pentamidine has been researched along with Toxoplasmosis, Cerebral in 17 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Toxoplasmosis, Cerebral: Infections of the BRAIN caused by the protozoan TOXOPLASMA gondii that primarily arise in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES (see also AIDS-RELATED OPPORTUNISTIC INFECTIONS). The infection may involve the brain diffusely or form discrete abscesses. Clinical manifestations include SEIZURES, altered mentation, headache, focal neurologic deficits, and INTRACRANIAL HYPERTENSION. (From Joynt, Clinical Neurology, 1998, Ch27, pp41-3)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate combined prophylaxis for Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis, 533 patients with symptomatic human immunodeficiency virus infection and/or CD4 lymphocyte counts of < 200/microL were randomized to receive dapsone/pyrimethamine (200/75 mg once weekly) or aerosolized pentamidine (300 mg every 4 weeks)." | 9.08 | Once-weekly administration of dapsone/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients. ( Heald, A; Hirschel, B; Iten, A; Lazzarin, A; Oertle, D; Opravil, M; Pechère, M; Praz, G; Rüttimann, S; von Overbeck, J, 1995) |
| " However, the impact of PCP prophylaxis on the incidence of bacterial pneumonia in HIV-positive patients using pentamidine or co-trimoxazole is still unknown." | 7.70 | [Incidence of bacterial pneumonia in HIV-positive patients treated with preventive co-trimoxazole or pentamidine]. ( Braun, J; Dalhoff, K; Friedrich, HJ; Kämmerer, R; Koch, A; Kothe, H, 1998) |
| "The incidence of Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis (TE) was analyzed in 83 human immunodeficiency virus (HIV)-infected patients who inhaled aerosolized pentamidine (AP) either for primary prophylaxis (group Ia) or secondary prophylaxis (group IIa) of PCP." | 7.68 | Prevention of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus infected patients: a clinical approach comparing aerosolized pentamidine and pyrimethamine/sulfadoxine. ( Gottschalk, J; Grünewald, T; Jautzke, G; Köppen, S; Pohle, HD; Ruf, B, 1992) |
| "Dapsone was more effective in the primary prophylaxis of toxoplasmic encephalitis, with six toxoplasmic encephalitis events occurring among those receiving aerosolized pentamidine, compared to none among those taking dapsone (p = 0." | 6.67 | Randomized trial of dapsone and aerosolized pentamidine for the prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis. ( Barr, M; Carlo, C; Chanin, E; Gregory, G; Kiely, S; Martin, M; Thorn, M; Thornton, J; Torres, RA, 1993) |
| "To evaluate combined prophylaxis for Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis, 533 patients with symptomatic human immunodeficiency virus infection and/or CD4 lymphocyte counts of < 200/microL were randomized to receive dapsone/pyrimethamine (200/75 mg once weekly) or aerosolized pentamidine (300 mg every 4 weeks)." | 5.08 | Once-weekly administration of dapsone/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients. ( Heald, A; Hirschel, B; Iten, A; Lazzarin, A; Oertle, D; Opravil, M; Pechère, M; Praz, G; Rüttimann, S; von Overbeck, J, 1995) |
| " However, the impact of PCP prophylaxis on the incidence of bacterial pneumonia in HIV-positive patients using pentamidine or co-trimoxazole is still unknown." | 3.70 | [Incidence of bacterial pneumonia in HIV-positive patients treated with preventive co-trimoxazole or pentamidine]. ( Braun, J; Dalhoff, K; Friedrich, HJ; Kämmerer, R; Koch, A; Kothe, H, 1998) |
| "No patient in the trimethoprim-sulfamethoxazole group and no patient seronegative for Toxoplasma gondii developed toxoplasmic encephalitis, compared with 12 of 36 (33%; 95% Cl, 19% to 51%) seropositive patients in the pentamidine group (trimethoprim-sulfamethoxazole compared with pentamidine, P = 0." | 3.68 | Low-dose trimethoprim-sulfamethoxazole prophylaxis for toxoplasmic encephalitis in patients with AIDS. ( Brew, BJ; Carr, A; Cooper, DA; Harkness, JL; Marriott, DJ; Penny, R; Tindall, B, 1992) |
| "The incidence of Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis (TE) was analyzed in 83 human immunodeficiency virus (HIV)-infected patients who inhaled aerosolized pentamidine (AP) either for primary prophylaxis (group Ia) or secondary prophylaxis (group IIa) of PCP." | 3.68 | Prevention of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus infected patients: a clinical approach comparing aerosolized pentamidine and pyrimethamine/sulfadoxine. ( Gottschalk, J; Grünewald, T; Jautzke, G; Köppen, S; Pohle, HD; Ruf, B, 1992) |
| "The prevention of cerebral toxoplasmosis and of Pneumocystis carinii pneumonia is an essential objective in the management of patients infected with HIV." | 2.68 | Prevention of Pneumocystis carinii pneumonia and of cerebral toxoplasmosis by roxithromycin in HIV-infected patients. ( Carles, M; Dellamonica, P; Durant, J; Hazime, F; Pechere, JC, 1995) |
| "Dapsone was more effective in the primary prophylaxis of toxoplasmic encephalitis, with six toxoplasmic encephalitis events occurring among those receiving aerosolized pentamidine, compared to none among those taking dapsone (p = 0." | 2.67 | Randomized trial of dapsone and aerosolized pentamidine for the prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis. ( Barr, M; Carlo, C; Chanin, E; Gregory, G; Kiely, S; Martin, M; Thorn, M; Thornton, J; Torres, RA, 1993) |
| "Nineteen episodes of cerebral toxoplasmosis were diagnosed during the study." | 2.67 | Trimethoprim-sulfamethoxazole versus aerosolized pentamidine for primary prophylaxis of Pneumocystis carinii pneumonia: a prospective, randomized, controlled clinical trial. LFPMI Study Group. Ligue Française de Prévention des Maladies Infectieuses. ( Beuscart, C; Borsa Lebas, F; Canton, P; Leclercq, P; Marchou, B; May, T; Micoud, M; Mouton, Y; Reynes, J; Saba, J, 1994) |
| "The risk to develop cerebral toxoplasmosis appeared significantly higher in the group of patients who stopped sulfamethoxazole-trimethoprim consecutively to cutaneous hypersensitivity." | 1.30 | [Cerebral toxoplasmosis in HIV infected patients intolerant of cotrimoxazole]. ( Beuscart, C; Canton, P; Leport, C; May, T; Rabaud, C; Reynes, J, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (88.24) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bejjanki, H | 1 |
| Olaoye, OA | 1 |
| Santos, AH | 1 |
| Koratala, A | 1 |
| Opravil, M | 2 |
| Pechère, M | 2 |
| Lazzarin, A | 3 |
| Heald, A | 2 |
| Rüttimann, S | 2 |
| Iten, A | 2 |
| Furrer, H | 1 |
| Oertle, D | 2 |
| Praz, G | 2 |
| Vuitton, DA | 1 |
| Hirschel, B | 1 |
| von Overbeck, J | 1 |
| Durant, J | 1 |
| Hazime, F | 1 |
| Carles, M | 1 |
| Pechere, JC | 1 |
| Dellamonica, P | 1 |
| Torres, RA | 1 |
| Barr, M | 1 |
| Thorn, M | 1 |
| Gregory, G | 1 |
| Kiely, S | 1 |
| Chanin, E | 1 |
| Carlo, C | 1 |
| Martin, M | 1 |
| Thornton, J | 1 |
| Tocchetti, A | 1 |
| Tambini, R | 1 |
| Allegro, A | 1 |
| Longoni, E | 1 |
| Rinaldi, E | 1 |
| May, T | 2 |
| Beuscart, C | 2 |
| Reynes, J | 2 |
| Marchou, B | 1 |
| Leclercq, P | 1 |
| Borsa Lebas, F | 1 |
| Saba, J | 1 |
| Micoud, M | 1 |
| Mouton, Y | 1 |
| Canton, P | 2 |
| Mallolas, J | 1 |
| Zamora, L | 1 |
| Gatell, JM | 1 |
| Miró, JM | 1 |
| Vernet, E | 1 |
| Valls, ME | 1 |
| Soriano, E | 1 |
| SanMiguel, JG | 1 |
| Girard, PM | 1 |
| Landman, R | 1 |
| Gaudebout, C | 2 |
| Olivares, R | 1 |
| Saimot, AG | 1 |
| Jelazko, P | 1 |
| Certain, A | 1 |
| Boué, F | 1 |
| Bouvet, E | 1 |
| Antinori, A | 2 |
| Murri, R | 1 |
| Ammassari, A | 1 |
| De Luca, A | 2 |
| Linzalone, A | 1 |
| Cingolani, A | 1 |
| Damiano, F | 1 |
| Maiuro, G | 1 |
| Vecchiet, J | 1 |
| Scoppettuolo, G | 1 |
| Rizzardi, GP | 1 |
| Musicco, M | 1 |
| Frigerio, D | 1 |
| Maillard, M | 1 |
| Lucchini, M | 1 |
| Moroni, M | 2 |
| Bossi, P | 1 |
| Caumes, E | 1 |
| Astagneau, P | 1 |
| Li, TS | 1 |
| Paris, L | 1 |
| Mengual, X | 1 |
| Katlama, C | 1 |
| Bricaire, F | 1 |
| Koch, A | 1 |
| Kothe, H | 1 |
| Braun, J | 1 |
| Kämmerer, R | 1 |
| Friedrich, HJ | 1 |
| Dalhoff, K | 1 |
| Mussini, C | 1 |
| Pezzotti, P | 1 |
| Govoni, A | 1 |
| Borghi, V | 1 |
| d'Arminio Monforte, A | 1 |
| Mongiardo, N | 1 |
| Cerri, MC | 1 |
| Chiodo, F | 1 |
| Concia, E | 1 |
| Bonazzi, L | 1 |
| Ortona, L | 1 |
| Esposito, R | 1 |
| Cossarizza, A | 1 |
| De Rienzo, B | 1 |
| Rabaud, C | 1 |
| Leport, C | 1 |
| Carr, A | 1 |
| Tindall, B | 1 |
| Brew, BJ | 1 |
| Marriott, DJ | 1 |
| Harkness, JL | 1 |
| Penny, R | 1 |
| Cooper, DA | 1 |
| Köppen, S | 1 |
| Grünewald, T | 1 |
| Jautzke, G | 1 |
| Gottschalk, J | 1 |
| Pohle, HD | 1 |
| Ruf, B | 1 |
11 trials available for pentamidine and Toxoplasmosis, Cerebral
| Article | Year |
|---|---|
Dapsone/pyrimethamine may prevent mycobacterial disease in immunosuppressed patients infected with the human immunodeficiency virus.
Topics: Adult; CD4 Lymphocyte Count; Dapsone; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Huma | 1995 |
Once-weekly administration of dapsone/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients.
Topics: Administration, Inhalation; Adult; AIDS-Related Opportunistic Infections; Animals; Dapsone; Drug Adm | 1995 |
Prevention of Pneumocystis carinii pneumonia and of cerebral toxoplasmosis by roxithromycin in HIV-infected patients.
Topics: Adult; AIDS-Related Opportunistic Infections; Candidiasis; Digestive System; Drug Therapy, Combinati | 1995 |
Randomized trial of dapsone and aerosolized pentamidine for the prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis.
Topics: Adult; Aerosols; AIDS-Related Opportunistic Infections; Dapsone; Encephalitis; Female; Humans; Male; | 1993 |
Four different regimens for prevention of Pneumocystis carinii pneumonia and toxoplasma encephalitis in HIV-infected patients.
Topics: Adult; AIDS-Related Opportunistic Infections; Dapsone; Drug Therapy, Combination; Female; Follow-Up | 1994 |
Trimethoprim-sulfamethoxazole versus aerosolized pentamidine for primary prophylaxis of Pneumocystis carinii pneumonia: a prospective, randomized, controlled clinical trial. LFPMI Study Group. Ligue Française de Prévention des Maladies Infectieuses.
Topics: Adult; Aerosols; AIDS-Related Opportunistic Infections; Female; Follow-Up Studies; HIV Infections; H | 1994 |
Primary prophylaxis for Pneumocystis carinii pneumonia: a randomized trial comparing cotrimoxazole, aerosolized pentamidine and dapsone plus pyrimethamine.
Topics: Adult; Aerosols; AIDS-Related Opportunistic Infections; Antifungal Agents; Dapsone; Drug Therapy, Co | 1993 |
Dapsone-pyrimethamine compared with aerosolized pentamidine as primary prophylaxis against Pneumocystis carinii pneumonia and toxoplasmosis in HIV infection. The PRIO Study Group.
Topics: Adult; AIDS-Related Complex; AIDS-Related Opportunistic Infections; Dapsone; Drug Combinations; Ence | 1993 |
Aerosolized pentamidine, cotrimoxazole and dapsone-pyrimethamine for primary prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Animals; Anti-Infe | 1995 |
Risks and benefits of aerosolized pentamidine and cotrimoxazole in primary prophylaxis of Pneumocystis carinii pneumonia in HIV-1-infected patients: a two-year Italian multicentric randomized controlled trial. The Italian PCP Study Group.
Topics: Adult; Aerosols; AIDS-Related Opportunistic Infections; Female; HIV-1; Humans; Male; Pentamidine; Pn | 1996 |
Discontinuation of primary prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus type I-infected patients: the changes in opportunistic prophylaxis study.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; AIDS-Related Opportunistic Infections; Anti-HIV Age | 2000 |
6 other studies available for pentamidine and Toxoplasmosis, Cerebral
| Article | Year |
|---|---|
Liver transplant, toxoplasmosis and kidney stones: connecting the dots.
Topics: Aftercare; Antimalarials; Antiprotozoal Agents; Atovaquone; Brain; Brain Edema; Female; Humans; Kidn | 2019 |
[Epidemiologic characteristics of cerebral toxoplasmosis in 399 HIV-infected patients followed between 1983 and 1994].
Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Anti-Infective Agents; Antibodies, Protozoan; | 1998 |
[Incidence of bacterial pneumonia in HIV-positive patients treated with preventive co-trimoxazole or pentamidine].
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antifungal Agents; CD4 Lymphocy | 1998 |
[Cerebral toxoplasmosis in HIV infected patients intolerant of cotrimoxazole].
Topics: AIDS-Related Opportunistic Infections; Drug Eruptions; Drug Therapy, Combination; Follow-Up Studies; | 1998 |
Low-dose trimethoprim-sulfamethoxazole prophylaxis for toxoplasmic encephalitis in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Animals; Antibodies, Protozoan; CD4-Positive T-Lymphocytes; Ence | 1992 |
Prevention of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus infected patients: a clinical approach comparing aerosolized pentamidine and pyrimethamine/sulfadoxine.
Topics: Adult; Aerosols; Aged; CD4-Positive T-Lymphocytes; Drug Combinations; Encephalitis; Female; HIV Infe | 1992 |