pentamidine has been researched along with Toxoplasmosis in 18 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Toxoplasmosis: The acquired form of infection by Toxoplasma gondii in animals and man.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For dapsone, among 100 patients given 100 mg daily instead of twice a week for 1 year (primary prophylaxis), seven fewer patients would develop P carinii pneumonia, but 17 more would have significant toxic reactions." | 4.79 | A meta-analysis of the relative efficacy and toxicity of Pneumocystis carinii prophylactic regimens. ( Cappelleri, JC; Ioannidis, JP; Lau, J; Sacks, HS; Skolnik, PR, 1996) |
| "In a meta-analysis, we examined the efficacy of aerosolized pentamidine, trimethoprim-sulfamethoxazole, and dapsone or dapsone/pyrimethamine for the prevention of Pneumocystis carinii pneumonia and toxoplasma encephalitis in patients with HIV infection." | 4.79 | Meta-analysis of prophylactic treatments against Pneumocystis carinii pneumonia and toxoplasma encephalitis in HIV-infected patients. ( Bucher, HC; Griffith, L; Guyatt, GH; Opravil, M, 1997) |
| "If pregnancy is pursued, the mother must be investigated for sexually transmitted diseases which are particularly frequent in this population and may have repercussions on the newborn." | 2.38 | [Pregnancy in HIV infected women. Current therapeutic indications]. ( Bongain, A; Fuzibet, JG; Gillet, JY; Pesce, A, 1992) |
| " Overall results from these studies indicate patients who are eligible for PCP prophylaxis should be advised to take double-strength trimethoprim/sulfamethoxazole (TMP/SMX) on a daily basis, a dosage found more effective than thrice-weekly." | 1.30 | Optimizing PCP therapy. ( Cadman, J; Torres, G, 1997) |
| "As the number of AIDS patients and the associated health care costs increase, home care for AIDS patients will continue to expand." | 1.28 | Home care for AIDS patients. ( Mello-Udine, L, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (16.67) | 18.7374 |
| 1990's | 14 (77.78) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee Loy, J | 1 |
| Koratala, A | 1 |
| De Los Santos, Y | 1 |
| Chamarthi, G | 1 |
| Santos, AH | 1 |
| Alquadan, KF | 1 |
| Ajisawa, A | 1 |
| Anastasi, JK | 1 |
| Rivera, J | 1 |
| Nielsen, TL | 1 |
| Jensen, BN | 1 |
| Nelsing, S | 1 |
| Mathiesen, LR | 1 |
| Skinhøj, P | 1 |
| Nielsen, JO | 1 |
| Ioannidis, JP | 1 |
| Cappelleri, JC | 1 |
| Skolnik, PR | 1 |
| Lau, J | 1 |
| Sacks, HS | 1 |
| Bucher, HC | 1 |
| Griffith, L | 1 |
| Guyatt, GH | 1 |
| Opravil, M | 1 |
| Sackoff, J | 1 |
| McFarland, J | 1 |
| Su, S | 1 |
| Bryan, E | 1 |
| Cheng, B | 1 |
| Torres, G | 1 |
| Cadman, J | 1 |
| Ryning, FW | 1 |
| Mills, J | 1 |
| Fleischer, NK | 1 |
| Mello-Udine, L | 1 |
| Gillet, JY | 1 |
| Bongain, A | 1 |
| Fuzibet, JG | 1 |
| Pesce, A | 1 |
| Hardy, WD | 2 |
| O'Farrell, N | 1 |
| Bradbeer, C | 1 |
| Fitt, S | 1 |
| Welch, JM | 1 |
| Bateman, NT | 1 |
| Soma, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Fluconazole, Clarithromycin, and Rifabutin on the Pharmacokinetics of Sulfamethoxazole and Dapsone and Their Hydroxylamine Metabolites[NCT00000826] | Phase 1 | 48 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for pentamidine and Toxoplasmosis
| Article | Year |
|---|---|
A meta-analysis of the relative efficacy and toxicity of Pneumocystis carinii prophylactic regimens.
Topics: AIDS-Related Opportunistic Infections; Dapsone; Dose-Response Relationship, Drug; Humans; Logistic M | 1996 |
Meta-analysis of prophylactic treatments against Pneumocystis carinii pneumonia and toxoplasma encephalitis in HIV-infected patients.
Topics: Administration, Inhalation; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antifungal | 1997 |
[Central nervous system involvement in parasitic tropical diseases].
Topics: Adult; Blood-Brain Barrier; Central Nervous System Diseases; Cysticercosis; Female; Hartmannella; Hu | 1979 |
[Pregnancy in HIV infected women. Current therapeutic indications].
Topics: Abortion, Therapeutic; Adult; CD4 Immunoadhesins; Female; HIV Infections; Humans; Immunization, Pass | 1992 |
Prophylaxis of AIDS-related opportunistic infections (OIs). Current status and future strategies.
Topics: Acquired Immunodeficiency Syndrome; Aerosols; Animals; Cryptococcosis; Cytomegalovirus Infections; D | 1991 |
Prophylaxis of AIDS-related opportunistic infections (OIs).
Topics: Acquired Immunodeficiency Syndrome; Cryptococcosis; Cytomegalovirus Infections; Dapsone; Drug Combin | 1989 |
3 trials available for pentamidine and Toxoplasmosis
| Article | Year |
|---|---|
Randomized study of sulfamethoxazole-trimethoprim versus aerosolized pentamidine for secondary prophylaxis of Pneumocystis carinii pneumonia in patients with AIDS.
Topics: Administration, Inhalation; Administration, Oral; Adult; Aerosols; Aged; AIDS-Related Opportunistic | 1995 |
Prophylaxis for opportunistic infections among HIV-infected patients receiving medical care.
Topics: Adolescent; Adult; AIDS-Related Opportunistic Infections; Analysis of Variance; Anti-Infective Agent | 1998 |
Prophylaxis of AIDS-related opportunistic infections (OIs). Current status and future strategies.
Topics: Acquired Immunodeficiency Syndrome; Aerosols; Animals; Cryptococcosis; Cytomegalovirus Infections; D | 1991 |
10 other studies available for pentamidine and Toxoplasmosis
| Article | Year |
|---|---|
Disseminated toxoplasmosis: a life-threatening complication of inadequate posttransplant prophylaxis.
Topics: Adult; Antibiotic Prophylaxis; Fatal Outcome; Heart; Humans; Kidney Failure, Chronic; Kidney Transpl | 2019 |
Drugs for AIDS and associated infections.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Amphotericin B; Antifunga | 1995 |
[Protozoan infections in AIDS].
Topics: Acquired Immunodeficiency Syndrome; Administration, Inhalation; AIDS-Related Opportunistic Infection | 1993 |
Understanding prophylactic therapy for HIV infections.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Cytomegalovirus Infections; Dru | 1994 |
Preventing opportunistic infections.
Topics: Acyclovir; AIDS-Related Opportunistic Infections; Clarithromycin; Clindamycin; Clinical Trials as To | 1995 |
Optimizing PCP therapy.
Topics: Aerosols; AIDS-Related Opportunistic Infections; Antifungal Agents; Atovaquone; CD4 Lymphocyte Count | 1997 |
Pneumocystis carinii, Toxoplasma gondii, Cytomegalovirus and the compromised host.
Topics: Adolescent; Adult; Animals; Cats; Child; Child, Preschool; Cytomegalovirus Infections; Female; Human | 1979 |
Home care for AIDS patients.
Topics: Acquired Immunodeficiency Syndrome; Cytomegalovirus Infections; Health Care Costs; Home Care Service | 1992 |
Cerebral toxoplasmosis and co-trimoxazole prophylaxis.
Topics: Acquired Immunodeficiency Syndrome; Brain Diseases; Humans; Pentamidine; Retrospective Studies; Toxo | 1991 |
[Diagnosis and therapy of parasitic lung diseases].
Topics: Humans; Lung Diseases, Parasitic; Pentamidine; Pneumocystis; Pneumonia, Pneumocystis; Pyrimethamine; | 1991 |