pentetic acid and Central Nervous System Disease studies

Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.

Research Excerpts

Excerpt	Relevance	Reference
"Gd-DTPA is a well-characterized, safe contrast agent frequently used in magnetic resonance imaging (MRI) of the central nervous system."	2.68	Safety and efficacy of dotarem (Gd-DOTA) versus magnevist (Gd-DTPA) in magnetic resonance imaging of the central nervous system. ( Kuijpers, TJ; Oudkerk, M; Sijens, PE; Van Beek, EJ, 1995)
" Safety analysis was performed on 2102 patients, in whom adverse events during and up to 24 h after injection were recorded."	2.68	Evaluation of the clinical safety of gadodiamide injection, a new nonionic MRI contrast medium for the central nervous system: a European perspective. ( Aslanian, V; Borseth, A; Bunouf, P; Lemaignen, H; Lundby, B; Svaland, MG, 1996)
" Adverse events were reported in 13 (4%) patients given gadodiamide injection and 8 (6%) given gadopentetate dimeglumine; few patients reported injection-associated discomfort."	2.68	MRI in children given gadodiamide injection: safety and efficacy in CNS and body indications. ( Gordon, P; Hugo, F; Lundby, B, 1996)
" Adverse events and serum bilirubin were the main safety parameters."	2.67	Comparison of the safety of standard and triple dose gadodiamide injection in MR imaging of the central nervous system. A double-blind study. ( Christensen, T; Lundorf, E; Svaland, MG, 1994)
" Adverse events were found with a similar frequency in the two groups (17."	2.67	Randomised double blind trial of the safety and efficacy of two gadolinium complexes (Gd-DTPA and Gd-DOTA). ( Berry, I; Brugières, P; de Schepper, AM; Degryse, HR; Gaston, A; Le Bras, F; Manelfe, C; Marsault, C; Parizel, PM; Wichmann, W, 1994)
" All patients received gadodiamide injection in a dosage of 0."	2.67	Multicenter study of gadodiamide injection as a contrast agent in MR imaging of the brain and spine. ( Aisen, AM; Bradley, WG; Brant-Zawadzki, M; Dreisbach, JN; Haughton, VM; Kumar, AJ; Maravilla, KR; McNamara, MT; Sze, G; Weinreb, JC, 1991)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (25.81)	18.7374
1990's	23 (74.19)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Chanalet, S	1
Masson, B	1
Boyer, L	1
Laffont, J	1
Bruneton, JN	1
Aslanian, V	2
Lemaignen, H	2
Bunouf, P	2
Schiratti, M	1
Lambrechts, M	1
Lundby, B	4
Borseth, A	2
Svaland, M	2
Akeson, P	1
Jonsson, E	2
Haugen, I	1
Holtås, S	2
Nelson, KL	2
Runge, VM	3
Oudkerk, M	1
Sijens, PE	1
Van Beek, EJ	1
Kuijpers, TJ	1
Mehta, RC	1
Pike, GB	1
Haros, SP	1
Enzmann, DR	1
Andrew, E	1
Hugo, F	2
LaFrance, N	1
Demaerel, P	1
Marchal, G	1
Wilms, G	1
Van Calenbergh, F	1
De Greef, D	1
Børseth, A	1
Baert, AL	1
Svaland, MG	2
Christensen, T	1
Lundorf, E	1
Brugières, P	1
Gaston, A	1
Degryse, HR	1
Parizel, PM	1
de Schepper, AM	1
Berry, I	1
Manelfe, C	1
Le Bras, F	1
Marsault, C	1
Wichmann, W	1
Haustein, J	2
Laniado, M	1
Niendorf, HP	2
Louton, T	1
Beck, W	1
Planitzer, J	1
Schöffel, M	1
Reiser, M	1
Kaiser, W	1
Schörner, W	1
Sze, G	2
Brant-Zawadzki, M	3
McNamara, MT	3
Haughton, VM	2
Kumar, AJ	2
Maravilla, KR	2
Aisen, AM	2
Dreisbach, JN	2
Bradley, WG	2
Weinreb, JC	2
Ekholm, S	1
Sandvik, L	1
Fagerlund, M	1
Isberg, B	1
Lindell, D	1
Lindén, B	1
Sjöberg, S	1
Thuomas , KA	1
Tollesson, PO	1
Gordon, P	1
Stevens, JM	1
Sty, JR	1
Babbitt, DP	1
D'Souza, B	1
Bolles, TF	1
Bydder, GM	1
Greco, A	1
Lanthiez, P	1
Quay, SC	1
Michelozzi, G	1
Gelblum, DY	2
Baierl, P	1
Mühlsteffen, A	1
Bauer, WM	1
Förster, C	1
Fendel, H	1
Grégoire, N	1
Momose, T	1
Rumeau, C	1
Perot, S	1
Girard, N	1
Lavanga, A	1
Salamon, G	1
Carollo, BR	1
Wolf, CR	1
Castronuovo, JJ	1
Chervu, LR	1
Milstein, DM	1
Powers, TA	1
Partain, CL	1
Kessler, RM	1
Freeman, MW	1
Robertson, RH	1
Wyatt, SH	1
Whelan, HT	1
Mano, I	1
Yoshida, H	1
Kono, T	1
Tsuchida, T	1
Terao, H	1
Iio, M	2
Haley, TJ	1

Trial	Enrollment	Study Type	Start Date	Status
Radiation-Free Heart Catheterization Using MRI[NCT02739087]	50 participants (Anticipated)	Interventional	2015-03-31	Active, not recruiting
MRI Assessment of Arrythmia Ablation Lesions[NCT02761343]	16 participants (Actual)	Interventional	2014-04-30	Completed
Technical Development of Interventional Cardiovascular Magnetic Resonance Imaging in Healthy Volunteers[NCT00720460]	107 participants (Actual)	Observational	2008-07-18	Terminated
XFM: (X-ray Fused With MRI) Guided Cardiac Catheterization[NCT02737579]	27 participants (Actual)	Interventional	2013-07-23	Active, not recruiting
Technical Development for Pediatric Cardiovascular MRI[NCT02892136]	5,000 participants (Anticipated)	Observational	2013-05-31	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Basic principles of MR contrast. Topics in magnetic resonance imaging : TMRI, 1995,Summer, Volume: 7, Issue:3 Topics: Central Nervous System Diseases; Contrast Media; Dextrans; Ferrosoferric Oxide; Gadolinium; Gadolini	1995
The spine and spinal cord. Current opinion in neurology and neurosurgery, 1990, Volume: 3, Issue:6 Topics: Central Nervous System Diseases; Gadolinium; Humans; Magnetic Resonance Imaging; Myelography; Pentet	1990
Technical advances in magnetic resonance imaging. Current opinion in neurology and neurosurgery, 1992, Volume: 5, Issue:6 Topics: Central Nervous System; Central Nervous System Diseases; Contrast Media; Gadolinium DTPA; Humans; Ma	1992
Pitfalls of contrast-enhanced imaging in the nervous system. Magnetic resonance in medicine, 1991, Volume: 22, Issue:2 Topics: Central Nervous System Diseases; Central Nervous System Neoplasms; Contrast Media; Costs and Cost An	1991
The role of gadolinium-diethylenetriaminepentaacetic acid in the evaluation of the central nervous system. Magnetic resonance quarterly, 1990, Volume: 6, Issue:2 Topics: Central Nervous System; Central Nervous System Diseases; Contrast Media; Female; Gadolinium; Gadolin	1990
Gd DTPA: a review of clinical indications in central nervous system magnetic resonance imaging. Radiographics : a review publication of the Radiological Society of North America, Inc, 1989, Volume: 9, Issue:5 Topics: Brain Neoplasms; Central Nervous System Diseases; Contrast Media; Gadolinium; Gadolinium DTPA; Human	1989
Saturnism, pediatric and adult lead poisoning. Clinical toxicology, 1971, Volume: 4, Issue:1 Topics: Adult; Central Nervous System Diseases; Chicago; Child; Child, Preschool; Edetic Acid; Environmental	1971

Article	Year
[Comparative studies of the tolerability of gadodiamide, dimeglumine gadopentetate and meglumine gadoterate in MRI tests of the central nervous system]. Journal de radiologie, 1995, Volume: 76, Issue:7 Topics: Adult; Central Nervous System Diseases; Contrast Media; Double-Blind Method; Drug Combinations; Drug	1995
[Clinical evaluation of the tolerability of gadodiamide, a new nonionic contrast agent in MRI of the central nervous system]. Journal de radiologie, 1995, Volume: 76, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Central Nervous System Diseases; Contrast Media; Female; Gadolinium	1995
Contrast-enhanced MRI of the central nervous system: comparison between gadodiamide injection and gadolinium-DTPA. Neuroradiology, 1995, Volume: 37, Issue:3 Topics: Central Nervous System Diseases; Contrast Media; Double-Blind Method; Female; Gadolinium; Gadolinium	1995
Safety and efficacy of dotarem (Gd-DOTA) versus magnevist (Gd-DTPA) in magnetic resonance imaging of the central nervous system. Investigative radiology, 1995, Volume: 30, Issue:2 Topics: Adult; Aged; Central Nervous System; Central Nervous System Diseases; Chi-Square Distribution; Contr	1995
Clinical experience with gadodiamide injection in magnetic resonance imaging of the central nervous system. Investigative radiology, 1994, Volume: 29 Suppl 2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Central Nervous System Diseases; Contrast Media; Double-	1994
Gadodiamide injection at 0.1 and 0.3 mmol/kg body weight: a phase III double-blind, parallel, randomised clinical investigation of known or suspected central nervous system lesions at 1.5 T. Neuroradiology, 1994, Volume: 36, Issue:5 Topics: Central Nervous System Diseases; Contrast Media; Double-Blind Method; Female; Gadolinium DTPA; Human	1994
Comparison of the safety of standard and triple dose gadodiamide injection in MR imaging of the central nervous system. A double-blind study. Acta radiologica (Stockholm, Sweden : 1987), 1994, Volume: 35, Issue:4 Topics: Adult; Aged; Bilirubin; Blood Pressure; Central Nervous System Diseases; Contrast Media; Double-Blin	1994
Randomised double blind trial of the safety and efficacy of two gadolinium complexes (Gd-DTPA and Gd-DOTA). Neuroradiology, 1994, Volume: 36, Issue:1 Topics: Adult; Central Nervous System Diseases; Contrast Media; Double-Blind Method; Female; Gadolinium DTPA	1994
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Triple-dose versus standard-dose gadopentetate dimeglumine: a randomized study in 199 patients. Radiology, 1993, Volume: 186, Issue:3 Topics: Adult; Central Nervous System Diseases; Contrast Media; Drug Combinations; Female; Gadolinium; Gadol	1993
Use of the magnetic resonance contrast agent gadodiamide in the central nervous system. Results of a multicenter trial. Investigative radiology, 1993, Volume: 28 Suppl 1 Topics: Central Nervous System Diseases; Contrast Media; Female; Gadolinium; Gadolinium DTPA; Humans; Inject	1993
Tolerance and efficacy of Omniscan (gadodiamide injection) in MR imaging of the central nervous system. Acta radiologica (Stockholm, Sweden : 1987), 1996, Volume: 37, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Central Nervous System Diseases; Contrast Media; Drug To	1996
Evaluation of the clinical safety of gadodiamide injection, a new nonionic MRI contrast medium for the central nervous system: a European perspective. Neuroradiology, 1996, Volume: 38, Issue:6 Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Central Nervous	1996
MRI in children given gadodiamide injection: safety and efficacy in CNS and body indications. European journal of radiology, 1996, Volume: 23, Issue:3 Topics: Adolescent; Central Nervous System Diseases; Child; Child, Preschool; Clinical Trials, Phase III as	1996
Multicenter study of gadodiamide injection as a contrast agent in MR imaging of the brain and spine. Radiology, 1991, Volume: 181, Issue:3 Topics: Brain; Central Nervous System Diseases; Contrast Media; Drug Evaluation; Female; Gadolinium DTPA; Hu	1991
Gadodiamide injection: nonionic gadolinium chelate for MR imaging of the brain and spine--phase II-III clinical trial. Radiology, 1990, Volume: 176, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain; Brain Neoplasms; Central Nervous System Diseases;	1990
Central nervous system lesions in pediatric patients: Gd-DTPA-enhanced MR imaging. Radiology, 1988, Volume: 169, Issue:3 Topics: Adolescent; Astrocytoma; Brain Neoplasms; Central Nervous System Diseases; Child; Child, Preschool;	1988

pentetic acid and Central Nervous System Disease

Research Excerpts

Research

Studies (31)

Authors

Clinical Trials (5)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Central nervous system tumor, infection, and infarction: detection with gadolinium-enhanced magnetization transfer MR imaging. Radiology, 1995, Volume: 195, Issue:1 Topics: Adult; Aged; Brain; Brain Neoplasms; Central Nervous System Diseases; Cerebral Infarction; Contrast	1995
Pediatric radionuclide ventriculography. Clinical nuclear medicine, 1979, Volume: 4, Issue:10 Topics: Central Nervous System Diseases; Cerebral Ventricles; Child; Child, Preschool; Humans; Indium; Infan	1979
Suitability of Yb 169 DTPA for cisternography. Seminars in nuclear medicine, 1977, Volume: 7, Issue:2 Topics: Animals; Central Nervous System Diseases; Dogs; Humans; Injections, Spinal; Pentetic Acid; Radioisot	1977
Comparison of plain and Gd-DTPA-enhanced MR-imaging in children. Pediatric radiology, 1990, Volume: 20, Issue:7 Topics: Adolescent; Brain Neoplasms; Central Nervous System Diseases; Child; Child, Preschool; Female; Gadol	1990
[Gadolinium-DTPA in the study of intracranial tumors in the adult]. Revue neurologique, 1990, Volume: 146, Issue:2 Topics: Adult; Aged; Brain Neoplasms; Central Nervous System Diseases; Female; Gadolinium DTPA; Glioma; Huma	1990
Altered distribution of technetium-99m sodium pertechnetate associated with antimicrobial therapy. Clinical nuclear medicine, 1985, Volume: 10, Issue:12 Topics: Aged; Anti-Bacterial Agents; Brain; Central Nervous System Diseases; Drug Interactions; Erythrocytes	1985
[The enhancement effects of Gd-DTPA for cerebrospinal lesions-- comparison with conventional T2-weighted images]. Rinsho hoshasen. Clinical radiography, 1987, Volume: 32, Issue:13 Topics: Central Nervous System Diseases; Contrast Media; Female; Gadolinium; Gadolinium DTPA; Humans; Magnet	1987
[Contrast-enhanced MRI and contrast medium development]. Nihon rinsho. Japanese journal of clinical medicine, 1987, Volume: 45, Issue:1 Topics: Central Nervous System Diseases; Contrast Media; Gadolinium; Gadolinium DTPA; Humans; Magnetic Reson	1987