pentamidine has been researched along with Electrocardiogram QT Prolonged in 6 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pentamidine is an antiprotozoal compound that clinically causes acquired long QT syndrome (acLQTS), which is associated with prolonged QT intervals, tachycardias, and sudden cardiac arrest." | 3.78 | Molecular determinants of pentamidine-induced hERG trafficking inhibition. ( Dennis, AT; Deschenes, I; Ficker, E; Nassal, D; Wan, H; Wang, L, 2012) |
| " Taken together, our data imply that chronic administration of pentamidine at clinically relevant exposure reduces the membrane expression of the hERG channel, which may most likely be the major mechanism of QT prolongation and torsade de pointes reported in man." | 1.33 | Pentamidine reduces hERG expression to prolong the QT interval. ( Bradley, JA; Chen, X; Cordes, JS; Lloyd, DB; Opsahl, AC; Sun, Z; Tengowski, MW; Zhou, J, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goineau, S | 1 |
| Castagné, V | 1 |
| Dennis, AT | 2 |
| Wang, L | 2 |
| Wan, H | 1 |
| Nassal, D | 1 |
| Deschenes, I | 1 |
| Ficker, E | 2 |
| Kuryshev, YA | 1 |
| Hawryluk, P | 1 |
| Wible, BA | 1 |
| Brown, AM | 1 |
| Kang, J | 1 |
| Chen, XL | 1 |
| Sawamura, K | 1 |
| Reynolds, W | 1 |
| Rampe, D | 1 |
| Eckhardt, LL | 1 |
| Rajamani, S | 1 |
| January, CT | 1 |
| Cordes, JS | 1 |
| Sun, Z | 1 |
| Lloyd, DB | 1 |
| Bradley, JA | 1 |
| Opsahl, AC | 1 |
| Tengowski, MW | 1 |
| Chen, X | 1 |
| Zhou, J | 1 |
| Thalhammer, C | 1 |
| Bogner, JR | 1 |
| Lohmöller, G | 1 |
6 other studies available for pentamidine and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Proarrhythmic risk assessment using conventional and new in vitro assays.
Topics: Action Potentials; Anti-Arrhythmia Agents; Arsenic; Dose-Response Relationship, Drug; Drug Discovery | 2017 |
Molecular determinants of pentamidine-induced hERG trafficking inhibition.
Topics: Antiprotozoal Agents; Binding Sites; Endoplasmic Reticulum; Ether-A-Go-Go Potassium Channels; Humans | 2012 |
Pentamidine-induced long QT syndrome and block of hERG trafficking.
Topics: Action Potentials; Animals; Antifungal Agents; Biological Transport; Cation Transport Proteins; Cell | 2005 |
Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome.
Topics: Antiprotozoal Agents; Humans; Long QT Syndrome; Myocardium; Pentamidine; Potassium Channels, Voltage | 2005 |
Pentamidine reduces hERG expression to prolong the QT interval.
Topics: Animals; Antiprotozoal Agents; Cell Line; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; | 2005 |
Chronic pentamidine aerosol prophylaxis does not induce QT prolongation.
Topics: Administration, Inhalation; Adult; Aerosols; AIDS-Related Opportunistic Infections; Cross-Sectional | 1993 |