacodynamic modeling in pediatric therapeutics.
Topics: Heart Defects, Congenital; Humans; Hypnotics and Sedatives; Pentobarbital | 2011 |
Sedation and imaging protocol.
Topics: Child; Child, Preschool; Chloral Hydrate; Electrocardiography; Fentanyl; Heart Defects, Congenital; | 1990 |
[Correction of congenital acyanotic heart defects].
Topics: Adolescent; Adult; Anesthesia, Endotracheal; Child; Cyanosis; Extracorporeal Circulation; Female; Ha | 1969 |