pentamidine has been researched along with Infections, Plasmodium in 10 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a case of East-African trypanosomiasis (EAT) in a 56-year-old Dutch woman returning from holiday in Tanzania and Kenya." | 1.48 | A case of delayed diagnosis of East-African trypanosomiasis in a Dutch traveller. ( Hanssen, JLJ; Scheper, H; van Lieshout, L; Visser, LG; Wijsman, CA, 2018) |
| " The orally bioavailable lead imidazolopiperazine confers complete causal prophylactic protection (15 milligrams/kilogram) in rodent models of malaria and shows potent in vivo blood-stage therapeutic activity." | 1.37 | Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. ( Barnes, SW; Bonamy, GM; Bopp, SE; Borboa, R; Bright, AT; Chatterjee, A; Che, J; Cohen, S; Dharia, NV; Diagana, TT; Fidock, DA; Froissard, P; Gagaring, K; Gettayacamin, M; Glynne, RJ; Gordon, P; Groessl, T; Kato, N; Kuhen, KL; Lee, MC; Mazier, D; McNamara, CW; Meister, S; Nagle, A; Nam, TG; Plouffe, DM; Richmond, W; Roland, J; Rottmann, M; Sattabongkot, J; Schultz, PG; Tuntland, T; Walker, JR; Winzeler, EA; Wu, T; Zhou, B; Zhou, Y, 2011) |
| " Six compounds, including 2,5-bis(4-guanylphenyl)furan (4) and its 3-chloro (32), 3,4-dichloro (31), 3-methyl (25), 3,4-dimethyl (20), and 3-chloro-4-methyl (38) derivatives, produced cures in mice at submilligram dosage levels; the 3,4-dimethyl (20) analogue exhibited a prolonged curative effect providing protection for 30 days after a single dose against a challenge by T." | 1.26 | Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)furans. ( Boykin, DW; Das, BP, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Das, BP | 1 |
| Boykin, DW | 1 |
| Rodríguez, F | 1 |
| Rozas, I | 1 |
| Kaiser, M | 1 |
| Brun, R | 1 |
| Nguyen, B | 1 |
| Wilson, WD | 1 |
| García, RN | 1 |
| Dardonville, C | 1 |
| Reid, CM | 1 |
| Ebikeme, C | 1 |
| Barrett, MP | 1 |
| Patzewitz, EM | 1 |
| Müller, S | 1 |
| Robins, DJ | 1 |
| Sutherland, A | 1 |
| Plouffe, D | 1 |
| Brinker, A | 1 |
| McNamara, C | 1 |
| Henson, K | 1 |
| Kato, N | 2 |
| Kuhen, K | 1 |
| Nagle, A | 2 |
| Adrián, F | 1 |
| Matzen, JT | 1 |
| Anderson, P | 1 |
| Nam, TG | 2 |
| Gray, NS | 1 |
| Chatterjee, A | 2 |
| Janes, J | 1 |
| Yan, SF | 1 |
| Trager, R | 1 |
| Caldwell, JS | 1 |
| Schultz, PG | 2 |
| Zhou, Y | 2 |
| Winzeler, EA | 2 |
| Patil, V | 1 |
| Guerrant, W | 1 |
| Chen, PC | 1 |
| Gryder, B | 1 |
| Benicewicz, DB | 1 |
| Khan, SI | 1 |
| Tekwani, BL | 1 |
| Oyelere, AK | 1 |
| Meister, S | 1 |
| Plouffe, DM | 1 |
| Kuhen, KL | 1 |
| Bonamy, GM | 1 |
| Wu, T | 1 |
| Barnes, SW | 1 |
| Bopp, SE | 1 |
| Borboa, R | 1 |
| Bright, AT | 1 |
| Che, J | 1 |
| Cohen, S | 1 |
| Dharia, NV | 1 |
| Gagaring, K | 1 |
| Gettayacamin, M | 1 |
| Gordon, P | 1 |
| Groessl, T | 1 |
| Lee, MC | 1 |
| McNamara, CW | 1 |
| Fidock, DA | 1 |
| Richmond, W | 1 |
| Roland, J | 1 |
| Rottmann, M | 1 |
| Zhou, B | 1 |
| Froissard, P | 1 |
| Glynne, RJ | 1 |
| Mazier, D | 1 |
| Sattabongkot, J | 1 |
| Tuntland, T | 1 |
| Walker, JR | 1 |
| Diagana, TT | 1 |
| Wijsman, CA | 1 |
| Hanssen, JLJ | 1 |
| Scheper, H | 1 |
| Visser, LG | 1 |
| van Lieshout, L | 1 |
| Fleischer, NK | 1 |
| Braendli, B | 1 |
| Dankwa, E | 1 |
| Junghanss, T | 1 |
| Nightingale, SL | 1 |
1 review available for pentamidine and Infections, Plasmodium
| Article | Year |
|---|---|
[Central nervous system involvement in parasitic tropical diseases].
Topics: Adult; Blood-Brain Barrier; Central Nervous System Diseases; Cysticercosis; Female; Hartmannella; Hu | 1979 |
1 trial available for pentamidine and Infections, Plasmodium
| Article | Year |
|---|---|
From the Food and Drug Administration.
Topics: Adenocarcinoma; Amidines; Anemia; Antimalarials; Clinical Trials as Topic; Colonic Neoplasms; Erythr | 1989 |
8 other studies available for pentamidine and Infections, Plasmodium
| Article | Year |
|---|---|
Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)furans.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Furans; Malaria; Mice; Plasmodium berghei; Structure-A | 1977 |
New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity.
Topics: Animals; Antimalarials; Cell Line; DNA; Female; Guanidines; Hemeproteins; Hemin; Imidazolines; Malar | 2008 |
Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles.
Topics: Animals; Antiprotozoal Agents; Aza Compounds; Humans; Kidney; Macrocyclic Compounds; Malaria; Models | 2008 |
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
Topics: Animals; Antimalarials; Cluster Analysis; Computational Biology; Drug Evaluation, Preclinical; Drug | 2008 |
Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group.
Topics: Antimalarials; Antiprotozoal Agents; Histone Deacetylase Inhibitors; Histone Deacetylases; Leishmani | 2010 |
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
Topics: Animals; Antimalarials; Cell Line, Tumor; Drug Discovery; Drug Evaluation, Preclinical; Drug Resista | 2011 |
A case of delayed diagnosis of East-African trypanosomiasis in a Dutch traveller.
Topics: Animals; Delayed Diagnosis; Diagnosis, Differential; Female; Humans; Kenya; Malaria; Middle Aged; Ne | 2018 |
[East African sleeping sickness (Trypanosoma rhodesiense infection) in 2 Swiss travelers to the tropics].
Topics: Adult; Animals; Diagnosis, Differential; Humans; Malaria; Male; Pentamidine; Rwanda; Switzerland; Tr | 1990 |