pentamidine has been researched along with Malaria, Falciparum in 7 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The amidoxime and N-methoxyamidine of 5a were the only produgs to provide cures (1/4 cures) in the same mouse model on oral dosage at 4x25mg/kg." | 1.36 | Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles. ( Boykin, DW; Branowska, D; Brun, R; Farahat, AA; Kumar, A; Liu, Y; Wenzler, T; Wilson, WD, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Avery, MA | 1 |
| Muraleedharan, KM | 1 |
| Desai, PV | 1 |
| Bandyopadhyaya, AK | 1 |
| Furtado, MM | 1 |
| Tekwani, BL | 1 |
| Hu, L | 1 |
| Arafa, RK | 2 |
| Ismail, MA | 1 |
| Patel, A | 1 |
| Munde, M | 1 |
| Wilson, WD | 3 |
| Wenzler, T | 3 |
| Brun, R | 3 |
| Boykin, DW | 2 |
| Branowska, D | 1 |
| Farahat, AA | 1 |
| Kumar, A | 1 |
| Liu, Y | 1 |
| Chai, Y | 1 |
| Bosc, D | 1 |
| Mouray, E | 1 |
| Cojean, S | 1 |
| Franco, CH | 1 |
| Loiseau, PM | 1 |
| Freitas-Junior, LH | 1 |
| Moraes, CB | 1 |
| Grellier, P | 1 |
| Dubois, J | 1 |
| Bray, PG | 1 |
| Barrett, MP | 1 |
| Ward, SA | 1 |
| de Koning, HP | 1 |
| Werbovetz, K | 1 |
2 reviews available for pentamidine and Malaria, Falciparum
| Article | Year |
|---|---|
Pentamidine uptake and resistance in pathogenic protozoa: past, present and future.
Topics: Animals; Antiprotozoal Agents; Drug Resistance; Humans; Leishmania mexicana; Leishmaniasis, Cutaneou | 2003 |
Diamidines as antitrypanosomal, antileishmanial and antimalarial agents.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Benzamidines; Chagas Disease; Clinical Trials as Topic | 2006 |
5 other studies available for pentamidine and Malaria, Falciparum
| Article | Year |
|---|---|
Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Artemisinins; Clone Cells; Drug Design; Inhibitory Con | 2003 |
Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.
Topics: Animals; Antiprotozoal Agents; Inhibitory Concentration 50; Malaria, Falciparum; Mice; Parasitic Sen | 2009 |
Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.
Topics: Administration, Oral; Animals; Antimalarials; Antiprotozoal Agents; Disease Models, Animal; DNA, Pro | 2010 |
Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents.
Topics: Amides; Animals; Antiprotozoal Agents; Cell Line; DNA; Guanidines; Humans; Malaria, Falciparum; Mode | 2011 |
Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors.
Topics: Alkyl and Aryl Transferases; Animals; Antiparasitic Agents; Cell Line; Enzyme Inhibitors; Humans; Im | 2016 |