pentamidine has been researched along with Sensitivity and Specificity in 22 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recurrent Pneumocystis carinii pneumonia is common in patients with the acquired immunodeficiency syndrome who receive prophylaxis with aerosolized pentamidine." | 3.68 | Diagnostic approach to Pneumocystis carinii pneumonia in the setting of prophylactic aerosolized pentamidine. ( Catanzaro, A; Metersky, ML, 1991) |
| " Fourteen compounds without previously known ototoxicity were discovered to be selectively toxic to hair cells." | 1.35 | Using the zebrafish lateral line to screen for ototoxicity. ( Chiu, LL; Cunningham, LL; Ou, HC; Raible, DW; Rubel, EW, 2008) |
| "In human African trypanosomiasis (HAT), two disease stages are defined: the first, or haemo-lymphatic stage, and the second, or meningo-encephalitic stage." | 1.32 | Stage determination and therapeutic decision in human African trypanosomiasis: value of polymerase chain reaction and immunoglobulin M quantification on the cerebrospinal fluid of sleeping sickness patients in Côte d'Ivoire. ( Büscher, P; Cuny, G; Djé, N; Garcia, A; Jamonneau, V; Lejon, V; Miezan, TW; N'Guessan, P; Solano, P, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (45.45) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Vogt, F | 1 |
| Mengesha, B | 1 |
| Asmamaw, H | 1 |
| Mekonnen, T | 1 |
| Fikre, H | 1 |
| Takele, Y | 1 |
| Adem, E | 1 |
| Mohammed, R | 1 |
| Ritmeijer, K | 1 |
| Adriaensen, W | 1 |
| Melsew, Y | 1 |
| van Griensven, J | 1 |
| Diro, E | 1 |
| Lim, KT | 1 |
| Zahari, Z | 1 |
| Amanah, A | 1 |
| Zainuddin, Z | 1 |
| Adenan, MI | 1 |
| Sarkar, A | 1 |
| Mandal, G | 1 |
| Singh, N | 1 |
| Sundar, S | 1 |
| Chatterjee, M | 1 |
| Sykes, ML | 1 |
| Avery, VM | 1 |
| Jamonneau, V | 1 |
| Solano, P | 1 |
| Garcia, A | 1 |
| Lejon, V | 1 |
| Djé, N | 1 |
| Miezan, TW | 1 |
| N'Guessan, P | 1 |
| Cuny, G | 1 |
| Büscher, P | 1 |
| Choudhury, K | 1 |
| Leibowitz, MJ | 1 |
| Munde, M | 1 |
| Ismail, MA | 1 |
| Arafa, R | 1 |
| Peixoto, P | 1 |
| Collar, CJ | 1 |
| Liu, Y | 1 |
| Hu, L | 1 |
| David-Cordonnier, MH | 1 |
| Lansiaux, A | 1 |
| Bailly, C | 1 |
| Boykin, DW | 1 |
| Wilson, WD | 1 |
| Chiu, LL | 1 |
| Cunningham, LL | 1 |
| Raible, DW | 1 |
| Rubel, EW | 1 |
| Ou, HC | 1 |
| Chandra, J | 1 |
| Patwari, AK | 1 |
| De Groof, D | 1 |
| Bruneel, H | 1 |
| Mungoma, K | 1 |
| Ruppol, JF | 1 |
| Tu, JV | 1 |
| Biem, HJ | 1 |
| Detsky, AS | 1 |
| Garzón, MJ | 1 |
| Rabanal, B | 1 |
| Ortiz, AI | 1 |
| Negro, A | 1 |
| Arastéh, KN | 1 |
| Simon, V | 1 |
| Musch, R | 1 |
| Weiss, RO | 1 |
| Przytarski, K | 1 |
| Futh, UM | 1 |
| Pleuger, F | 1 |
| Huhn, D | 1 |
| L'age, MP | 1 |
| Reisner, HM | 1 |
| Gray, DR | 1 |
| Jones, SK | 1 |
| Rose, BG | 1 |
| Tidwell, RR | 1 |
| Nacher, M | 1 |
| Carme, B | 1 |
| Sainte Marie, D | 1 |
| Couppié, P | 1 |
| Clyti, E | 1 |
| Guibert, P | 1 |
| Pradinaud, R | 1 |
| Delgado, G | 1 |
| Puentes, F | 1 |
| Moreno, A | 1 |
| Patarroyo, ME | 1 |
| Levine, SJ | 1 |
| Kennedy, D | 1 |
| Shelhamer, JH | 1 |
| Kovacs, A | 1 |
| Feuerstein, IM | 1 |
| Gill, VJ | 1 |
| Stock, F | 1 |
| Solomon, D | 1 |
| Boylen, CT | 1 |
| Masur, H | 1 |
| Fahy, JV | 1 |
| Chin, DP | 1 |
| Schnapp, LM | 1 |
| Steiger, DJ | 1 |
| Schaumberg, TH | 1 |
| Geaghan, SM | 1 |
| Klein, JS | 1 |
| Hopewell, PC | 1 |
| Freedberg, KA | 1 |
| Tosteson, AN | 1 |
| Cohen, CJ | 1 |
| Cotton, DJ | 1 |
| Castellano, AR | 1 |
| Nettleman, MD | 1 |
| Metersky, ML | 1 |
| Catanzaro, A | 1 |
1 review available for pentamidine and Sensitivity and Specificity
| Article | Year |
|---|---|
Diagnosis and treatment of kala-azar.
Topics: Allopurinol; Amphotericin B; Antimony Sodium Gluconate; Child; Combined Modality Therapy; Humans; Ke | 1994 |
1 trial available for pentamidine and Sensitivity and Specificity
| Article | Year |
|---|---|
Antigen Detection in Urine for Noninvasive Diagnosis and Treatment Monitoring of Visceral Leishmaniasis in Human Immunodeficiency Virus Coinfected Patients: An Exploratory Analysis from Ethiopia.
Topics: Adult; Antigens, Protozoan; Antiprotozoal Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphoc | 2018 |
20 other studies available for pentamidine and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Development of resazurin-based assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei rhodesiense strain STIB 900 for the identification of potential anti-trypanosomal agents.
Topics: Animals; Cell Line; Cell Survival; Cost-Benefit Analysis; Dose-Response Relationship, Drug; High-Thr | 2016 |
Flow cytometric determination of intracellular non-protein thiols in Leishmania promastigotes using 5-chloromethyl fluorescein diacetate.
Topics: Animals; Antimony Sodium Gluconate; Antiprotozoal Agents; Culture Media, Serum-Free; Flow Cytometry; | 2009 |
Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.
Topics: Animals; Diminazene; Humans; Indicators and Reagents; Oxazines; Pentamidine; Sensitivity and Specifi | 2009 |
Stage determination and therapeutic decision in human African trypanosomiasis: value of polymerase chain reaction and immunoglobulin M quantification on the cerebrospinal fluid of sleeping sickness patients in Côte d'Ivoire.
Topics: Animals; Antibodies, Protozoan; DNA, Protozoan; Humans; Immunoglobulin M; Latex Fixation Tests; Leuk | 2003 |
Pentamidine-induced alteration in restriction endonuclease cleavage of plasmid DNA.
Topics: Base Composition; Base Sequence; Binding Sites; Deoxyribonuclease I; DNA Footprinting; DNA Restricti | 2003 |
Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif.
Topics: Amino Acid Motifs; Base Pairing; Base Sequence; Binding Sites; Biosensing Techniques; Calorimetry; D | 2007 |
Using the zebrafish lateral line to screen for ototoxicity.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluatio | 2008 |
[A strategy to control Trypanosomiasis due to Trypanosoma brucei gambiense in an endemic region of Zaire. Association of a serological test and early treatment of suspected cases. Preliminary results].
Topics: Agglutination Tests; Animals; Clinical Protocols; Communicable Disease Control; Communicable Disease | 1993 |
Bronchoscopy versus empirical therapy in HIV-infected patients with presumptive Pneumocystis carinii pneumonia. A decision analysis.
Topics: AIDS-Related Opportunistic Infections; Biopsy; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoscopy; | 1993 |
Determination of pentamidine in serum and urine by micellar electrokinetic chromatography.
Topics: Animals; Antiprotozoal Agents; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Hydro | 1997 |
Sensitivity and specificity of indirect immunofluorescence and Grocott-technique in comparison with immunocytology (alkaline phosphatase anti alkaline phosphatase = APAAP) for the diagnosis of Pneumocystis carinii in broncho-alveolar lavage (BAL).
Topics: Adult; AIDS-Related Opportunistic Infections; Antifungal Agents; Bronchoalveolar Lavage Fluid; Diagn | 1998 |
Immunoassays for pentamidine and related compounds: development of a facile inhibitory ELISA suitable for clinical use.
Topics: Animals; Enzyme-Linked Immunosorbent Assay; Haptens; Immune Sera; Immunization; Maleic Anhydrides; M | 2000 |
Influence of clinical presentation on the efficacy of a short course of pentamidine in the treatment of cutaneous leishmaniasis in French Guiana.
Topics: AIDS-Related Opportunistic Infections; Antiprotozoal Agents; Confidence Intervals; French Guiana; Hu | 2001 |
Flow cytometry, a useful tool for detecting the lethal effect of pentamidine on Leishmania viannia complex promastigote forms.
Topics: Animals; Antimony Sodium Gluconate; Antiprotozoal Agents; Drug Resistance; Flow Cytometry; Humans; L | 2001 |
Diagnosis of Pneumocystis carinii pneumonia by multiple lobe, site-directed bronchoalveolar lavage with immunofluorescent monoclonal antibody staining in human immunodeficiency virus-infected patients receiving aerosolized pentamidine chemoprophylaxis.
Topics: Administration, Inhalation; Adult; Aerosols; AIDS-Related Opportunistic Infections; Biopsy; Bronchoa | 1992 |
Effect of aerosolized pentamidine prophylaxis on the clinical severity and diagnosis of Pneumocystis carinii pneumonia.
Topics: Administration, Inhalation; Adult; Aerosols; AIDS-Related Opportunistic Infections; Cohort Studies; | 1992 |
Primary prophylaxis for Pneumocystis carinii pneumonia in HIV-infected people with CD4 counts below 200/mm3: a cost-effectiveness analysis.
Topics: Acquired Immunodeficiency Syndrome; Aerosols; Antiviral Agents; CD4-Positive T-Lymphocytes; Cost-Ben | 1991 |
Cost and benefit of secondary prophylaxis for Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Aerosols; Clinical Protocols; Cost-Benefit | 1991 |
Diagnostic approach to Pneumocystis carinii pneumonia in the setting of prophylactic aerosolized pentamidine.
Topics: Acquired Immunodeficiency Syndrome; Administration, Inhalation; Adult; Humans; Length of Stay; Male; | 1991 |