pentetic acid and Cystic Fibrosis

pentetic acid has been researched along with Cystic Fibrosis in 7 studies

Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.

Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.

Research

Studies (7)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Absorptive Clearance Rate After Hypertonic Saline Inhalation

The absorption rate of In-DTPA after the inhalation of hypertonic saline (NCT01223183)
Timeframe: 80 minutes after radiopharmaceutical inhalation

Absorptive Clearance Rate After Isotonic Saline Inhalation

The absorption rate of Indium 111 diethylenetriaminepentaacetic acid (In-DTPA) in the airways after the inhalation of isotonic saline (NCT01223183)
Timeframe: 80 minutes after radiopharmaceutical inhalation

Mucociliary Clearance Rate After Hypertonic Saline Inhalation

The clearance rate of Tc-SC after the inhalation of hypertonic saline (NCT01223183)
Timeframe: 80 minutes after radiopharmaceutical inhalation

Mucociliary Clearance Rate After Isotonic Saline Inhalation

The clearance rate of Tc-SC after the inhalation of isotonic saline (NCT01223183)
Timeframe: 80 minutes after radiopharmaceutical inhalation

Absorptive Clearance Rate

Absorptive Clearance Rate measured 80 minutes after radiopharmaceutical inhalation. Absorptive clearance is the absorptive component of the clearance of In-DTPA from the lungs. (NCT01486199)
Timeframe: t=2 years

Absorptive Clearance Rate

Absorptive clearance rate measured 80 minutes after radiopharmaceutical inhalation. Absorptive clearance is the absorptive component of the clearance of Indium 111-diethylenetriaminepentaacetic acid (In-DTPA) from the lungs. (NCT01486199)
Timeframe: study day 1

Mucociliary Clearance Rate

Mucociliary clearance rate measured 80 minutes after radiopharmaceutical inhalation. Mucociliary clearance rate is the rate of clearance of Technetium sulfur colloid (Tc-SC) from the lungs. (NCT01486199)
Timeframe: study day 1

Mucociliary Clearance Rate

Mucociliary clearance rate measured 80 minutes after radiopharmaceutical inhalation. Mucociliary clearance rate is the rate of clearance of Technetium sulfur colloid (Tc-SC) from the lungs. (NCT01486199)
Timeframe: t=2 years, measure made 80 minutes after radiopharmaceutical inhalation

Absorptive Clearance Rate

The absorptive clearance rate is the percentage of the radiolabeled small molecule DTPA that is cleared through absorption over a 60 minute period. Total DTPA clearance includes absorptive and mucociliary components. The mucociliary component is determined by measuring the clearance of a radiolabeled particle over the same period (Technetium 99m sulfur colloid; Tc-SC), and subtracted from total DTPA clearance in order to determine the absorptive component. Here we specifically report absorption from the central lung zone to capture the behavior within the airways. (NCT00541190)
Timeframe: single measurement

Mucociliary Clearance Rate

"Mucociliary clearance rate represents the rate at which the lungs clear an inhaled particulate. Here it specifically represents the percentage of inhaled Technetium 99m sulfur colloid cleared from the lungs over a 60 minute period. This is reported based on whole lung areas to allow comparisons with previous studies." (NCT00541190)
Timeframe: single measurement

Trials

3 trials available for pentetic acid and Cystic Fibrosis

Other Studies

4 other studies available for pentetic acid and Cystic Fibrosis