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pentamidine and Malaria

pentamidine has been researched along with Malaria in 10 studies

Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.

Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.

Research Excerpts

ExcerptRelevanceReference
"We present a case of East-African trypanosomiasis (EAT) in a 56-year-old Dutch woman returning from holiday in Tanzania and Kenya."1.48A case of delayed diagnosis of East-African trypanosomiasis in a Dutch traveller. ( Hanssen, JLJ; Scheper, H; van Lieshout, L; Visser, LG; Wijsman, CA, 2018)
" The orally bioavailable lead imidazolopiperazine confers complete causal prophylactic protection (15 milligrams/kilogram) in rodent models of malaria and shows potent in vivo blood-stage therapeutic activity."1.37Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. ( Barnes, SW; Bonamy, GM; Bopp, SE; Borboa, R; Bright, AT; Chatterjee, A; Che, J; Cohen, S; Dharia, NV; Diagana, TT; Fidock, DA; Froissard, P; Gagaring, K; Gettayacamin, M; Glynne, RJ; Gordon, P; Groessl, T; Kato, N; Kuhen, KL; Lee, MC; Mazier, D; McNamara, CW; Meister, S; Nagle, A; Nam, TG; Plouffe, DM; Richmond, W; Roland, J; Rottmann, M; Sattabongkot, J; Schultz, PG; Tuntland, T; Walker, JR; Winzeler, EA; Wu, T; Zhou, B; Zhou, Y, 2011)
" Six compounds, including 2,5-bis(4-guanylphenyl)furan (4) and its 3-chloro (32), 3,4-dichloro (31), 3-methyl (25), 3,4-dimethyl (20), and 3-chloro-4-methyl (38) derivatives, produced cures in mice at submilligram dosage levels; the 3,4-dimethyl (20) analogue exhibited a prolonged curative effect providing protection for 30 days after a single dose against a challenge by T."1.26Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)furans. ( Boykin, DW; Das, BP, 1977)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19903 (30.00)18.7374
1990's1 (10.00)18.2507
2000's3 (30.00)29.6817
2010's3 (30.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Das, BP1
Boykin, DW1
Rodríguez, F1
Rozas, I1
Kaiser, M1
Brun, R1
Nguyen, B1
Wilson, WD1
García, RN1
Dardonville, C1
Reid, CM1
Ebikeme, C1
Barrett, MP1
Patzewitz, EM1
Müller, S1
Robins, DJ1
Sutherland, A1
Plouffe, D1
Brinker, A1
McNamara, C1
Henson, K1
Kato, N2
Kuhen, K1
Nagle, A2
Adrián, F1
Matzen, JT1
Anderson, P1
Nam, TG2
Gray, NS1
Chatterjee, A2
Janes, J1
Yan, SF1
Trager, R1
Caldwell, JS1
Schultz, PG2
Zhou, Y2
Winzeler, EA2
Patil, V1
Guerrant, W1
Chen, PC1
Gryder, B1
Benicewicz, DB1
Khan, SI1
Tekwani, BL1
Oyelere, AK1
Meister, S1
Plouffe, DM1
Kuhen, KL1
Bonamy, GM1
Wu, T1
Barnes, SW1
Bopp, SE1
Borboa, R1
Bright, AT1
Che, J1
Cohen, S1
Dharia, NV1
Gagaring, K1
Gettayacamin, M1
Gordon, P1
Groessl, T1
Lee, MC1
McNamara, CW1
Fidock, DA1
Richmond, W1
Roland, J1
Rottmann, M1
Zhou, B1
Froissard, P1
Glynne, RJ1
Mazier, D1
Sattabongkot, J1
Tuntland, T1
Walker, JR1
Diagana, TT1
Wijsman, CA1
Hanssen, JLJ1
Scheper, H1
Visser, LG1
van Lieshout, L1
Fleischer, NK1
Braendli, B1
Dankwa, E1
Junghanss, T1
Nightingale, SL1

Reviews

1 review available for pentamidine and Malaria

ArticleYear
[Central nervous system involvement in parasitic tropical diseases].
    Die Medizinische Welt, 1979, Nov-02, Volume: 30, Issue:44

    Topics: Adult; Blood-Brain Barrier; Central Nervous System Diseases; Cysticercosis; Female; Hartmannella; Hu

1979

Trials

1 trial available for pentamidine and Malaria

ArticleYear
From the Food and Drug Administration.
    JAMA, 1989, Jul-14, Volume: 262, Issue:2

    Topics: Adenocarcinoma; Amidines; Anemia; Antimalarials; Clinical Trials as Topic; Colonic Neoplasms; Erythr

1989

Other Studies

8 other studies available for pentamidine and Malaria

ArticleYear
Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)furans.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:4

    Topics: Animals; Antimalarials; Antiprotozoal Agents; Furans; Malaria; Mice; Plasmodium berghei; Structure-A

1977
New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity.
    Journal of medicinal chemistry, 2008, Feb-28, Volume: 51, Issue:4

    Topics: Animals; Antimalarials; Cell Line; DNA; Female; Guanidines; Hemeproteins; Hemin; Imidazolines; Malar

2008
Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles.
    Bioorganic & medicinal chemistry letters, 2008, Apr-01, Volume: 18, Issue:7

    Topics: Animals; Antiprotozoal Agents; Aza Compounds; Humans; Kidney; Macrocyclic Compounds; Malaria; Models

2008
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, Jul-01, Volume: 105, Issue:26

    Topics: Animals; Antimalarials; Cluster Analysis; Computational Biology; Drug Evaluation, Preclinical; Drug

2008
Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group.
    Bioorganic & medicinal chemistry, 2010, Jan-01, Volume: 18, Issue:1

    Topics: Antimalarials; Antiprotozoal Agents; Histone Deacetylase Inhibitors; Histone Deacetylases; Leishmani

2010
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
    Science (New York, N.Y.), 2011, Dec-09, Volume: 334, Issue:6061

    Topics: Animals; Antimalarials; Cell Line, Tumor; Drug Discovery; Drug Evaluation, Preclinical; Drug Resista

2011
A case of delayed diagnosis of East-African trypanosomiasis in a Dutch traveller.
    Journal of travel medicine, 2018, 01-01, Volume: 25, Issue:1

    Topics: Animals; Delayed Diagnosis; Diagnosis, Differential; Female; Humans; Kenya; Malaria; Middle Aged; Ne

2018
[East African sleeping sickness (Trypanosoma rhodesiense infection) in 2 Swiss travelers to the tropics].
    Schweizerische medizinische Wochenschrift, 1990, Sep-15, Volume: 120, Issue:37

    Topics: Adult; Animals; Diagnosis, Differential; Humans; Malaria; Male; Pentamidine; Rwanda; Switzerland; Tr

1990