pentamidine has been researched along with Torsade de Pointes in 18 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " pentamidine therapy in HIV-infected patients has been associated in case reports and one uncontrolled prospective series with frequent prolongation of the rate-corrected QT interval (QTc) and a high risk for potentially lethal ventricular arrhythmias, especially torsade de pointes." | 9.08 | A prospective study of the effect of I.V. pentamidine therapy on ventricular arrhythmias and QTc prolongation in HIV-infected patients. ( Costantino, T; Girgis, I; Gualberti, J; Langan, L; Malek, S; McGinn, TG; Mustaciuolo, V, 1997) |
| "There have been 15 published cases of probable pentamidine-induced torsade de pointes (TdP)." | 7.69 | Incidence of cardiac arrhythmias during intravenous pentamidine therapy in HIV-infected patients. ( Coyne, PE; Eisenhauer, MD; Eliasson, AH; Taylor, AJ; Wortham, DC, 1994) |
| "Pentamidine isethionate induced torsades de pointes in a 33-year-old woman with acute myelogenous leukemia." | 7.69 | Torsades de pointes complicating pentamidine therapy of Pneumocystis carinii pneumonia in acute myelogenous leukemia. ( Harano, H; Kanamori, H; Matsuzaki, M; Mohri, H; Ochiai, H; Ogawa, K; Okubo, T; Otsuka, M; Sasaki, S; Sumita, S; Taguchi, J, 1997) |
| "His episodes of torsade de pointes were refractory to the usual therapy." | 5.28 | Torsade de pointes after inhaled pentamidine. ( Coodley, G; Engrav, MB; Magnusson, AR, 1992) |
| " pentamidine therapy in HIV-infected patients has been associated in case reports and one uncontrolled prospective series with frequent prolongation of the rate-corrected QT interval (QTc) and a high risk for potentially lethal ventricular arrhythmias, especially torsade de pointes." | 5.08 | A prospective study of the effect of I.V. pentamidine therapy on ventricular arrhythmias and QTc prolongation in HIV-infected patients. ( Costantino, T; Girgis, I; Gualberti, J; Langan, L; Malek, S; McGinn, TG; Mustaciuolo, V, 1997) |
| "Pentamidine isethionate has been associated with ventricular tachyarrhythmias, including torsade de pointes." | 4.78 | Case report: pentamidine and polymorphic ventricular tachycardia revisited. ( Andriole, VT; Kocheril, AG; Mani, S, 1993) |
| "There have been 15 published cases of probable pentamidine-induced torsade de pointes (TdP)." | 3.69 | Incidence of cardiac arrhythmias during intravenous pentamidine therapy in HIV-infected patients. ( Coyne, PE; Eisenhauer, MD; Eliasson, AH; Taylor, AJ; Wortham, DC, 1994) |
| "Pentamidine isethionate induced torsades de pointes in a 33-year-old woman with acute myelogenous leukemia." | 3.69 | Torsades de pointes complicating pentamidine therapy of Pneumocystis carinii pneumonia in acute myelogenous leukemia. ( Harano, H; Kanamori, H; Matsuzaki, M; Mohri, H; Ochiai, H; Ogawa, K; Okubo, T; Otsuka, M; Sasaki, S; Sumita, S; Taguchi, J, 1997) |
| "A 43-year-old woman with AIDS experienced pentamidine-induced TdP." | 2.38 | Prolonged recurrence of pentamidine-induced torsades de pointes. ( Bjornson, DC; Cortese, LM; Dacey, MJ; Gasser, RA; Oster, CN, 1992) |
| "We evaluated the effect of chronic Pneumocystis carinii pneumonia (PCP) prophylaxis, with a once a month dose of 300 mg of inhalatory pentamidine isethionate, on QT interval duration." | 1.30 | Inhalatory pentamidine therapy and the duration of the QT interval in HIV-infected patients. ( Cardoso, JS; Conde, C; Lecour, H; Mota-Miranda, A; Moura, B; Rocha-Gonçalves, F, 1997) |
| "His episodes of torsade de pointes were refractory to the usual therapy." | 1.28 | Torsade de pointes after inhaled pentamidine. ( Coodley, G; Engrav, MB; Magnusson, AR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (88.89) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kroll, CR | 1 |
| Gettes, LS | 1 |
| Katchman, AN | 1 |
| Koerner, J | 1 |
| Tosaka, T | 1 |
| Woosley, RL | 2 |
| Ebert, SN | 1 |
| Olree, K | 1 |
| Stein-Gocken, J | 1 |
| Farquhar Zanetti, LA | 1 |
| Oliphant, CM | 1 |
| Eisenhauer, MD | 1 |
| Eliasson, AH | 2 |
| Taylor, AJ | 2 |
| Coyne, PE | 2 |
| Wortham, DC | 1 |
| Harel, Y | 1 |
| Scott, WA | 1 |
| Szeinberg, A | 1 |
| Barzilay, Z | 1 |
| Miller, HC | 1 |
| Mani, S | 1 |
| Kocheril, AG | 1 |
| Andriole, VT | 1 |
| Cardoso, JS | 1 |
| Mota-Miranda, A | 1 |
| Conde, C | 1 |
| Moura, B | 1 |
| Rocha-Gonçalves, F | 1 |
| Lecour, H | 1 |
| Girgis, I | 1 |
| Gualberti, J | 1 |
| Langan, L | 1 |
| Malek, S | 1 |
| Mustaciuolo, V | 1 |
| Costantino, T | 1 |
| McGinn, TG | 1 |
| Otsuka, M | 1 |
| Kanamori, H | 1 |
| Sasaki, S | 1 |
| Taguchi, J | 1 |
| Harano, H | 1 |
| Ogawa, K | 1 |
| Matsuzaki, M | 1 |
| Mohri, H | 1 |
| Okubo, T | 1 |
| Sumita, S | 1 |
| Ochiai, H | 1 |
| Engrav, MB | 1 |
| Coodley, G | 1 |
| Magnusson, AR | 1 |
| Cortese, LM | 1 |
| Gasser, RA | 1 |
| Bjornson, DC | 1 |
| Dacey, MJ | 1 |
| Oster, CN | 1 |
| Quadrel, MA | 1 |
| Atkin, SH | 1 |
| Jaker, MA | 1 |
| Lortholary, O | 1 |
| Caumes, E | 1 |
| Valentin, MA | 1 |
| Katlama, C | 1 |
| Danis, M | 1 |
| Gentilini, M | 1 |
| Gonzalez, A | 1 |
| Sager, PT | 1 |
| Akil, B | 1 |
| Rahimtoola, SH | 1 |
| Bhandari, AK | 1 |
| Hull, RW | 1 |
| Stein, KM | 1 |
| Haronian, H | 1 |
| Mensah, GA | 1 |
| Acosta, A | 1 |
| Jacobs, J | 1 |
| Kligfield, P | 1 |
5 reviews available for pentamidine and Torsade de Pointes
| Article | Year |
|---|---|
Torsade de pointes and elevated magnesium and calcium requirements associated with intravenous pentamidine.
Topics: Adult; AIDS-Related Opportunistic Infections; Electrocardiography; Humans; Hypocalcemia; Infusions, | 1994 |
Pentamidine-induced torsades de pointes.
Topics: Adult; Child; Humans; Male; Middle Aged; Pentamidine; Pneumonia, Pneumocystis; Torsades de Pointes | 1993 |
Case report: pentamidine and polymorphic ventricular tachycardia revisited.
Topics: Adult; Humans; Male; Pentamidine; Pneumonia, Pneumocystis; Torsades de Pointes | 1993 |
Prolonged recurrence of pentamidine-induced torsades de pointes.
Topics: Acquired Immunodeficiency Syndrome; Adult; Female; Humans; Infusions, Intravenous; Pentamidine; Pneu | 1992 |
Delayed cardiotoxicity during treatment with intravenous pentamidine: two case reports and a review of the literature.
Topics: Adult; Female; Humans; Infusions, Intravenous; Male; Pentamidine; Pneumonia, Pneumocystis; Time Fact | 1992 |
1 trial available for pentamidine and Torsade de Pointes
| Article | Year |
|---|---|
A prospective study of the effect of I.V. pentamidine therapy on ventricular arrhythmias and QTc prolongation in HIV-infected patients.
Topics: Adult; Anti-Infective Agents; Arrhythmias, Cardiac; Echocardiography; Echocardiography, Doppler; Ele | 1997 |
12 other studies available for pentamidine and Torsade de Pointes
| Article | Year |
|---|---|
T wave alternans and Torsades de Pointes after the use of intravenous pentamidine.
Topics: Antiprotozoal Agents; Electrocardiography; Female; HIV Infections; Humans; Infusions, Intravenous; M | 2002 |
Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs.
Topics: Animals; Arsenic Trioxide; Arsenicals; Cells, Cultured; Electrocardiography; ERG1 Potassium Channel; | 2006 |
Pentamidine-induced torsades de pointes.
Topics: Female; Fever of Unknown Origin; HIV Seropositivity; Humans; Middle Aged; Pentamidine; Pneumonia, Pn | 1994 |
Incidence of cardiac arrhythmias during intravenous pentamidine therapy in HIV-infected patients.
Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Arrhythmias, Cardiac; Cohort Studies; Dose-Respo | 1994 |
Cardiac arrest after intravenous pentamidine in an infant.
Topics: Female; Heart Arrest; Humans; Infant; Injections, Intravenous; Pentamidine; Pneumonia, Pneumocystis; | 1993 |
Inhalatory pentamidine therapy and the duration of the QT interval in HIV-infected patients.
Topics: Administration, Inhalation; Adult; Antibiotic Prophylaxis; Antifungal Agents; CD4 Lymphocyte Count; | 1997 |
Torsades de pointes complicating pentamidine therapy of Pneumocystis carinii pneumonia in acute myelogenous leukemia.
Topics: Adult; Antifungal Agents; Cardiac Pacing, Artificial; Electrocardiography; Female; Follow-Up Studies | 1997 |
Torsade de pointes after inhaled pentamidine.
Topics: Acquired Immunodeficiency Syndrome; Administration, Inhalation; Adult; Combined Modality Therapy; El | 1992 |
[Cardiac complications of pentamidine isethionate. Report of a case].
Topics: Adult; HIV Seropositivity; Humans; Male; Pentamidine; Torsades de Pointes | 1991 |
Pentamidine-induced torsade de pointes.
Topics: Acquired Immunodeficiency Syndrome; Adult; Electrocardiography; Female; Humans; Male; Opportunistic | 1991 |
Pentamidine-induced torsades de pointes: safe completion of therapy with inhaled pentamidine.
Topics: Administration, Inhalation; Adult; Humans; Injections, Intravenous; Male; Pentamidine; Torsades de P | 1991 |
Ventricular tachycardia and torsades de pointes complicating pentamidine therapy of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Heart Ventricles; Humans; Pentamidine; Pneumonia, Pneumoc | 1990 |