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pentamidine and Pregnancy

pentamidine has been researched along with Pregnancy in 16 studies

Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"Pentamidine's kinetics were assessed in the following maternal compartments over a 12-hour period in 16 timed-pregnant rats: serum, liver, and kidney."5.28Pharmacokinetics of pentamidine in Sprague-Dawley rats in late pregnancy. ( Bawdon, RE; Ghali, FE; Harstad, TH; Knoll, KA; Little, BB; Roe, DA; Sobhi, S, 1991)
" The primary safety outcome was the frequency and severity of adverse events."2.82Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial. ( Bernhard, SC; Bilenge, CM; Blum, J; Burri, C; Dala, A; Deo, GK; Dituvanga, ND; Franco, JR; Kuikumbi, FM; Lubaki, JP; Macharia, S; Mesu, VK; Mintwo, AF; Mpanya, A; Mpoto, AM; Munungi, AK; Munungu, BF; Mutantu, PN; N'tombe, PM; Olson, CA; Pohlig, G; Tidwell, RR, 2016)
"If pregnancy is pursued, the mother must be investigated for sexually transmitted diseases which are particularly frequent in this population and may have repercussions on the newborn."2.38[Pregnancy in HIV infected women. Current therapeutic indications]. ( Bongain, A; Fuzibet, JG; Gillet, JY; Pesce, A, 1992)
"Pneumocystis carinii pneumonia is the most common life-threatening disease diagnosed in patients infected with the human immunodeficiency virus (HIV)."2.38Aerosolized pentamidine in HIV. Promising new treatment for Pneumocystis carinii pneumonia. ( Sarti, GM, 1989)
"Pentamidine was without teratogenic effects in rats when administered in doses similar to those recommended for adult humans; however, it appears to have an embryocidal effect when given in those same doses during embryogenesis."1.28Embryofetal effects of pentamidine isethionate administered to pregnant Sprague-Dawley rats. ( Bawdon, RE; Gilstrap, LC; Harstad, TW; Knoll, K; Little, BB; Roe, D, 1990)
"Pentamidine was added to the maternal circulation at therapeutic concentrations (2 micrograms/ml)."1.28Determination of pentamidine transfer in the in vitro perfused human cotyledon with high-performance liquid chromatography. ( Bawdon, RE; Fortunato, SJ, 1989)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19906 (37.50)18.7374
1990's8 (50.00)18.2507
2000's1 (6.25)29.6817
2010's1 (6.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pohlig, G1
Bernhard, SC1
Blum, J1
Burri, C1
Mpanya, A1
Lubaki, JP1
Mpoto, AM1
Munungu, BF1
N'tombe, PM1
Deo, GK1
Mutantu, PN1
Kuikumbi, FM1
Mintwo, AF1
Munungi, AK1
Dala, A1
Macharia, S1
Bilenge, CM1
Mesu, VK1
Franco, JR1
Dituvanga, ND1
Tidwell, RR1
Olson, CA1
Nadjm, B1
Van Tulleken, C1
Macdonald, D1
Chiodini, PL1
GREEN, HN1
HOPEWELL, JD1
THRELFALL, CJ1
Hoernle, EH1
Reid, TE1
Ito, S1
Koren, G1
Ajisawa, A1
Moreno, JD2
Minkoff, H1
Gillet, JY1
Bongain, A1
Fuzibet, JG1
Pesce, A1
Little, BB2
Harstad, TH1
Bawdon, RE3
Sobhi, S1
Roe, DA1
Knoll, KA1
Ghali, FE1
Minkoff, HL1
Harstad, TW1
Knoll, K1
Roe, D1
Gilstrap, LC1
Sarti, GM1
Fortunato, SJ1
Conover, B1
Goldsmith, JC1
Buehler, BA1
Maloley, PA1
Windle, ML1

Reviews

3 reviews available for pentamidine and Pregnancy

ArticleYear
Human immunodeficiency virus infection in children.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1995, May-01, Volume: 52, Issue:9

    Topics: Adolescent; AIDS-Related Opportunistic Infections; Child; Child, Preschool; Dapsone; Didanosine; Dru

1995
[Pregnancy in HIV infected women. Current therapeutic indications].
    Presse medicale (Paris, France : 1983), 1992, Feb-01, Volume: 21, Issue:4

    Topics: Abortion, Therapeutic; Adult; CD4 Immunoadhesins; Female; HIV Infections; Humans; Immunization, Pass

1992
Aerosolized pentamidine in HIV. Promising new treatment for Pneumocystis carinii pneumonia.
    Postgraduate medicine, 1989, Volume: 86, Issue:2

    Topics: Aerosols; Amidines; Animals; Anti-Infective Agents; Child; Drug Combinations; Female; HIV Seropositi

1989

Trials

1 trial available for pentamidine and Pregnancy

ArticleYear
Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial.
    PLoS neglected tropical diseases, 2016, Volume: 10, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Angola; Benzamidines; Child; Democratic Republic of t

2016

Other Studies

12 other studies available for pentamidine and Pregnancy

ArticleYear
East African trypanosomiasis in a pregnant traveler.
    Emerging infectious diseases, 2009, Volume: 15, Issue:11

    Topics: Adult; Communicable Diseases, Emerging; Female; Humans; Infant, Newborn; London; Pentamidine; Pregna

2009
Plasma pentose levels in pre-eclampsia and their aetiological significance.
    British medical journal, 1951, Sep-08, Volume: 2, Issue:4731

    Topics: Female; Humans; Pentamidine; Pentoses; Plasma; Pre-Eclampsia; Pregnancy

1951
Estimation of fetal risk from aerosolized pentamidine in pregnant healthcare workers.
    Chest, 1994, Volume: 106, Issue:5

    Topics: Aerosols; Dose-Response Relationship, Drug; Female; Fetus; Health Personnel; Humans; Occupational Ex

1994
[Protozoan infections in AIDS].
    Nihon rinsho. Japanese journal of clinical medicine, 1993, Volume: 51 Suppl

    Topics: Acquired Immunodeficiency Syndrome; Administration, Inhalation; AIDS-Related Opportunistic Infection

1993
Human immunodeficiency virus infection during pregnancy.
    Clinical obstetrics and gynecology, 1992, Volume: 35, Issue:4

    Topics: Abnormalities, Drug-Induced; AIDS Serodiagnosis; Ethics, Medical; Female; HIV Infections; Humans; In

1992
Pharmacokinetics of pentamidine in Sprague-Dawley rats in late pregnancy.
    American journal of obstetrics and gynecology, 1991, Volume: 164, Issue:3

    Topics: Animals; Brain; Female; Fetus; Maternal-Fetal Exchange; Pentamidine; Pregnancy; Pregnancy, Animal; R

1991
Drug prophylaxis for human immunodeficiency virus-infected pregnant women: ethical considerations.
    American journal of obstetrics and gynecology, 1990, Volume: 163, Issue:4 Pt 1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antibodies, Anti-Idiotypic; Antigens, CD; CD4 Immunoadhes

1990
Embryofetal effects of pentamidine isethionate administered to pregnant Sprague-Dawley rats.
    American journal of obstetrics and gynecology, 1990, Volume: 163, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Female; Fetus; Maternal-Fetal Exchange; Pentam

1990
Guidelines for prophylaxis against Pneumocystis carinii pneumonia for persons infected with human immunodeficiency virus.
    MMWR supplements, 1989, Jun-16, Volume: 38, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aerosols; Child; Drug Combinations; Female; Humans; Infan

1989
From the Centers for Disease Control. Guidelines for prophylaxis against Pneumocystis carinii pneumonia for persons infected with human immunodeficiency virus.
    JAMA, 1989, Jul-21, Volume: 262, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aerosols; Anti-Bacterial Agents; Child; Drug Combinations

1989
Determination of pentamidine transfer in the in vitro perfused human cotyledon with high-performance liquid chromatography.
    American journal of obstetrics and gynecology, 1989, Volume: 160, Issue:3

    Topics: Amidines; Chromatography, High Pressure Liquid; Female; Humans; Maternal-Fetal Exchange; Osmolar Con

1989
Aerosolized pentamidine and pregnancy.
    Annals of internal medicine, 1988, Dec-01, Volume: 109, Issue:11

    Topics: Aerosols; Air Pollutants, Occupational; Amidines; Female; Health Occupations; Humans; Pentamidine; P

1988