pentamidine has been researched along with Rhabdomyolysis in 5 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Rhabdomyolysis: Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report 2 patients who developed pentamidine-induced rhabdomyolysis during treatment of leishmaniasis." | 7.71 | [Rhabdomyolysis induced by pentamidine (Pentacarinat) during treatment of cutaneous leishmaniasis: 2 cases]. ( Heid, E; Lieber-Mbomeyo, A; Lipsker, D; Miléa, M, 2002) |
| "A 31-year-old man with acquired immunodeficiency syndrome and biopsy-proved Pneumocystis carinii pneumonia developed acute renal failure, elevated creatinine kinase levels, and myoglobin in both serum and urine while being treated with pentamidine." | 7.67 | Pentamidine treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Association with acute renal failure and myoglobinuria. ( Johnson, ES; Perez, G; Sensakovic, JW; Smith, LG; Suarez, M, 1985) |
| "We report 2 patients who developed pentamidine-induced rhabdomyolysis during treatment of leishmaniasis." | 3.71 | [Rhabdomyolysis induced by pentamidine (Pentacarinat) during treatment of cutaneous leishmaniasis: 2 cases]. ( Heid, E; Lieber-Mbomeyo, A; Lipsker, D; Miléa, M, 2002) |
| "A 31-year-old man with acquired immunodeficiency syndrome and biopsy-proved Pneumocystis carinii pneumonia developed acute renal failure, elevated creatinine kinase levels, and myoglobin in both serum and urine while being treated with pentamidine." | 3.67 | Pentamidine treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Association with acute renal failure and myoglobinuria. ( Johnson, ES; Perez, G; Sensakovic, JW; Smith, LG; Suarez, M, 1985) |
| "Extensive rhabdomyolysis was observed in all cases tested: this side-effect has not been reported." | 1.32 | [Management of American cutaneous leishmaniasis. Outcome apropos of 326 cases treated with high-dose pentamidine isethionate]. ( Banzet, S; Boutin, JP; Chaudier, B; Chouc, C; Dampierre, H; Garnotel, E; Hovette, P; Kraemer, P; Lepage, J; Lightburn, E; Meynard, JB; Morand, JJ; Morillon, M; Pages, F; Patte, JH, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Delobel, P | 1 |
| Pradinaud, R | 1 |
| Lightburn, E | 1 |
| Morand, JJ | 1 |
| Meynard, JB | 1 |
| Kraemer, P | 1 |
| Chaudier, B | 1 |
| Pages, F | 1 |
| Garnotel, E | 1 |
| Patte, JH | 1 |
| Banzet, S | 1 |
| Dampierre, H | 1 |
| Lepage, J | 1 |
| Morillon, M | 1 |
| Boutin, JP | 1 |
| Hovette, P | 1 |
| Chouc, C | 1 |
| Hauben, M | 1 |
| Reich, L | 1 |
| Lieber-Mbomeyo, A | 1 |
| Lipsker, D | 1 |
| Miléa, M | 1 |
| Heid, E | 1 |
| Sensakovic, JW | 1 |
| Suarez, M | 1 |
| Perez, G | 1 |
| Johnson, ES | 1 |
| Smith, LG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 3 Open-label Study of Efficacy and Safety of Miltefosine or Thermotherapy vs Glucantime for Cutaneous Leishmaniasis in Colombia.[NCT00471705] | Phase 3 | 437 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Complete Clinical response: Initial cure plus the absence of recurrences or mucosal lesions for 6 months after the end of treatment.~Note: nitial cure: Complete re-epithelialization of all ulcers and complete disappearance of the induration up to 3 months after the end of treatment." (NCT00471705)
Timeframe: Until 6 months posttreatment
| Intervention | participants (Number) |
|---|---|
| Miltefosine | 85 |
| Glucantime® | 103 |
| Thermotherapy | 86 |
At least 50% increase in lesion size at the end of treatment, absence of clinical response at 6 weeks, or any sign of lesion activity 3 months after the end of treatment (NCT00471705)
Timeframe: Until 3 months posttreatment
| Intervention | participants (Number) |
|---|---|
| Miltefosine | 34 |
| Glucantime® | 14 |
| Thermotherapy | 42 |
Reactivation of the lesion at the original site after cure or mucosal compromise during follow-up. (NCT00471705)
Timeframe: Until 6 months post-treatment
| Intervention | Participants (Number) |
|---|---|
| Miltefosine | 3 |
| Glucantime® | 4 |
| Thermotherapy | 6 |
5 other studies available for pentamidine and Rhabdomyolysis
| Article | Year |
|---|---|
Rhabdomyolysis associated with pentamidine isethionate therapy for American cutaneous leishmaniasis.
Topics: Antiprotozoal Agents; Creatine Kinase; Humans; Injections, Intramuscular; Leishmaniasis, Cutaneous; | 2003 |
[Management of American cutaneous leishmaniasis. Outcome apropos of 326 cases treated with high-dose pentamidine isethionate].
Topics: Antiprotozoal Agents; France; French Guiana; Humans; Injections, Intramuscular; Leishmaniasis, Cutan | 2003 |
A case report of rhabdomyolysis with pentamidine that prompted a retrospective evaluation of a pharmacovigilance tool under investigation.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Infective Agents; Humans; Pentamidine; Review Literatu | 2004 |
[Rhabdomyolysis induced by pentamidine (Pentacarinat) during treatment of cutaneous leishmaniasis: 2 cases].
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Injections, Intramusc | 2002 |
Pentamidine treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Association with acute renal failure and myoglobinuria.
Topics: Acquired Immunodeficiency Syndrome; Acute Kidney Injury; Adult; Amidines; Humans; Male; Myoglobinuri | 1985 |