pentamidine has been researched along with Trypanosomiasis in 47 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Trypanosomiasis: Infection with protozoa of the genus TRYPANOSOMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin was not effective." | 1.39 | Evaluation of trypanocidal drugs used for human African trypanosomosis against Trypanosoma lewisi. ( Bucheton, B; Courtois, P; Cuny, G; Daulouède, S; Dethoua, M; Nzoumbou-Boko, R; Semballa, S; Truc, P; Vincendeau, P, 2013) |
| "Iridium was completely eliminated from the serum 700 hours post-treatment." | 1.30 | Trypanocidal effect of Ir-(COD)-pentamidine tetraphenylborate on Trypanosoma brucei and T. b. gambiense rodent models and serum kinetics in sheep. ( Craciunescu, DG; Daulouède, S; Dreyfuss, G; Lachâtre, G; Loiseau, PM; Vincendeau, P, 1997) |
| " Six compounds, including 2,5-bis(4-guanylphenyl)furan (4) and its 3-chloro (32), 3,4-dichloro (31), 3-methyl (25), 3,4-dimethyl (20), and 3-chloro-4-methyl (38) derivatives, produced cures in mice at submilligram dosage levels; the 3,4-dimethyl (20) analogue exhibited a prolonged curative effect providing protection for 30 days after a single dose against a challenge by T." | 1.26 | Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)furans. ( Boykin, DW; Das, BP, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (63.83) | 18.7374 |
| 1990's | 1 (2.13) | 18.2507 |
| 2000's | 7 (14.89) | 29.6817 |
| 2010's | 9 (19.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Das, BP | 1 |
| Boykin, DW | 4 |
| Donkor, IO | 1 |
| Huang, TL | 1 |
| Tao, B | 1 |
| Rattendi, D | 1 |
| Lane, S | 1 |
| Vargas, M | 1 |
| Goldberg, B | 1 |
| Bacchi, C | 1 |
| Bakunov, SA | 3 |
| Bakunova, SM | 3 |
| Wenzler, T | 3 |
| Barszcz, T | 3 |
| Werbovetz, KA | 3 |
| Brun, R | 5 |
| Tidwell, RR | 5 |
| Patrick, DA | 2 |
| Jones, SK | 2 |
| Kumar, A | 3 |
| Bosc, D | 1 |
| Mouray, E | 1 |
| Cojean, S | 1 |
| Franco, CH | 1 |
| Loiseau, PM | 2 |
| Freitas-Junior, LH | 1 |
| Moraes, CB | 2 |
| Grellier, P | 1 |
| Dubois, J | 1 |
| Buchynskyy, A | 1 |
| Gillespie, JR | 1 |
| Hulverson, MA | 1 |
| McQueen, J | 1 |
| Creason, SA | 1 |
| Ranade, RM | 1 |
| Duster, NA | 1 |
| Gelb, MH | 1 |
| Buckner, FS | 1 |
| Linciano, P | 1 |
| Pozzi, C | 1 |
| Iacono, LD | 1 |
| di Pisa, F | 1 |
| Landi, G | 1 |
| Bonucci, A | 1 |
| Gul, S | 1 |
| Kuzikov, M | 1 |
| Ellinger, B | 1 |
| Witt, G | 1 |
| Santarem, N | 1 |
| Baptista, C | 1 |
| Franco, C | 1 |
| Müller, W | 1 |
| Wittig, U | 1 |
| Luciani, R | 1 |
| Sesenna, A | 1 |
| Quotadamo, A | 1 |
| Ferrari, S | 1 |
| Pöhner, I | 1 |
| Cordeiro-da-Silva, A | 1 |
| Mangani, S | 1 |
| Costantino, L | 1 |
| Costi, MP | 1 |
| Dethoua, M | 1 |
| Nzoumbou-Boko, R | 1 |
| Truc, P | 1 |
| Daulouède, S | 2 |
| Courtois, P | 1 |
| Bucheton, B | 1 |
| Cuny, G | 1 |
| Semballa, S | 1 |
| Vincendeau, P | 2 |
| LANNOY, L | 1 |
| CHABOUD, G | 1 |
| Kumar, EV | 1 |
| Ohemeng, KA | 1 |
| Bridges, AS | 1 |
| Gillingwater, K | 2 |
| Anbazhagan, M | 1 |
| Ismail, MA | 1 |
| Arafa, RK | 1 |
| Stephens, CE | 1 |
| Rosquete, LI | 1 |
| Cabrera-Serra, MG | 1 |
| Piñero, JE | 1 |
| Martín-Rodríguez, P | 1 |
| Fernández-Pérez, L | 1 |
| Luis, JG | 1 |
| McNaughton-Smith, G | 1 |
| Abad-Grillo, T | 1 |
| Verma, A | 1 |
| Manchanda, S | 1 |
| Kumar, N | 1 |
| Sharma, A | 1 |
| Goel, M | 1 |
| Banerjee, PS | 1 |
| Garg, R | 1 |
| Singh, BP | 1 |
| Balharbi, F | 1 |
| Lejon, V | 1 |
| Deborggraeve, S | 1 |
| Singh Rana, UV | 1 |
| Puliyel, J | 1 |
| Baker, N | 1 |
| Glover, L | 1 |
| Munday, JC | 1 |
| Aguinaga Andrés, D | 1 |
| Barrett, MP | 1 |
| de Koning, HP | 2 |
| Horn, D | 1 |
| Ruiz, JA | 1 |
| Simarro, PP | 1 |
| Josenando, T | 1 |
| CAMAND, M | 1 |
| CAMOU, M | 1 |
| VERCELLOTTI, M | 1 |
| BURKE, J | 1 |
| DE SCHEITZ, L | 1 |
| VAN HOYE, R | 1 |
| KERNEVEZ, H | 1 |
| CHASSAIN, J | 1 |
| LE GAC, P | 4 |
| MULET, M | 1 |
| LOTTE, AJ | 1 |
| PILLE, G | 1 |
| GELFAND, M | 1 |
| ALVES, WD | 1 |
| COSAR, C | 1 |
| DUCROT, R | 1 |
| GAILLIOT, P | 1 |
| BAGET, J | 1 |
| GALL, D | 1 |
| MASSEGUIN, A | 1 |
| CAUSSE, M | 1 |
| RICOSSE, M | 1 |
| NEUJEAN, G | 1 |
| KLINKHAMER, LV | 1 |
| HAWKING, F | 2 |
| SEN, AB | 1 |
| FERREIRA, FS | 1 |
| de ALMEIDA, CL | 1 |
| PINTO, AR | 1 |
| SCAILLET, L | 2 |
| HADDAD, E | 2 |
| DIALLO, J | 1 |
| JONCHERE, H | 1 |
| ZIEGLER, P | 1 |
| DEOM, J | 1 |
| Bridges, DJ | 1 |
| Gould, MK | 1 |
| Nerima, B | 1 |
| Mäser, P | 1 |
| Burchmore, RJ | 1 |
| Akpa, PO | 1 |
| Ezeokonkwo, RC | 1 |
| Eze, CA | 1 |
| Anene, BM | 1 |
| Dreyfuss, G | 1 |
| Lachâtre, G | 1 |
| Craciunescu, DG | 1 |
| Briggaman, RA | 1 |
| Fleischer, NK | 1 |
| Ercoli, N | 1 |
2 reviews available for pentamidine and Trypanosomiasis
| Article | Year |
|---|---|
The aromatic diamidines.
Topics: Amidines; Animals; Dermatomycoses; Humans; Leishmaniasis; Mice; Mycoses; Pentamidine; Pneumonia, Pne | 1977 |
[Central nervous system involvement in parasitic tropical diseases].
Topics: Adult; Blood-Brain Barrier; Central Nervous System Diseases; Cysticercosis; Female; Hartmannella; Hu | 1979 |
45 other studies available for pentamidine and Trypanosomiasis
| Article | Year |
|---|---|
Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)furans.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Furans; Malaria; Mice; Plasmodium berghei; Structure-A | 1977 |
Trypanocidal activity of conformationally restricted pentamidine congeners.
Topics: Amidines; Animals; Cations; Cattle; DNA; Drug Resistance; Female; Mice; Molecular Conformation; Pent | 2003 |
Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans.
Topics: Animals; Antiprotozoal Agents; Benzofurans; Cations; Disease Models, Animal; Leishmania; Mice; Molec | 2008 |
Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives.
Topics: Animals; Antiprotozoal Agents; Dose-Response Relationship, Drug; Leishmania donovani; Mice; Molecula | 2013 |
Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors.
Topics: Alkyl and Aryl Transferases; Animals; Antiparasitic Agents; Cell Line; Enzyme Inhibitors; Humans; Im | 2016 |
Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Benzamides; Biological Availability; Drug Disco | 2017 |
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.
Topics: Animals; Antiprotozoal Agents; Benzothiazoles; Binding Sites; Catalytic Domain; Crystallography, X-R | 2019 |
Evaluation of trypanocidal drugs used for human African trypanosomosis against Trypanosoma lewisi.
Topics: Animals; Eflornithine; Female; Humans; Immunocompromised Host; Inhibitory Concentration 50; Melarsop | 2013 |
Curative and preventive actions of diamidino-diphén noxypentane on Trypanosoma equinum infections.
Topics: Animals; Humans; Mites; Pentamidine; Trypanosomiasis | 1948 |
Structure-activity study of pentamidine analogues as antiprotozoal agents.
Topics: Animals; Antimalarials; Cadaverine; Drug Resistance; Female; Imidazoles; Leishmania donovani; Mice; | 2009 |
In vivo investigations of selected diamidine compounds against Trypanosoma evansi using a mouse model.
Topics: Animals; Disease Models, Animal; Female; Mice; Parasitic Sensitivity Tests; Pentamidine; Trypanocida | 2009 |
In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi.
Topics: Amidines; Animals; Arsenicals; Cells, Cultured; Diminazene; Drug Resistance; Female; Inhibitory Conc | 2010 |
Synthesis and in vitro antiprotozoal evaluation of substituted phenalenone analogues.
Topics: Antiprotozoal Agents; Cell Line, Tumor; Humans; Leishmaniasis; Pentamidine; Phenalenes; Trypanosoma | 2010 |
Trypanosoma lewisi or T. lewisi-like infection in a 37-day-old Indian infant.
Topics: Amphotericin B; Anti-Bacterial Agents; Antiprotozoal Agents; Ceftriaxone; Humans; Infant; Male; Pent | 2011 |
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes.
Topics: Animals; Aquaporin 2; Aquaporin 3; Cell Line; Drug Resistance; Flagella; High-Throughput Screening A | 2012 |
Control of human African trypanosomiasis in the Quiçama focus, Angola.
Topics: Angola; Communicable Disease Control; Endemic Diseases; Humans; Melarsoprol; Pentamidine; Risk Facto | 2002 |
[p-p-Diamidino-di-phenoxy-pentane therapy of dourine].
Topics: Animals; Dourine; Horse Diseases; Horses; Pentamidine; Pentanes; Trypanosomiasis | 1952 |
[Report on pentamidine chemoprophylaxis in the region of Kasai subsector of Lower Kwilu, Foreami].
Topics: Animals; Biomedical Research; Chemoprevention; Pentamidine; Trypanosomiasis | 1953 |
[Pentamidine therapy and its results in the territory of Dungu].
Topics: Animals; Pentamidine; Trypanosomiasis | 1953 |
[Results obtained in French Equatorial Africa by the use of diamidines in the chemoprophylaxis of human trypanosomiasis from 1946 to 1949].
Topics: Africa; Chemoprevention; Humans; Language; Pentamidine; Trypanosomiasis | 1951 |
[Trypanosomiasis in Ubangui-Shari; focus at Bimbo; prevention with lomidine].
Topics: Biomedical Research; Humans; Pentamidine; Trypanosomiasis | 1953 |
[Interpretation of experimental results in the chemo-prophylaxis of trypanosomiasis gambiense].
Topics: Amidines; Animals; Biomedical Research; Black People; Humans; Pentamidine; Trypanosoma brucei gambie | 1953 |
[Pharmacologic comments on the diamidines and their use in trypanosomiasis].
Topics: Amidines; Animals; Black People; Humans; Pentamidine; Stilbenes; Trypanosomiasis; Trypanosomiasis, A | 1953 |
Three early cases of Rhodesian sleeping sickness treated with pentamidine isethionate.
Topics: Animals; Black People; Humans; Pentamidine; Trypanosomiasis; Trypanosomiasis, African | 1954 |
[Study of the suramin pentamidine salt].
Topics: Pentamidine; Sodium Chloride; Sodium Chloride, Dietary; Suramin; Trypanosomiasis | 1954 |
The chemoprophylaxis of sleeping sickness with the diamidines.
Topics: Amidines; Animals; Chemoprevention; Humans; Pentamidine; Trypanosomiasis; Trypanosomiasis, African | 1954 |
[Preliminary note on combined lomidine and moranyl in the prevention of sleeping sickness].
Topics: Amidines; Animals; Biomedical Research; Humans; Pentamidine; Suramin; Trypanosomiasis; Trypanosomias | 1955 |
Trypanosomiasis in Oubangui-Chari; principal reservoirs of infection and the results of chemoprophylaxis with pentamidine and lomidine.
Topics: Animals; Black People; Chemoprevention; Humans; Pentamidine; Trypanosomiasis; Trypanosomiasis, Afric | 1953 |
[Chemotherapy and chemoprophylaxis of sleeping sickness caused by Trypanosoma gambiense].
Topics: Animals; Arsenicals; Chemoprevention; Humans; Pentamidine; Suramin; Trypanosoma brucei gambiense; Tr | 1959 |
Hypoglycaemia during pentamidine treatment for trypanosomiasis.
Topics: Humans; Hypoglycemia; Pancreatic Diseases; Pentamidine; Trypanosomiasis | 1958 |
The trypanocidal action of homidium, quinapyramine and suramin.
Topics: Animals; Arsenicals; Ethidium; Mice; Pentamidine; Quinolines; Quinolinium Compounds; Suramin; Trypan | 1960 |
Trypanocidal action of p-biguanidoacetophenone amidinohydrazone.
Topics: Acetophenones; Animals; Guanidine; Guanidines; Mice; Pentamidine; Trypanocidal Agents; Trypanosoma b | 1962 |
[Extensive measures of chemoprophylaxis by intramuscular injection of aromatic diamidines (lomidine) applied for many years with the aim of eradication of sleeping sickness in the territories of French Africa contaminated by that endemia].
Topics: Africa; Amidines; Animals; Chemoprevention; Humans; Injections, Intramuscular; Pentamidine; Trypanos | 1954 |
[Results of pentamidine chemoprophylaxis; changes in the population contagion index and the Glossina infestation index].
Topics: Animals; Chemoprevention; Communicable Diseases; Glossinidae; Parasitic Diseases; Pentamidine; Trypa | 1950 |
[Trypanosomiasis in the sector of the cataracts; consideration after 18 months of chemo-prophylaxis by pentamidine].
Topics: Cataract; Pentamidine; Trypanosomiasis | 1950 |
[Results with diamidine chemoprophylaxy in the special sector No. 3 at Gueckedou-Kissidougou (Guinea)].
Topics: Amidines; Animals; Guinea; Humans; Pentamidine; Trypanosomiasis | 1951 |
[Trypanosomiasis in Oubangui-Chari with focus at Nola; pentamidine and lomidine prophylaxis].
Topics: Animals; Humans; Lepidoptera; Nitroarginine; Pentamidine; Trypanosomiasis | 1951 |
[Diamidine therapy of the lymphatic-blood phase of human trypanosomiasis in French Equatorial Africa].
Topics: Africa; Amidines; Animals; Humans; Language; Lymphatic Vessels; Pentamidine; Trypanosomiasis | 1951 |
[Trypanosomiasis in Oubangui-Chari with focus at Ouham; prevention by lomidine].
Topics: Biomedical Research; Humans; Pentamidine; Trypanosomiasis | 1952 |
[Trypanosomiasis in cataracts; Initial results of chemoprophylaxis with pentamidine].
Topics: Cataract; Pentamidine; Trypanosomiasis | 1949 |
[Pentamidine treatment of bovine trypanosomiasis due to T. congolense, T. vivax and T. theileri].
Topics: Animals; Cattle; Humans; Pentamidine; Trypanosomiasis; Trypanosomiasis, Bovine | 1950 |
Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes.
Topics: Animals; Arsenicals; Carrier Proteins; Drug Resistance; Female; Nucleoside Transport Proteins; Penta | 2007 |
Comparative efficacy assessment of pentamidine isethionate and diminazene aceturate in the chemotherapy of Trypanosoma brucei brucei infection in dogs.
Topics: Animals; Blood Cell Count; Body Temperature; Diminazene; Dog Diseases; Dogs; Enzymes; Female; Hemogl | 2008 |
Trypanocidal effect of Ir-(COD)-pentamidine tetraphenylborate on Trypanosoma brucei and T. b. gambiense rodent models and serum kinetics in sheep.
Topics: Animals; Female; Iridium; Mice; Pentamidine; Sheep; Trypanocidal Agents; Trypanosoma brucei brucei; | 1997 |
True and false prophylaxis in experimental trypanosomiasis.
Topics: Amidines; Animals; Cycloparaffins; Dose-Response Relationship, Drug; Mice; Pentamidine; Rats; Time F | 1978 |