pentamidine has been researched along with Malignant Melanoma in 4 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pentamidine is a small molecule inhibitor of the Ca(+)-binding protein S100B and disrupts the S100B-p53 protein-protein interaction; this is thought to restore wild-type p53 tumour suppressor function in melanoma." | 7.76 | The effect of pentamidine on melanoma ex vivo. ( Cree, IA; Glaysher, S; Knight, LA; Peregrin, K; Smith, J; Stewart, BJ; Weber, DJ, 2010) |
| "Pentamidine is a small molecule inhibitor of the Ca(+)-binding protein S100B and disrupts the S100B-p53 protein-protein interaction; this is thought to restore wild-type p53 tumour suppressor function in melanoma." | 3.76 | The effect of pentamidine on melanoma ex vivo. ( Cree, IA; Glaysher, S; Knight, LA; Peregrin, K; Smith, J; Stewart, BJ; Weber, DJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Markowitz, J | 1 |
| Chen, I | 1 |
| Gitti, R | 1 |
| Baldisseri, DM | 1 |
| Pan, Y | 1 |
| Udan, R | 1 |
| Carrier, F | 1 |
| MacKerell, AD | 1 |
| Weber, DJ | 2 |
| Yoshimura, C | 1 |
| Miyafusa, T | 1 |
| Tsumoto, K | 1 |
| Smith, J | 1 |
| Stewart, BJ | 1 |
| Glaysher, S | 1 |
| Peregrin, K | 1 |
| Knight, LA | 1 |
| Cree, IA | 1 |
| Libby, PR | 1 |
| Porter, CW | 1 |
4 other studies available for pentamidine and Malignant Melanoma
| Article | Year |
|---|---|
Identification and characterization of small molecule inhibitors of the calcium-dependent S100B-p53 tumor suppressor interaction.
Topics: Antineoplastic Agents; Binding Sites; Calcium; Cell Line, Tumor; Databases, Factual; Holoenzymes; Hu | 2004 |
Identification of small-molecule inhibitors of the human S100B-p53 interaction and evaluation of their activity in human melanoma cells.
Topics: Cell Line, Tumor; Cell Survival; Humans; Melanoma; Protein Interaction Maps; Recombinant Proteins; S | 2013 |
The effect of pentamidine on melanoma ex vivo.
Topics: Adenosine Triphosphate; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Humans; In Vitro Tec | 2010 |
Inhibition of enzymes of polyamine back-conversion by pentamidine and berenil.
Topics: Acetyltransferases; Animals; Diminazene; Humans; Kinetics; Leukemia L1210; Melanoma; Mice; Oxidoredu | 1992 |