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pentamidine and Melanoma

pentamidine has been researched along with Melanoma in 4 studies

Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"Pentamidine is a small molecule inhibitor of the Ca(+)-binding protein S100B and disrupts the S100B-p53 protein-protein interaction; this is thought to restore wild-type p53 tumour suppressor function in melanoma."7.76The effect of pentamidine on melanoma ex vivo. ( Cree, IA; Glaysher, S; Knight, LA; Peregrin, K; Smith, J; Stewart, BJ; Weber, DJ, 2010)
"Pentamidine is a small molecule inhibitor of the Ca(+)-binding protein S100B and disrupts the S100B-p53 protein-protein interaction; this is thought to restore wild-type p53 tumour suppressor function in melanoma."3.76The effect of pentamidine on melanoma ex vivo. ( Cree, IA; Glaysher, S; Knight, LA; Peregrin, K; Smith, J; Stewart, BJ; Weber, DJ, 2010)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Markowitz, J1
Chen, I1
Gitti, R1
Baldisseri, DM1
Pan, Y1
Udan, R1
Carrier, F1
MacKerell, AD1
Weber, DJ2
Yoshimura, C1
Miyafusa, T1
Tsumoto, K1
Smith, J1
Stewart, BJ1
Glaysher, S1
Peregrin, K1
Knight, LA1
Cree, IA1
Libby, PR1
Porter, CW1

Other Studies

4 other studies available for pentamidine and Melanoma

ArticleYear
Identification and characterization of small molecule inhibitors of the calcium-dependent S100B-p53 tumor suppressor interaction.
    Journal of medicinal chemistry, 2004, Oct-07, Volume: 47, Issue:21

    Topics: Antineoplastic Agents; Binding Sites; Calcium; Cell Line, Tumor; Databases, Factual; Holoenzymes; Hu

2004
Identification of small-molecule inhibitors of the human S100B-p53 interaction and evaluation of their activity in human melanoma cells.
    Bioorganic & medicinal chemistry, 2013, Mar-01, Volume: 21, Issue:5

    Topics: Cell Line, Tumor; Cell Survival; Humans; Melanoma; Protein Interaction Maps; Recombinant Proteins; S

2013
The effect of pentamidine on melanoma ex vivo.
    Anti-cancer drugs, 2010, Volume: 21, Issue:2

    Topics: Adenosine Triphosphate; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Humans; In Vitro Tec

2010
Inhibition of enzymes of polyamine back-conversion by pentamidine and berenil.
    Biochemical pharmacology, 1992, Aug-18, Volume: 44, Issue:4

    Topics: Acetyltransferases; Animals; Diminazene; Humans; Kinetics; Leukemia L1210; Melanoma; Mice; Oxidoredu

1992