pentamidine has been researched along with Melanoma in 4 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Excerpt | Relevance | Reference |
---|---|---|
"Pentamidine is a small molecule inhibitor of the Ca(+)-binding protein S100B and disrupts the S100B-p53 protein-protein interaction; this is thought to restore wild-type p53 tumour suppressor function in melanoma." | 7.76 | The effect of pentamidine on melanoma ex vivo. ( Cree, IA; Glaysher, S; Knight, LA; Peregrin, K; Smith, J; Stewart, BJ; Weber, DJ, 2010) |
"Pentamidine is a small molecule inhibitor of the Ca(+)-binding protein S100B and disrupts the S100B-p53 protein-protein interaction; this is thought to restore wild-type p53 tumour suppressor function in melanoma." | 3.76 | The effect of pentamidine on melanoma ex vivo. ( Cree, IA; Glaysher, S; Knight, LA; Peregrin, K; Smith, J; Stewart, BJ; Weber, DJ, 2010) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (25.00) | 18.2507 |
2000's | 1 (25.00) | 29.6817 |
2010's | 2 (50.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Markowitz, J | 1 |
Chen, I | 1 |
Gitti, R | 1 |
Baldisseri, DM | 1 |
Pan, Y | 1 |
Udan, R | 1 |
Carrier, F | 1 |
MacKerell, AD | 1 |
Weber, DJ | 2 |
Yoshimura, C | 1 |
Miyafusa, T | 1 |
Tsumoto, K | 1 |
Smith, J | 1 |
Stewart, BJ | 1 |
Glaysher, S | 1 |
Peregrin, K | 1 |
Knight, LA | 1 |
Cree, IA | 1 |
Libby, PR | 1 |
Porter, CW | 1 |
4 other studies available for pentamidine and Melanoma
Article | Year |
---|---|
Identification and characterization of small molecule inhibitors of the calcium-dependent S100B-p53 tumor suppressor interaction.
Topics: Antineoplastic Agents; Binding Sites; Calcium; Cell Line, Tumor; Databases, Factual; Holoenzymes; Hu | 2004 |
Identification of small-molecule inhibitors of the human S100B-p53 interaction and evaluation of their activity in human melanoma cells.
Topics: Cell Line, Tumor; Cell Survival; Humans; Melanoma; Protein Interaction Maps; Recombinant Proteins; S | 2013 |
The effect of pentamidine on melanoma ex vivo.
Topics: Adenosine Triphosphate; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Humans; In Vitro Tec | 2010 |
Inhibition of enzymes of polyamine back-conversion by pentamidine and berenil.
Topics: Acetyltransferases; Animals; Diminazene; Humans; Kinetics; Leukemia L1210; Melanoma; Mice; Oxidoredu | 1992 |