pentamidine has been researched along with Pneumocystis Infections in 35 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Pneumocystis Infections: Infections with species in the genus PNEUMOCYSTIS, a fungus causing interstitial plasma cell pneumonia (PNEUMONIA, PNEUMOCYSTIS) and other infections in humans and other MAMMALS. Immunocompromised patients, especially those with AIDS, are particularly susceptible to these infections. Extrapulmonary sites are rare but seen occasionally.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The incidences of pentamidine-associated nephrotoxicity and hyperkalemia were determined from a retrospective review of records in AIDS patients using standard definitions for both toxicities." | 7.68 | Pentamidine-associated nephrotoxicity and hyperkalemia in patients with AIDS. ( Bailie, GR; Briceland, LL, 1991) |
| "Pneumocystis carinii infection of the thyroid gland has previously been described in only four living patients with acquired immunodeficiency syndrome, three of whom had been receiving inhaled pentamidine prophylaxis against P carinii pneumonia." | 4.78 | Pneumocystis carinii thyroiditis. Report of three cases and review of the literature. ( Axline, SG; Greaves, TS; Guttler, R; McGill, JJ; Singer, PA, 1993) |
| "The incidences of pentamidine-associated nephrotoxicity and hyperkalemia were determined from a retrospective review of records in AIDS patients using standard definitions for both toxicities." | 3.68 | Pentamidine-associated nephrotoxicity and hyperkalemia in patients with AIDS. ( Bailie, GR; Briceland, LL, 1991) |
| "Pneumothorax has been reported in several cases." | 1.37 | Fatal bilateral pneumothoraces following administration of aerosolised pentamidine. ( Green, A; Milne, N; Ong, BB, 2011) |
| "We report a case of splenic pneumocystosis in a human immunodeficiency virus-positive individual treated prophylactically with aerosolized pentamidine." | 1.29 | [Extra-pulmonary pneumocystosis in the course of AIDS. Report of a case]. ( Marche, C; Potet, F; Terris, B, 1996) |
| "Choroiditis was a preterminal diagnosis for three patients--two with associated disseminated pneumocystosis." | 1.28 | Pneumocystis carinii choroiditis in patients with AIDS: clinical features, response to therapy, and outcome. ( Benson, CA; Deutsch, T; Finn, WG; Kessler, HA; Murphy, RL; Noskin, GA; Pottage, JC; Roth, SI; Sha, BE, 1992) |
| "Extrapulmonary Pneumocystis carinii infections in AIDS are still rare although the number of cases is increasing." | 1.28 | Dissemination of Pneumocystis carinii in patients with AIDS. ( Junge, J; Nielsen, TN; Witt, K, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 30 (85.71) | 18.2507 |
| 2000's | 4 (11.43) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boykin, DW | 1 |
| Kumar, A | 1 |
| Spychala, J | 1 |
| Zhou, M | 1 |
| Lombardy, RJ | 1 |
| Wilson, WD | 1 |
| Dykstra, CC | 1 |
| Jones, SK | 1 |
| Hall, JE | 1 |
| Tidwell, RR | 1 |
| O'Neal, CB | 1 |
| Ball, SC | 1 |
| Green, A | 1 |
| Milne, N | 1 |
| Ong, BB | 1 |
| Rodriguez, M | 1 |
| Fishman, JA | 2 |
| O'Leary, TJ | 1 |
| Tsai, MM | 1 |
| Wright, CF | 1 |
| Cushion, MT | 2 |
| MartÃnez, MJ | 1 |
| de Otero, J | 1 |
| Vallano, A | 1 |
| Ribera, E | 1 |
| Hughes, WT | 1 |
| Killmar, JT | 1 |
| Oz, HS | 1 |
| Contini, C | 1 |
| Romani, R | 1 |
| Vullo, V | 1 |
| Delia, S | 1 |
| Sorice, F | 1 |
| Riquet, M | 1 |
| Chouaid, C | 1 |
| Saab, M | 1 |
| Hubsch, JP | 1 |
| Guillon, JM | 1 |
| Klotz, BL | 1 |
| Carnot, F | 1 |
| Lalonde, L | 1 |
| Allaire, GS | 1 |
| Sebag, M | 1 |
| Lamer, L | 1 |
| Marcil, G | 1 |
| Gervais, A | 1 |
| Sylla, G | 1 |
| Kullean, N | 1 |
| Lafferre, A | 1 |
| Mussard, F | 1 |
| Rossi, P | 1 |
| Jayes, RL | 1 |
| Kamerow, HN | 1 |
| Hasselquist, SM | 1 |
| Delaney, MD | 1 |
| Parenti, DM | 1 |
| Guttler, R | 1 |
| Singer, PA | 1 |
| Axline, SG | 1 |
| Greaves, TS | 1 |
| McGill, JJ | 1 |
| Ng, VL | 1 |
| Geaghan, SM | 1 |
| Leoung, G | 1 |
| Shiboski, S | 1 |
| Fahy, J | 1 |
| Schnapp, L | 1 |
| Yajko, DM | 1 |
| Hopewell, PC | 1 |
| Hadley, WK | 1 |
| Bazin, C | 1 |
| Hazera, P | 1 |
| Greder, A | 1 |
| Cren, P | 1 |
| Lechevalier, B | 1 |
| Gallet, E | 1 |
| Charbonneau, P | 1 |
| Boldorini, R | 1 |
| Guzzetti, S | 1 |
| Meroni, L | 1 |
| Quirino, T | 1 |
| Cristina, S | 1 |
| Monga, G | 1 |
| Terris, B | 1 |
| Marche, C | 1 |
| Potet, F | 1 |
| Kaplanski, G | 1 |
| Granel, B | 1 |
| Di Stefano, D | 1 |
| Durand, JM | 1 |
| Soubeyrand, J | 1 |
| Coyle, P | 1 |
| Carr, AD | 1 |
| Depczynski, BB | 1 |
| Chisholm, DJ | 1 |
| Yoshida, EM | 1 |
| Filipenko, D | 1 |
| Phillips, P | 1 |
| Montaner, JS | 1 |
| Whittaker, JS | 1 |
| Machado, CM | 1 |
| Macedo, MC | 1 |
| Medeiros, RS | 1 |
| Massumoto, C | 1 |
| Silva, AC | 1 |
| Castelli, JB | 1 |
| Silva, RL | 1 |
| Ostronoff, M | 1 |
| Dulley, FL | 1 |
| Taguchi, H | 1 |
| Takahashi, T | 1 |
| Wada, Y | 1 |
| Nakamura, T | 1 |
| Iwamoto, A | 1 |
| Ioannidis, JP | 1 |
| Dixon, DO | 1 |
| McIntosh, M | 1 |
| Albert, JM | 1 |
| Bozzette, SA | 1 |
| Schnittman, SM | 1 |
| Collins, M | 1 |
| Hazra, B | 1 |
| Kaneshiro, ES | 1 |
| Vasconcelles, MJ | 1 |
| Bernardo, MV | 1 |
| King, C | 1 |
| Weller, EA | 1 |
| Antin, JH | 1 |
| Dieterich, DT | 1 |
| Lew, EA | 1 |
| Bacon, DJ | 1 |
| Pearlman, KI | 1 |
| Scholes, JV | 1 |
| Sha, BE | 1 |
| Benson, CA | 1 |
| Deutsch, T | 1 |
| Noskin, GA | 1 |
| Murphy, RL | 1 |
| Pottage, JC | 1 |
| Finn, WG | 1 |
| Roth, SI | 1 |
| Kessler, HA | 1 |
| Fan-Havard, P | 1 |
| Balembits, B | 1 |
| Koudobine, L | 1 |
| DeRoux, SJ | 1 |
| Adsay, NV | 1 |
| Ioachim, HL | 1 |
| Briceland, LL | 1 |
| Bailie, GR | 1 |
| Witt, K | 1 |
| Nielsen, TN | 1 |
| Junge, J | 1 |
| Foster, RE | 1 |
| Lowder, CY | 1 |
| Meisler, DM | 1 |
| Huang, SS | 1 |
| Longworth, DL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Trial of Three Anti-Pneumocystis Agents Plus Zidovudine for the Primary Prevention of Serious Infections in Patients With Advanced HIV Infection[NCT00000991] | Phase 3 | 600 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for pentamidine and Pneumocystis Infections
| Article | Year |
|---|---|
Prevention of infection due to Pneumocystis spp. in human immunodeficiency virus-negative immunocompromised patients.
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Bone Marrow Transplantation; Humans; Immun | 2004 |
Pneumocystis carinii thyroiditis. Report of three cases and review of the literature.
Topics: Adult; AIDS-Related Opportunistic Infections; Humans; Male; Pentamidine; Pneumocystis Infections; Pn | 1993 |
Treatment of infection due to Pneumocystis carinii.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Atovaquone; Clindamycin; Dapsone; Eflornithine; Humans | 1998 |
Gastrointestinal pneumocystosis in HIV-infected patients on aerosolized pentamidine: report of five cases and literature review.
Topics: Adult; Aerosols; Gastrointestinal Diseases; HIV Infections; Humans; Male; Middle Aged; Pentamidine; | 1992 |
1 trial available for pentamidine and Pneumocystis Infections
| Article | Year |
|---|---|
Aerosolized pentamidine as pneumocystis prophylaxis after bone marrow transplantation is inferior to other regimens and is associated with decreased survival and an increased risk of other infections.
Topics: Administration, Inhalation; Adolescent; Adult; Aerosol Propellants; Aged; Antifungal Agents; Bone Ma | 2000 |
30 other studies available for pentamidine and Pneumocystis Infections
| Article | Year |
|---|---|
Dicationic diarylfurans as anti-Pneumocystis carinii agents.
Topics: Animals; Antifungal Agents; Base Sequence; Binding Sites; Cations; DNA, Protozoan; Furans; Giardia l | 1995 |
Splenic pneumocystosis: an atypical presentation of extrapulmonary Pneumocystis infection.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antifungal Agents; Atovaquone; Female | 2008 |
Fatal bilateral pneumothoraces following administration of aerosolised pentamidine.
Topics: Administration, Inhalation; AIDS-Related Opportunistic Infections; Antifungal Agents; Asthma; Forens | 2011 |
Drugs for AIDS and associated infections.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Amphotericin B; Antifunga | 1995 |
Use of semiquantitative PCR to assess onset and treatment of Pneumocystis carinii infection in rat model.
Topics: Animals; Base Sequence; Bronchoalveolar Lavage Fluid; DNA, Fungal; Immunosuppression Therapy; Molecu | 1995 |
[Macroscopic hematuria secondary to the administration of intravenous pentamidine].
Topics: Adult; AIDS-Related Opportunistic Infections; Female; Hematuria; Humans; Injections, Intravenous; Pe | 1995 |
Relative potency of 10 drugs with anti-Pneumocystis carinii activity in an animal model.
Topics: Animals; Anti-Infective Agents; Atovaquone; Azithromycin; Clarithromycin; Clindamycin; Clinical Tria | 1994 |
Detection of Pneumocystis carinii in urinary samples from a patient with AIDS despite prophylactic treatment with aerosolized pentamidine.
Topics: Adult; Aerosols; AIDS-Related Opportunistic Infections; Bacteriuria; Fatal Outcome; Female; Humans; | 1994 |
[Extrapulmonary intrathoracic pneumocystosis. Apropos of 4 cases in HIV positive patients].
Topics: Administration, Inhalation; Adult; AIDS-Related Opportunistic Infections; CD4-Positive T-Lymphocytes | 1993 |
Pneumocystis carinii choroidopathy and aerosolized pentamidine prophylaxis in a patient with AIDS.
Topics: Adult; Aerosols; AIDS-Related Opportunistic Infections; Choroiditis; Eye Infections, Fungal; Humans; | 1993 |
[Spontaneous pneumothorax disclosing isolated pleural involvement caused by Pneumocystis carinii in an AIDS patient].
Topics: Administration, Inhalation; Adult; AIDS-Related Opportunistic Infections; Humans; Male; Pentamidine; | 1993 |
Disseminated pneumocystosis presenting as a pleural effusion.
Topics: Administration, Inhalation; Adult; Humans; Injections, Intravenous; Male; Pentamidine; Pleural Effus | 1993 |
Lack of effect of prophylactic aerosolized pentamidine on the detection of Pneumocystis carinii in induced sputum or bronchoalveolar lavage specimens.
Topics: Aerosols; AIDS-Related Opportunistic Infections; Bronchoalveolar Lavage Fluid; Humans; Pentamidine; | 1993 |
[Extrapulmonary and disseminated pneumocystosis in HIV infection].
Topics: Adult; AIDS-Related Opportunistic Infections; Bone Marrow Diseases; Female; HIV Infections; Humans; | 1993 |
Acute hepatic and renal failure caused by Pneumocystis carinii in patients with AIDS.
Topics: Adult; AIDS-Related Opportunistic Infections; Antifungal Agents; Fatal Outcome; Female; Humans; Live | 1995 |
[Extra-pulmonary pneumocystosis in the course of AIDS. Report of a case].
Topics: Adult; AIDS-Related Opportunistic Infections; Antifungal Agents; Bronchoalveolar Lavage Fluid; Femal | 1996 |
Pleural pseudotumoral mass revealing an extrapulmonary Pneumocystis carinii infection.
Topics: Adult; Aerosols; AIDS-Related Opportunistic Infections; Antifungal Agents; Diagnosis, Differential; | 1996 |
Diabetes mellitus associated with pentamidine use in HIV-infected patients.
Topics: Adult; Antifungal Agents; Diabetes Complications; Diabetes Mellitus; Humans; Middle Aged; Pentamidin | 1996 |
AIDS-related extrapulmonary Pneumocystis carinii infection presenting as a solitary rectal ulcer.
Topics: Adult; Aerosols; AIDS-Related Opportunistic Infections; Antifungal Agents; Biopsy; Humans; Male; Pen | 1996 |
Primary Pneumocystis carinii prophylaxis with aerosolized pentamidine after bone marrow transplantation.
Topics: Aerosols; Bone Marrow Transplantation; Female; Humans; Immunocompromised Host; Male; Pentamidine; Pn | 1998 |
Pentamidine-induced hemolytic anemia in an AIDS patient.
Topics: AIDS-Related Opportunistic Infections; Anemia, Hemolytic; Antifungal Agents; Humans; Male; Middle Ag | 1999 |
Relationship between event rates and treatment effects in clinical site differences within multicenter trials: an example from primary Pneumocystis carinii prophylaxis.
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Controlled Clinical Trials as Topic; D | 1999 |
Effects of atovaquone and diospyrin-based drugs on the cellular ATP of Pneumocystis carinii f. sp. carinii.
Topics: Adenosine Triphosphate; Animals; Antifungal Agents; Atovaquone; Dose-Response Relationship, Drug; Ma | 2000 |
Pneumocystis carinii choroiditis in patients with AIDS: clinical features, response to therapy, and outcome.
Topics: Adult; AIDS-Related Opportunistic Infections; Choroiditis; Eye; Female; Humans; Male; Pentamidine; P | 1992 |
Pneumocystis carinii in AIDS patients.
Topics: Acquired Immunodeficiency Syndrome; Contraindications; Humans; Nursing, Practical; Opportunistic Inf | 1992 |
[Pentacarinat as an aerosol].
Topics: Aerosols; Humans; Pentamidine; Pneumocystis Infections | 1992 |
Disseminated pneumocystosis without pulmonary involvement during prophylactic aerosolized pentamidine therapy in a patient with the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Administration, Inhalation; Autopsy; Humans; Male; Middle Aged; | 1991 |
Pentamidine-associated nephrotoxicity and hyperkalemia in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Monitoring; Female; HIV Infections; Humans; Hyperkal | 1991 |
Dissemination of Pneumocystis carinii in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Aerosols; Humans; Kidney; Liver; Lung; Male; Middle Aged; Pentam | 1991 |
Presumed Pneumocystis carinii choroiditis. Unifocal presentation, regression with intravenous pentamidine, and choroiditis recurrence.
Topics: Acquired Immunodeficiency Syndrome; Administration, Inhalation; Adult; Choroiditis; Eye Infections, | 1991 |