pentamidine has been researched along with Lung Neoplasms in 3 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorpromazine is a potent and specific inhibitor of the mitotic kinesin KSP/Eg5 and inhibits tumor cell proliferation through mitotic arrest and accumulation of monopolar spindles." | 1.34 | The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action. ( Avery, W; Borisy, AA; Elliott, P; Johansen, L; Keegan, M; Keith, CT; Lee, MS; Wilson, A; Zhang, Y, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, MS | 1 |
| Johansen, L | 1 |
| Zhang, Y | 1 |
| Wilson, A | 1 |
| Keegan, M | 1 |
| Avery, W | 1 |
| Elliott, P | 1 |
| Borisy, AA | 1 |
| Keith, CT | 1 |
| Anees, M | 1 |
| Steven, FS | 1 |
| Polushina, OA | 1 |
| Lian, NV | 1 |
| Bogdashin, IV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Repurposing the Antipsychotic Drug Chlorpromazine as a Therapeutic Agent in the Combined Treatment of Newly Diagnosed Glioblastoma Multiforme[NCT04224441] | Phase 2 | 41 participants (Anticipated) | Interventional | 2019-12-15 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for pentamidine and Lung Neoplasms
| Article | Year |
|---|---|
The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antiprotozoal Agents; Antipsychotic Agents; | 2007 |
Inhibition of a tumour protease with 3,4-dichloroisocoumarin, pentamidine-isethionate and guanidino derivatives.
Topics: Benzoates; Binding, Competitive; Carboxylic Ester Hydrolases; Carcinoma, Squamous Cell; Cell Membran | 1994 |
[Changes in the cytostatic and cytotoxic activities of the peripheral blood lymphocytes in the surgical treatment of lung cancer patients].
Topics: Adult; Autonomic Nerve Block; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Humans; Im | 1992 |