pentamidine has been researched along with Pregnancy in 16 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pentamidine's kinetics were assessed in the following maternal compartments over a 12-hour period in 16 timed-pregnant rats: serum, liver, and kidney." | 5.28 | Pharmacokinetics of pentamidine in Sprague-Dawley rats in late pregnancy. ( Bawdon, RE; Ghali, FE; Harstad, TH; Knoll, KA; Little, BB; Roe, DA; Sobhi, S, 1991) |
| " The primary safety outcome was the frequency and severity of adverse events." | 2.82 | Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial. ( Bernhard, SC; Bilenge, CM; Blum, J; Burri, C; Dala, A; Deo, GK; Dituvanga, ND; Franco, JR; Kuikumbi, FM; Lubaki, JP; Macharia, S; Mesu, VK; Mintwo, AF; Mpanya, A; Mpoto, AM; Munungi, AK; Munungu, BF; Mutantu, PN; N'tombe, PM; Olson, CA; Pohlig, G; Tidwell, RR, 2016) |
| "If pregnancy is pursued, the mother must be investigated for sexually transmitted diseases which are particularly frequent in this population and may have repercussions on the newborn." | 2.38 | [Pregnancy in HIV infected women. Current therapeutic indications]. ( Bongain, A; Fuzibet, JG; Gillet, JY; Pesce, A, 1992) |
| "Pneumocystis carinii pneumonia is the most common life-threatening disease diagnosed in patients infected with the human immunodeficiency virus (HIV)." | 2.38 | Aerosolized pentamidine in HIV. Promising new treatment for Pneumocystis carinii pneumonia. ( Sarti, GM, 1989) |
| "Pentamidine was without teratogenic effects in rats when administered in doses similar to those recommended for adult humans; however, it appears to have an embryocidal effect when given in those same doses during embryogenesis." | 1.28 | Embryofetal effects of pentamidine isethionate administered to pregnant Sprague-Dawley rats. ( Bawdon, RE; Gilstrap, LC; Harstad, TW; Knoll, K; Little, BB; Roe, D, 1990) |
| "Pentamidine was added to the maternal circulation at therapeutic concentrations (2 micrograms/ml)." | 1.28 | Determination of pentamidine transfer in the in vitro perfused human cotyledon with high-performance liquid chromatography. ( Bawdon, RE; Fortunato, SJ, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (37.50) | 18.7374 |
| 1990's | 8 (50.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pohlig, G | 1 |
| Bernhard, SC | 1 |
| Blum, J | 1 |
| Burri, C | 1 |
| Mpanya, A | 1 |
| Lubaki, JP | 1 |
| Mpoto, AM | 1 |
| Munungu, BF | 1 |
| N'tombe, PM | 1 |
| Deo, GK | 1 |
| Mutantu, PN | 1 |
| Kuikumbi, FM | 1 |
| Mintwo, AF | 1 |
| Munungi, AK | 1 |
| Dala, A | 1 |
| Macharia, S | 1 |
| Bilenge, CM | 1 |
| Mesu, VK | 1 |
| Franco, JR | 1 |
| Dituvanga, ND | 1 |
| Tidwell, RR | 1 |
| Olson, CA | 1 |
| Nadjm, B | 1 |
| Van Tulleken, C | 1 |
| Macdonald, D | 1 |
| Chiodini, PL | 1 |
| GREEN, HN | 1 |
| HOPEWELL, JD | 1 |
| THRELFALL, CJ | 1 |
| Hoernle, EH | 1 |
| Reid, TE | 1 |
| Ito, S | 1 |
| Koren, G | 1 |
| Ajisawa, A | 1 |
| Moreno, JD | 2 |
| Minkoff, H | 1 |
| Gillet, JY | 1 |
| Bongain, A | 1 |
| Fuzibet, JG | 1 |
| Pesce, A | 1 |
| Little, BB | 2 |
| Harstad, TH | 1 |
| Bawdon, RE | 3 |
| Sobhi, S | 1 |
| Roe, DA | 1 |
| Knoll, KA | 1 |
| Ghali, FE | 1 |
| Minkoff, HL | 1 |
| Harstad, TW | 1 |
| Knoll, K | 1 |
| Roe, D | 1 |
| Gilstrap, LC | 1 |
| Sarti, GM | 1 |
| Fortunato, SJ | 1 |
| Conover, B | 1 |
| Goldsmith, JC | 1 |
| Buehler, BA | 1 |
| Maloley, PA | 1 |
| Windle, ML | 1 |
3 reviews available for pentamidine and Pregnancy
| Article | Year |
|---|---|
Human immunodeficiency virus infection in children.
Topics: Adolescent; AIDS-Related Opportunistic Infections; Child; Child, Preschool; Dapsone; Didanosine; Dru | 1995 |
[Pregnancy in HIV infected women. Current therapeutic indications].
Topics: Abortion, Therapeutic; Adult; CD4 Immunoadhesins; Female; HIV Infections; Humans; Immunization, Pass | 1992 |
Aerosolized pentamidine in HIV. Promising new treatment for Pneumocystis carinii pneumonia.
Topics: Aerosols; Amidines; Animals; Anti-Infective Agents; Child; Drug Combinations; Female; HIV Seropositi | 1989 |
1 trial available for pentamidine and Pregnancy
| Article | Year |
|---|---|
Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial.
Topics: Administration, Oral; Adolescent; Adult; Aged; Angola; Benzamidines; Child; Democratic Republic of t | 2016 |
12 other studies available for pentamidine and Pregnancy
| Article | Year |
|---|---|
East African trypanosomiasis in a pregnant traveler.
Topics: Adult; Communicable Diseases, Emerging; Female; Humans; Infant, Newborn; London; Pentamidine; Pregna | 2009 |
Plasma pentose levels in pre-eclampsia and their aetiological significance.
Topics: Female; Humans; Pentamidine; Pentoses; Plasma; Pre-Eclampsia; Pregnancy | 1951 |
Estimation of fetal risk from aerosolized pentamidine in pregnant healthcare workers.
Topics: Aerosols; Dose-Response Relationship, Drug; Female; Fetus; Health Personnel; Humans; Occupational Ex | 1994 |
[Protozoan infections in AIDS].
Topics: Acquired Immunodeficiency Syndrome; Administration, Inhalation; AIDS-Related Opportunistic Infection | 1993 |
Human immunodeficiency virus infection during pregnancy.
Topics: Abnormalities, Drug-Induced; AIDS Serodiagnosis; Ethics, Medical; Female; HIV Infections; Humans; In | 1992 |
Pharmacokinetics of pentamidine in Sprague-Dawley rats in late pregnancy.
Topics: Animals; Brain; Female; Fetus; Maternal-Fetal Exchange; Pentamidine; Pregnancy; Pregnancy, Animal; R | 1991 |
Drug prophylaxis for human immunodeficiency virus-infected pregnant women: ethical considerations.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antibodies, Anti-Idiotypic; Antigens, CD; CD4 Immunoadhes | 1990 |
Embryofetal effects of pentamidine isethionate administered to pregnant Sprague-Dawley rats.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Female; Fetus; Maternal-Fetal Exchange; Pentam | 1990 |
Guidelines for prophylaxis against Pneumocystis carinii pneumonia for persons infected with human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aerosols; Child; Drug Combinations; Female; Humans; Infan | 1989 |
From the Centers for Disease Control. Guidelines for prophylaxis against Pneumocystis carinii pneumonia for persons infected with human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aerosols; Anti-Bacterial Agents; Child; Drug Combinations | 1989 |
Determination of pentamidine transfer in the in vitro perfused human cotyledon with high-performance liquid chromatography.
Topics: Amidines; Chromatography, High Pressure Liquid; Female; Humans; Maternal-Fetal Exchange; Osmolar Con | 1989 |
Aerosolized pentamidine and pregnancy.
Topics: Aerosols; Air Pollutants, Occupational; Amidines; Female; Health Occupations; Humans; Pentamidine; P | 1988 |