Page last updated: 2024-11-02

pentamidine and Leukemia

pentamidine has been researched along with Leukemia in 12 studies

Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"Aerodigestive adverse effects (AD-AE) during intravenous pentamidine (IV-P) infusion for Pneumocystis jiroveci pneumonia prophylaxis are uncommon in retrospective chart review studies."1.62Aerodigestive adverse effects during intravenous pentamidine infusion for Pneumocystis jirovecii pneumonia prophylaxis. ( George, A; McGraw, BJ; Rademacher, H; Savaşan, S; Sokolowski, C, 2021)
"No toxic side effects and no pneumocystis carinii pneumonia were observed."1.28[Initial experiences with pentamidine aerosol in prevention of Pneumocystis carinii pneumonia following bone marrow transplantation]. ( Ehninger, G; Haen, M; Link, H; Schwardt, A; Vöhringer, HF; Wingen, FJ, 1990)
"Between 1976 and 1983, 53 cases of Pneumocystis carinii pneumonia were documented at the Mayo Clinic."1.27Pneumocystis carinii pneumonia. Review of 53 cases. ( Peters, SG; Prakash, UB, 1987)
"Analysis of 194 patients with confirmed Pneumocystis carinii pneumonia in the United States over a 3-year period revealed that P."1.26Pneumocystis carinii pneumonia in the United States: epidemiologic, diagnostic, and clinical features. ( Krogstad, DJ; Perl, DP; Rawson, PG; Schultz, MG; Walzer, PD, 1976)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19905 (41.67)18.7374
1990's3 (25.00)18.2507
2000's1 (8.33)29.6817
2010's2 (16.67)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Eadsforth, TC1
Pinto, A1
Luciani, R1
Tamborini, L1
Cullia, G1
De Micheli, C1
Marinelli, L1
Cosconati, S1
Novellino, E1
Lo Presti, L1
Cordeiro da Silva, A1
Conti, P1
Hunter, WN1
Costi, MP1
Savaşan, S1
George, A1
Sokolowski, C1
McGraw, BJ1
Rademacher, H1
Yan, L1
Yan, C1
Qian, K1
Su, H1
Kofsky-Wofford, SA1
Lee, WC1
Zhao, X1
Ho, MC1
Ivanov, I1
Zheng, YG1
Milstone, AM1
Balakrishnan, SL1
Foster, CB1
Chen, A1
Siegel, SE1
Wolff, LJ1
Baehner, RL1
Hammond, D1
Tadesse, A1
Gebre-Hiwot, A1
Asres, K1
Djote, M1
Frommel, D1
Link, H2
Vöhringer, HF2
Wingen, F1
Brägas, B1
Schwardt, A2
Ehninger, G2
DeVita, VT1
Goodell, B1
Hubbard, S1
Geelhoed, GW1
Young, RC1
Walzer, PD1
Perl, DP1
Krogstad, DJ1
Rawson, PG1
Schultz, MG1
Helmer, RE1
Wingen, FJ1
Haen, M1
Peters, SG1
Prakash, UB1

Trials

1 trial available for pentamidine and Leukemia

ArticleYear
Treatment of Pneumocystis carinii pneumonitis. A comparative trial of sulfamethoxazole-trimethoprim v pentamidine in pediatric patients with cancer: report from the Children's Cancer Study Group.
    American journal of diseases of children (1960), 1984, Volume: 138, Issue:11

    Topics: Acute Disease; Adolescent; Adult; Amidines; Child; Child, Preschool; Clinical Trials as Topic; Drug

1984

Other Studies

11 other studies available for pentamidine and Leukemia

ArticleYear
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity.
    Journal of medicinal chemistry, 2015, Oct-22, Volume: 58, Issue:20

    Topics: Animals; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Leukemia; Macrophages; Meth

2015
Aerodigestive adverse effects during intravenous pentamidine infusion for Pneumocystis jirovecii pneumonia prophylaxis.
    Pediatric blood & cancer, 2021, Volume: 68, Issue:1

    Topics: Adolescent; Adult; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Child,

2021
Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
    Journal of medicinal chemistry, 2014, Mar-27, Volume: 57, Issue:6

    Topics: Binding, Competitive; Catalytic Domain; Cell Line, Tumor; Cell Membrane Permeability; Cell Prolifera

2014
Failure of intravenous pentamidine prophylaxis to prevent pneumocystis pneumonia in a pediatric hematopoietic stem cell transplant (HSCT) patient.
    Pediatric blood & cancer, 2006, Volume: 47, Issue:6

    Topics: Acute Disease; Antibiotic Prophylaxis; Disease Progression; Fatal Outcome; Hematopoietic Stem Cell T

2006
The in vitro activity of Vernonia amygdalina on Leishmania aethiopica.
    Ethiopian medical journal, 1993, Volume: 31, Issue:3

    Topics: Animals; Biological Assay; Cell Line; Chloroform; Colorimetry; Drug Evaluation, Preclinical; Ethiopi

1993
Pentamidine aerosol for prophylaxis of Pneumocystis carinii pneumonia after BMT.
    Bone marrow transplantation, 1993, Volume: 11, Issue:5

    Topics: Administration, Inhalation; Adult; Bone Marrow Transplantation; Female; Hodgkin Disease; Humans; Leu

1993
Pneumocystis pneumonia in patients with cancer: clinical setting.
    National Cancer Institute monograph, 1976, Volume: 43

    Topics: Adrenal Cortex Hormones; Diagnosis, Differential; Humans; Immunologic Deficiency Syndromes; Immunosu

1976
Pneumocystis carinii pneumonia in the United States: epidemiologic, diagnostic, and clinical features.
    National Cancer Institute monograph, 1976, Volume: 43

    Topics: Adolescent; Adult; Age Factors; Aged; Black People; Child; Child, Preschool; Female; Humans; Immunol

1976
Hazard of folinic acid with pyrimethamine and sulfadiazine.
    Annals of internal medicine, 1975, Volume: 82, Issue:1

    Topics: Amidines; Drug Combinations; Drug Interactions; Humans; Leucovorin; Leukemia; Pentamidine; Pneumonia

1975
[Initial experiences with pentamidine aerosol in prevention of Pneumocystis carinii pneumonia following bone marrow transplantation].
    Medizinische Klinik (Munich, Germany : 1983), 1990, Volume: 85 Suppl 2

    Topics: Administration, Inhalation; Adolescent; Adult; Bone Marrow Transplantation; Humans; Leukemia; Lympho

1990
Pneumocystis carinii pneumonia. Review of 53 cases.
    The American journal of medicine, 1987, Volume: 82, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Drug Combinations; Female; Humans; Leuk

1987