pentamidine has been researched along with Plasmodium falciparum Malaria in 7 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The amidoxime and N-methoxyamidine of 5a were the only produgs to provide cures (1/4 cures) in the same mouse model on oral dosage at 4x25mg/kg." | 1.36 | Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles. ( Boykin, DW; Branowska, D; Brun, R; Farahat, AA; Kumar, A; Liu, Y; Wenzler, T; Wilson, WD, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Avery, MA | 1 |
| Muraleedharan, KM | 1 |
| Desai, PV | 1 |
| Bandyopadhyaya, AK | 1 |
| Furtado, MM | 1 |
| Tekwani, BL | 1 |
| Hu, L | 1 |
| Arafa, RK | 2 |
| Ismail, MA | 1 |
| Patel, A | 1 |
| Munde, M | 1 |
| Wilson, WD | 3 |
| Wenzler, T | 3 |
| Brun, R | 3 |
| Boykin, DW | 2 |
| Branowska, D | 1 |
| Farahat, AA | 1 |
| Kumar, A | 1 |
| Liu, Y | 1 |
| Chai, Y | 1 |
| Bosc, D | 1 |
| Mouray, E | 1 |
| Cojean, S | 1 |
| Franco, CH | 1 |
| Loiseau, PM | 1 |
| Freitas-Junior, LH | 1 |
| Moraes, CB | 1 |
| Grellier, P | 1 |
| Dubois, J | 1 |
| Bray, PG | 1 |
| Barrett, MP | 1 |
| Ward, SA | 1 |
| de Koning, HP | 1 |
| Werbovetz, K | 1 |
2 reviews available for pentamidine and Plasmodium falciparum Malaria
| Article | Year |
|---|---|
Pentamidine uptake and resistance in pathogenic protozoa: past, present and future.
Topics: Animals; Antiprotozoal Agents; Drug Resistance; Humans; Leishmania mexicana; Leishmaniasis, Cutaneou | 2003 |
Diamidines as antitrypanosomal, antileishmanial and antimalarial agents.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Benzamidines; Chagas Disease; Clinical Trials as Topic | 2006 |
5 other studies available for pentamidine and Plasmodium falciparum Malaria
| Article | Year |
|---|---|
Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Artemisinins; Clone Cells; Drug Design; Inhibitory Con | 2003 |
Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.
Topics: Animals; Antiprotozoal Agents; Inhibitory Concentration 50; Malaria, Falciparum; Mice; Parasitic Sen | 2009 |
Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.
Topics: Administration, Oral; Animals; Antimalarials; Antiprotozoal Agents; Disease Models, Animal; DNA, Pro | 2010 |
Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents.
Topics: Amides; Animals; Antiprotozoal Agents; Cell Line; DNA; Guanidines; Humans; Malaria, Falciparum; Mode | 2011 |
Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors.
Topics: Alkyl and Aryl Transferases; Animals; Antiparasitic Agents; Cell Line; Enzyme Inhibitors; Humans; Im | 2016 |