pentamidine has been researched along with Leukemia in 12 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aerodigestive adverse effects (AD-AE) during intravenous pentamidine (IV-P) infusion for Pneumocystis jiroveci pneumonia prophylaxis are uncommon in retrospective chart review studies." | 1.62 | Aerodigestive adverse effects during intravenous pentamidine infusion for Pneumocystis jirovecii pneumonia prophylaxis. ( George, A; McGraw, BJ; Rademacher, H; Savaşan, S; Sokolowski, C, 2021) |
| "No toxic side effects and no pneumocystis carinii pneumonia were observed." | 1.28 | [Initial experiences with pentamidine aerosol in prevention of Pneumocystis carinii pneumonia following bone marrow transplantation]. ( Ehninger, G; Haen, M; Link, H; Schwardt, A; Vöhringer, HF; Wingen, FJ, 1990) |
| "Between 1976 and 1983, 53 cases of Pneumocystis carinii pneumonia were documented at the Mayo Clinic." | 1.27 | Pneumocystis carinii pneumonia. Review of 53 cases. ( Peters, SG; Prakash, UB, 1987) |
| "Analysis of 194 patients with confirmed Pneumocystis carinii pneumonia in the United States over a 3-year period revealed that P." | 1.26 | Pneumocystis carinii pneumonia in the United States: epidemiologic, diagnostic, and clinical features. ( Krogstad, DJ; Perl, DP; Rawson, PG; Schultz, MG; Walzer, PD, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Eadsforth, TC | 1 |
| Pinto, A | 1 |
| Luciani, R | 1 |
| Tamborini, L | 1 |
| Cullia, G | 1 |
| De Micheli, C | 1 |
| Marinelli, L | 1 |
| Cosconati, S | 1 |
| Novellino, E | 1 |
| Lo Presti, L | 1 |
| Cordeiro da Silva, A | 1 |
| Conti, P | 1 |
| Hunter, WN | 1 |
| Costi, MP | 1 |
| Savaşan, S | 1 |
| George, A | 1 |
| Sokolowski, C | 1 |
| McGraw, BJ | 1 |
| Rademacher, H | 1 |
| Yan, L | 1 |
| Yan, C | 1 |
| Qian, K | 1 |
| Su, H | 1 |
| Kofsky-Wofford, SA | 1 |
| Lee, WC | 1 |
| Zhao, X | 1 |
| Ho, MC | 1 |
| Ivanov, I | 1 |
| Zheng, YG | 1 |
| Milstone, AM | 1 |
| Balakrishnan, SL | 1 |
| Foster, CB | 1 |
| Chen, A | 1 |
| Siegel, SE | 1 |
| Wolff, LJ | 1 |
| Baehner, RL | 1 |
| Hammond, D | 1 |
| Tadesse, A | 1 |
| Gebre-Hiwot, A | 1 |
| Asres, K | 1 |
| Djote, M | 1 |
| Frommel, D | 1 |
| Link, H | 2 |
| Vöhringer, HF | 2 |
| Wingen, F | 1 |
| Brägas, B | 1 |
| Schwardt, A | 2 |
| Ehninger, G | 2 |
| DeVita, VT | 1 |
| Goodell, B | 1 |
| Hubbard, S | 1 |
| Geelhoed, GW | 1 |
| Young, RC | 1 |
| Walzer, PD | 1 |
| Perl, DP | 1 |
| Krogstad, DJ | 1 |
| Rawson, PG | 1 |
| Schultz, MG | 1 |
| Helmer, RE | 1 |
| Wingen, FJ | 1 |
| Haen, M | 1 |
| Peters, SG | 1 |
| Prakash, UB | 1 |
1 trial available for pentamidine and Leukemia
| Article | Year |
|---|---|
Treatment of Pneumocystis carinii pneumonitis. A comparative trial of sulfamethoxazole-trimethoprim v pentamidine in pediatric patients with cancer: report from the Children's Cancer Study Group.
Topics: Acute Disease; Adolescent; Adult; Amidines; Child; Child, Preschool; Clinical Trials as Topic; Drug | 1984 |
11 other studies available for pentamidine and Leukemia
| Article | Year |
|---|---|
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity.
Topics: Animals; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Leukemia; Macrophages; Meth | 2015 |
Aerodigestive adverse effects during intravenous pentamidine infusion for Pneumocystis jirovecii pneumonia prophylaxis.
Topics: Adolescent; Adult; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Child, | 2021 |
Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
Topics: Binding, Competitive; Catalytic Domain; Cell Line, Tumor; Cell Membrane Permeability; Cell Prolifera | 2014 |
Failure of intravenous pentamidine prophylaxis to prevent pneumocystis pneumonia in a pediatric hematopoietic stem cell transplant (HSCT) patient.
Topics: Acute Disease; Antibiotic Prophylaxis; Disease Progression; Fatal Outcome; Hematopoietic Stem Cell T | 2006 |
The in vitro activity of Vernonia amygdalina on Leishmania aethiopica.
Topics: Animals; Biological Assay; Cell Line; Chloroform; Colorimetry; Drug Evaluation, Preclinical; Ethiopi | 1993 |
Pentamidine aerosol for prophylaxis of Pneumocystis carinii pneumonia after BMT.
Topics: Administration, Inhalation; Adult; Bone Marrow Transplantation; Female; Hodgkin Disease; Humans; Leu | 1993 |
Pneumocystis pneumonia in patients with cancer: clinical setting.
Topics: Adrenal Cortex Hormones; Diagnosis, Differential; Humans; Immunologic Deficiency Syndromes; Immunosu | 1976 |
Pneumocystis carinii pneumonia in the United States: epidemiologic, diagnostic, and clinical features.
Topics: Adolescent; Adult; Age Factors; Aged; Black People; Child; Child, Preschool; Female; Humans; Immunol | 1976 |
Hazard of folinic acid with pyrimethamine and sulfadiazine.
Topics: Amidines; Drug Combinations; Drug Interactions; Humans; Leucovorin; Leukemia; Pentamidine; Pneumonia | 1975 |
[Initial experiences with pentamidine aerosol in prevention of Pneumocystis carinii pneumonia following bone marrow transplantation].
Topics: Administration, Inhalation; Adolescent; Adult; Bone Marrow Transplantation; Humans; Leukemia; Lympho | 1990 |
Pneumocystis carinii pneumonia. Review of 53 cases.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Drug Combinations; Female; Humans; Leuk | 1987 |